Autoimmunity and longevity: presence of antinuclear antibodies is not associated with the rate of inflammation or mortality in nonagenarians.

abstract：:The present study was designed to determine whether the memory sparing effects of dietary restriction during aging could be through an effect on ionotropic glutamate receptors. Quantitative autoradiography was performed on 3, 10, and 26 month old mice to examine the density changes of NMDA, AMPA and kainate binding si...

journal_title：Mechanisms of ageing and development

authors： Magnusson KR

更新日期：1997-05-01 00:00:00

abstract：:Vascular tree development depends on the timely differentiation of endothelial and vascular smooth muscle cells. These latter are key players in the formation of the vascular scaffold that offers resistance to the blood flow. This review aims at providing an overview on the role of PDE5, the cGMP-specific phosphodiest...

journal_title：Mechanisms of ageing and development

authors： Cesarini V,Guida E,Campolo F,Crescioli C,Di Baldassarre A,Pisano C,Balistreri CR,Ruvolo G,Jannini EA,Dolci S

更新日期：2020-09-01 00:00:00

abstract：:Mycobacteria are an important group of pathogenic bacteria. We generated a series of DNA repair deficient strains of Mycobacterium smegmatis, a model organism, to understand the importance of various DNA repair proteins (UvrB, Ung, UdgB, MutY and Fpg) in survival of the pathogenic strains. Here, we compared tolerance ...

journal_title：Mechanisms of ageing and development

authors： Rex K,Kurthkoti K,Varshney U

更新日期：2013-10-01 00:00:00

abstract：:Calorie restriction (CR) extends life span and retards many age-related cellular and molecular changes in laboratory rodents. However, neither the breadth of its effects, its underlying mechanisms, nor the limits of its action is fully understood. Expression levels of 588 genes in livers from 3- and 24-month-old ad li...

journal_title：Mechanisms of ageing and development

authors： Han E,Hilsenbeck SG,Richardson A,Nelson JF

更新日期：2000-06-20 00:00:00

abstract：:Thymic atrophy or thymus absence causes depressed thyroid-thymus axis (TTA) efficiency in old, young propyl-thiouracil (PTU) (experimental hypothyroidism) and in young-adult thymectomised (Tx) mice, respectively. Altered zinc turnover may be also involved in depressed TTA efficiency. Zinc turnover is under the control...

journal_title：Mechanisms of ageing and development

authors： Mocchegiani E,Giacconi R,Cipriano C,Gasparini N,Orlando F,Stecconi R,Muzzioli M,Isani G,Carpenè E

更新日期：2002-03-31 00:00:00

abstract：:The steroid hormone ecdysone influences Drosophila lifespan. Longevity is extended in mutants deficient for ecdysone synthesis or mutants of the ecdysone receptor (EcR). However, the underlying mechanisms remain unclear. Here we conditionally inactivated EcR by RNA interference or expression of dominant negative forms...

journal_title：Mechanisms of ageing and development

authors： Tricoire H,Battisti V,Trannoy S,Lasbleiz C,Pret AM,Monnier V

更新日期：2009-08-01 00:00:00

abstract：:While deviations from the optimal phenotype are deleterious, increased variation can prevent population extinction under severe stresses. Cell division asymmetry is an important source of microbial phenotypic heterogeneity. A consecutive set of asymmetric divisions can cause the gradual accumulation of deleterious fac...

journal_title：Mechanisms of ageing and development

authors： Knorre DA,Azbarova AV,Galkina KV,Feniouk BA,Severin FF

更新日期：2018-12-01 00:00:00

abstract：:The present study examined the effect of repeated vaccination and of dehydroepiandrosterone (DHEA) treatment on the immune response to influenza vaccine in elderly subjects. Seventy-one elderly volunteers, aged 61-89 years, enrolled in a prospective randomized, double-blind study to receive either DHEA (50 mg qd p.o. ...

journal_title：Mechanisms of ageing and development

authors： Ben-Yehuda A,Danenberg HD,Zakay-Rones Z,Gross DJ,Friedman G

更新日期：1998-05-15 00:00:00

abstract：:The age-dependent drop in mixed lymphocyte reactivity and responsiveness to concanavalin A of lymph node and spleen cells of C57Bl/6J female mice were studied. The relative decrease in mixed lymphocyte reactivity was shown to be the same whether mounted against H-2 or Mls incompatibile stimulator cells. The time of pe...

journal_title：Mechanisms of ageing and development

authors： Gershon H,Merhav S,Abraham C

更新日期：1979-01-01 00:00:00

abstract：:Relationships between nutrition and longevity are of growing interest. Here we analysed the influences of dietary restriction on the survival of Drosophila exposed to atmospheric oxygen or to chronic hypoxia. Dietary restriction was achieved by food dilution, by sucrose restriction or by yeast restriction. Sucrose and...

