Age-related defects in Th1 and Th2 cytokine production by human T cells can be dissociated from altered frequencies of CD45RA+ and CD45RO+ T cell subsets.

abstract：:Mycobacteria are an important group of pathogenic bacteria. We generated a series of DNA repair deficient strains of Mycobacterium smegmatis, a model organism, to understand the importance of various DNA repair proteins (UvrB, Ung, UdgB, MutY and Fpg) in survival of the pathogenic strains. Here, we compared tolerance ...

journal_title：Mechanisms of ageing and development

authors： Rex K,Kurthkoti K,Varshney U

更新日期：2013-10-01 00:00:00

abstract：:Confluent late passage WI-38 human diploid fibroblast cultures grown in the presence or absence of hydrocortisone for fifteen population doublings were measured cytochemically for DNA, nuclear RNA, basic nuclear protein and acidic nuclear protein content during a 12-hour interval following a medium-change stimulation....

journal_title：Mechanisms of ageing and development

authors： Docherty PA,Anthony A,Mitchell RB

更新日期：1981-11-01 00:00:00

abstract：:In most species, females live longer than males. An understanding of this female longevity advantage will likely uncover novel anti-aging therapeutic targets. Here we investigated the transcriptomic responses in the hypothalamus - a key organ for somatic aging control - to the introduction of a simple aging-related mo...

journal_title：Mechanisms of ageing and development

authors： van Gastel J,Cai H,Cong WN,Chadwick W,Daimon C,Leysen H,Hendrickx JO,De Schepper R,Vangenechten L,Van Turnhout J,Verswyvel J,Becker KG,Zhang Y,Lehrmann E,Wood WH 3rd,Martin B,Maudsley S

更新日期：2019-12-01 00:00:00

abstract：:Aging is a complex physiological process by which the functions of many organ systems deteriorate. Growing evidence shows that age-related changes and damage are causally related to oxidative stress and inflammatory responses from reactive species. The aim of this study was to identify differentially expressed genes i...

journal_title：Mechanisms of ageing and development

authors： Sung B,Jung KJ,Song HS,Son MJ,Yu BP,Chung HY

更新日期：2005-08-01 00:00:00

abstract：:Hepatocyte morphology of the three zones of the liver lobule was evaluated by stereological analysis in 3-month-old and 35-month-old virgin female WAG/Rij rats. In the old rats, the volume of the nucleus and cytoplasm, and volume densities of smooth endoplasmic reticulum and lysosomes were increased in all areas of th...

journal_title：Mechanisms of ageing and development

authors： Meihuizen SP,Blansjaar N

更新日期：1980-06-01 00:00:00

abstract：:Chronic oxidative stress is generally believed to be a major etiologic factor in the aging process. In addition to modulation of signaling processes and oxidation of cellular proteins and lipids, reactive oxygen species (ROS) induce multiple damages in both nuclear and mitochondrial genomes, most of which are repaired...

journal_title：Mechanisms of ageing and development

authors： Szczesny B,Bhakat KK,Mitra S,Boldogh I

更新日期：2004-10-01 00:00:00

abstract：:In this article we review the abnormalities in immune function which have been described in relation to ageing. It is suggested that thymic involution may not be the only underlying cause. Many similar changes can be induced by the endotoxins from the cell walls of Gram-negative bacteria. The colon is a large reposito...

journal_title：Mechanisms of ageing and development

authors： Horan MA,Fox RA

更新日期：1984-08-01 00:00:00

abstract：:It strikes me that among our relatively small community of gerontologists concerned with genetic approaches to our science, there is somewhat of a dichotomization. On the one hand, there are those of us, like myself, who tend to be dour 'complificationists'. Journalists talk to us, but are usually disappointed by the ...

journal_title：Mechanisms of ageing and development

authors： Martin GM

更新日期：2002-01-01 00:00:00

abstract：:The general objective of this study was to examine the relationship between oxygen free radicals and the aging process. The rate of superoxide anion radical (O2.-) generation was measured in liver sub-mitochondrial particles from mouse, rat, rabbit, pig and cow, and in flight muscle sub-mitochondrial particles from th...

journal_title：Mechanisms of ageing and development

authors： Sohal RS,Svensson I,Sohal BH,Brunk UT

更新日期：1989-08-01 00:00:00

abstract：:Age-specific mortality rates from stomach cancer (SC) in Japan from 1950 through 1993 were subjected to longitudinal Gompertzian analysis. Age-specific SC mortality rate distributions between ages 45 and 75 years were highly Gompertzian for each- and every year for both men and women. Between 1950 and 1993, age-adjust...

