Nutritional influences on immune response in healthy aged persons.

abstract：:To examine the effect of an aging environment on sister chromatid exchange (SCE) induction, Ehrlich ascites tumor (EAT) cells were introduced into young and old C57BL/6J mice. Background SCE levels were not significantly different in either EAT cell or normal bone marrow cell populations between young and old animals....

journal_title：Mechanisms of ageing and development

authors： Schneider EL,Lewis J

更新日期：1981-12-01 00:00:00

abstract：:To investigate the relationship between immunological potential and advance of age, patterns of humoral immune response in different aged rabbits were compared. In the primary response, the appearance of total antibody and the arrival to its peak level were retarded by advance of age. On the other hand, the appearance...

journal_title：Mechanisms of ageing and development

authors： Nomaguchi T,Okuma-Sakurai Y,Kimura I

更新日期：1976-01-01 00:00:00

abstract：:We compared cardiovascular responses to various adrenergic agonists in conscious 3-month and 12-month old rats that had been treated with propranolol daily for 7 days, to determine whether changes in beta-adrenergic hypersensitivity induced by abrupt propranolol withdrawal would differ with age. Depressor and tachycar...

journal_title：Mechanisms of ageing and development

authors： Teräväinen TL,Buñag RD

更新日期：1992-03-15 00:00:00

abstract：:Interfibrillar mitochondria (IFM) of the heart in aged Fischer 344 rats show a biochemical defect which might be reflected in their morphology. We examined by high resolution scanning electron microscopy over 5500 mitochondria to determine if a concomitant structural alteration existed. This methodology provides a mea...

journal_title：Mechanisms of ageing and development

authors： Riva A,Tandler B,Lesnefsky EJ,Conti G,Loffredo F,Vazquez E,Hoppel CL

更新日期：2006-12-01 00:00:00

abstract：:Longevity regulatory genes include the Forkhead transcription factor FOXO, in addition to NAD-dependent histone deacetylase silent information regulator 2 (Sir2). The FOXO/DAF-16 family of transcription factors constitute an evolutionarily conserved subgroup within a larger family known as winged helix or Forkhead tra...

journal_title：Mechanisms of ageing and development

authors： Xuan Z,Zhang MQ

更新日期：2005-01-01 00:00:00

abstract：:This paper is part of a series aimed to investigate the mechanism of the action of Folcysteine, a substance that has the capacity to release in the body active -SH groups and has been proved to be effective in the control of menopausal troubles. As an experimental model the ovariectomized rat, rather similar, from the...

journal_title：Mechanisms of ageing and development

authors： Moldoveanu E,Klein R,Bartoc R,Bruhis S,Oeriu I

更新日期：1975-09-01 00:00:00

abstract：:The serotonin content of platelets, serum and plasma from rats of various ages was examined. In male rats, platelet serotonin content, which was about 0.65 nmol/10(8) platelets at young age (6-7 months), increased slightly at middle age (12-14 months) but decreased markedly at old age (25-26 months). Significant diffe...

journal_title：Mechanisms of ageing and development

authors： Yonezawa Y,Kondo H,Nomaguchi TA

更新日期：1989-01-01 00:00:00

abstract：:The incidence of chronic diseases such as cardiovascular diseases is lower in Mediterranean Southern Europe than Northern Europe. This may be due to a lower level of oxidative stress and a higher antioxidant status in people living around the Mediterranean Sea. Oxidative stress may influence the rate of shortening of ...

journal_title：Mechanisms of ageing and development

authors： de Vos-Houben JM,Ottenheim NR,Kafatos A,Buijsse B,Hageman GJ,Kromhout D,Giltay EJ

更新日期：2012-06-01 00:00:00

abstract：:The steroid hormone ecdysone influences Drosophila lifespan. Longevity is extended in mutants deficient for ecdysone synthesis or mutants of the ecdysone receptor (EcR). However, the underlying mechanisms remain unclear. Here we conditionally inactivated EcR by RNA interference or expression of dominant negative forms...

journal_title：Mechanisms of ageing and development

authors： Tricoire H,Battisti V,Trannoy S,Lasbleiz C,Pret AM,Monnier V

更新日期：2009-08-01 00:00:00

abstract：:The various phases of homo- and heteroclonal encounters between stolons of Podocoryne carnea M. Sars have been studied with the light and electron microscope. The first clone-unspecific actions and reactions to an imminent encounter between the outgrowing tip of stolon and the subterminal part of an opposed homologous...

