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The use of information theory for the evaluation of biomarkers of aging and physiological age.

Abstract：

:The present work explores the application of information theoretical measures, such as entropy and normalized mutual information, for research of biomarkers of aging. The use of information theory affords unique methodological advantages for the study of aging processes, as it allows evaluating non-linear relations between biological parameters, providing the precise quantitative strength of those relations, both for individual and multiple parameters, showing cumulative or synergistic effect. Here we illustrate those capabilities utilizing a dataset on heart disease, including diagnostic parameters routinely available to physicians. The use of information-theoretical methods, utilizing normalized mutual information, revealed the exact amount of information that various diagnostic parameters or their combinations contained about the persons' age. Based on those exact informative values for the correlation of measured parameters with age, we constructed a diagnostic rule (a decision tree) to evaluate physiological age, as compared to chronological age. The present data illustrated that younger subjects suffering from heart disease showed characteristics of people of higher age (higher physiological age). Utilizing information-theoretical measures, with additional data, it may be possible to create further clinically applicable information-theory-based markers and models for the evaluation of physiological age, its relation to age-related diseases and its potential modifications by therapeutic interventions.

journal_name

Mech Ageing Dev

journal_title

Mechanisms of ageing and development

authors

Blokh D,Stambler I

doi

10.1016/j.mad.2017.01.003

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

23-29

eissn

0047-6374

issn

1872-6216

pii

S0047-6374(16)30156-7

journal_volume

163

pub_type

杂志文章

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