Changes in the male rat hepatic cytochrome P-450 level, heme oxygenase and delta-aminolevulinic acid synthase activities at various stages of life.

abstract：:The potential gain in life expectancy which could result from the complete elimination of mortality from cancer in the U.S. would not exceed 3 years if one were to consider cancer independently of other causes of death. In this paper, we review evidence of trade-offs between cancer and aging as well as between cancer ...

journal_title：Mechanisms of ageing and development

authors： Yashin AI,Ukraintseva SV,Akushevich IV,Arbeev KG,Kulminski A,Akushevich L

更新日期：2009-01-01 00:00:00

abstract：:The present work explores the application of information theoretical measures, such as entropy and normalized mutual information, for research of biomarkers of aging. The use of information theory affords unique methodological advantages for the study of aging processes, as it allows evaluating non-linear relations be...

journal_title：Mechanisms of ageing and development

authors： Blokh D,Stambler I

更新日期：2017-04-01 00:00:00

abstract：:In an attempt to determine the relevance of the free radical theory of ageing to age changes discernible in connective tissue parameters, a small colony of C3H/He and LAF1 mice was set up, with sample culled at intervals throughout the lifespan to provide experimental samples. To half of the stock a dietary supplement...

journal_title：Mechanisms of ageing and development

authors： Blackett AD,Hall DA

更新日期：1980-11-01 00:00:00

abstract：:The kinetics of accumulation and loss of zinc from the liver following subcutaneous administration of 10 mg of zinc per kg were examined in young adult (6 months old) and old (24 months old) male C57BL/6J mice. After zinc treatment, total liver zinc concentrations rose equally in both groups and returned to basal leve...

journal_title：Mechanisms of ageing and development

authors： Thomas DJ,Winchurch RA,Adler WH

更新日期：1989-03-01 00:00:00

abstract：:The identification of predictive markers of life span would help to unravel the underlying mechanisms influencing ageing and longevity. For this aim, 30 variables including immune functions, inflammatory-oxidative stress state and behavioural characteristics were investigated in ICR-CD1 female mice at the adult age (N...

journal_title：Mechanisms of ageing and development

authors： Martínez de Toda I,Vida C,Sanz San Miguel L,De la Fuente M

更新日期：2019-09-01 00:00:00

abstract：:T cell activation involves events at the plasma membrane; therefore, molecules such as long chain omega-3 fatty acids that alter the structure of the plasma membrane may affect the activation of aged T cells. In this project we investigated whether the incorporation of omega-3 fatty acids (from fish oil), in the prese...

journal_title：Mechanisms of ageing and development

authors： VanMeter AR,Ehringer WD,Stillwell W,Blumenthal EJ,Jenski LJ

更新日期：1994-08-01 00:00:00

abstract：:Morphometric comparison of freeze-fractured mitochondria in flight muscles of adult (37-day-old) and old (68-day-old) houseflies revealed a 28% decrease of cristae in the old flies. The major membrane change with age was an increase in the 90-120-A particles in the inner membrane external face concomitant with a loss ...

journal_title：Mechanisms of ageing and development

authors： Turturro A,Shafiq SA

更新日期：1981-06-01 00:00:00

abstract：:As the endothelium ages it may become more susceptible to damage by atherogenic plasma components such as toxic lipid oxidation products. Vitamin E (vit E) might prove to be anti-atherogenic by reducing oxidative injury. This study investigated the effects of age and chronic exposure to fatty acid hydroperoxides (OFA)...

journal_title：Mechanisms of ageing and development

authors： Boissonneault GA,Hennig B,Wang Y,Wood CL

更新日期：1990-10-01 00:00:00

abstract：:Mouse mammary gland displays an irreversible decline in growth rate when propagated by serial transplantation in gland-free mammary fat pads of isogeneic mice. Because transplanted fragments of gland contain both mammary epithelial and stromal elements, the present study was undertaken to distinguish between two possi...

journal_title：Mechanisms of ageing and development

authors： Daniel CW,Shannon JM,Cunha GR

更新日期：1983-11-01 00:00:00

abstract：:The localization of the beta/A4 amyloid precursor protein (APP) was studied in the human lumbar paravertebral sympathetic ganglia of subjects of different ages, free of neurologic disease, using combined immunohistochemistry and image analysis techniques (optic microdensitometry). To ascertain which cells displayed AP...

