Intracellular nucleotides of lymphocytes and granulocytes from normal ageing subjects.

abstract：:Mouse mammary gland displays an irreversible decline in growth rate when propagated by serial transplantation in gland-free mammary fat pads of isogeneic mice. Because transplanted fragments of gland contain both mammary epithelial and stromal elements, the present study was undertaken to distinguish between two possi...

journal_title：Mechanisms of ageing and development

authors： Daniel CW,Shannon JM,Cunha GR

更新日期：1983-11-01 00:00:00

abstract：:Aging is a biological process associated with impairment of mitochondrial bioenergetic function, increased oxidative stress, attenuated ability to respond to stresses and increased risk in contracting age-associated diseases. When mitochondria are subjected to oxidative stress, accompanied by calcium overload and ATP ...

journal_title：Mechanisms of ageing and development

authors： Paradies G,Paradies V,Ruggiero FM,Petrosillo G

更新日期：2013-01-01 00:00:00

abstract：:The purpose of this study was to test the hypothesis that regular exercise training in elderly people affects the type 1/type 2 balance. Nine elderly women who train by walking (mean+/-S.E.M., age 63+/-1 years, VO2 peak 32.2+/-1.0 ml kg(-1) min(-1)), 12 age-matched untrained women (63+/-1 years, 27.8+/-0.9 ml kg(-1) m...

journal_title：Mechanisms of ageing and development

authors： Ogawa K,Oka J,Yamakawa J,Higuchi M

更新日期：2003-08-01 00:00:00

abstract：:In predicting the degree of brain atrophy as measured by CT, the AGP score and a few clinical variables were of some remarkable value. Especially the variables related to memory disorders and lack of insight are easily and reliably assessed during the course of the examination. In comparison to other more widely used ...

journal_title：Mechanisms of ageing and development

authors： Gutzmann H,Avdaloff W

更新日期：1980-11-01 00:00:00

abstract：:Possible alterations in the population of poly(A)(+)mRNA during ageing were investigated by translation in vitro of poly(A)(+)mRNA from the liver, kidney and brain of male ddY mice of different ages. [35S]Methionine-labeled translation products were analysed by two-dimensional polyacrylamide gel electrophoresis follow...

journal_title：Mechanisms of ageing and development

authors： Anzai K,Imazato C,Goto S

更新日期：1983-10-01 00:00:00

abstract：:Thymic atrophy or thymus absence causes depressed thyroid-thymus axis (TTA) efficiency in old, young propyl-thiouracil (PTU) (experimental hypothyroidism) and in young-adult thymectomised (Tx) mice, respectively. Altered zinc turnover may be also involved in depressed TTA efficiency. Zinc turnover is under the control...

journal_title：Mechanisms of ageing and development

authors： Mocchegiani E,Giacconi R,Cipriano C,Gasparini N,Orlando F,Stecconi R,Muzzioli M,Isani G,Carpenè E

更新日期：2002-03-31 00:00:00

abstract：:As a prerequisite to investigating the specification and differentiation of cardiac tissue in vitro, the ontogeny of a number of putative cardiac-specific, and striated muscle-specific gene transcripts has been studied. The probes used include cDNAs of alpha-actins, myosin heavy chains, myosin light chains, alpha-trop...

journal_title：Mechanisms of ageing and development

authors： Murrell WG,Masters CJ,Willis RJ,Crane DI

更新日期：1994-12-16 00:00:00

abstract：:Cellular senescence is a fundamental trait of many eukaryotic organisms. Senescent cells participate both in the developmental program and in normal ageing and age-related diseases. Senescence of proliferation-prone cells is a state of permanent cell cycle arrest accompanied by metabolic activity manifested by high se...

journal_title：Mechanisms of ageing and development

authors： Bielak-Zmijewska A,Mosieniak G,Sikora E

更新日期：2018-03-01 00:00:00

abstract：:While deviations from the optimal phenotype are deleterious, increased variation can prevent population extinction under severe stresses. Cell division asymmetry is an important source of microbial phenotypic heterogeneity. A consecutive set of asymmetric divisions can cause the gradual accumulation of deleterious fac...

journal_title：Mechanisms of ageing and development

authors： Knorre DA,Azbarova AV,Galkina KV,Feniouk BA,Severin FF

更新日期：2018-12-01 00:00:00

abstract：:We have previously reported that two or more different subpopulations of bone marrow stem cells exist in mice as determined by cycling status of day-8 and day-14 CFU-S in long term bromodeoxyuridine (BrdU) infusion studies. In the present report, comparisons between cycling of stem cell subpopulations in old and young...

