Effect of age and carbon tetrachloride on cytokine concentrations in rat liver.

abstract：:The occurrence of inactive enzyme molecules in a variety of tissues and animal species has been shown to be of a general nature. The levels of inactive enzyme molecules found in old animals were produced by amino acid analogs in young animals. These levels have been shown to be initially detrimental but subsequently t...

journal_title：Mechanisms of ageing and development

authors： Gershon D

更新日期：1979-02-01 00:00:00

abstract：:In this paper, some of the key findings of the last decade will briefly be surveyed and, where possible, be related to two separate computer simulation models which have been designed to determine the validity of certain widely accepted dogmas and to define the limits and restrictions imposed by attrition of or ambigu...

journal_title：Mechanisms of ageing and development

authors： Strehler BL,Freeman MR

更新日期：1980-09-01 00:00:00

abstract：:Motor neurons and ventral root motor fibres innervating extensor digitorum longus (EDL) muscle in rats of 0.5-3.5 months of age were studied by HRP-retrograde labelling and in vivo muscle tension recording, respectively. EDL nucleus size increased with age but motor neurons number and size did not change. Twitch and t...

journal_title：Mechanisms of ageing and development

authors： Cuppini R,Ambrogini P

更新日期：1996-12-20 00:00:00

abstract：:Age-related changes in blood-brain barrier permeability to macromolecules were investigated during electrically induced seizures. Evans-blue was used as the barrier tracer. There was no change in the permeability of the blood brain barrier associated with aging in the rats. However, the extravasation of Evans-blue alb...

journal_title：Mechanisms of ageing and development

authors： Oztas B,Kaya M,Camurcu S

更新日期：1990-02-01 00:00:00

abstract：:The healing of normal incisional wounds and ischemic flap wounds was investigated in young (10 weeks) and old (102-104 weeks) rats, together with the effect of treatment with hyperbaric oxygen on day 0-3 of healing. After 10 days of healing all biomechanical strength parameters of normal wounds were decreased by 30-40...

journal_title：Mechanisms of ageing and development

authors： Quirinia A,Viidik A

更新日期：1996-10-25 00:00:00

abstract：:Atypical bodies (ABs), related to aging, are described in the central nervous system of normal aged hamsters. Our study used ultrastructural microscopy and quantitative stereology analysis to study these structures in the hypothalamus and brain stem of 3, 6, 12, 18, 24 and 30 month-old hamsters. We found that these co...

journal_title：Mechanisms of ageing and development

authors： Navarro A,González del Rey C,Tolivia J,Alvarez-Uría M

更新日期：1996-09-09 00:00:00

abstract：:Formalinized Mycoplasma pulmonis was used to immunize 3 different age groups of Fischer 344 rats. A specific antibody to this antigen was detected in both saliva and lung lavage fluids and differences were noted in the elicitation of secretory antibody between the different ages of the animals. Few statistical differe...

journal_title：Mechanisms of ageing and development

authors： Steffen MJ,Ebersole JL

更新日期：1992-11-01 00:00:00

abstract：:Calorie restriction (CR) extends life span and retards many age-related cellular and molecular changes in laboratory rodents. However, neither the breadth of its effects, its underlying mechanisms, nor the limits of its action is fully understood. Expression levels of 588 genes in livers from 3- and 24-month-old ad li...

journal_title：Mechanisms of ageing and development

authors： Han E,Hilsenbeck SG,Richardson A,Nelson JF

更新日期：2000-06-20 00:00:00

abstract：:In yeast, increasing the copy number of the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase Sir2 extends lifespan, which can be inhibited by nicotinamide (Nam), the end-product of Sir2-mediated NAD-breakdown. Furthermore, the yeast pyrazinamidase/nicotinamidase PNC-1 can extend yeast lifespan by converti...

journal_title：Mechanisms of ageing and development

authors： van der Horst A,Schavemaker JM,Pellis-van Berkel W,Burgering BM

更新日期：2007-04-01 00:00:00

abstract：:Skeletal muscle ageing is characterized by faulty degenerative/regenerative processes that promote the decline of its mass, strength, and endurance. In this study, we used a transcriptional profiling method to better understand the molecular pathways and factors that contribute to these processes. To more appropriatel...

journal_title：Mechanisms of ageing and development

authors： Scimè A,Desrosiers J,Trensz F,Palidwor GA,Caron AZ,Andrade-Navarro MA,Grenier G

更新日期：2010-01-01 00:00:00

abstract：:Age-associated changes in lung structure and function are some of the most important predictors of overall health, cognitive activities and longevity. Common to all aging cells is an increase in oxidatively modified DNA bases, primarily 8-oxo-7,8-dihydroguanine (8-oxoG). It is repaired via DNA base excision repair pat...

