Aging and sister chromatid exchange. VIII. Effect of the aging environment on sister chromatid exchange induction and cell cycle kinetics in Ehrlich ascites tumor cells. A brief note.

abstract：:A nuclease that releases noncomplementary nucleotides from the 3'-end of DNA was isolated and highly purified from rat liver extract. The d(T9-C) priming activities for DNA synthesis in vitro by DNA polymerases alpha and beta were recovered by the addition of this enzyme, which itself does not contain a DNA polymerase...

journal_title：Mechanisms of ageing and development

authors： Taguchi T,Toda T,Fukuda M,Ohashi M

更新日期：1998-01-12 00:00:00

abstract：:The paper of Kitani cited in the title has raised an apparent contradiction regarding the validity of certain aspects of the membrane hypothesis of aging (MHA). He collected data showing that a number of detoxifying liver enzyme activities, although decline with age in male Fischer 344 rats, remain at an unchanged lev...

journal_title：Mechanisms of ageing and development

authors： Zs-Nagy I

更新日期：2001-06-01 00:00:00

abstract：:The influence of age on liver gene expression was investigated in two strains of H-2 congenic mice. In B10.RIII mice (H-2r), basal P1- and P3-450 RNA levels progressively decreased 65 and 95%, respectively, between 4 and 28 months of age (P less than or equal to 0.05). Polyaromatic hydrocarbon (PAH) induced P1- and P3...

journal_title：Mechanisms of ageing and development

authors： Mote PL,Grizzle JM,Walford RL,Spindler SR

更新日期：1990-03-31 00:00:00

abstract：:Dietary factors have a profound effect on many aspects of health including ageing and do so, at least partly, through interactions with the genome which result in altered gene expression. The application of high throughput genomics technologies in nutritional research (nutrigenomics) offers a new approach to understan...

journal_title：Mechanisms of ageing and development

authors： Mathers JC

更新日期：2006-06-01 00:00:00

abstract：:Cell proliferation, cell injury and aging are connected with changes in the cell membrane structure. Apparently these changes activate, in mammalian as well as in plant cells, lipases which liberate polyunsaturated fatty acids (PUFAs). PUFAs are the substrates for lipoxygenases which convert them to corresponding hydr...

journal_title：Mechanisms of ageing and development

authors： Spiteller G

更新日期：2001-05-31 00:00:00

abstract：:Food intake, body weight and serum LH, FSH, progesterone and oestradiol-17 beta were monitored from weaning to puberty in fully fed females housed in groups of four or individually and in females individually housed and dietary restricted. Restriction of food intake from weaning delayed the onset of puberty (34-39 day...

journal_title：Mechanisms of ageing and development

authors： Holehan AM,Merry BJ

更新日期：1985-11-01 00:00:00

abstract：:The basic genetic defect in the Hutchinson-Gilford Progeria Syndrome (progeria), a premature aging syndrome, is unknown. To investigate possible defects in hyaluronic acid (HA) metabolism in this disease, the urinary excretion of HA was studied. Urine specimens from 11 patients with this disorder were examined for HA ...

journal_title：Mechanisms of ageing and development

authors： Zebrower M,Kieras FJ,Brown WT

更新日期：1986-06-01 00:00:00

abstract：:Caloric restriction has been extensively investigated as an intervention that both extends lifespan and delays age-related disease in mammals. In mice, much interest has centered on evaluating gene expression changes induced by caloric restriction (CR) in particular tissue types, but the overall systemic effect of CR ...

journal_title：Mechanisms of ageing and development

authors： Swindell WR

更新日期：2008-03-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) establishes a highly prevalent life-long latent infection. Though generally subclinical, HCMV infection may have severe consequences during fetal development and in immunocompromised individuals. Based on epidemiological studies HCMV(+) serology has been associated with the development of ...

journal_title：Mechanisms of ageing and development

authors： López-Botet M,Muntasell A,Martínez-Rodríguez JE,López-Montañés M,Costa-García M,Pupuleku A

更新日期：2016-09-01 00:00:00

abstract：:Mortality trends in industrialized countries are characterized by declines in vascular disease (ischemic heart disease and stroke) and rises in cancers and degenerative diseases. These trends are typically analyzed by examining each disorder in isolation using the perspective of genetic and environmental influences. H...