journal_title：Mechanisms of ageing and development

authors： Pietrzyk ME,Wolf NS,Priestley GV

更新日期：1989-07-01 00:00:00

abstract：:Perceived age is an easily accessible biomarker of aging. Here, we studied its relation to DNA methylation age (DNAm age) as introduced in (Horvath, 2013) in 180 elderly Danish twins. We found perceived age and DNAm age to be associated with chronological age (P=0.04 resp. P=2.2e-10) when correcting for gender, but di...

journal_title：Mechanisms of ageing and development

authors： Debrabant B,Soerensen M,Christiansen L,Tan Q,McGue M,Christensen K,Hjelmborg J

更新日期：2018-01-01 00:00:00

abstract：:Survival characteristics of seven different populations of the mollusc Lymnaea stagnalis were studied under constant culture conditions. On the basis of these characteristics four populations were considered as healthy and three as infected. In the healthy populations senescence started at an age of about 200 days, 50...

journal_title：Mechanisms of ageing and development

authors： Janse C,Slob W,Popelier CM,Vogelaar JW

更新日期：1988-03-01 00:00:00

abstract：:Hypertension is a common age-related disease, along with vascular and neurodegenerative diseases. Vascular ageing increases during hypertension, but hypertension itself accelerates vascular ageing, thus creating a vicious circle. Vascular stiffening, endothelial dysfunction, impaired contractility and vasorelaxation a...

journal_title：Mechanisms of ageing and development

authors： Forte M,Stanzione R,Cotugno M,Bianchi F,Marchitti S,Rubattu S

更新日期：2020-07-01 00:00:00

abstract：:Considerable amount of data has accumulated during the past few years showing several changes in gene expression as a function of age. However, the basic mechanism of aging still remains poorly understood. In this review, we have mainly analysed the data pertaining to the hypothesis that aging is associated with genet...

journal_title：Mechanisms of ageing and development

authors： Thakur MK,Oka T,Natori Y

更新日期：1993-01-01 00:00:00

abstract：:The influence of age on liver gene expression was investigated in two strains of H-2 congenic mice. In B10.RIII mice (H-2r), basal P1- and P3-450 RNA levels progressively decreased 65 and 95%, respectively, between 4 and 28 months of age (P less than or equal to 0.05). Polyaromatic hydrocarbon (PAH) induced P1- and P3...

journal_title：Mechanisms of ageing and development

authors： Mote PL,Grizzle JM,Walford RL,Spindler SR

更新日期：1990-03-31 00:00:00

abstract：:This investigation represents the largest study so far published on human DNA damage and aging. The subject of this investigation is damage, determined as DNA alterations which give rise to complete molecular breaks in the course of treatment of purified DNA solutions with single-strand-specific nucleases. The DNA is ...

journal_title：Mechanisms of ageing and development

authors： Zahn RK,Reinmüller J,Beyer R,Pondeljak V

更新日期：1987-11-01 00:00:00

abstract：:A subset of 43 [35S]methionine labeled mitochondrial proteins, identified on two dimensional electrophoresis gels of whole body extracts of adult Drosophila, were compared between two age groups. These flies, which except for their spermatocytes consist entirely of postmitotic cells, were 6 days old and 38 days old, w...

journal_title：Mechanisms of ageing and development

authors： Fleming JE,Melnikoff PS,Latter GI,Chandra D,Bensch KG

更新日期：1986-03-01 00:00:00

abstract：:Long-Evans female rats three weeks, three months and 13-14 months of age were placed on tryptophan-deficient diets for periods ranging from a few months to nearly two years. Growth was interupted during the period of tryptophan-deficiency, but when the animals were returned to a complete diet, they gained weight and g...

journal_title：Mechanisms of ageing and development

authors： Segall PE,Timiras PS

更新日期：1976-03-01 00:00:00

abstract：:The serotonin content of platelets, serum and plasma from rats of various ages was examined. In male rats, platelet serotonin content, which was about 0.65 nmol/10(8) platelets at young age (6-7 months), increased slightly at middle age (12-14 months) but decreased markedly at old age (25-26 months). Significant diffe...

journal_title：Mechanisms of ageing and development

authors： Yonezawa Y,Kondo H,Nomaguchi TA

更新日期：1989-01-01 00:00:00

abstract：:Gut microbiota is among the factors that may be involved in healthy aging. Broader and geographically spread studies on gut microbiota of centenarians can help in identifying a common signature of longevity. We identified an endogamous Indian population with high centenarian prevalence. Here, we compared the gut micro...

journal_title：Mechanisms of ageing and development

authors： Tuikhar N,Keisam S,Labala RK,Imrat,Ramakrishnan P,Arunkumar MC,Ahmed G,Biagi E,Jeyaram K

