Age associated increase of single-stranded regions in the DNA of mouse brain and liver cells.

abstract：:The extracellular matrix (ECM) is an intricate network that provides structural and anchoring support to cells in order to stabilize cell morphology and tissue architecture. The ECM also controls many aspects of the cell's dynamic behavior and fate through its ongoing, bidirectional interaction with cells. These inter...

journal_title：Mechanisms of ageing and development

authors： De Luca M

更新日期：2019-01-01 00:00:00

abstract：:The age-related studies of chromatin and DNA has attracted significant interest in recent years. However, individual works describe only some and a few of the many changes of chromatin. It is often difficult to decide whether these changes have secondary or primary nature. The overview of these studies makes it possib...

journal_title：Mechanisms of ageing and development

authors： Medvedev ZA

更新日期：1984-12-01 00:00:00

abstract：:As a prerequisite to investigating the specification and differentiation of cardiac tissue in vitro, the ontogeny of a number of putative cardiac-specific, and striated muscle-specific gene transcripts has been studied. The probes used include cDNAs of alpha-actins, myosin heavy chains, myosin light chains, alpha-trop...

journal_title：Mechanisms of ageing and development

authors： Murrell WG,Masters CJ,Willis RJ,Crane DI

更新日期：1994-12-16 00:00:00

abstract：:Considerable amount of data has accumulated during the past few years showing several changes in gene expression as a function of age. However, the basic mechanism of aging still remains poorly understood. In this review, we have mainly analysed the data pertaining to the hypothesis that aging is associated with genet...

journal_title：Mechanisms of ageing and development

authors： Thakur MK,Oka T,Natori Y

更新日期：1993-01-01 00:00:00

abstract：:This review addresses a novel facet of human T cell biology that constitutes a fundamental problem for long-term maintenance of immunological memory against viruses. The finite proliferative capacity of human T lymphocytes is sufficiently great to accommodate the waves of clonal expansion associated with primary and e...

journal_title：Mechanisms of ageing and development

authors： Effros RB

更新日期：2000-12-20 00:00:00

abstract：:Age is the only one non-modifiable risk of cerebral ischemia. Advances in stroke medicine and behavioral adaptation to stroke risk factors and comorbidities was successful in decreasing stroke incidence and increasing the number of stroke survivors in western societies. Comorbidities aggravates the outcome after cereb...

journal_title：Mechanisms of ageing and development

authors： Popa-Wagner A,Petcu EB,Capitanescu B,Hermann DM,Radu E,Gresita A

更新日期：2020-09-01 00:00:00

abstract：:We examined physiological changes in CD5(+) B lymphocytes in mice associated with aging (from 1 or 5 to 50 weeks of age). The most predominant populations of lymphocytes among these mice were mainly CD5(-) B cells in the spleen and peritoneal cavity, and T cells in the thymus. However, in the spleen, CD5(+) B cells in...

journal_title：Mechanisms of ageing and development

authors： Watanabe K,Watanabe M,Maruoka H,Amino N,Iwatani Y

更新日期：2001-10-01 00:00:00

abstract：:Lipid peroxidation, one of the most common expressions of oxidative stress, may be altered during normal physiological states including development. We have examined the changes in lipid peroxidation in rat brain, a tissue highly susceptible to oxidative damage, during this physiological state. In vivo lipid peroxidat...

journal_title：Mechanisms of ageing and development

authors： Pushpendran CK,Subramanian M,Devasagayam TP

更新日期：1994-03-01 00:00:00

abstract：:Neurons that degenerate in the brains of persons with Alzheimer's disease accumulate mitochondrial amyloid precursor protein (APP), which is thought to negatively affect mitochondrial function and cellular homeostasis. Because proteins that enter mitochondria require assistance from chaperone proteins, we hypothesized...

journal_title：Mechanisms of ageing and development

authors： Yang TT,Hsu CT,Kuo YM

更新日期：2009-09-01 00:00:00

abstract：:Elastase and lipid levels of the plasmas of subjects and of those who have suffered a stroke have been measured, and it has been shown that the normal age related fall in elastase content is mirrored more closely by the fall in high density lipoprotein cholesterol than by changes in total cholesterol. After a stroke a...

journal_title：Mechanisms of ageing and development

authors： Hall DA,Elridi SS,Zajac A,Middleton RS

更新日期：1980-11-01 00:00:00

abstract：:Senescence is a biological process that induces a permanent cell cycle arrest and a specific gene expression program in response to various stressors. Following studies over the last few decades, the concept of senescence has evolved from an antiproliferative mechanism in cancer (oncogene-induced senescence) to a crit...