journal_title：Mechanisms of ageing and development

authors： Riggs JE,Millecchia RJ

更新日期：1992-09-01 00:00:00

abstract：:Population studies have demonstrated that telomere length (TL) displays great diversity among different populations. Previously described controversial findings associated longevity with specific mitochondrial DNA haplogroups (hgs) (e.g., J and U). These observations may be influenced by population diversity, geograph...

journal_title：Mechanisms of ageing and development

authors： Zole E,Elferts D,Kimsis J,Krumina A,Narels K,Pole I,Ranka R,Pliss L

更新日期：2015-01-01 00:00:00

abstract：:The quantification of plasmatic HLA class-I molecules (sHLA-I) was realized by a sandwich ELISA using a monomorphic mAb (W6/32). sHLA-I concentration is significantly increased in the elderly group (>50 years, 0.429+/-0.301 microg ml(-1)) as compared to the young group (<50 years, 0.126+/-0.085 microg ml(-1)). The var...

journal_title：Mechanisms of ageing and development

authors： Le Morvan C,Cogné M,Drouet M

更新日期：2001-03-01 00:00:00

abstract：:The efficient use of nutrients is important in development and aging. In this study, we asked if the protein repair methyltransferase has a related or additional role in energy metabolism and stress response in the nematode Caenorhabditis elegans. Worms lacking the pcm-1 gene encoding this enzyme exhibit reduced longe...

journal_title：Mechanisms of ageing and development

authors： Gomez TA,Banfield KL,Clarke SG

更新日期：2008-12-01 00:00:00

abstract：:The effects of ageing and of exercise on muscle mass, fiber cross-sectional area, and fiber type composition of a weight-bearing muscle, the soleus and a non-weight-bearing muscle, the extensor digitorum longus (EDL) were investigated in female Long-Evans rats. The animals were exercised by means of voluntary wheel ru...

journal_title：Mechanisms of ageing and development

authors： Brown M,Ross TP,Holloszy JO

更新日期：1992-03-15 00:00:00

abstract：:Age-specific mortality from carcinoma of the prostate was analyzed by drawing a line between the value at age 52 years and that at age 87. Slope of the line was relatively constant for the pooled years 1962-1966, 1967-1971 and 1972-1976 (maximum variation from the mean of 4.5%). However, the slope was 17.7% greater fo...

journal_title：Mechanisms of ageing and development

authors： Clive JM,Spencer RP

更新日期：1995-08-31 00:00:00

abstract：:The present study examined the effect of repeated vaccination and of dehydroepiandrosterone (DHEA) treatment on the immune response to influenza vaccine in elderly subjects. Seventy-one elderly volunteers, aged 61-89 years, enrolled in a prospective randomized, double-blind study to receive either DHEA (50 mg qd p.o. ...

journal_title：Mechanisms of ageing and development

authors： Ben-Yehuda A,Danenberg HD,Zakay-Rones Z,Gross DJ,Friedman G

更新日期：1998-05-15 00:00:00

abstract：:Both vascular relaxation and cAMP accumulation mediated by beta adrenergic agonists declines with increasing age. We have developed a method to measure the biologically relevant cAMP bound to the regulatory subunits of cAMP-dependent protein kinase in rat aorta. In homogenates of rat aorta, binding of [3H]cAMP was sat...

journal_title：Mechanisms of ageing and development

authors： Chin JH,Hoffman BB

更新日期：1990-04-09 00:00:00

abstract：:Amyloidosis refers to a group of protein folding diseases. Various innocuous and soluble proteins in physiological conditions polymerize to insoluble amyloid fibrils in several serious diseases, including Alzheimer's disease (AD) and prion diseases. In addition, senile amyloidosis is a form of amyloidosis in which the...

journal_title：Mechanisms of ageing and development

authors： Xing Y,Higuchi K

更新日期：2002-11-01 00:00:00

abstract：:Significant changes are observed in wet weight, microsomal protein content and enzymes of purified rough and smooth microsomes of liver during postnatal development and ageing of female Wistar rats. Protein content of total microsomes increases up to 15 days of age and remains steady during subsequent development, unl...

journal_title：Mechanisms of ageing and development

authors： Devasagayam TP,Pushpendran CK,Eapen J

更新日期：1983-03-01 00:00:00

abstract：:The combined grafting of young bone marrow and newborn thymus performed in old mice was effective in restoring the impaired immune functions, but the same treatment performed in middle-aged adult mice had no effect on the life span of C3H/MTV female mice. Sequential multiple newborn thymus graftings starting at young ...

