The use of information theory for the evaluation of biomarkers of aging and physiological age.


:The present work explores the application of information theoretical measures, such as entropy and normalized mutual information, for research of biomarkers of aging. The use of information theory affords unique methodological advantages for the study of aging processes, as it allows evaluating non-linear relations between biological parameters, providing the precise quantitative strength of those relations, both for individual and multiple parameters, showing cumulative or synergistic effect. Here we illustrate those capabilities utilizing a dataset on heart disease, including diagnostic parameters routinely available to physicians. The use of information-theoretical methods, utilizing normalized mutual information, revealed the exact amount of information that various diagnostic parameters or their combinations contained about the persons' age. Based on those exact informative values for the correlation of measured parameters with age, we constructed a diagnostic rule (a decision tree) to evaluate physiological age, as compared to chronological age. The present data illustrated that younger subjects suffering from heart disease showed characteristics of people of higher age (higher physiological age). Utilizing information-theoretical measures, with additional data, it may be possible to create further clinically applicable information-theory-based markers and models for the evaluation of physiological age, its relation to age-related diseases and its potential modifications by therapeutic interventions.


Mech Ageing Dev


Blokh D,Stambler I




Has Abstract


2017-04-01 00:00:00












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    abstract::DNA synthesis is a remarkably vulnerable phase in the cell cycle. In addition to introduction of errors during semi-conservative replication, the inherently labile structure of the replication fork, as well as numerous pitfalls encountered in the course of fork progression, make the normally stable double stranded mol...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审


    authors: Ruzankina Y,Asare A,Brown EJ

    更新日期:2008-07-01 00:00:00

  • SIRT1 is required for the effects of rapamycin on high glucose-inducing mesangial cells senescence.

    abstract::The mTOR deregulation has a role in chronic kidney disease including diabetic nephropathy. SIRT1 is an important participant in renal cytoprotective responses to aging and stress. However, whether both mTOR and SIRT1 are involved in high glucose-inducing mesangial cells (MCs) senescence still remains to be explored. H...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Zhang S,Cai G,Fu B,Feng Z,Ding R,Bai X,Liu W,Zhuo L,Sun L,Liu F,Chen X

    更新日期:2012-06-01 00:00:00

  • Analysis of UV-induced damage and repair in young and senescent human dermal fibroblasts using the comet assay.

    abstract::A major cause of ageing is thought to be the accumulation of damage to macromolecules. Accumulation to DNA damage in cells therefore presupposes that aged cells are unable to repair this damage. We have used the in vitro model of cellular ageing to test the idea that senescent cells are deficient in some aspect of DNA...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Al-Baker EA,Oshin M,Hutchison CJ,Kill IR

    更新日期:2005-06-01 00:00:00

  • Biphasic effects of dietary antioxidants on oxidative stress-mediated carcinogenesis.

    abstract::There is now strong evidence implicating the generation of reactive oxygen species (ROS) and the corresponding response to oxidative stress as key factors in the pathogenesis of several human diseases including cancer, atherosclerosis, and neurodegenerative disorders, and in ageing. The carcinogenicity of oxidative st...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章,评审


    authors: Lee KW,Lee HJ

    更新日期:2006-05-01 00:00:00

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    abstract::Age related changes in some aspects of glutamate metabolism were followed in the brain of a short lived species of tropical murrel, Channa punctatus. Both ammonia and glutamine contents of brain increased with advancing age of the murrel. The glutamate dehydrogenase activity of brain increased during maturation phase ...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Mahapatro N,Patnaik BK

    更新日期:1993-05-01 00:00:00

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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    更新日期:1995-06-30 00:00:00

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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    更新日期:1992-06-01 00:00:00

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    abstract::Lipofuscin accumulation in cultured rat myocardial cells is considered an index of intra-lysosomal oxidative reactions and was registered by autofluorescence measurements. Lipofuscinogenesis in secondary lysosomes is thought to be a consequence of Fenton reactions, and is much enhanced by oxidative stress obtained by ...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    更新日期:1992-09-01 00:00:00

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    abstract::The decline in the lymphoproliferative response to mitogenic stimuli shows marked heterogeneity in elderly individuals. Adequate nutriture is required for optimal immune function, yet nutritional status may be compromised in the elderly. To address whether this variation in the proliferative response of elderly indivi...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    更新日期:1995-07-14 00:00:00

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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    更新日期:2006-09-01 00:00:00

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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    更新日期:1986-11-28 00:00:00

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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    更新日期:1992-02-01 00:00:00

  • On the role of genes relative to the environment in carcinogenesis.