journal_title：Mechanisms of ageing and development

authors： German P,Saenz D,Szaniszlo P,Aguilera-Aguirre L,Pan L,Hegde ML,Bacsi A,Hajas G,Radak Z,Ba X,Mitra S,Papaconstantinou J,Boldogh I

更新日期：2017-01-01 00:00:00

abstract：:In an attempt to determine the relevance of the free radical theory of ageing to age changes discernible in connective tissue parameters, a small colony of C3H/He and LAF1 mice was set up, with sample culled at intervals throughout the lifespan to provide experimental samples. To half of the stock a dietary supplement...

journal_title：Mechanisms of ageing and development

authors： Blackett AD,Hall DA

更新日期：1980-11-01 00:00:00

abstract：:It has been approximately 25 years since Dr. Rosenberg first brought attention to sarcopenia. To date, this aging-associated condition is recognized as a chronic loss of muscle mass and is usually accompanied by dynapenia. Despite its poly-etiological factors, sarcopenia has a strong neurogenic component underlying th...

journal_title：Mechanisms of ageing and development

authors： Kwan P

更新日期：2013-09-01 00:00:00

abstract：:We showed earlier that life spans of murine B lymphocytes could be estimated by measuring the functional reactivities of normal B cells upon transfer into x-linked immunodeficient (xid) mice, which do not respond to anti-mouse IgM (anti-mu) antibodies and thymic-independent type-2 (TI-2) antigens. Here the same approa...

journal_title：Mechanisms of ageing and development

authors： Udhayakumar V,Goud SN,Cross RJ,Subbarao B

更新日期：1991-12-02 00:00:00

abstract：:The effect of age on potassium (K+)-induced norepinephrine release in the heart was studied in 6- and 24-month-old male Fischer-344 rats. Isolated hearts were perfused with Krebs-Ringer solution according to Langendorff method. K+ was employed as 2 ml bolus at the concentrations, of 70, 90, 100 and 120 microM. Norepin...

journal_title：Mechanisms of ageing and development

authors： Tumer N,Ryan PJ,Roberts J

更新日期：1990-03-01 00:00:00

abstract：:Senescence is thought to play an important role in the progressive age-related decline in tissue integrity and concomitant diseases, but not much is known about the complex interplay between upstream regulators and downstream effectors. We profiled whole genome gene expression of non-stressed and rotenone-stressed hum...

journal_title：Mechanisms of ageing and development

authors： Dekker P,Gunn D,McBryan T,Dirks RW,van Heemst D,Lim FL,Jochemsen AG,Verlaan-de Vries M,Nagel J,Adams PD,Tanke HJ,Westendorp RG,Maier AB

更新日期：2012-07-01 00:00:00

abstract：:The observations of the loss of cholinergic function in neocortex and hippocampus in Alzheimer's disease (AD) developed the hypothesis that replacement of cholinergic function may be of therapeutic benefit to AD patients. The different approaches proposed or tested included intervention with acetylcholine (ACh) precur...

journal_title：Mechanisms of ageing and development

authors： Amenta F,Parnetti L,Gallai V,Wallin A

更新日期：2001-11-01 00:00:00

abstract：:Age-adjusted mortality rates for breast cancer (BC) in the United States from 1962 to 1987 were subjected to longitudinal Gompertzian analysis. Age-adjusted BC mortality rate distributions for women display two distinct Gompertzian slopes. Between age 15 and 40 years, age-adjusted BC mortality rate distributions inter...

journal_title：Mechanisms of ageing and development

authors： Riggs JE

更新日期：1991-10-01 00:00:00

abstract：:In mammals, proliferation is rapid in many tissues during early postnatal life, causing rapid somatic growth. This robust proliferation is then suppressed as the animal approaches adult size, bringing many tissues to a quiescent state where proliferation occurs only as needed to replace dying cells. Recent evidence su...

journal_title：Mechanisms of ageing and development

authors： Lui JC,Chen W,Barnes KM,Baron J

更新日期：2010-10-01 00:00:00

abstract：:Epigenetic disruption has been implicated in many diseases of aging, and age-associated DNA methylation changes at specific genomic loci in humans are strongly correlated with chronological age. The aim of this study was to explore the specificity of selected age-associated differentially methylated positions (aDMPs) ...

