Current status of age altered enzymes: alternative mechanisms.

abstract：:Expression of dystrophin and the dystrophin-related protein utrophin has been studied in the human fetal brain both in vivo and in vitro. Results showed that both these proteins were developmentally regulated, even if their expression followed a different pattern. Utrophin was found since very early stages of developm...

journal_title：Mechanisms of ageing and development

authors： Sogos V,Curto M,Reali C,Gremo F

更新日期：2002-03-15 00:00:00

abstract：:Changes in glycosaminoglycans during in vitro aging were investigated in human diploid fibroblasts. The cells were found to produce predominantly hyaluronate and smaller amounts of chondroitin 4-sulfate, chondroitin 6-sulfate, dermatan sulfate and heparan sulfate. Accumulation of heparan sulfate on the cell surface wa...

journal_title：Mechanisms of ageing and development

authors： Matuoka K,Mitsui Y

更新日期：1981-02-01 00:00:00

abstract：:To test the validity of estimating age-related changes in rat liver nuclear RNA synthesis by following the incorporation of radioactive nucleotides into an acid-insoluble product, age-related changes in endogenous nucleotide concentration were investigated. Both the total nucleotide and the nucleoside monophosphate (N...

journal_title：Mechanisms of ageing and development

authors： Bolla RI,Miller JK

更新日期：1980-02-01 00:00:00

abstract：:Healthy elderly (80+/-5 years) with different nutritional status were compared to young healthy adults (25+/-5 years) to quantify the relative influences of aging and nutrition on immune response. Aged persons, without alteration of their nutritional status, had lower CD3+, CD8+, and CD45RA+ as well as higher CD2+CD3-...

journal_title：Mechanisms of ageing and development

authors： Mazari L,Lesourd BM

更新日期：1998-08-01 00:00:00

abstract：:The data concerning the effects of age on the brainstem are scarce and few works are devoted to the human vestibular nuclear complex. The study of the effects of aging in the vestibular nuclei could have clinical interest due to the high prevalence of balance control and gait problems in the elderly. We have used in t...

journal_title：Mechanisms of ageing and development

authors： Alvarez JC,Díaz C,Suárez C,Fernández JA,González del Rey C,Navarro A,Tolivia J

更新日期：2000-04-14 00:00:00

abstract：:The effect of aging on patterns of food intake and nutrient selection was investigated using a longitudinal study. Male (n = 10) and female (n = 10) Wistar-Lou rats from 4 to 28 months of age were repeatedly submitted to a macronutrient self-selection (S-S) regimen while controls were maintained under a standard chow ...

journal_title：Mechanisms of ageing and development

authors： Veyrat-Durebex C,Boghossian S,Alliot J

更新日期：1998-07-15 00:00:00

abstract：:Age-dependent renal damage is influenced by genetic background and the Fisher344xBrown Norway (F344xBN) rat is resistant to glomerular injury. In vulnerable strains, a fall in renal nitric oxide synthase (NOS) contributes to age-dependent renal damage. Here, we investigated renal NOS in young (3 months) and old (30 mo...

journal_title：Mechanisms of ageing and development

authors： Moningka NC,Sasser JM,Croker B,Carter C,Baylis C

更新日期：2011-01-01 00:00:00

abstract：:Replicative senescence in human diploid fibroblasts is characterised by an exhaustion of proliferative potential and permanent cell cycle arrest. During senescence, telomere shortening-generated DNA damage activates p53 pathway that upregulates cell cycle inhibitors, such as p21. Human p400 ATPase is a chromatin remod...

journal_title：Mechanisms of ageing and development

authors： Lee K,Lau ZZ,Meredith C,Park JH

更新日期：2012-11-01 00:00:00

abstract：:In this paper we examined the impact of age on cognitive functions and the age-related modifications of egr1 expression, an inducible transcription factor with a confirmed role in synaptic plasticity and regulation of the proteasome activity, on pet dogs. Additionally, we examined the age-related changes of some eleme...

journal_title：Mechanisms of ageing and development

authors： Ghi P,Di Brisco F,Dallorto D,Osella MC,Orsetti M

更新日期：2009-05-01 00:00:00

abstract：:The purpose of this research is to determine possible causes and mechanisms involved in the age-associated decline in mitochondrial activity. We have focused on cytochrome c oxidase because it is comprised of both nuclear and mitochondrial-encoded subunits and may provide some insight into the coordination of the two ...

journal_title：Mechanisms of ageing and development

authors： Hudson EK,Tsuchiya N,Hansford RG

更新日期：1998-06-15 00:00:00

abstract：:Quantitative methods for the study of aging in single organisms of the suctorian protozoan Tokophrya infusionum are described. New cell lines are initiated by metamorphosis of a ciliated embryo to form a sessile adult. The life history of adult cells consists of a sequence of age-related stages, culminating in cessati...

