Altered T cell signalling in ageing.

Abstract:

:T cell responses are altered in the aged in a manner usually interpreted as detrimental to host defences against infectious agents and possibly also against cancer. T cell dysregulation may be caused by any or a combination of stem cell deficits, compromised T cell differentiation, inefficient antigen processing and presentation by antigen presenting cells, suboptimal processing of the antigenic signal by T cells or inability of the T cell to respond appropriately thereafter. This review will focus on altered T cell signalling in ageing, encompassing not only alterations in signal transduction by the antigen-specific T cell receptor, but changes in the balance of positive and negative T cell costimulation and the resultant modified cytokine environment, the response to which is itself altered in ageing.

journal_name

Mech Ageing Dev

authors

Pawelec G,Hirokawa K,Fülöp T

doi

10.1016/s0047-6374(01)00290-1

subject

Has Abstract

pub_date

2001-09-30 00:00:00

pages

1613-37

issue

14

eissn

0047-6374

issn

1872-6216

pii

S0047-6374(01)00290-1

journal_volume

122

pub_type

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