journal_title：Mechanisms of ageing and development

authors： Imaizumi Y

更新日期：1995-11-24 00:00:00

abstract：:Keratinocytes and fibroblasts were obtained from upper arm biopsies of young (22-27 years) and old (60-82 years) adult donors. Keratinocytes were grown in serum-free medium containing variable quantities of either epidermal growth factor (EGF) or a bovine hypothalamic extract known to contain keratinocyte growth facto...

journal_title：Mechanisms of ageing and development

authors： Stanulis-Praeger BM,Gilchrest BA

更新日期：1986-07-01 00:00:00

abstract：:In order to determine whether the function of alveolar macrophages (AM) is modulated by aging, we measured the TNF-alpha production, phagocytic function, and surface antigen expression of AM from young and old mice. When AM were primed by IFN-gamma (500 units/ml) and triggered by LPS (100 micrograms/ml), TNF-alpha pro...

journal_title：Mechanisms of ageing and development

authors： Higashimoto Y,Fukuchi Y,Shimada Y,Ishida K,Ohata M,Furuse T,Shu C,Teramoto S,Matsuse T,Sudo E

更新日期：1993-07-01 00:00:00

abstract：:The number of senescent cells in the skin is increasing with age. Numerous studies have attempted to elucidate the role of these cells in normal aging of the skin as well as in age-related skin conditions. In recent years, attempts have also been made to find treatments that aim either to cleanse the skin tissues of s...

journal_title：Mechanisms of ageing and development

authors： Georgakopoulou EA,Valsamidi C,Veroutis D,Havaki S

更新日期：2021-01-01 00:00:00

abstract：:Hematopoietic stem cell performance and identity, crucial for homeostasis of the blood-forming system, is governed by extrinsic factors found in the bone marrow microenvironment. Communication within hematopoietic stem cell niches occurs via soluble factors or cell-to-cell contacts between niche and blood-forming cell...

journal_title：Mechanisms of ageing and development

authors： Böhm L,Helbing DL,Oraha N,Morrison H

更新日期：2020-10-01 00:00:00

abstract：:The age-related changes in the distribution of enkephalin-immunoreactive (ENK-IR) nerve fibers in relation to the principal neurons were studied in 23 human sympathetic ganglia from patients aged between 22 and 98 years. There were no age-related changes in the diameter of nerve cells and the packing density of the ne...

journal_title：Mechanisms of ageing and development

authors： Järvi R,Helen P,Pelto-Huikko M,Rapoport SI,Hervonen A

更新日期：1988-08-01 00:00:00

abstract：:Tumor cells express NADPH oxidase-1 (NOX1) in their membrane and control NOX1-based intercellular reactive oxygen and nitrogen species (ROS/RNS)-dependent apoptosis-inducing signaling through membrane-associated catalase and superoxide dismutase. TREATMENT:of tumor cells with high concentrations of H2O2, peroxnitrite...

journal_title：Mechanisms of ageing and development

authors： Bauer G

更新日期：2018-06-01 00:00:00

abstract：:The proto-oncogene c-fos (the cellular homolog of v-fos, Finkel-Biskis-Jenkins (FBJ) murine osteogenic sarcoma virus) encodes a major component of the activator protein-1 (AP-1) transcription factor. Serum stimulation as well as oxidizing treatments induce transitory increases in c-fos mRNA abundance. The induction of...

journal_title：Mechanisms of ageing and development

authors： Keogh BP,Tresini M,Cristofalo VJ,Allen RG

更新日期：1996-03-29 00:00:00

abstract：:Twenty-six institutionalized elderly subjects, selected as healthy according to the SENIEUR protocol, were compared to adult controls to establish correlations between affective disorders and immune abnormalities and to investigate underlying neuroendocrine mechanisms. After an extensive psychodiagnostic examination, ...

journal_title：Mechanisms of ageing and development

authors： Bartoloni C,Guidi L,Frasca D,Antico L,Pili R,Cursi F,Di Giovanni A,Rumi C,Menini E,Carbonin P

更新日期：1991-09-01 00:00:00

abstract：:The activity of low Km cAMP-phosphodiesterase (PDE) was determined in extracts of prostate and heart of adult (10-12 months old) and aged (32-35 months old) Sprague-Dawley rats; the enzyme's response to endogenous inhibitors extracted from the two organs was analyzed by kinetic studies. Different mechanisms of inhibit...

journal_title：Mechanisms of ageing and development

authors： Moses MA,Szabo EI,Terner C

更新日期：1987-07-01 00:00:00

abstract：:The B cell responsiveness mediated by T cells has been evaluated in 50 aged donors by using a Pokeweed mitogen (PWM)-driven differentiation system. Peripheral blood mononuclear cells (PBMC) from aged donors exhibited a lower plaque-forming cell (PFC) generation in comparison with young donors. Similar results were obt...