journal_title：Mechanisms of ageing and development

authors： Calzada B,Cabal A,Naves FJ,del Valle ME,Represa JJ,Vega JA

更新日期：1994-10-20 00:00:00

abstract：:The circulating antibody titers to bovine serum albumin (BSA) were determined for two groups of aged Fischer 344 rats obtained form the National Institute on Aging. One group received a single immunization of BSA in complete Freund's adjuvant, and the second group was immunized three times at two-week intervals with t...

journal_title：Mechanisms of ageing and development

authors： Kaplan PJ,Caperna TJ,Garvey JS

更新日期：1981-05-01 00:00:00

abstract：:The health status of the oldest old, the fastest increasing population segment worldwide, progressively becomes more heterogeneous, and this peculiarity represents a major obstacle to their classification. We compared the effectiveness of four previously proposed criteria (Franceschi et al., 2000; Evert et al., 2003; ...

journal_title：Mechanisms of ageing and development

authors： Cevenini E,Cotichini R,Stazi MA,Toccaceli V,Scurti M,Mari V,Berardelli M,Passarino G,Jeune B,Franceschi C,GEHA Project Consortium.

更新日期：2013-11-01 00:00:00

abstract：:Quantitative measurements of glycogen in aging bruchids showed there was a considerable decrease (> 50%) with age except on the fifth day when an increase was observed, followed by a decrease on the sixth day. The variations in glycogen content with age suggests that glycogen serves as one of the energy sources respon...

journal_title：Mechanisms of ageing and development

authors： Sharma SP,Sharma G

更新日期：1980-01-01 00:00:00

abstract：:Protein oxidation, one of a number of brain biomarkers of oxidative stress, is increased in several age-related neurodegenerative disorders or animal models thereof, including Alzheimer's disease, Huntington's disease, prion disorders, such as Creutzfeld-Jakob disease, and alpha-synuclein disorders, such as Parkinson'...

journal_title：Mechanisms of ageing and development

authors： Butterfield DA,Kanski J

更新日期：2001-07-15 00:00:00

abstract：:The effects of ageing and of exercise on muscle mass, fiber cross-sectional area, and fiber type composition of a weight-bearing muscle, the soleus and a non-weight-bearing muscle, the extensor digitorum longus (EDL) were investigated in female Long-Evans rats. The animals were exercised by means of voluntary wheel ru...

journal_title：Mechanisms of ageing and development

authors： Brown M,Ross TP,Holloszy JO

更新日期：1992-03-15 00:00:00

abstract：:In this paper, we approach the problem of attempting to understand senescence by understanding the complexity and hierarchical structure of mammalian organisms. To do this, we make use of some concepts from abstract relational biology; in particular, graph theory. We subsequently utilize these concepts to develop the ...

journal_title：Mechanisms of ageing and development

authors： Witten M

更新日期：1984-10-31 00:00:00

abstract：:Age-related changes in blood-brain barrier permeability to macromolecules were investigated during electrically induced seizures. Evans-blue was used as the barrier tracer. There was no change in the permeability of the blood brain barrier associated with aging in the rats. However, the extravasation of Evans-blue alb...

journal_title：Mechanisms of ageing and development

authors： Oztas B,Kaya M,Camurcu S

更新日期：1990-02-01 00:00:00

abstract：:This cross-sectional study was conducted among a rural elderly population of 725 individuals aged over 60 years from Eastern India to assess the association of multiple chronic diseases with frailty and dependence. Multimorbidity, frailty, and dependence were assessed using prevalidated tools. Regression models were u...

journal_title：Mechanisms of ageing and development

authors： Kshatri JS,Palo SK,Bhoi T,Barik SR,Pati S

更新日期：2020-12-01 00:00:00

abstract：:As measured by X-ray microanalysis of frozen-dried cryosections, physiological concentrations of phosphorus, Na+, K+ and Mg2+ show a biphasic age dependence in some compartments of rat hepatocytes, especially in the regions of condensed chromatin associated with the actively transcribed genes. This could be consistent...

journal_title：Mechanisms of ageing and development

authors： von Zglinicki T,Bimmler M

更新日期：1987-04-01 00:00:00

abstract：:In this study, we proposed a hypothesis that chromatin of mouse hepatocytes exhibits age-related reduction of fractal dimension. This hypothesis was based on previously published works demonstrating that complexity of biological systems such as tissues, decreases during the process of physiological aging. Liver tissue...

