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Comparison of telomere length between population-specific mitochondrial haplogroups among different age groups in a Latvian population.

Abstract：

:Population studies have demonstrated that telomere length (TL) displays great diversity among different populations. Previously described controversial findings associated longevity with specific mitochondrial DNA haplogroups (hgs) (e.g., J and U). These observations may be influenced by population diversity, geographic location, and/or specific historic background. The aims of this study were to identify a specific hg which correlates with aging in a Latvian populating and to evaluate the possible association of TL variability with specific mitochondrial hgs. The results show no significant correlation between TL, mitochondrial DNA hgs and longevity. A slight increase in frequency was observed among centenarians of hg H; however, these findings were not statistically significant. TL did not show any statically significant difference, only hg W had slightly longer telomeres among others. An insignificant increase in TL was observed in the 55-89 age group of hg W but in the <90 age group for hg J which also had the longest TL in the 20-45 age group. In conclusion this study indicates that specific mitochondrial DNA hgs do not have a significant, if any, influence on the variation of TL in Latvians.

journal_name

Mech Ageing Dev

journal_title

Mechanisms of ageing and development

authors

Zole E,Elferts D,Kimsis J,Krumina A,Narels K,Pole I,Ranka R,Pliss L

doi

10.1016/j.mad.2015.01.002

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

13-7

eissn

0047-6374

issn

1872-6216

pii

S0047-6374(15)00003-2

journal_volume

145

pub_type

杂志文章

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