journal_title：Mechanisms of ageing and development

authors： Karakashian SJ,Lanners HN,Rudzinska MA

更新日期：1984-08-01 00:00:00

abstract：:In most species, females live longer than males. An understanding of this female longevity advantage will likely uncover novel anti-aging therapeutic targets. Here we investigated the transcriptomic responses in the hypothalamus - a key organ for somatic aging control - to the introduction of a simple aging-related mo...

journal_title：Mechanisms of ageing and development

authors： van Gastel J,Cai H,Cong WN,Chadwick W,Daimon C,Leysen H,Hendrickx JO,De Schepper R,Vangenechten L,Van Turnhout J,Verswyvel J,Becker KG,Zhang Y,Lehrmann E,Wood WH 3rd,Martin B,Maudsley S

更新日期：2019-12-01 00:00:00

abstract：:The release of cytokines is of crucial importance in the regulation of the type and magnitude of the immune response in the elderly. A number of studies have shown different levels of cytokine production in the elderly. In the present study, a range of polymorphisms were chosen within the genes of cytokines (IL-2, IL-...

journal_title：Mechanisms of ageing and development

authors： Ross OA,Curran MD,Meenagh A,Williams F,Barnett YA,Middleton D,Rea IM

更新日期：2003-02-01 00:00:00

abstract：:One to 24 month old rats were anesthetized with alpha-chloralose, their cerebral cortices exposed surgically and subjected in vivo to stimulation by norepinephrine (1.0mM for 5 minutes) or electrical pulses (100 pulses/s for 10 s). After microwave fixation, cortical samples were analyzed for cyclic-AMP by the Gilman m...

journal_title：Mechanisms of ageing and development

authors： Berg A,Zimmerman ID

更新日期：1975-09-01 00:00:00

abstract：:Oxidative stress may contribute to the cellular alterations, which occur as the result of aging, and the nervous system is particularly vulnerable to aging associated oxidative injury. The multicatalytic proteasome (MCP) is responsible for the majority of protein degradation and is sensitive to oxidative stress. To de...

journal_title：Mechanisms of ageing and development

authors： Keller JN,Hanni KB,Markesbery WR

更新日期：2000-01-24 00:00:00

abstract：:The intralobular distribution of three lysosomal enzymes, acid phosphatase, N-acetyl-beta-D-glucosaminidase, and beta-D-glucuronidase, was investigated in hepatocytes of 3-, 12-, 24-, and 36-month-old rats. The distribution pattern changed with age. In young rats, the activity was higher in the peripheral area than in...

journal_title：Mechanisms of ageing and development

authors： van Manen R,de Priester W,Knook DL

更新日期：1983-06-01 00:00:00

abstract：:The effect of the oral administration of 0.150 mg/m2 clonidine on the plasma level of human growth hormone (hGH) was studied in 53 adults (25 males and 28 females) aged from 28 to 68 years, of which 15 were healthy volunteers and 38 were hypertensive. Both the normal and hypertensive subjects of both sexes showed an a...

journal_title：Mechanisms of ageing and development

authors： Gil-Ad I,Gurewitz R,Marcovici O,Rosenfeld J,Laron Z

更新日期：1984-09-01 00:00:00

abstract：:The basic genetic defect in the Hutchinson-Gilford Progeria Syndrome (progeria), a premature aging syndrome, is unknown. To investigate possible defects in hyaluronic acid (HA) metabolism in this disease, the urinary excretion of HA was studied. Urine specimens from 11 patients with this disorder were examined for HA ...

journal_title：Mechanisms of ageing and development

authors： Zebrower M,Kieras FJ,Brown WT

更新日期：1986-06-01 00:00:00

abstract：:Nearly 40 years ago it was proposed that accumulation of mutations or increased levels of DNA damage might contribute to aging processes. Despite several correlative studies in this area, the answer as to whether genomic integrity contributes to aging has remained illusive. More recently it has been hypothesized that ...

journal_title：Mechanisms of ageing and development

authors： Walter CA,Grabowski DT,Street KA,Conrad CC,Richardson A

更新日期：1997-12-01 00:00:00

abstract：:A comparison was made of the resting membrane potential (MP) as well as the MP responses to K+, ACTH and gamma-MSH of superfused adrenocortical, zona fasciculata cells from young (Y) and old (O) male rats. The resting MP of these cells did not vary with age. However, the MP responses to altered extracellular [K+] vari...

