The Caenorhabditis elegans nicotinamidase PNC-1 enhances survival.

abstract：:There is currently of a great interest investigating the role of nutrition in the prevention of age-associated disorders. The present study aimed to evaluate, on a particular strain of mice, the efficacy of alternate-day fasting on the mitochondrial production of free radical species and on the incidence of a specific...

journal_title：Mechanisms of ageing and development

authors： Descamps O,Riondel J,Ducros V,Roussel AM

更新日期：2005-11-01 00:00:00

abstract：:Caloric restriction (CR) is the most effective intervention to improve health span and extend lifespan in preclinical models. This anti-aging effect of CR is related to attenuation of oxidative damage in various tissues, with divergent results in the brain. We addressed how brain oxidoreductive balance would be modula...

journal_title：Mechanisms of ageing and development

authors： Moyse E,Arsenault M,Gaudreau P,Ferland G,Ramassamy C

更新日期：2019-04-01 00:00:00

abstract：:Levels of the beta-subunit of nerve growth factor (beta-NGF) were determined in various tissues from senescence-accelerated mice (SAM-P/8) and compared with those from senescence-resistant control mice (SAM-R/1) at 4 months of age. (1) In SAM-P/8, the testis was 30% larger in terms of wet weight than that from SAM-R/1...

journal_title：Mechanisms of ageing and development

authors： Katoh-Semba R,Semba R,Kashiwamata S,Kato K

更新日期：1991-06-14 00:00:00

abstract：:Cell proliferation, cell injury and aging are connected with changes in the cell membrane structure. Apparently these changes activate, in mammalian as well as in plant cells, lipases which liberate polyunsaturated fatty acids (PUFAs). PUFAs are the substrates for lipoxygenases which convert them to corresponding hydr...

journal_title：Mechanisms of ageing and development

authors： Spiteller G

更新日期：2001-05-31 00:00:00

abstract：:In this study, we showed that in flies kept for 2 weeks at 1 (terrestrial gravity), 3 or 5 x g (hypergravity, HG) before transfer to 1 x g, resistance to heat remained higher in HG flies for several weeks after the transfer. The measurement of heat shock protein 70 (hsp70) indicated no induction of the protein in HG, ...

journal_title：Mechanisms of ageing and development

authors： Minois N,Guinaudy MJ,Payre F,Le Bourg E

更新日期：1999-06-01 00:00:00

abstract：:The most relevant theories on the sex-dependent longevity at population level are critically re-examined in the light of the knowledge available today on the aging process at cellular and molecular level. The aim of this perspective is to help in the understanding of the cellular and molecular bases of longevity and t...

journal_title：Mechanisms of ageing and development

authors： Magnani M,Accorsi A

更新日期：1993-12-15 00:00:00

abstract：:Epigenetic modifications, including changes in DNA methylation, have been implicated in a wide range of diseases including neurological diseases such as Alzheimer's. The role of dietary folate in providing methyl groups required for maintenance and modulation of DNA methylation makes it a nutrient of interest in Alzhe...

journal_title：Mechanisms of ageing and development

authors： Robinson N,Grabowski P,Rehman I

更新日期：2018-09-01 00:00:00

abstract：:The identification of predictive markers of life span would help to unravel the underlying mechanisms influencing ageing and longevity. For this aim, 30 variables including immune functions, inflammatory-oxidative stress state and behavioural characteristics were investigated in ICR-CD1 female mice at the adult age (N...

journal_title：Mechanisms of ageing and development

authors： Martínez de Toda I,Vida C,Sanz San Miguel L,De la Fuente M

更新日期：2019-09-01 00:00:00

abstract：:Cellular senescence is a fundamental trait of many eukaryotic organisms. Senescent cells participate both in the developmental program and in normal ageing and age-related diseases. Senescence of proliferation-prone cells is a state of permanent cell cycle arrest accompanied by metabolic activity manifested by high se...

journal_title：Mechanisms of ageing and development

authors： Bielak-Zmijewska A,Mosieniak G,Sikora E

更新日期：2018-03-01 00:00:00

abstract：:The age-related studies of chromatin and DNA has attracted significant interest in recent years. However, individual works describe only some and a few of the many changes of chromatin. It is often difficult to decide whether these changes have secondary or primary nature. The overview of these studies makes it possib...

journal_title：Mechanisms of ageing and development

authors： Medvedev ZA

更新日期：1984-12-01 00:00:00

abstract：:The age-related changes in the distribution of enkephalin-immunoreactive (ENK-IR) nerve fibers in relation to the principal neurons were studied in 23 human sympathetic ganglia from patients aged between 22 and 98 years. There were no age-related changes in the diameter of nerve cells and the packing density of the ne...