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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    更新日期:2003-03-01 00:00:00

  • Effects of glutaraldehyde and other drugs on concanavalin A-mediated red blood cell adsorption to nonsenescent, senescent and transformed human fibroblasts.

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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    更新日期:1979-11-01 00:00:00

  • Analysis of mortality rate from carcinoma of prostate.

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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Clive JM,Spencer RP

    更新日期:1995-08-31 00:00:00

  • Studying the cerebellar DNA damage response in the tissue culture dish.

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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    更新日期:2013-10-01 00:00:00

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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    更新日期:1985-11-01 00:00:00

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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    更新日期:1990-11-01 00:00:00

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    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


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    更新日期:1998-01-30 00:00:00

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    abstract::The kinetics of accumulation and loss of zinc from the liver following subcutaneous administration of 10 mg of zinc per kg were examined in young adult (6 months old) and old (24 months old) male C57BL/6J mice. After zinc treatment, total liver zinc concentrations rose equally in both groups and returned to basal leve...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Thomas DJ,Winchurch RA,Adler WH

    更新日期:1989-03-01 00:00:00

  • An in vitro analysis of murine hemopoietic fibroblastoid progenitors and fibroblastoid cell function during aging.

    abstract::We determined the number of fibroblastoid progenitors (fibroblastoid colony-forming units, CFU-F) in femurs and spleens derived from (CBA X C57BL)F1 mice of different ages. The femoral CFU-F population size increased from 350 at 1 week of age and plateaued at approximately 1900 CFU-F at 8 weeks of age. The mean incide...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Brockbank KG,Ploemacher RE,van Peer CM

    更新日期:1983-05-01 00:00:00

  • Age-related increases in mitogenic responses and natural immunity to a syngeneic fibrosarcoma in rats.

    abstract::An increase in natural (innate) immunity with age (through 65 weeks) of NBR rats to a syngeneic methylcholanthrene-induced fibrosarcoma (MCA) is described. This increase is characterized by the appearance of spontaneous tumor regressor animals and an increase in the incidence of tumor non-takes by rats 45 weeks of age...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Hollingsworth MA,Barrowclough J,Evans DL

    更新日期:1981-09-01 00:00:00

  • The proliferative capacities of popliteal lymph node lymphocytes and of their functionally distinct T-cell subpopulations from young-adult and old mice.

    abstract::Young adult and old mice were immunized by footpad injection of dinitrophenyl-conjugated bovine gamma-globulin (DNP-BGG) in complete Freund's adjuvant. A comparison of lymph node weight and total number of nucleated cells per lymph node as a function of time after antigen injection demonstrated a significantly greater...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Perkins EH,Glover PL

    更新日期:1983-02-01 00:00:00

  • Coenzyme Q content in synaptic and non-synaptic mitochondria from different brain regions in the ageing rat.

    abstract::We investigated the Coenzyme Q (CoQ) content of different mitochondrial fractions [free mitochondria (FM), synaptic heavy (HM) and light mitochondria (LM)] from three brain areas (cortex, striatum, hippocampus) of rats at different ages. In rats from 2 to 26 months of age, we observed only small differences in total C...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Battino M,Gorini A,Villa RF,Genova ML,Bovina C,Sassi S,Littarru GP,Lenaz G

    更新日期:1995-03-17 00:00:00

  • Effect of age on the expression of antioxidant enzymes in male Fischer F344 rats.

    abstract::Age-related changes in the activities of superoxide dismutase, catalase, and glutathione peroxidase were determined in brain, heart, hepatocytes, intestinal mucosa, and kidney from male Fischer F344 rats. Superoxide dismutase activity decreased significantly with age in all five tissues studied. The activity of catala...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Rao G,Xia E,Richardson A

    更新日期:1990-03-31 00:00:00

  • Chromosome dosage as a life span determinant in Caenorhabiditis elegans.

    abstract::Caenorhabiditis elegans males live longer than hermaphrodites when cultured individually. Since hermaphrodites contain a pair of X chromosomes (XX) and males are XO (there is no Y chromosome in C. elegans), we questioned whether chromosomal differences per se might impact life span. The use of mutations in the sex-det...

    journal_title:Mechanisms of ageing and development

    pub_type: 杂志文章


    authors: Hartman PS,Ishii N

    更新日期:2007-07-01 00:00:00