journal_title：Mechanisms of ageing and development

authors： Tardent P,Jauch U

更新日期：1983-03-01 00:00:00

abstract：:We examined physiological changes in CD5(+) B lymphocytes in mice associated with aging (from 1 or 5 to 50 weeks of age). The most predominant populations of lymphocytes among these mice were mainly CD5(-) B cells in the spleen and peritoneal cavity, and T cells in the thymus. However, in the spleen, CD5(+) B cells in...

journal_title：Mechanisms of ageing and development

authors： Watanabe K,Watanabe M,Maruoka H,Amino N,Iwatani Y

更新日期：2001-10-01 00:00:00

abstract：:Considerable amount of data has accumulated during the past few years showing several changes in gene expression as a function of age. However, the basic mechanism of aging still remains poorly understood. In this review, we have mainly analysed the data pertaining to the hypothesis that aging is associated with genet...

journal_title：Mechanisms of ageing and development

authors： Thakur MK,Oka T,Natori Y

更新日期：1993-01-01 00:00:00

abstract：:Nitric oxide synthase (NOS) activity was enhanced in human umbilical vein endothelial cells (HUVECs) by the combined stimulation with IFN-gamma plus IL-1beta, TNF-alpha and LPS which was accompanied by cell death. DNA analysis of the NOS induced dead HUVECs showed that internucleosomal DNA fragmentation had occurred, ...

journal_title：Mechanisms of ageing and development

authors： Sato I,Kaji K,Murota S

更新日期：1995-06-30 00:00:00

abstract：:The objective of the this study was to determine the cytokine profile of aging mice and to establish whether changes in cytokine production account for the fact that aging mice develop a milder disease than the young in response to induced experimental systemic lupus erythematosus (SLE). Cytokine secretion was evaluat...

journal_title：Mechanisms of ageing and development

authors： Segal R,Dayan M,Globerson A,Habut B,Shearer GM,Mozes E

更新日期：1997-06-01 00:00:00

abstract：:The aim of the present study was to measure protein synthesis in regenerating liver and to evaluate the impact of malnutrition in young and old rats. Two groups of male Wistar rats were used: young rats (4 months old) and old rats (18 months old). The rats were allocated to malnutrition or ordinary food intake for 1 w...

journal_title：Mechanisms of ageing and development

authors： Carrillo MC,Carnovale CE,Favre C,Monti JA,Scapini C

更新日期：1996-10-04 00:00:00

abstract：:In yeast, increasing the copy number of the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase Sir2 extends lifespan, which can be inhibited by nicotinamide (Nam), the end-product of Sir2-mediated NAD-breakdown. Furthermore, the yeast pyrazinamidase/nicotinamidase PNC-1 can extend yeast lifespan by converti...

journal_title：Mechanisms of ageing and development

authors： van der Horst A,Schavemaker JM,Pellis-van Berkel W,Burgering BM

更新日期：2007-04-01 00:00:00

abstract：:Both vascular relaxation and cAMP accumulation mediated by beta adrenergic agonists declines with increasing age. We have developed a method to measure the biologically relevant cAMP bound to the regulatory subunits of cAMP-dependent protein kinase in rat aorta. In homogenates of rat aorta, binding of [3H]cAMP was sat...

journal_title：Mechanisms of ageing and development

authors： Chin JH,Hoffman BB

更新日期：1990-04-09 00:00:00

abstract：:Evolution of longevity of the ungulates, carnivores and primates is reviewed. Special emphasis is focused on recent evolutionary history of longevity along the hominid ancestral-descendant sequence leading to modern man. Maximum life span potential (MLP) or the change in MLP is predicted in extinct species by (1) a ph...

journal_title：Mechanisms of ageing and development

authors： Cutler RG

更新日期：1979-02-01 00:00:00

abstract：:The polyphenol quercetin has recently been found to extend lifespan and increase stress resistance in the nematode Caenorhabditis elegans. The forkhead transcription factor DAF-16 has previously been linked to these effects. However, by using a daf-16(mgDf50) mutant strain, we show that quercetin exposure leads to inc...

journal_title：Mechanisms of ageing and development

authors： Saul N,Pietsch K,Menzel R,Steinberg CE

更新日期：2008-10-01 00:00:00

abstract：:The age-dependent drop in mixed lymphocyte reactivity and responsiveness to concanavalin A of lymph node and spleen cells of C57Bl/6J female mice were studied. The relative decrease in mixed lymphocyte reactivity was shown to be the same whether mounted against H-2 or Mls incompatibile stimulator cells. The time of pe...

journal_title：Mechanisms of ageing and development

authors： Gershon H,Merhav S,Abraham C

更新日期：1979-01-01 00:00:00

abstract：:Senescence is a biological process that induces a permanent cell cycle arrest and a specific gene expression program in response to various stressors. Following studies over the last few decades, the concept of senescence has evolved from an antiproliferative mechanism in cancer (oncogene-induced senescence) to a crit...