journal_title：Mechanisms of ageing and development

authors： Pantic I,Petrovic D,Paunovic J,Vucevic D,Radosavljevic T,Pantic S

更新日期：2016-07-01 00:00:00

abstract：:The lifespan of the nematode, Caenorhabditis elegans, can be extended by mutations affecting components of the insulin-like growth factor (IGF) signaling cascade or by overexpression of SIR2, an NAD+-dependent protein deacetylase. The mammalian homologue of SIR2, Sirt1, has been shown to modulate the activity of FoxO,...

journal_title：Mechanisms of ageing and development

authors： Lemieux ME,Yang X,Jardine K,He X,Jacobsen KX,Staines WA,Harper ME,McBurney MW

更新日期：2005-10-01 00:00:00

abstract：:Periodontal diseases are partly attributable to periodontopathic bacteria found in the host, whereas, butyric acid (BA) is a common secondary metabolite produced by periodontopathic bacterial pathogens. BA has been linked to oxidative stress induction while oxidative stress has long been associated with the ageing pro...

journal_title：Mechanisms of ageing and development

authors： Cueno ME,Seki K,Ochiai K,Imai K

更新日期：2017-03-01 00:00:00

abstract：:Changes in glycosaminoglycans during in vitro aging were investigated in human diploid fibroblasts. The cells were found to produce predominantly hyaluronate and smaller amounts of chondroitin 4-sulfate, chondroitin 6-sulfate, dermatan sulfate and heparan sulfate. Accumulation of heparan sulfate on the cell surface wa...

journal_title：Mechanisms of ageing and development

authors： Matuoka K,Mitsui Y

更新日期：1981-02-01 00:00:00

abstract：:This review addresses a novel facet of human T cell biology that constitutes a fundamental problem for long-term maintenance of immunological memory against viruses. The finite proliferative capacity of human T lymphocytes is sufficiently great to accommodate the waves of clonal expansion associated with primary and e...

journal_title：Mechanisms of ageing and development

authors： Effros RB

更新日期：2000-12-20 00:00:00

abstract：:Interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) concentrations were measured in livers of young-adult and old rats administered carbon tetrachloride or vehicle. IL-1beta levels were higher and IL-6 levels were lower in old rats than in young-adult rats. Carbon tetrachlor...

journal_title：Mechanisms of ageing and development

authors： Rikans LE,DeCicco LA,Hornbrook KR,Yamano T

更新日期：1999-05-03 00:00:00

abstract：:The development and aging of the nucleolus and nucleus in layer V pyramidal cells in the hamster cerebrum were studied by light and electron microscopy. The nucleoli appeared in the newborn as occasional fibrillar masses adjacent to peripherally placed bodies of chromatin. By maturity, a single, generally central, nuc...

journal_title：Mechanisms of ageing and development

authors： Buschmann MB,LaVelle A

更新日期：1981-04-01 00:00:00

abstract：:Falls following a meal occur commonly in older persons. These falls have been related to a decrease in postprandial blood pressure due to carbohydrates in the meal. The mechanism by which this occurs is not known. In this study, we examined the possible role of a vasodilatory peptide, calcitonin gene-related peptide (...

journal_title：Mechanisms of ageing and development

authors： Edwards BJ,Perry HM 3rd,Kaiser FE,Morley JE,Kraenzle D,Stevenson R,Kreutter D

更新日期：1996-06-07 00:00:00

abstract：:Nearly 40 years ago it was proposed that accumulation of mutations or increased levels of DNA damage might contribute to aging processes. Despite several correlative studies in this area, the answer as to whether genomic integrity contributes to aging has remained illusive. More recently it has been hypothesized that ...

journal_title：Mechanisms of ageing and development

authors： Walter CA,Grabowski DT,Street KA,Conrad CC,Richardson A

更新日期：1997-12-01 00:00:00

abstract：:Several technologies that emerged in the post-genomic era have been particularly useful in dissecting the molecular mechanisms of complex biological processes through the systems approach. Here, we review how three of these technologies, namely transcriptional profiling, large-scale RNA interference (RNAi) and genome-...

journal_title：Mechanisms of ageing and development

authors： Lim CA,Ng HH

更新日期：2007-01-01 00:00:00

abstract：:The serotonin content of platelets, serum and plasma from rats of various ages was examined. In male rats, platelet serotonin content, which was about 0.65 nmol/10(8) platelets at young age (6-7 months), increased slightly at middle age (12-14 months) but decreased markedly at old age (25-26 months). Significant diffe...

journal_title：Mechanisms of ageing and development

authors： Yonezawa Y,Kondo H,Nomaguchi TA

更新日期：1989-01-01 00:00:00