The emerging role of iron dyshomeostasis in the mitochondrial decay of aging.

abstract：:Bone marrow (BM) from young (3 months) and old (24 months) C57BL/6J mice were tested for the total number of colony forming units, which remain unchanged with age. The BM from both groups was used to reconstitute syngeneic, lethally irradiated mice that were 3 months' old. The reconstituted mice were followed for a pe...

journal_title：Mechanisms of ageing and development

authors： Gozes Y,Umiel T,Trainin N

更新日期：1982-03-01 00:00:00

abstract：:The activities of the low-Km and high-Km forms of cyclic AMP phosphodiesterase (PDE) were determined in extracts prepared from epididymis and prostate taken from adult (10-12 months) and from aged (32-35 months) rats. The maximum velocity V of low-Km PDE in the epididymis of normal adult rats (approx. 300 pmoles/min p...

journal_title：Mechanisms of ageing and development

authors： Razzaboni B,Terner C

更新日期：1988-04-01 00:00:00

abstract：:It has been shown that enhanced levels of p53 activity contribute to reduced cancer susceptibility in mice, however longevity is compromised due to the onset of an early-ageing phenotype. The effects of enhanced levels of p53 in these in mice could therefore have implications for human premature ageing disorders. We e...

journal_title：Mechanisms of ageing and development

authors： O'Neill M,Núñez F,Melton DW

更新日期：2003-05-01 00:00:00

abstract：:Impaired lymphocyte and granulocyte function in the aged may, in part, reflect intrinsic aged-related biochemical alterations. In this study we compared the ribonucleotide contents of lymphocytes and granulocytes from young and old subjects evaluated by means of an HPLC-anion exchange method. We found that in general ...

journal_title：Mechanisms of ageing and development

authors： Borzì RM,Dal Monte P,Uguccioni M,Meliconi R,Facchini A

更新日期：1992-06-01 00:00:00

abstract：OBJECTIVES:To investigate whether systemic inflammation in acutely admitted older medical patients (age >65 years) is associated with physical performance and organ dysfunction. Organ dysfunction´s association with physical performance, and whether these associations are mediated by systemic inflammation, was also inve...

journal_title：Mechanisms of ageing and development

authors： Klausen HH,Bodilsen AC,Petersen J,Bandholm T,Haupt T,Sivertsen DM,Andersen O

更新日期：2017-06-01 00:00:00

abstract：:It has been shown in several studies that 2-mercaptoethanol (2-ME) improves the life span and aspects of life performance of laboratory animals. To obtain further details on the beneficial effects of 2-ME, a long-term study has been performed on male CBA/Ca inbred mice treated with this antioxidant. Four month-old mic...

journal_title：Mechanisms of ageing and development

authors： Pénzes L,Noble RC,Beregi E,Imre S,Izsák J,Regius O

更新日期：1988-10-01 00:00:00

abstract：:In the present study, a number of physiological and behavioral measures that are related to metabolism were continuously monitored in 19-month-old male Fischer 344 rats that were fed ad libitum or fed a caloric restricted diet. Caloric restricted rats ate fewer meals but consumed more food during each meal and spent m...

journal_title：Mechanisms of ageing and development

authors： Duffy PH,Feuers RJ,Leakey JA,Nakamura K,Turturro A,Hart RW

更新日期：1989-05-01 00:00:00

abstract：:Ageing of WI-38 fibroblasts in culture was used as a model in order to investigate the evolution and the alteration of the key antioxidant enzyme glutathione peroxidase. The activity of glutathione peroxidase is influenced by the presence of selenium in the culture medium and we have also shown that the specific activ...

journal_title：Mechanisms of ageing and development

authors： Pigeolet E,Remacle J

更新日期：1991-04-01 00:00:00

abstract：:The microtubule-associated protein tau, and the cytoplasmic protein ubiquitin, are constituents of pathological neurofibrillary tangles found in Alzheimer's disease. In order to see if there is any physiological relationship between these proteins in a functioning human system, human neuroblastoma (LAN-5) cells were g...

journal_title：Mechanisms of ageing and development

authors： Mesco ER,Timiras PS

更新日期：1991-11-15 00:00:00

abstract：:We have developed a relatively rapid, safe and simple method for the quantification of sjTREC levels in samples of peripheral blood. The assay uses an image analysis package to measure the brightness of PCR product bands on an image of the standard agarose gel. Comparison of the brightness of the band with that obtain...

journal_title：Mechanisms of ageing and development

authors： Aspinall R,Pido J,Andrew D

更新日期：2000-12-20 00:00:00

abstract：:Fluorescent microspheres were used to measure antibody-induced capping of leukocyte membrane proteins that are immunologically related to band 3, the anion exchanger of the erythrocyte. The degree of capping was found to increase with donor age. Surface labeling and capping characteristics of cells from healthy, age-m...