journal_title：Mechanisms of ageing and development

authors： Spiers H,Hannon E,Wells S,Williams B,Fernandes C,Mill J

更新日期：2016-03-01 00:00:00

abstract：:Adult Wistar NIN (WNIN) rats (6 months old) of both sexes were orally fed Amalakirasayana at a dose of 4.5 g per kg body weight, five days in a week. The Amalakirasayana was prepared by Arya Vaidya Sala, Kottakkal, Kerala, India, which is considered as gold standard. After 3, 9 and 15 months of such therapeutic regime...

journal_title：Mechanisms of ageing and development

authors： Swain U,Sindhu KK,Boda U,Pothani S,Giridharan NV,Raghunath M,Rao KS

更新日期：2012-04-01 00:00:00

abstract：:The endothelin-1 (ET-1) concentrations were measured by RIA in the media of confluent monolayer cultures of rat articular chondrocyte (RAC) exposed to fetal calf serum (FCS) and several growth factors and cytokines. The cells were obtained from 1- and 18-month-old rats. First passage cells were starved in Dulbecco's m...

journal_title：Mechanisms of ageing and development

authors： Messai H,Khatib AM,Lebrun G,Aubin P,Florina M,Jean F,Mitrovic DR

更新日期：2000-02-22 00:00:00

abstract：:Hepatic microsomal monooxygenase induction was investigated in young-adult and middle-aged male Fischer 344 rats. Monooxygenase components and drug metabolism activities were determined in liver microsomes prepared from rats treated with phenobarbital (PB, beta-naphthoflavone (BNF) or methyltestosterone (MT) and compa...

journal_title：Mechanisms of ageing and development

authors： Rikans LE,Notley BA

更新日期：1981-01-01 00:00:00

abstract：:The objective of the this study was to determine the cytokine profile of aging mice and to establish whether changes in cytokine production account for the fact that aging mice develop a milder disease than the young in response to induced experimental systemic lupus erythematosus (SLE). Cytokine secretion was evaluat...

journal_title：Mechanisms of ageing and development

authors： Segal R,Dayan M,Globerson A,Habut B,Shearer GM,Mozes E

更新日期：1997-06-01 00:00:00

abstract：:Amyloidosis refers to a group of protein folding diseases. Various innocuous and soluble proteins in physiological conditions polymerize to insoluble amyloid fibrils in several serious diseases, including Alzheimer's disease (AD) and prion diseases. In addition, senile amyloidosis is a form of amyloidosis in which the...

journal_title：Mechanisms of ageing and development

authors： Xing Y,Higuchi K

更新日期：2002-11-01 00:00:00

abstract：:Preclinical and clinical studies suggest that specific subsets of cells isolated from the peripheral blood, play an essential role in the imbalance of damage and repair during age-associated diseases, such as metabolic syndrome, diabetes, atherosclerosis, neurodegenerative diseases, osteoporosis and cancer. Endogenous...

journal_title：Mechanisms of ageing and development

authors： Madonna R,Novo G,Balistreri CR

更新日期：2016-10-01 00:00:00

abstract：:In this paper we examined the impact of age on cognitive functions and the age-related modifications of egr1 expression, an inducible transcription factor with a confirmed role in synaptic plasticity and regulation of the proteasome activity, on pet dogs. Additionally, we examined the age-related changes of some eleme...

journal_title：Mechanisms of ageing and development

authors： Ghi P,Di Brisco F,Dallorto D,Osella MC,Orsetti M

更新日期：2009-05-01 00:00:00

abstract：:The effect of various immunosuppressive treatments on mean life-span and disease incidence have been studied. Significant life shortening was seen only in mice which recieved X-irradiation early in life and can be ascribed primarily to an increased incidence of certain malignancies. Marginal life shortening was seen i...

journal_title：Mechanisms of ageing and development

authors： Peter CP,Perkins EH,Peterson WJ,Walburg HE,Makinodan T

更新日期：1975-05-01 00:00:00

abstract：:Protein synthetic activity was determined in postmitochondrial preparations from heart, brain, kidney, liver and skeletal muscle of 5-26-month-old female C57B1/6J mice. An age-dependent decrease in the rate of protein synthesis was exhibited by all preparations except heart muscle. A 65% decrease in translational rate...

journal_title：Mechanisms of ageing and development

authors： Blazejowski CA,Webster GC

更新日期：1983-03-01 00:00:00

abstract：:delta-Aminolevulinic acid synthase and heme oxygenase are closely functionally connected with the hepatic microsomal mixed function oxydase system. There is a wide range of changes in microsomal heme oxygenase activity, cytochrome P-450 level and mitochondrial delta-aminolevulinic acid synthase activity in rat livers ...

journal_title：Mechanisms of ageing and development

authors： Plewka A,Bienioszek M,Plewka D

更新日期：1994-05-01 00:00:00