Age-related modifications of egr1 expression and ubiquitin-proteasome components in pet dog hippocampus.

abstract：:The process of epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) after cataract surgery contributes to tissue fibrosis, wound healing and lens regeneration via a mechanism not yet fully understood. Here, we show that tropomyosin 2 (Tpm2) plays a critical role in wound healing and lens aging. Post...

journal_title：Mechanisms of ageing and development

authors： Shibata T,Shibata S,Ishigaki Y,Kiyokawa E,Ikawa M,Singh DP,Sasaki H,Kubo E

更新日期：2018-04-01 00:00:00

abstract：:Long-Evans female rats three weeks, three months and 13-14 months of age were placed on tryptophan-deficient diets for periods ranging from a few months to nearly two years. Growth was interupted during the period of tryptophan-deficiency, but when the animals were returned to a complete diet, they gained weight and g...

journal_title：Mechanisms of ageing and development

authors： Segall PE,Timiras PS

更新日期：1976-03-01 00:00:00

abstract：:Epigenetic disruption has been implicated in many diseases of aging, and age-associated DNA methylation changes at specific genomic loci in humans are strongly correlated with chronological age. The aim of this study was to explore the specificity of selected age-associated differentially methylated positions (aDMPs) ...

journal_title：Mechanisms of ageing and development

authors： Spiers H,Hannon E,Wells S,Williams B,Fernandes C,Mill J

更新日期：2016-03-01 00:00:00

abstract：:Aflatoxin B1(AFB1)-glutathione(GSH) conjugation is the major pathway for the detoxification of aflatoxin metabolites. This reaction is catalysed by GSH S-transferase (GST) and play a major role in modulation of AFB1 adduct formation to nuclear DNA. Changes recorded in hepatic GST activity during development of rats ca...

journal_title：Mechanisms of ageing and development

authors： Allameh A,Farahani M,Zarghi A

更新日期：2000-05-18 00:00:00

abstract：:Evolution of longevity of the ungulates, carnivores and primates is reviewed. Special emphasis is focused on recent evolutionary history of longevity along the hominid ancestral-descendant sequence leading to modern man. Maximum life span potential (MLP) or the change in MLP is predicted in extinct species by (1) a ph...

journal_title：Mechanisms of ageing and development

authors： Cutler RG

更新日期：1979-02-01 00:00:00

abstract：:Morphological studies on spontaneous systemic amyloidosis were conducted on 222 senescence-accelerated mice (SAM) (P) and on 150 mice in the senescence-resistant series (R). Among the pathologic findings, amyloidosis showed the highest incidence in both SAM (79.7%) and R (32.7%). Although an extensive deposition of am...

journal_title：Mechanisms of ageing and development

authors： Takeshita S,Hosokawa M,Irino M,Higuchi K,Shimizu K,Yasuhira K,Takeda T

更新日期：1982-09-01 00:00:00

abstract：:To explore whether catecholaminergic lesions produced chemically in the nucleus tractus solitarius (NTS) would alter the baroreflex impairment that normally occurs with age, we compared baroreflex responses in 3- and 14-month-old rats given bilateral microinjections of 6-hydroxydopamine (6-OHDA) or its vehicle into th...

journal_title：Mechanisms of ageing and development

authors： Itoh H,Buñag RD

更新日期：1992-06-01 00:00:00

abstract：:Significant changes are observed in wet weight, microsomal protein content and enzymes of purified rough and smooth microsomes of liver during postnatal development and ageing of female Wistar rats. Protein content of total microsomes increases up to 15 days of age and remains steady during subsequent development, unl...

journal_title：Mechanisms of ageing and development

authors： Devasagayam TP,Pushpendran CK,Eapen J

更新日期：1983-03-01 00:00:00

abstract：:In this paper, some of the key findings of the last decade will briefly be surveyed and, where possible, be related to two separate computer simulation models which have been designed to determine the validity of certain widely accepted dogmas and to define the limits and restrictions imposed by attrition of or ambigu...

journal_title：Mechanisms of ageing and development

authors： Strehler BL,Freeman MR

更新日期：1980-09-01 00:00:00

abstract：:Food intake, body weight and serum LH, FSH, progesterone and oestradiol-17 beta were monitored from weaning to puberty in fully fed females housed in groups of four or individually and in females individually housed and dietary restricted. Restriction of food intake from weaning delayed the onset of puberty (34-39 day...