journal_title：Mechanisms of ageing and development

authors： Hirokawa K,Utsuyama M

更新日期：1989-07-01 00:00:00

abstract：:The antigen-specific antibody secretion in vitro after immunisation with the primary T-cell dependent antigen Helix pomatia Haemocyanin (HPH) was investigated in both young and elderly individuals, who all met the health admission criteria for immunogerontological studies as detailed in the SENIEUR protocol. In additi...

journal_title：Mechanisms of ageing and development

authors： De Greef GE,Van Staalduinen GJ,Van Doorninck H,Van Tol MJ,Hijmans W

更新日期：1992-01-01 00:00:00

abstract：:This is the first in a series of articles in which we intend to critically review some of the currently used models in gerontology research and evaluate their contribution to advancing our understanding of the phenomenon of senescence. The major theories of aging are considered. We discuss what makes a model useful in...

journal_title：Mechanisms of ageing and development

authors： Gershon H,Gershon D

更新日期：2000-08-15 00:00:00

abstract：:Motor neurons and ventral root motor fibres innervating extensor digitorum longus (EDL) muscle in rats of 0.5-3.5 months of age were studied by HRP-retrograde labelling and in vivo muscle tension recording, respectively. EDL nucleus size increased with age but motor neurons number and size did not change. Twitch and t...

journal_title：Mechanisms of ageing and development

authors： Cuppini R,Ambrogini P

更新日期：1996-12-20 00:00:00

abstract：:In this paper, we approach the problem of attempting to understand senescence by understanding the complexity and hierarchical structure of mammalian organisms. To do this, we make use of some concepts from abstract relational biology; in particular, graph theory. We subsequently utilize these concepts to develop the ...

journal_title：Mechanisms of ageing and development

authors： Witten M

更新日期：1984-10-31 00:00:00

abstract：:The presence of damaged and microbial DNA can pose a threat to the survival of organisms. Cells express various sensors that recognize specific aspects of such potentially dangerous DNA. Recognition of damaged or microbial DNA by sensors induces cellular processes that are important for DNA repair and inflammation. He...

journal_title：Mechanisms of ageing and development

authors： Gasser S,Zhang WYL,Tan NYJ,Tripathi S,Suter MA,Chew ZH,Khatoo M,Ngeow J,Cheung FSG

更新日期：2017-07-01 00:00:00

abstract：:Anucleate minicells produced by a mutated strain of Escherichia coli remain metabolically active for up to 48 h at 37 degrees C. Minicells of increasing age have been infected with the coliphage T7. Infection results in the onset of transcription and translation producing T7 encoded polypeptides. Quantitative and qual...

journal_title：Mechanisms of ageing and development

authors： Libby RT,Shaw JE,Reeve JN

更新日期：1984-10-15 00:00:00

abstract：:Aging and HIV disease show certain immunological similarities. In both situations, control over viral infection is diminished, and there is an increase in certain types of cancer. The immune cell type responsible for controlling viral infections and cancer is the so-called CD8 or cytotoxic T cell. In elderly persons a...

journal_title：Mechanisms of ageing and development

authors： Effros RB

更新日期：2004-02-01 00:00:00

abstract：:The tumor suppressors p16(INK4a) and p53 have been implicated as contributors to age-associated stem cell decline. Key functions of p53 are the induction of cell cycle arrest, senescence, or apoptosis in response to DNA damage. Here, we examine senescence, apoptosis, and DNA damage responses in a mouse accelerated agi...

journal_title：Mechanisms of ageing and development

authors： Hinkal GW,Gatza CE,Parikh N,Donehower LA

更新日期：2009-04-01 00:00:00

abstract：:The results of this study show that an isogeneic barrier to the successful adoptive immunotherapy of Mycobacterium tuberculosis infected mice is progressively lost as these animals age. This was shown in this study by the demonstration that increasing levels of transferred acquired specific resistance could be conferr...

journal_title：Mechanisms of ageing and development

authors： Orme IM

更新日期：1988-12-01 00:00:00

abstract：:Normal diploid Syrian hamster dermal mesenchymal cell strains, regardless of the age of the tissue of origin, exhibit in vitro cellular senescence. The frequency of spontaneous escape from senescence and conversion to a permanent cell line is less than 5% among replicate flasks. The overall pattern of senescence of ce...

journal_title：Mechanisms of ageing and development

authors： Bruce SA,Deamond SF,Ts'o PO

更新日期：1986-04-01 00:00:00