journal_title：Mechanisms of ageing and development

authors： Engler M,Fidan M,Nandi S,Cirstea IC

更新日期：2020-12-09 00:00:00

abstract：:The aim of the present study was to measure protein synthesis in regenerating liver and to evaluate the impact of malnutrition in young and old rats. Two groups of male Wistar rats were used: young rats (4 months old) and old rats (18 months old). The rats were allocated to malnutrition or ordinary food intake for 1 w...

journal_title：Mechanisms of ageing and development

authors： Carrillo MC,Carnovale CE,Favre C,Monti JA,Scapini C

更新日期：1996-10-04 00:00:00

abstract：:In the present study, a number of physiological and behavioral measures that are related to metabolism were continuously monitored in 19-month-old male Fischer 344 rats that were fed ad libitum or fed a caloric restricted diet. Caloric restricted rats ate fewer meals but consumed more food during each meal and spent m...

journal_title：Mechanisms of ageing and development

authors： Duffy PH,Feuers RJ,Leakey JA,Nakamura K,Turturro A,Hart RW

更新日期：1989-05-01 00:00:00

abstract：:The decline in phytohemagglutinin (PHA) responsiveness of spleen cells from aged mice was studied in an effort to determine the nature of the depressed PHA reactivity. The reduced response of DNA synthesis (thymidine incorporation) to PHA stimulation could not be attributed to a decreased viability of spleen lymphocyt...

journal_title：Mechanisms of ageing and development

authors： Hung CY,Perkins EH,Yang WK

更新日期：1975-01-01 00:00:00

abstract：:Morphometric comparison of freeze-fractured mitochondria in flight muscles of adult (37-day-old) and old (68-day-old) houseflies revealed a 28% decrease of cristae in the old flies. The major membrane change with age was an increase in the 90-120-A particles in the inner membrane external face concomitant with a loss ...

journal_title：Mechanisms of ageing and development

authors： Turturro A,Shafiq SA

更新日期：1981-06-01 00:00:00

abstract：:This paper presents evidence derived from the selective use of codons in ca. 40 eukaryotic genes (or messages derived from them) that codon usage is one of the most conserved features of messages for specific cell products. The theory has been developed by several investigations that the kinds of products of many if n...

journal_title：Mechanisms of ageing and development

authors： Strehler B,North D

更新日期：1982-04-01 00:00:00

abstract：:The purpose of the present study was to investigate the effect of aging on silica-induced lung toxicity. In young animals silica induced a significant increase in bronchoalveolar lavage tumor necrosis factor-alpha (TNF), lactate dehydrogenase as well as in cell numbers, which correlate with increased collagen depositi...

journal_title：Mechanisms of ageing and development

authors： Corsini E,Giani A,Peano S,Marinovich M,Galli CL

更新日期：2004-02-01 00:00:00

abstract：:We have isolated a new type of Paramecium tetraurelia mutant, named rie-2, that has a long immaturity period until autogamy. We previously isolated such an autogamy mutant, designated rie-1. These two mutants had some additional common features such as dependence of the occurrence of autogamy on the temperature, invol...

journal_title：Mechanisms of ageing and development

authors： Komori R,Sato H,Harumoto T,Takagi Y

更新日期：2005-06-01 00:00:00

abstract：:A population of 291 healthy North American Black subjects of different ages was studied for immunoglobulin (Ig) allotypes and the prevalence of autoantibodies, to determine possible associations between Ig allotypes and age, autoantibodies and age, and Ig allotypes and autoantibodies. Indirect immunofluorescence was u...

journal_title：Mechanisms of ageing and development

authors： Ockhuizen T,Pandey JP,Galbraith GM,Fudenberg HH,Hames CG

更新日期：1982-06-01 00:00:00

abstract：:Activity of (Na+,K+)ATP-ase measured by means of influx of 86Rb was compared in lymphocytes from young, middle-age and old people. It was found that the (sensitive to ouabain) activity of (Na+,K+)ATPase was significantly diminished in the lymphocytes from aged subjects. ...

journal_title：Mechanisms of ageing and development

authors： Witkowski JM,Mysliwski A,Mysliwska J

更新日期：1985-12-01 00:00:00

abstract：:The impairment of brown adipose tissue (BAT) thermogenic activity with aging has been well documented. The current study investigated the effect of swimming training on BAT activity in 2-month-old (young) and 26-month-old (old) male mice. The trained mice underwent a 6-week swimming program (1 h/day, 5 days/week) in w...