journal_title：Mechanisms of ageing and development

authors： Antonaci S,Jirillo E,Gallitelli M,Garofalo AR,Bonomo L

更新日期：1987-11-01 00:00:00

abstract：:T cell responses are altered in the aged in a manner usually interpreted as detrimental to host defences against infectious agents and possibly also against cancer. T cell dysregulation may be caused by any or a combination of stem cell deficits, compromised T cell differentiation, inefficient antigen processing and p...

journal_title：Mechanisms of ageing and development

authors： Pawelec G,Hirokawa K,Fülöp T

更新日期：2001-09-30 00:00:00

abstract：:Cellular and organismal decline is, in part, believed to be a consequence of oxygen and nitrogen-based reactants which persistently damage macromolecules throughout a lifetime. The resulting accumulation of damaged molecules eventually seriously compromises essential functions of cells leading to their death. Excessiv...

journal_title：Mechanisms of ageing and development

authors： Reiter RJ,Tan DX,Burkhardt S

更新日期：2002-04-30 00:00:00

abstract：:The plasma disappearance of endotoxin and endotoxin-induced hepatic injury were studied in two rat models: the aging rat and the subacutely hypervitaminotic A rat. The choice of these models was based on their respective association with a decreased or increased Kupffer cell endocytic activity. The half-life of endoto...

journal_title：Mechanisms of ageing and development

authors： Hendriks HF,Horan MA,Durham SK,Earnest DL,Brouwer A,Hollander CF,Knook DL

更新日期：1987-12-01 00:00:00

abstract：:At various time intervals (10, 15, 20, 25, 30 min) after injection of 3H-fucose into the medial septal nucleus of young adult (3 months old) and senescent (25 months old) Fischer-344 rats, the specific activities of trichloroacetic acid-phosphotungstic acid (TCA-PTA) soluble and insoluble fractions were determined in ...

journal_title：Mechanisms of ageing and development

authors： Geinisman Y,Bondareff W,Telser A

更新日期：1977-09-01 00:00:00

abstract：:Putrescine, spermidine, spermine and two unknowns designated as A and B were detected in first seedling leaves of barley (Hordeum vulgare L. var. Wolfe). The levels of these polyamines in first seedling leaves from 4-day-old barley plants grown in darkness or in light were comparable and did not change significantly a...

journal_title：Mechanisms of ageing and development

authors： Srivastava BI

更新日期：1987-09-14 00:00:00

abstract：:Interfibrillar mitochondria (IFM) of the heart in aged Fischer 344 rats show a biochemical defect which might be reflected in their morphology. We examined by high resolution scanning electron microscopy over 5500 mitochondria to determine if a concomitant structural alteration existed. This methodology provides a mea...

journal_title：Mechanisms of ageing and development

authors： Riva A,Tandler B,Lesnefsky EJ,Conti G,Loffredo F,Vazquez E,Hoppel CL

更新日期：2006-12-01 00:00:00

abstract：:Expression of dystrophin and the dystrophin-related protein utrophin has been studied in the human fetal brain both in vivo and in vitro. Results showed that both these proteins were developmentally regulated, even if their expression followed a different pattern. Utrophin was found since very early stages of developm...

journal_title：Mechanisms of ageing and development

authors： Sogos V,Curto M,Reali C,Gremo F

更新日期：2002-03-15 00:00:00

abstract：:A 3'-->5' exonuclease found in rat liver excises mispaired nucleotides at the 3'-hydroxyl end of primer chains such as poly dA-d(T9-C). Consequently, the priming activity of the chain from which the mispaired base was cut is greatly increased during DNA synthesis. These results suggest that the 3'-->5' exonuclease act...

journal_title：Mechanisms of ageing and development

authors： Taguchi T,Fukuda M,Toda T,Ohashi M

更新日期：1998-09-15 00:00:00

abstract：:In this paper, some of the key findings of the last decade will briefly be surveyed and, where possible, be related to two separate computer simulation models which have been designed to determine the validity of certain widely accepted dogmas and to define the limits and restrictions imposed by attrition of or ambigu...

journal_title：Mechanisms of ageing and development

authors： Strehler BL,Freeman MR

更新日期：1980-09-01 00:00:00

abstract：:Significant changes are observed in wet weight, microsomal protein content and enzymes of purified rough and smooth microsomes of liver during postnatal development and ageing of female Wistar rats. Protein content of total microsomes increases up to 15 days of age and remains steady during subsequent development, unl...

journal_title：Mechanisms of ageing and development

authors： Devasagayam TP,Pushpendran CK,Eapen J

更新日期：1983-03-01 00:00:00