journal_title：Mechanisms of ageing and development

authors： Vigne P,Frelin C

更新日期：2007-05-01 00:00:00

abstract：:Recent studies show that cellular and mitochondrial iron increases with age. Iron overload, especially in mitochondria, increases the availability of redox-active iron, which may be a causal factor in the extensive age-related biomolecular oxidative damage observed in aged organisms. Such damage is thought to play a m...

journal_title：Mechanisms of ageing and development

authors： Xu J,Marzetti E,Seo AY,Kim JS,Prolla TA,Leeuwenburgh C

更新日期：2010-07-01 00:00:00

abstract：:In a longitudinal design in which each animal was examined repeatedly throughout its life, we used flow cytometry to determine the numbers or proportions of a variety of T lymphocyte subsets in the peripheral blood of mice aged 8-20 months. Half of the 128 mice were given a low calorie diet which is known to extend li...

journal_title：Mechanisms of ageing and development

authors： Miller RA

更新日期：1997-06-01 00:00:00

abstract：:Survival characteristics of seven different populations of the mollusc Lymnaea stagnalis were studied under constant culture conditions. On the basis of these characteristics four populations were considered as healthy and three as infected. In the healthy populations senescence started at an age of about 200 days, 50...

journal_title：Mechanisms of ageing and development

authors： Janse C,Slob W,Popelier CM,Vogelaar JW

更新日期：1988-03-01 00:00:00

abstract：:Previous reports suggest that 33 degrees C is the optimum temperature for the long-term culture of murine bone marrow in vitro. We found that horse serum was an important variable determining our ability to culture marrow from immature (less than 10 weeks) mice at 37 degrees C. While some batches supported growth othe...

journal_title：Mechanisms of ageing and development

authors： Lipschitz DA,Udupa KB

更新日期：1984-01-01 00:00:00

abstract：:The localization of the beta/A4 amyloid precursor protein (APP) was studied in the human lumbar paravertebral sympathetic ganglia of subjects of different ages, free of neurologic disease, using combined immunohistochemistry and image analysis techniques (optic microdensitometry). To ascertain which cells displayed AP...

journal_title：Mechanisms of ageing and development

authors： Calzada B,Cabal A,Naves FJ,del Valle ME,Represa JJ,Vega JA

更新日期：1994-10-20 00:00:00

abstract：:We investigated the Coenzyme Q (CoQ) content of different mitochondrial fractions [free mitochondria (FM), synaptic heavy (HM) and light mitochondria (LM)] from three brain areas (cortex, striatum, hippocampus) of rats at different ages. In rats from 2 to 26 months of age, we observed only small differences in total C...

journal_title：Mechanisms of ageing and development

authors： Battino M,Gorini A,Villa RF,Genova ML,Bovina C,Sassi S,Littarru GP,Lenaz G

更新日期：1995-03-17 00:00:00

abstract：:We examined physiological changes in CD5(+) B lymphocytes in mice associated with aging (from 1 or 5 to 50 weeks of age). The most predominant populations of lymphocytes among these mice were mainly CD5(-) B cells in the spleen and peritoneal cavity, and T cells in the thymus. However, in the spleen, CD5(+) B cells in...

journal_title：Mechanisms of ageing and development

authors： Watanabe K,Watanabe M,Maruoka H,Amino N,Iwatani Y

更新日期：2001-10-01 00:00:00

abstract：:Taurine is a sulfur amino acid that is present in high concentration in mammalian tissues and previously has been reported to decline in a number of tissues with advancing age. The aims of the present study were to examine: (1) the effects of dietary taurine supplementation; (2) the effects of taurine-free diets; (3) ...

journal_title：Mechanisms of ageing and development

authors： Dawson R Jr,Liu S,Eppler B,Patterson T

更新日期：1999-02-01 00:00:00

abstract：:Active oxygen species have been considered to be responsible for the aging process and for the induction and initiation of neoplastic processes. The effect of hydrogen peroxide, an active oxygen species, was investigated in the chromosomes of three young women (20-21 years of age) and of three elderly women (73-79 yea...

journal_title：Mechanisms of ageing and development

authors： Smith Mde A,Bortolotto MH,Melaragno MI,Toniolo Neto J

更新日期：1990-11-01 00:00:00

abstract：:Older adults who are at risk of developing influenza illness, have a low level of influenza virus-stimulated cytotoxic T lymphocyte (CTL) activity as measured by an assay of granzyme B (GrB). The purpose of this study was to determine whether aging affected memory CTL populations identified by GrB expression in influe...