journal_title：Mechanisms of ageing and development

authors： Holehan AM,Merry BJ

更新日期：1985-11-01 00:00:00

abstract：:Oxidative stress may contribute to the cellular alterations, which occur as the result of aging, and the nervous system is particularly vulnerable to aging associated oxidative injury. The multicatalytic proteasome (MCP) is responsible for the majority of protein degradation and is sensitive to oxidative stress. To de...

journal_title：Mechanisms of ageing and development

authors： Keller JN,Hanni KB,Markesbery WR

更新日期：2000-01-24 00:00:00

abstract：:The antigen-specific antibody secretion in vitro after immunisation with the primary T-cell dependent antigen Helix pomatia Haemocyanin (HPH) was investigated in both young and elderly individuals, who all met the health admission criteria for immunogerontological studies as detailed in the SENIEUR protocol. In additi...

journal_title：Mechanisms of ageing and development

authors： De Greef GE,Van Staalduinen GJ,Van Doorninck H,Van Tol MJ,Hijmans W

更新日期：1992-01-01 00:00:00

abstract：:The present review focuses on the effect of aging on flow-mediated outward remodeling (FMR) via alterations in estrogen metabolism, oxidative stress and inflammation. In ischemic disorders, the ability of the vasculature to adapt or remodel determines the quality of the recovery. FMR, which has a key role in revascula...

journal_title：Mechanisms of ageing and development

authors： Chehaitly A,Vessieres E,Guihot AL,Henrion D

更新日期：2020-12-14 00:00:00

abstract：:We have developed a cell model for loss of differentiated gene expression in cellular aging. Over long periods in culture, bovine adrenocortical cells lose expression of a specialized gene, steroid 17 alpha-hydroxylase. The decline in expression of 17 alpha-hydroxylase in mass cultures and clones of bovine adrenocorti...

journal_title：Mechanisms of ageing and development

authors： Hornsby PJ,Yang LQ

更新日期：1991-04-01 00:00:00

abstract：:The age-dependent drop in mixed lymphocyte reactivity and responsiveness to concanavalin A of lymph node and spleen cells of C57Bl/6J female mice were studied. The relative decrease in mixed lymphocyte reactivity was shown to be the same whether mounted against H-2 or Mls incompatibile stimulator cells. The time of pe...

journal_title：Mechanisms of ageing and development

authors： Gershon H,Merhav S,Abraham C

更新日期：1979-01-01 00:00:00

abstract：:The DNA repair capabilities of cultured hepatocytes derived from five mammalian species in response to a broad range of ultraviolet light exposures were measured. Differences in the induction of DNA repair synthesis and the proportion of responding cells were noted only for the lowest fluences. These differences appea...

journal_title：Mechanisms of ageing and development

authors： Maslansky CJ,Williams GM

更新日期：1985-02-01 00:00:00

abstract：:We have examined the effects of aging on guinea pig biliary motility both in vitro and in vivo. The first experiment compared contractile tension of gallbladder strips from young adult (6-12 months old) and 3-year-old guinea pigs in vitro. Contraction of gallbladder strips from the young guinea pigs was twice as force...

journal_title：Mechanisms of ageing and development

authors： Poston GJ,Singh P,Maclellan DG,Yao CZ,Uchida T,Townsend CM Jr,Thompson JC

更新日期：1988-12-01 00:00:00

abstract：:Age-related changes in the activities of superoxide dismutase, catalase, and glutathione peroxidase were determined in brain, heart, hepatocytes, intestinal mucosa, and kidney from male Fischer F344 rats. Superoxide dismutase activity decreased significantly with age in all five tissues studied. The activity of catala...

journal_title：Mechanisms of ageing and development

authors： Rao G,Xia E,Richardson A

更新日期：1990-03-31 00:00:00

abstract：:A comprehensive study on GSH metabolism in relation to some markers of oxidative and energy status in rat cerebral cortex as a function of age was performed. Reduced GSH, total GSH and the GSH Redox Index decreased both during growth (defined as the period between 1 and 5 months) and during aging (defined as the perio...

journal_title：Mechanisms of ageing and development

authors： Iantomasi T,Favilli F,Marraccini P,Stio M,Treves C,Quattrone A,Capaccioli S,Vincenzini MT,Quatrone A corrected to Quattrone A

更新日期：1993-08-01 00:00:00

abstract：:The steroid hormone ecdysone influences Drosophila lifespan. Longevity is extended in mutants deficient for ecdysone synthesis or mutants of the ecdysone receptor (EcR). However, the underlying mechanisms remain unclear. Here we conditionally inactivated EcR by RNA interference or expression of dominant negative forms...