journal_title：Mechanisms of ageing and development

authors： Oh-ishi S,Kizaki T,Toshinai K,Haga S,Fukuda K,Nagata N,Ohno H

更新日期：1996-08-15 00:00:00

abstract：:Food restriction is known to ameliorate many of the adverse physiologic effects of age. In this study, we have examined the effect of food restriction on the induction of the gluconeogenic enzyme, phosphoenolpyruvate carboxykinase (PEPCK) in liver and kidney following a 12-h fasting period in young (6 month) and old (...

journal_title：Mechanisms of ageing and development

authors： Van Remmen H,Ward WF

更新日期：1998-09-01 00:00:00

abstract：:Hepatocytes isolated from 6-, 12-, 18-, and 30-month-old female Fischer F344 rats were examined by scanning electron microscopy. No significant change in cell size with age was observed. However, the surface morphology of the cells isolated from the older animals exhibited a significant increase in surface folds. This...

journal_title：Mechanisms of ageing and development

authors： Engelmann GL,Richardson A,Katz A,Fierer JA

更新日期：1981-01-01 00:00:00

abstract：:The steroid hormone ecdysone influences Drosophila lifespan. Longevity is extended in mutants deficient for ecdysone synthesis or mutants of the ecdysone receptor (EcR). However, the underlying mechanisms remain unclear. Here we conditionally inactivated EcR by RNA interference or expression of dominant negative forms...

journal_title：Mechanisms of ageing and development

authors： Tricoire H,Battisti V,Trannoy S,Lasbleiz C,Pret AM,Monnier V

更新日期：2009-08-01 00:00:00

abstract：:Because muscle satellite cells have been implicated in the process of muscle growth and mass regulation, as well as regeneration, alterations in the capacity of satellite cells to differentiate and accumulate muscle specific proteins during aging could play a role in the process of senile muscle atrophy. Skeletal musc...

journal_title：Mechanisms of ageing and development

authors： Allen RE,McAllister PK,Masak KC,Anderson GR

更新日期：1982-01-01 00:00:00

abstract：:Oxidative damage to macromolecules, including lipids, has been hypothesized as a mechanism of aging. One end product of lipid peroxidation, malondialdehyde (MDA), is often quantified as a measure of oxidative damage to lipids. We used a commercial colorimetric assay for MDA (Bioxytech LPO-586, Oxis International, Port...

journal_title：Mechanisms of ageing and development

authors： Gerhard GS,Kaufmann EJ,Wang X,Erikson KM,Abraham J,Grundy M,Beard JL,Chorney MJ

更新日期：2002-01-01 00:00:00

abstract：:To gain insight into the anti-ageing mechanisms of caloric restriction (CR), liver mitochondria were isolated from male Brown-Norway rats of different ages (fully fed control and CR) and various specific markers of non-enzymatic protein modification (by oxidative, glyco- and lipoxidative-reactions) were measured by GC...

journal_title：Mechanisms of ageing and development

authors： Lambert AJ,Portero-Otin M,Pamplona R,Merry BJ

更新日期：2004-08-01 00:00:00

abstract：:The responses of the left and right ventricles (LV and RV) to physical conditioning in cold (25 degrees C) and thermoneutral temperatures (35 degrees C), with special reference to lactate dehydrogenase (LDH) and its isoenzyme profile, were studied in the 2-month (young)- and 12-month (middle-aged)-old rats. Moderate h...

journal_title：Mechanisms of ageing and development

authors： Prathima S,Devi SA

更新日期：1999-04-01 00:00:00

abstract：:The functional deterioration of an organism with age causes the major problem of maintaining the quality of life at old age. Degenerative changes in the organism may to some extent reflect alterations that can be observed in cells during in vitro replicative senescence. At the cellular level, the receptor-mediated end...

journal_title：Mechanisms of ageing and development

authors： Park SC

更新日期：2002-04-30 00:00:00

abstract：:Researchers and clinicians interested in human diseases of DNA repair deficiency and premature aging gathered at the National Conference Center in Lansdowne, Virginia on 5-8 September 2006 to attend a workshop co-organized by Vilhelm Bohr (National Institute of Aging) and Kenneth Kraemer (National Cancer Institute). A...

journal_title：Mechanisms of ageing and development

authors： Kraemer KH,Sander M,Bohr VA

更新日期：2007-02-01 00:00:00