journal_title：Mechanisms of ageing and development

authors： Xie D,McElhaney JE

更新日期：2007-05-01 00:00:00

abstract：:The polyphenol quercetin has recently been found to extend lifespan and increase stress resistance in the nematode Caenorhabditis elegans. The forkhead transcription factor DAF-16 has previously been linked to these effects. However, by using a daf-16(mgDf50) mutant strain, we show that quercetin exposure leads to inc...

journal_title：Mechanisms of ageing and development

authors： Saul N,Pietsch K,Menzel R,Steinberg CE

更新日期：2008-10-01 00:00:00

abstract：:The activity of rat heart succinate dehydrogenase (SDH) increases 1.7-fold in old animals (Vitorica, J., Cano, J., Satrústegui, J. and Machado, A., Mech. Ageing Dev., 16 (1981) 105-116). This increase is due to an increase in enzyme protein itself because: (a) the activation state of the enzyme does not vary with age;...

journal_title：Mechanisms of ageing and development

authors： Velez M,Machado A,Satrústegui J

更新日期：1985-11-01 00:00:00

abstract：:The data concerning the effects of age on the brainstem are scarce and few works are devoted to the human vestibular nuclear complex. The study of the effects of aging in the vestibular nuclei could have clinical interest due to the high prevalence of balance control and gait problems in the elderly. We have used in t...

journal_title：Mechanisms of ageing and development

authors： Alvarez JC,Díaz C,Suárez C,Fernández JA,González del Rey C,Navarro A,Tolivia J

更新日期：2000-04-14 00:00:00

abstract：:Oxidative stress may contribute to the cellular alterations, which occur as the result of aging, and the nervous system is particularly vulnerable to aging associated oxidative injury. The multicatalytic proteasome (MCP) is responsible for the majority of protein degradation and is sensitive to oxidative stress. To de...

journal_title：Mechanisms of ageing and development

authors： Keller JN,Hanni KB,Markesbery WR

更新日期：2000-01-24 00:00:00

abstract：:Chondrocytes derived from chick embryos can be successfully implanted in defects of adult chick articular cartilage surfaces. Such implants thrive in their implantation site and create a new articular surface. The chondrocytes mature and hypertrophy in the orthotopic site without invoking an immune response. Eventuall...

journal_title：Mechanisms of ageing and development

authors： Robinson D,Halperin N,Nevo Z

更新日期：1989-10-01 00:00:00

abstract：:There is an alteration of the immune response in aging that leads to the increased incidence of infections, cancers and autoimmune disorders. The aim of the present study was to investigate whether there exists changes in signal transduction under the IL-2 receptor stimulation and the role of plasma membrane cholester...

journal_title：Mechanisms of ageing and development

authors： Fülöp T Jr,Douziech N,Goulet AC,Desgeorges S,Linteau A,Lacombe G,Dupuis G

更新日期：2001-09-15 00:00:00

abstract：:We have isolated a new type of Paramecium tetraurelia mutant, named rie-2, that has a long immaturity period until autogamy. We previously isolated such an autogamy mutant, designated rie-1. These two mutants had some additional common features such as dependence of the occurrence of autogamy on the temperature, invol...

journal_title：Mechanisms of ageing and development

authors： Komori R,Sato H,Harumoto T,Takagi Y

更新日期：2005-06-01 00:00:00

abstract：:The general objective of this study was to examine the relationship between oxygen free radicals and the aging process. The rate of superoxide anion radical (O2.-) generation was measured in liver sub-mitochondrial particles from mouse, rat, rabbit, pig and cow, and in flight muscle sub-mitochondrial particles from th...

journal_title：Mechanisms of ageing and development

authors： Sohal RS,Svensson I,Sohal BH,Brunk UT

更新日期：1989-08-01 00:00:00

abstract：:Functional defects that accumulate in the T cell compartment are thought to be responsible for the pronounced immunodeficiency that develops during ageing, and reduced production of T cells by the thymus as it undergoes involution has been suggested to contribute to this phenomenon. Understanding the mechanisms respon...

journal_title：Mechanisms of ageing and development

authors： Montecino-Rodriguez E,Dorshkind K

更新日期：1997-02-01 00:00:00

abstract：:Previous studies from this laboratory have documented a progressive age-related decline in trophic hormone (or second messenger cAMP) stimulated corticosterone production in isolated adrenocortical cells. In the current study, we examined the possibility that the aging process exerts this effect by interfering with an...

journal_title：Mechanisms of ageing and development

authors： Azhar S,Reaven E

更新日期：1994-11-25 00:00:00