journal_title：Mechanisms of ageing and development

authors： Engler M,Fidan M,Nandi S,Cirstea IC

更新日期：2020-12-09 00:00:00

abstract：:Age-related variations in the stromal cell population of human bone marrow were studied by means of a cloning assay. It was found that these cells are heterogeneous both in division capacity and in morphology. Fibroblast-like progenitor cells could be distinguished from epithelial-like cells, having only a very limite...

journal_title：Mechanisms of ageing and development

authors： Mets T,Verdonk G

更新日期：1981-01-01 00:00:00

abstract：:Prostaglandin (PG) synthesis by human embryo lung fibroblasts in culture was determined with increasing population doubling. These cultures synthesized PGE2, PGF2 alpha, PGI2 (prostacyclin) and TXA2 (thromboxane A2) in response to fetal bovine serum or ascorbic acid. Changes in prostaglandin synthesis by these cells d...

journal_title：Mechanisms of ageing and development

authors： Polgar P,Taylor L

更新日期：1980-04-01 00:00:00

abstract：:Age-specific mortality rates from breast cancer (BC) in Japan from 1950 through 1993 were subjected to longitudinal Gompertzian and Weibull analyses. Age-specific BC mortality rate distributions between the ages of 30 and 75 years were Gompertzian in each year. Between 1950 and 1993, age-adjusted BC mortality rates in...

journal_title：Mechanisms of ageing and development

authors： Imaizumi Y

更新日期：1996-07-17 00:00:00

abstract：:Overproduction of oxidants and free radicals in ageing tissues induces nitro-oxidative stress, which has recently been implicated in the pathogenesis of cardiovascular dysfunction associated with ageing. Peroxynitrite, a strong cytotoxic oxidant damages proteins and DNA and activates several pathways causing tissue in...

journal_title：Mechanisms of ageing and development

authors： Radovits T,Seres L,Gero D,Lin LN,Beller CJ,Chen SH,Zotkina J,Berger I,Groves JT,Szabó C,Szabó G

更新日期：2007-02-01 00:00:00

abstract：:Chromosome analyses and Ig level determinations were carried out on seventeen aged men and women, 83--100 years of age. In men, significant correlations were found between hypodiploidy and IgA (gamma = 0.95) and between monosomy C and IgG (gamma = 0.79) while in women, monosomy G and IgG were significantly correlated ...

journal_title：Mechanisms of ageing and development

authors： Matsuyama SS,Cohen D,Jarvik LF

更新日期：1978-12-01 00:00:00

abstract：:Hypertension is a main risk factor for cerebrovascular disease, including vascular dementia. The present study was designed to evaluate if hypertension-dependent changes of the hippocampus of spontaneously hypertensive rats (SHR) of different ages were related with those occurring in vascular dementia. The hippocampus...

journal_title：Mechanisms of ageing and development

authors： Sabbatini M,Catalani A,Consoli C,Marletta N,Tomassoni D,Avola R

更新日期：2002-03-15 00:00:00

abstract：:The kinetics of accumulation and loss of zinc from the liver following subcutaneous administration of 10 mg of zinc per kg were examined in young adult (6 months old) and old (24 months old) male C57BL/6J mice. After zinc treatment, total liver zinc concentrations rose equally in both groups and returned to basal leve...

journal_title：Mechanisms of ageing and development

authors： Thomas DJ,Winchurch RA,Adler WH

更新日期：1989-03-01 00:00:00

abstract：:Elderly people are at risk from an increased incidence of infections. Therefore we have studied the correlation between the production of several immunological parameters such as interferon-gamma (IFN-gamma), interferon-alpha-2 (IFN-alpha-2), interleukin-2 (IL-2), soluble interleukin-2 receptors (sIL-2R) and interleuk...

journal_title：Mechanisms of ageing and development

authors： Sindermann J,Kruse A,Frercks HJ,Schütz RM,Kirchner H

更新日期：1993-08-01 00:00:00

abstract：:There is an alteration of the immune response in aging that leads to the increased incidence of infections, cancers and autoimmune disorders. The aim of the present study was to investigate whether there exists changes in signal transduction under the IL-2 receptor stimulation and the role of plasma membrane cholester...

journal_title：Mechanisms of ageing and development

authors： Fülöp T Jr,Douziech N,Goulet AC,Desgeorges S,Linteau A,Lacombe G,Dupuis G

更新日期：2001-09-15 00:00:00