journal_title：Mechanisms of ageing and development

authors： Tricoire H,Battisti V,Trannoy S,Lasbleiz C,Pret AM,Monnier V

更新日期：2009-08-01 00:00:00

abstract：:Quantitative methods for the study of aging in single organisms of the suctorian protozoan Tokophrya infusionum are described. New cell lines are initiated by metamorphosis of a ciliated embryo to form a sessile adult. The life history of adult cells consists of a sequence of age-related stages, culminating in cessati...

journal_title：Mechanisms of ageing and development

authors： Karakashian SJ,Lanners HN,Rudzinska MA

更新日期：1984-08-01 00:00:00

abstract：:Tumor cells express NADPH oxidase-1 (NOX1) in their membrane and control NOX1-based intercellular reactive oxygen and nitrogen species (ROS/RNS)-dependent apoptosis-inducing signaling through membrane-associated catalase and superoxide dismutase. TREATMENT:of tumor cells with high concentrations of H2O2, peroxnitrite...

journal_title：Mechanisms of ageing and development

authors： Bauer G

更新日期：2018-06-01 00:00:00

abstract：:Experimental studies have not shown that the 'common' clinical experience, which suggests that wound healing is impaired in an old organism, is valid for healthy old experimental animals. We have developed a model in the rat for ischemic wound healing by using an H-shaped double skin flap, where the test wound is the ...

journal_title：Mechanisms of ageing and development

authors： Quirinia A,Viidik A

更新日期：1991-05-01 00:00:00

abstract：:The B cell responsiveness mediated by T cells has been evaluated in 50 aged donors by using a Pokeweed mitogen (PWM)-driven differentiation system. Peripheral blood mononuclear cells (PBMC) from aged donors exhibited a lower plaque-forming cell (PFC) generation in comparison with young donors. Similar results were obt...

journal_title：Mechanisms of ageing and development

authors： Antonaci S,Jirillo E,Gallitelli M,Garofalo AR,Bonomo L

更新日期：1987-11-01 00:00:00

abstract：:Food restriction is known to ameliorate many of the adverse physiologic effects of age. In this study, we have examined the effect of food restriction on the induction of the gluconeogenic enzyme, phosphoenolpyruvate carboxykinase (PEPCK) in liver and kidney following a 12-h fasting period in young (6 month) and old (...

journal_title：Mechanisms of ageing and development

authors： Van Remmen H,Ward WF

更新日期：1998-09-01 00:00:00

abstract：:The effects of long-term caloric restriction on the hepatic phase II drug metabolizing enzymes were investigated in the male Fischer 344 rat. Rats that had been restricted to 60% of their pair-fed control consumption from 14 weeks post-partum exhibited altered conjugating enzyme activities at 22 months. Caloric restri...

journal_title：Mechanisms of ageing and development

authors： Leakey JA,Cunny HC,Bazare J Jr,Webb PJ,Lipscomb JC,Slikker W Jr,Feuers RJ,Duffy PH,Hart RW

更新日期：1989-05-01 00:00:00

abstract：:The efficient use of nutrients is important in development and aging. In this study, we asked if the protein repair methyltransferase has a related or additional role in energy metabolism and stress response in the nematode Caenorhabditis elegans. Worms lacking the pcm-1 gene encoding this enzyme exhibit reduced longe...

journal_title：Mechanisms of ageing and development

authors： Gomez TA,Banfield KL,Clarke SG

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVES:To investigate whether systemic inflammation in acutely admitted older medical patients (age >65 years) is associated with physical performance and organ dysfunction. Organ dysfunction´s association with physical performance, and whether these associations are mediated by systemic inflammation, was also inve...

journal_title：Mechanisms of ageing and development

authors： Klausen HH,Bodilsen AC,Petersen J,Bandholm T,Haupt T,Sivertsen DM,Andersen O

更新日期：2017-06-01 00:00:00

abstract：:T cell activation involves events at the plasma membrane; therefore, molecules such as long chain omega-3 fatty acids that alter the structure of the plasma membrane may affect the activation of aged T cells. In this project we investigated whether the incorporation of omega-3 fatty acids (from fish oil), in the prese...

journal_title：Mechanisms of ageing and development

authors： VanMeter AR,Ehringer WD,Stillwell W,Blumenthal EJ,Jenski LJ

更新日期：1994-08-01 00:00:00

abstract：:The combined grafting of young bone marrow and newborn thymus performed in old mice was effective in restoring the impaired immune functions, but the same treatment performed in middle-aged adult mice had no effect on the life span of C3H/MTV female mice. Sequential multiple newborn thymus graftings starting at young ...

journal_title：Mechanisms of ageing and development

authors： Hirokawa K,Utsuyama M

更新日期：1989-07-01 00:00:00