更新日期：2019-04-01 00:00:00

abstract：:In the lung of Rana perezi no differences as a function of age have been found for any of the five major antioxidant enzymes, reduced (GSH), oxidized (GSSG) or glutathione ratio (GSSG/GSH), oxygen consumption (VO2) and for in vivo or in vitro stimulated tissue peroxidation. This frog shows a moderate rate of oxygen co...

journal_title：Mechanisms of ageing and development

authors： Perez-Campo R,López-Torres M,Paton D,Sequeros E,Barja de Quiroga G

更新日期：1990-12-01 00:00:00

abstract：:We have examined the effects of aging on guinea pig biliary motility both in vitro and in vivo. The first experiment compared contractile tension of gallbladder strips from young adult (6-12 months old) and 3-year-old guinea pigs in vitro. Contraction of gallbladder strips from the young guinea pigs was twice as force...

journal_title：Mechanisms of ageing and development

authors： Poston GJ,Singh P,Maclellan DG,Yao CZ,Uchida T,Townsend CM Jr,Thompson JC

更新日期：1988-12-01 00:00:00

abstract：:A comparison is made between how bacteria and men use their DNA to accomplish any major biological function. To make this comparison, a modified cybernetic analysis was used. This new type of cybernetic analysis makes a distinction between controlled and regulated systems and may permit an extension of cybernetics int...

journal_title：Mechanisms of ageing and development

authors： Denckla WD

更新日期：1977-03-01 00:00:00

abstract：:Primatologists have recognized that non-humans undergo the menopause [Biol. Reprod. 68 (2003) 10], which is preceded by years of irregular cycles and decreased fecundity. The similarity of reproductive changes between humans and baboons suggests that the aging female baboon is a particularly promising model to study h...

journal_title：Mechanisms of ageing and development

authors： Martin LJ,Carey KD,Comuzzie AG

更新日期：2003-08-01 00:00:00

abstract：:The present study investigated whether age-related changes in the production of Th1 and Th2 cytokines by human T cells might be linked to altered frequencies of naive (CD45RA+) and memory (CD45RO+) T cell subsets. T cells from healthy elderly humans (n = 32) stimulated with anti-CD3epsilon monoclonal antibody OKT3 plu...

journal_title：Mechanisms of ageing and development

authors： Karanfilov CI,Liu B,Fox CC,Lakshmanan RR,Whisler RL

更新日期：1999-08-30 00:00:00

abstract：:The plasma disappearance of endotoxin and endotoxin-induced hepatic injury were studied in two rat models: the aging rat and the subacutely hypervitaminotic A rat. The choice of these models was based on their respective association with a decreased or increased Kupffer cell endocytic activity. The half-life of endoto...

journal_title：Mechanisms of ageing and development

authors： Hendriks HF,Horan MA,Durham SK,Earnest DL,Brouwer A,Hollander CF,Knook DL

更新日期：1987-12-01 00:00:00

abstract：:Motor neurons and ventral root motor fibres innervating extensor digitorum longus (EDL) muscle in rats of 0.5-3.5 months of age were studied by HRP-retrograde labelling and in vivo muscle tension recording, respectively. EDL nucleus size increased with age but motor neurons number and size did not change. Twitch and t...

journal_title：Mechanisms of ageing and development

authors： Cuppini R,Ambrogini P

更新日期：1996-12-20 00:00:00

abstract：:Dietary factors have a profound effect on many aspects of health including ageing and do so, at least partly, through interactions with the genome which result in altered gene expression. The application of high throughput genomics technologies in nutritional research (nutrigenomics) offers a new approach to understan...

journal_title：Mechanisms of ageing and development

authors： Mathers JC

更新日期：2006-06-01 00:00:00

abstract：:Changes in the T-lymphocyte compartment represent the most critical component of immunological aging. Recent studies have demonstrated that the age-related decline in T-cell-mediated immunity is a multifactorial phenomenon affecting T-cell subset composition as well as several proximal events such as protein tyrosine ...

journal_title：Mechanisms of ageing and development

authors： Chakravarti B,Abraham GN

更新日期：1999-05-17 00:00:00

abstract：:The various phases of homo- and heteroclonal encounters between stolons of Podocoryne carnea M. Sars have been studied with the light and electron microscope. The first clone-unspecific actions and reactions to an imminent encounter between the outgrowing tip of stolon and the subterminal part of an opposed homologous...

journal_title：Mechanisms of ageing and development

authors： Tardent P,Jauch U

更新日期：1983-03-01 00:00:00