journal_title：Mechanisms of ageing and development

authors： Lymangrover JR,Valego NK,Shilling RD

更新日期：1988-06-01 00:00:00

abstract：:There are multiple lines of evidence showing that oxidative stress and aberrant mitogenic signaling play an important role in the pathogenesis of Alzheimer disease. However, the chronological relationship between these and other events associated with disease pathogenesis is not known. Given the important role that mi...

journal_title：Mechanisms of ageing and development

authors： Zhu X,Castellani RJ,Takeda A,Nunomura A,Atwood CS,Perry G,Smith MA

更新日期：2001-12-01 00:00:00

abstract：:It has been approximately 25 years since Dr. Rosenberg first brought attention to sarcopenia. To date, this aging-associated condition is recognized as a chronic loss of muscle mass and is usually accompanied by dynapenia. Despite its poly-etiological factors, sarcopenia has a strong neurogenic component underlying th...

journal_title：Mechanisms of ageing and development

authors： Kwan P

更新日期：2013-09-01 00:00:00

abstract：:The present study examined the effect of repeated vaccination and of dehydroepiandrosterone (DHEA) treatment on the immune response to influenza vaccine in elderly subjects. Seventy-one elderly volunteers, aged 61-89 years, enrolled in a prospective randomized, double-blind study to receive either DHEA (50 mg qd p.o. ...

journal_title：Mechanisms of ageing and development

authors： Ben-Yehuda A,Danenberg HD,Zakay-Rones Z,Gross DJ,Friedman G

更新日期：1998-05-15 00:00:00

abstract：:The purpose of this study was to test the hypothesis that regular exercise training in elderly people affects the type 1/type 2 balance. Nine elderly women who train by walking (mean+/-S.E.M., age 63+/-1 years, VO2 peak 32.2+/-1.0 ml kg(-1) min(-1)), 12 age-matched untrained women (63+/-1 years, 27.8+/-0.9 ml kg(-1) m...

journal_title：Mechanisms of ageing and development

authors： Ogawa K,Oka J,Yamakawa J,Higuchi M

更新日期：2003-08-01 00:00:00

abstract：:Putrescine, spermidine, spermine and two unknowns designated as A and B were detected in first seedling leaves of barley (Hordeum vulgare L. var. Wolfe). The levels of these polyamines in first seedling leaves from 4-day-old barley plants grown in darkness or in light were comparable and did not change significantly a...

journal_title：Mechanisms of ageing and development

authors： Srivastava BI

更新日期：1987-09-14 00:00:00

abstract：:Ageing of WI-38 fibroblasts in culture was used as a model in order to investigate the evolution and the alteration of the key antioxidant enzyme glutathione peroxidase. The activity of glutathione peroxidase is influenced by the presence of selenium in the culture medium and we have also shown that the specific activ...

journal_title：Mechanisms of ageing and development

authors： Pigeolet E,Remacle J

更新日期：1991-04-01 00:00:00

abstract：:It has been previously well documented that partial pressure of oxygen (PO2) and weight-specific rate of O2 consumption in chick embryo (Gallus gallus domesticus) transiently increase midway through the 21-day in ovo incubation period. The present study found that these oxidative changes were paralleled by the concent...

journal_title：Mechanisms of ageing and development

authors： Wilson JX,Lui EM,Del Maestro RF

更新日期：1992-08-01 00:00:00

abstract：:The effects of long-term caloric restriction on the hepatic phase II drug metabolizing enzymes were investigated in the male Fischer 344 rat. Rats that had been restricted to 60% of their pair-fed control consumption from 14 weeks post-partum exhibited altered conjugating enzyme activities at 22 months. Caloric restri...

journal_title：Mechanisms of ageing and development

authors： Leakey JA,Cunny HC,Bazare J Jr,Webb PJ,Lipscomb JC,Slikker W Jr,Feuers RJ,Duffy PH,Hart RW

更新日期：1989-05-01 00:00:00

abstract：:In agreement with previous studies we show an age-related increase in serum levels of hyaluronic acid in healthy individuals. Levels in Down's syndrome persons were slightly higher, especially in those with hypothyroidism. This provides further evidence that the normal ageing process is accelerated in Down's syndrome....

journal_title：Mechanisms of ageing and development

authors： Hutchin T,Martin L,Prasher V,Sinclair AJ

更新日期：1998-12-01 00:00:00

abstract：:Relationships between nutrition and longevity are of growing interest. Here we analysed the influences of dietary restriction on the survival of Drosophila exposed to atmospheric oxygen or to chronic hypoxia. Dietary restriction was achieved by food dilution, by sucrose restriction or by yeast restriction. Sucrose and...

journal_title：Mechanisms of ageing and development

authors： Vigne P,Frelin C

更新日期：2007-05-01 00:00:00