journal_title：Mechanisms of ageing and development

authors： Bosman GJ,Steetzel BD,De Man AJ,Van Kalmthout PJ,Visser FE,De Grip WJ

更新日期：1995-04-21 00:00:00

abstract：:Quantitative methods for the study of aging in single organisms of the suctorian protozoan Tokophrya infusionum are described. New cell lines are initiated by metamorphosis of a ciliated embryo to form a sessile adult. The life history of adult cells consists of a sequence of age-related stages, culminating in cessati...

journal_title：Mechanisms of ageing and development

authors： Karakashian SJ,Lanners HN,Rudzinska MA

更新日期：1984-08-01 00:00:00

abstract：:To gain insight into the anti-ageing mechanisms of caloric restriction (CR), liver mitochondria were isolated from male Brown-Norway rats of different ages (fully fed control and CR) and various specific markers of non-enzymatic protein modification (by oxidative, glyco- and lipoxidative-reactions) were measured by GC...

journal_title：Mechanisms of ageing and development

authors： Lambert AJ,Portero-Otin M,Pamplona R,Merry BJ

更新日期：2004-08-01 00:00:00

abstract：:Aging and HIV disease show certain immunological similarities. In both situations, control over viral infection is diminished, and there is an increase in certain types of cancer. The immune cell type responsible for controlling viral infections and cancer is the so-called CD8 or cytotoxic T cell. In elderly persons a...

journal_title：Mechanisms of ageing and development

authors： Effros RB

更新日期：2004-02-01 00:00:00

abstract：:The proto-oncogene c-fos (the cellular homolog of v-fos, Finkel-Biskis-Jenkins (FBJ) murine osteogenic sarcoma virus) encodes a major component of the activator protein-1 (AP-1) transcription factor. Serum stimulation as well as oxidizing treatments induce transitory increases in c-fos mRNA abundance. The induction of...

journal_title：Mechanisms of ageing and development

authors： Keogh BP,Tresini M,Cristofalo VJ,Allen RG

更新日期：1996-03-29 00:00:00

abstract：:Published data on age-related human biological functions are surveyed. For the many showing a linear decrease, regressions were calculated, or existing functions extrapolated, to yield an intercept on the abscissa. The values of chi(0), the age at which a function ceases, provide a tentative common means of comparison...

journal_title：Mechanisms of ageing and development

authors： Weale RA

更新日期：1993-06-01 00:00:00

abstract：:As a prerequisite to investigating the specification and differentiation of cardiac tissue in vitro, the ontogeny of a number of putative cardiac-specific, and striated muscle-specific gene transcripts has been studied. The probes used include cDNAs of alpha-actins, myosin heavy chains, myosin light chains, alpha-trop...

journal_title：Mechanisms of ageing and development

authors： Murrell WG,Masters CJ,Willis RJ,Crane DI

更新日期：1994-12-16 00:00:00

abstract：:The mTOR deregulation has a role in chronic kidney disease including diabetic nephropathy. SIRT1 is an important participant in renal cytoprotective responses to aging and stress. However, whether both mTOR and SIRT1 are involved in high glucose-inducing mesangial cells (MCs) senescence still remains to be explored. H...

journal_title：Mechanisms of ageing and development

authors： Zhang S,Cai G,Fu B,Feng Z,Ding R,Bai X,Liu W,Zhuo L,Sun L,Liu F,Chen X

更新日期：2012-06-01 00:00:00

abstract：:Hematological deficiencies increase with aging leading to anemias, reduced hematopoietic stress responses and myelodysplasias. This study tested the hypothesis that side population hematopoietic stem cells (SP-HSC) would decrease with aging, correlating with IGF-1 and IL-6 levels and increases in bone marrow fat. Marr...

journal_title：Mechanisms of ageing and development

authors： Brusnahan SK,McGuire TR,Jackson JD,Lane JT,Garvin KL,O'Kane BJ,Berger AM,Tuljapurkar SR,Kessinger MA,Sharp JG

更新日期：2010-11-01 00:00:00

abstract：:Aging is a biological process associated with impairment of mitochondrial bioenergetic function, increased oxidative stress, attenuated ability to respond to stresses and increased risk in contracting age-associated diseases. When mitochondria are subjected to oxidative stress, accompanied by calcium overload and ATP ...

