Abstract:
:The activity of rat heart succinate dehydrogenase (SDH) increases 1.7-fold in old animals (Vitorica, J., Cano, J., Satrústegui, J. and Machado, A., Mech. Ageing Dev., 16 (1981) 105-116). This increase is due to an increase in enzyme protein itself because: (a) the activation state of the enzyme does not vary with age; and (b) the increase of activity is paralleled by an increase in immunoprecipitable SDH in old rat heart mitochondria. SDH from old rat heart mitochondria differs in a number of ways from that of young animals: (a) The km value for succinate increases with age. (b) The thermostability decreases, and the activation energy in the 20-40 degrees C interval is higher in old animals. (c) The breaking points of the Arrhenius plots of SDH are shifted to higher values. (d) Reactivity towards N-ethylmaleimide in succinate protected mitochondria decreases with age.
journal_name
Mech Ageing Devjournal_title
Mechanisms of ageing and developmentauthors
Velez M,Machado A,Satrústegui Jdoi
10.1016/0047-6374(85)90076-4subject
Has Abstractpub_date
1985-11-01 00:00:00pages
131-40issue
2-3eissn
0047-6374issn
1872-6216pii
0047-6374(85)90076-4journal_volume
32pub_type
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journal_title:Mechanisms of ageing and development
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journal_title:Mechanisms of ageing and development
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
doi:10.1016/j.mad.2003.10.007
更新日期:2004-01-01 00:00:00
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journal_title:Mechanisms of ageing and development
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journal_title:Mechanisms of ageing and development
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
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更新日期:1990-05-30 00:00:00
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journal_title:Mechanisms of ageing and development
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
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更新日期:1994-07-01 00:00:00
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journal_title:Mechanisms of ageing and development
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