Periodontal disease level-butyric acid putatively contributes to the ageing blood: A proposed link between periodontal diseases and the ageing process.


:Periodontal diseases are partly attributable to periodontopathic bacteria found in the host, whereas, butyric acid (BA) is a common secondary metabolite produced by periodontopathic bacterial pathogens. BA has been linked to oxidative stress induction while oxidative stress has long been associated with the ageing process. However, the possible link between BA-induced oxidative stress and the ageing process has never been elucidated. Here, we attempted to show the possible role of periodontal diseaselevel-BA (PDL-BA) in influencing the rat blood ageing process. We injected PDL-BA into the young rat gingiva and, after 24h, heart blood extraction was performed. Blood obtained from PDL-BA-treated young rats was compared to untreated young and middle-aged rats. We found that cytosolic, but not mitochondrial, heme was affected 24h post-injection. In addition, we observed that PDL-BA treatment altered blood NOX activation, NADPH-related oxidative stress components (H2O2 and GR), calcium homeostasis, cell death signals (CASP3 and CASP1), and age-related markers (SIRT1 and mTOR) in young rats, with some components more closely mimicking levels found in middle-aged rats. In this regard, we propose that PDL-BA may play a role in contributing to the rat blood ageing process.


Mech Ageing Dev


Cueno ME,Seki K,Ochiai K,Imai K




Has Abstract


2017-03-01 00:00:00












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    abstract::The general objective of this study was to examine the relationship between oxygen free radicals and the aging process. The rate of superoxide anion radical (O2.-) generation was measured in liver sub-mitochondrial particles from mouse, rat, rabbit, pig and cow, and in flight muscle sub-mitochondrial particles from th...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审


    authors: Sohal RS,Svensson I,Sohal BH,Brunk UT

    更新日期:1989-08-01 00:00:00

  • The role of DNA damage and repair in aging: new approaches to an old problem.

    abstract::DNA damage and mutations have been implicated as key causal events in the biological process of aging. In this context, it has been hypothesized that the complex of genome maintenance systems acts as a longevity assurance system by signaling and repairing damage or removing cells that are beyond repair. In the past, v...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审


    authors: Vijg J

    更新日期:2008-07-01 00:00:00

  • Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controls.

    abstract::In this investigation the effect of 4 months of 40% restriction of calories on defined markers of oxidative, glycoxidative or lipoxidative damage to heart mitochondrial proteins was studied. The protein markers assessed were N(epsilon)-(carboxyethyl)lysine (CEL), N(epsilon)-(carboxymethyl)lysine (CML), N(epsilon)-(mal...

    journal_title:Mechanisms of ageing and development

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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    journal_title:Mechanisms of ageing and development

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    authors: Blokh D,Stambler I

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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审


    authors: Knorre DA,Azbarova AV,Galkina KV,Feniouk BA,Severin FF

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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审


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    journal_title:Mechanisms of ageing and development

    pub_type: 评论,杂志文章


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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    journal_title:Mechanisms of ageing and development

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    pub_type: 杂志文章


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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审


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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    更新日期:1977-07-01 00:00:00

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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    更新日期:2001-12-01 00:00:00

  • Age-related delay in recovery of beta-adrenergic sensitivity after abrupt propranolol withdrawal in rats.

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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    更新日期:1992-03-15 00:00:00

  • Role of hypothalamus in aging and its underlying cellular mechanisms.

    abstract::Aging is characterized by a progressive loss of several physiological functions that can cause various age-related disorders. Several factors have been identified as causes of aging to elucidate the decline in functions. Various aspects of physiological deterioration are controlled by the hypothalamus, a critical brai...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审


    authors: Kim K,Choe HK

    更新日期:2019-01-01 00:00:00

  • Age-dependent modulation of DNA repair enzymes by covalent modification and subcellular distribution.

    abstract::Chronic oxidative stress is generally believed to be a major etiologic factor in the aging process. In addition to modulation of signaling processes and oxidation of cellular proteins and lipids, reactive oxygen species (ROS) induce multiple damages in both nuclear and mitochondrial genomes, most of which are repaired...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    更新日期:2004-10-01 00:00:00

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    abstract::In the rat, kininogens are produced from two distinctly regulated gene families, T- and K-kininogens. We have previously established that T-kininogen (T-KG, thiostatin) gene expression is increased in the liver of old rats, as compared to their younger counterparts. In this report, we have used Northern blot analysis ...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Sierra F

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  • Age related changes in population of peripheral T cells: towards a model of immunosenescence.

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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Romanyukha AA,Yashin AI

    更新日期:2003-04-01 00:00:00

  • Analysis of mortality rate from carcinoma of prostate.

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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Clive JM,Spencer RP

    更新日期:1995-08-31 00:00:00

  • The epigenetic alterations of endogenous retroelements in aging.

    abstract::Endogenous retroelements, transposons that mobilize through RNA intermediates, include some of the most abundant repetitive sequences of the human genome, such as Alu and LINE-1 sequences, and human endogenous retroviruses. Recent discoveries demonstrate that these mobile genetic elements not only act as intragenomic ...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审


    authors: Cardelli M

    更新日期:2018-09-01 00:00:00

  • Changes in the amount and level of phosphorylation of p56(lck) in PBL from aging humans.

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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Guidi L,Antico L,Bartoloni C,Costanzo M,Errani A,Tricerri A,Vangeli M,Doria G,Gatta L,Goso C,Mancino L,Frasca D

    更新日期:1998-05-15 00:00:00