journal_title：Mechanisms of ageing and development

authors： Järvi R,Helen P,Pelto-Huikko M,Rapoport SI,Hervonen A

更新日期：1988-08-01 00:00:00

abstract：:Several technologies that emerged in the post-genomic era have been particularly useful in dissecting the molecular mechanisms of complex biological processes through the systems approach. Here, we review how three of these technologies, namely transcriptional profiling, large-scale RNA interference (RNAi) and genome-...

journal_title：Mechanisms of ageing and development

authors： Lim CA,Ng HH

更新日期：2007-01-01 00:00:00

abstract：:The antigen-specific antibody secretion in vitro after immunisation with the primary T-cell dependent antigen Helix pomatia Haemocyanin (HPH) was investigated in both young and elderly individuals, who all met the health admission criteria for immunogerontological studies as detailed in the SENIEUR protocol. In additi...

journal_title：Mechanisms of ageing and development

authors： De Greef GE,Van Staalduinen GJ,Van Doorninck H,Van Tol MJ,Hijmans W

更新日期：1992-01-01 00:00:00

abstract：:Human diploid cells, TIG-7, were serially cultivated under 1%, 5% or 21% (air) oxygen. The limit of their cumulative population doublings was extended by 16% or 10% under 1% or 5% oxygen, respectively, as compared with that under 21% oxygen. When TIG-7 cells were serially cultivated in the presence of 10 mM or 20 mM 3...

journal_title：Mechanisms of ageing and development

authors： Yuan H,Kaneko T,Matsuo M

更新日期：1995-07-14 00:00:00

abstract：:Previous studies have suggested a possible relationship between the ubiquitin-proteasome pathway and some pathological manifestations of Alzheimer's disease (AD). This study investigated the possibility that the Abeta peptides interact with the ubiquitin-proteasome pathway inside neuronal cells. The ubiquitin-proteaso...

journal_title：Mechanisms of ageing and development

authors： Oh S,Hong HS,Hwang E,Sim HJ,Lee W,Shin SJ,Mook-Jung I

更新日期：2005-12-01 00:00:00

abstract：:This paper is part of a series aimed to investigate the mechanism of the action of Folcysteine, a substance that has the capacity to release in the body active -SH groups and has been proved to be effective in the control of menopausal troubles. As an experimental model the ovariectomized rat, rather similar, from the...

journal_title：Mechanisms of ageing and development

authors： Moldoveanu E,Klein R,Bartoc R,Bruhis S,Oeriu I

更新日期：1975-09-01 00:00:00

abstract：:To determine the effects of prolonged hypoxia and hypoxia-reoxygenation in senescent blood vessels, isolated aortic rings from 4- and 24-month-old (mo) Wistar rats were submitted to prolonged hypoxia (50 min) or hypoxia/reoxygenation (20 min/30 min) and contractile function recorded. Phenylephrine-induced contraction ...

journal_title：Mechanisms of ageing and development

authors： Besse S,Tanguy S,Boucher F,Bulteau AL,Riou B,de Leiris J,Swynghedauw B

更新日期：2002-02-01 00:00:00

abstract：:The ability of resting and dividing rabbit articular chondrocytes to repair low doses of ultraviolet (UV) damage was measured through removal of UV endonuclease-sensitive sites (ESS, pyrimidines dimers) as measured by alkaline elution. The repair of damage was significantly (P less than 0.001) greater in dividing than...

journal_title：Mechanisms of ageing and development

authors： Lipman JM,Setlow RB

更新日期：1987-09-30 00:00:00

abstract：:The effects of ageing and of exercise on muscle mass, fiber cross-sectional area, and fiber type composition of a weight-bearing muscle, the soleus and a non-weight-bearing muscle, the extensor digitorum longus (EDL) were investigated in female Long-Evans rats. The animals were exercised by means of voluntary wheel ru...

journal_title：Mechanisms of ageing and development

authors： Brown M,Ross TP,Holloszy JO

更新日期：1992-03-15 00:00:00

abstract：:This study attempts to elucidate the molecular mechanisms underlying the ageing-dependent cAMP profiles in human diploid fibroblasts stimulated by lysophosphatidic acid (LPA). In senescent cells, LPA-dependent Gialpha activation was reduced, with a consequent reduction in Gi-suppressed cAMP levels, without alterations...

journal_title：Mechanisms of ageing and development

authors： Jang IS,Rhim JH,Kim KT,Cho KA,Yeo EJ,Park SC

更新日期：2006-05-01 00:00:00

abstract：:Chronic oxidative stress is generally believed to be a major etiologic factor in the aging process. In addition to modulation of signaling processes and oxidation of cellular proteins and lipids, reactive oxygen species (ROS) induce multiple damages in both nuclear and mitochondrial genomes, most of which are repaired...