journal_title：Mechanisms of ageing and development

authors： Paradies G,Paradies V,Ruggiero FM,Petrosillo G

更新日期：2013-01-01 00:00:00

abstract：:Chronic oxidative stress is generally believed to be a major etiologic factor in the aging process. In addition to modulation of signaling processes and oxidation of cellular proteins and lipids, reactive oxygen species (ROS) induce multiple damages in both nuclear and mitochondrial genomes, most of which are repaired...

journal_title：Mechanisms of ageing and development

authors： Szczesny B,Bhakat KK,Mitra S,Boldogh I

更新日期：2004-10-01 00:00:00

abstract：:Rats from one month to 22 months of age were subjected to in vivo brain microdialysis under a free-moving condition. The 3,4-dihydroxyphenylacetic acid level in the striatum reached a maximum at 3 months old. However, both basal and potassium-induced dopamine release were maximal at 1.5 months, which represents sexual...

journal_title：Mechanisms of ageing and development

authors： Nakano M,Mizuno T

更新日期：1996-02-24 00:00:00

abstract：:Nearly 40 years ago it was proposed that accumulation of mutations or increased levels of DNA damage might contribute to aging processes. Despite several correlative studies in this area, the answer as to whether genomic integrity contributes to aging has remained illusive. More recently it has been hypothesized that ...

journal_title：Mechanisms of ageing and development

authors： Walter CA,Grabowski DT,Street KA,Conrad CC,Richardson A

更新日期：1997-12-01 00:00:00

abstract：:Nitric oxide synthase (NOS) activity was enhanced in human umbilical vein endothelial cells (HUVECs) by the combined stimulation with IFN-gamma plus IL-1beta, TNF-alpha and LPS which was accompanied by cell death. DNA analysis of the NOS induced dead HUVECs showed that internucleosomal DNA fragmentation had occurred, ...

journal_title：Mechanisms of ageing and development

authors： Sato I,Kaji K,Murota S

更新日期：1995-06-30 00:00:00

abstract：:Human cytomegalovirus (HCMV) establishes a highly prevalent life-long latent infection. Though generally subclinical, HCMV infection may have severe consequences during fetal development and in immunocompromised individuals. Based on epidemiological studies HCMV(+) serology has been associated with the development of ...

journal_title：Mechanisms of ageing and development

authors： López-Botet M,Muntasell A,Martínez-Rodríguez JE,López-Montañés M,Costa-García M,Pupuleku A

更新日期：2016-09-01 00:00:00

abstract：:Epigenetic modifications, including changes in DNA methylation, have been implicated in a wide range of diseases including neurological diseases such as Alzheimer's. The role of dietary folate in providing methyl groups required for maintenance and modulation of DNA methylation makes it a nutrient of interest in Alzhe...

journal_title：Mechanisms of ageing and development

authors： Robinson N,Grabowski P,Rehman I

更新日期：2018-09-01 00:00:00

abstract：:The present study aimed to reveal aging-related changes in the skeletal muscle of SD rats by comparing transcriptome analysis, integrated with muscle physiological parameters. Ten rats aged 25 months were set as the old group (OG) and ten rats aged 6 months were set as the young group (YG). After 6 weeks of feeding, t...

journal_title：Mechanisms of ageing and development

authors： Zhou J,Liao Z,Chen J,Zhao K,Xiao Q

更新日期：2018-01-01 00:00:00

abstract：:Endogenous retroelements, transposons that mobilize through RNA intermediates, include some of the most abundant repetitive sequences of the human genome, such as Alu and LINE-1 sequences, and human endogenous retroviruses. Recent discoveries demonstrate that these mobile genetic elements not only act as intragenomic ...

journal_title：Mechanisms of ageing and development

authors： Cardelli M

更新日期：2018-09-01 00:00:00

abstract：:Nuclear envelopes of mammalian cells contain a nucleoside triphosphatase which is probably involved in mRNA transport through the nuclear membrane. The activity of the enzyme, studied in RNA-depleted nuclear ghosts, can be stimulated by poly(A) or by poly(A) (+)mRNA. Using nuclear ghost preparations from mature (8-10 ...

journal_title：Mechanisms of ageing and development

authors： Bernd A,Schröder HC,Zahn RK,Müller WE

更新日期：1982-12-01 00:00:00

abstract：:In yeast, increasing the copy number of the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase Sir2 extends lifespan, which can be inhibited by nicotinamide (Nam), the end-product of Sir2-mediated NAD-breakdown. Furthermore, the yeast pyrazinamidase/nicotinamidase PNC-1 can extend yeast lifespan by converti...

journal_title：Mechanisms of ageing and development

authors： van der Horst A,Schavemaker JM,Pellis-van Berkel W,Burgering BM

更新日期：2007-04-01 00:00:00