journal_title：Mechanisms of ageing and development

authors： Szczesny B,Bhakat KK,Mitra S,Boldogh I

更新日期：2004-10-01 00:00:00

abstract：:Thymic atrophy or thymus absence causes depressed thyroid-thymus axis (TTA) efficiency in old, young propyl-thiouracil (PTU) (experimental hypothyroidism) and in young-adult thymectomised (Tx) mice, respectively. Altered zinc turnover may be also involved in depressed TTA efficiency. Zinc turnover is under the control...

journal_title：Mechanisms of ageing and development

authors： Mocchegiani E,Giacconi R,Cipriano C,Gasparini N,Orlando F,Stecconi R,Muzzioli M,Isani G,Carpenè E

更新日期：2002-03-31 00:00:00

abstract：:Highly purified DNA has been prepared from human muscle tissue and treated with three different single-strand specific desoxyribonucleases. The molecular weight of treated individual DNA molecules was determined by length measurements. Average DNA molecular weights and their standard deviations were correlated to the ...

journal_title：Mechanisms of ageing and development

authors： Zahn RK

更新日期：1983-07-01 00:00:00

abstract：:We investigated the production of IL-2 and IFN-gamma (Th1 type) and IL-4 (Th2 type) cytokines by mitogen-activated spleen cells from young, adult and old mice. Cytokine production was evaluated in culture supernatants by CTLL proliferation (IL-2), ELISA (IFN-gamma), CT4.S proliferation (IL-4) and in mRNA extracted fro...

journal_title：Mechanisms of ageing and development

authors： Frasca D,Pucci S,Goso C,Barattini P,Barile S,Pioli C,Doria G

更新日期：1997-02-01 00:00:00

abstract：:Food intake, body weight and serum LH, FSH, progesterone and oestradiol-17 beta were monitored from weaning to puberty in fully fed females housed in groups of four or individually and in females individually housed and dietary restricted. Restriction of food intake from weaning delayed the onset of puberty (34-39 day...

journal_title：Mechanisms of ageing and development

authors： Holehan AM,Merry BJ

更新日期：1985-11-01 00:00:00

abstract：:The bone marrow of old adult mice ( approximately 2 years old) has reduced B lymphopoiesis; however, whether the B1 pathway in adult bone marrow is also compromised in senescence is not known. Herein, we show that phenotypic (IgM(-)Lin(-)CD93(+)[AA4.1(+)] CD19(+)B220(low/-)) B1 progenitors are retained in old bone mar...

journal_title：Mechanisms of ageing and development

authors： Alter-Wolf S,Blomberg BB,Riley RL

更新日期：2009-06-01 00:00:00

abstract：:Previous reports suggest that 33 degrees C is the optimum temperature for the long-term culture of murine bone marrow in vitro. We found that horse serum was an important variable determining our ability to culture marrow from immature (less than 10 weeks) mice at 37 degrees C. While some batches supported growth othe...

journal_title：Mechanisms of ageing and development

authors： Lipschitz DA,Udupa KB

更新日期：1984-01-01 00:00:00

abstract：:Mortality trends in industrialized countries are characterized by declines in vascular disease (ischemic heart disease and stroke) and rises in cancers and degenerative diseases. These trends are typically analyzed by examining each disorder in isolation using the perspective of genetic and environmental influences. H...

journal_title：Mechanisms of ageing and development

authors： Riggs JE,Millecchia RJ

更新日期：1992-09-01 00:00:00

abstract：:We showed earlier that life spans of murine B lymphocytes could be estimated by measuring the functional reactivities of normal B cells upon transfer into x-linked immunodeficient (xid) mice, which do not respond to anti-mouse IgM (anti-mu) antibodies and thymic-independent type-2 (TI-2) antigens. Here the same approa...

journal_title：Mechanisms of ageing and development

authors： Udhayakumar V,Goud SN,Cross RJ,Subbarao B

更新日期：1991-12-02 00:00:00

abstract：:Hypertension is a common age-related disease, along with vascular and neurodegenerative diseases. Vascular ageing increases during hypertension, but hypertension itself accelerates vascular ageing, thus creating a vicious circle. Vascular stiffening, endothelial dysfunction, impaired contractility and vasorelaxation a...

journal_title：Mechanisms of ageing and development

authors： Forte M,Stanzione R,Cotugno M,Bianchi F,Marchitti S,Rubattu S

更新日期：2020-07-01 00:00:00