Ro5-4864, a synthetic ligand of peripheral benzodiazepine receptor, reduces aging-associated myelin degeneration in the sciatic nerve of male rats.

abstract：:Changes in the T-lymphocyte compartment represent the most critical component of immunological aging. Recent studies have demonstrated that the age-related decline in T-cell-mediated immunity is a multifactorial phenomenon affecting T-cell subset composition as well as several proximal events such as protein tyrosine ...

journal_title：Mechanisms of ageing and development

authors： Chakravarti B,Abraham GN

更新日期：1999-05-17 00:00:00

abstract：:In this paper, we presented the results of analysis of experimental evidence for the decline of the human immune system functioning with age using mathematical model of immunosenescence. The most prominent changes in this system are related to the decline in the T-cellular immunity. These include the decline in the na...

journal_title：Mechanisms of ageing and development

authors： Romanyukha AA,Yashin AI

更新日期：2003-04-01 00:00:00

abstract：:Manganese superoxide dismutase (MnSOD or SOD2) is a key mitochondrial enzymatic antioxidant. Arguably the most striking phenotype associated with complete loss of SOD2 in flies and mice is shortened life span. To further explore the role of SOD2 in protecting animals from aging and age-associated pathology, we generat...

journal_title：Mechanisms of ageing and development

authors： Paul A,Belton A,Nag S,Martin I,Grotewiel MS,Duttaroy A

更新日期：2007-11-01 00:00:00

abstract：:This investigation represents the largest study so far published on human DNA damage and aging. The subject of this investigation is damage, determined as DNA alterations which give rise to complete molecular breaks in the course of treatment of purified DNA solutions with single-strand-specific nucleases. The DNA is ...

journal_title：Mechanisms of ageing and development

authors： Zahn RK,Reinmüller J,Beyer R,Pondeljak V

更新日期：1987-11-01 00:00:00

abstract：:Young adult and old mice were immunized by footpad injection of dinitrophenyl-conjugated bovine gamma-globulin (DNP-BGG) in complete Freund's adjuvant. A comparison of lymph node weight and total number of nucleated cells per lymph node as a function of time after antigen injection demonstrated a significantly greater...

journal_title：Mechanisms of ageing and development

authors： Perkins EH,Glover PL

更新日期：1983-02-01 00:00:00

abstract：:The age-related changes of the ciliary muscle of human eyes (33-87 years) were studied on histological meridional sections. Eighty-five melanoma eyes and 10 eyes of normal donors were investigated. The total area and the length of the muscle, the area of the three main portions and the distance of the inner apex of th...

journal_title：Mechanisms of ageing and development

authors： Tamm S,Tamm E,Rohen JW

更新日期：1992-02-01 00:00:00

abstract：:Caloric restriction has been extensively investigated as an intervention that both extends lifespan and delays age-related disease in mammals. In mice, much interest has centered on evaluating gene expression changes induced by caloric restriction (CR) in particular tissue types, but the overall systemic effect of CR ...

journal_title：Mechanisms of ageing and development

authors： Swindell WR

更新日期：2008-03-01 00:00:00

abstract：:We investigated the Coenzyme Q (CoQ) content of different mitochondrial fractions [free mitochondria (FM), synaptic heavy (HM) and light mitochondria (LM)] from three brain areas (cortex, striatum, hippocampus) of rats at different ages. In rats from 2 to 26 months of age, we observed only small differences in total C...

journal_title：Mechanisms of ageing and development

authors： Battino M,Gorini A,Villa RF,Genova ML,Bovina C,Sassi S,Littarru GP,Lenaz G

更新日期：1995-03-17 00:00:00

abstract：:Mortality trends in industrialized countries are characterized by declines in vascular disease (ischemic heart disease and stroke) and rises in cancers and degenerative diseases. These trends are typically analyzed by examining each disorder in isolation using the perspective of genetic and environmental influences. H...

journal_title：Mechanisms of ageing and development

authors： Riggs JE,Millecchia RJ

更新日期：1992-09-01 00:00:00

abstract：:The quantification of plasmatic HLA class-I molecules (sHLA-I) was realized by a sandwich ELISA using a monomorphic mAb (W6/32). sHLA-I concentration is significantly increased in the elderly group (>50 years, 0.429+/-0.301 microg ml(-1)) as compared to the young group (<50 years, 0.126+/-0.085 microg ml(-1)). The var...

journal_title：Mechanisms of ageing and development

authors： Le Morvan C,Cogné M,Drouet M

更新日期：2001-03-01 00:00:00

abstract：:We examined the effects of voluntary exercise on glucose transporter concentration in skeletal muscle from young adult and old female Long-Evans rats. Rats had free access to voluntary running wheels beginning at 4 months of age or remained sedentary. Exercising rats ran approximately 7.5, 6.2, 5.6 and 5.3 km/day duri...

journal_title：Mechanisms of ageing and development

authors： Gulve EA,Rodnick KJ,Henriksen EJ,Holloszy JO

更新日期：1993-02-01 00:00:00

abstract：:Considerable evidence points to an accumulation of somatic mutations in older cells and organisms but the causal role of mutations in the ageing process is still unclear. In addition to demonstrating that mutations accumulate, it is important to address the question of whether they do so at a sufficient rate and with ...

journal_title：Mechanisms of ageing and development

authors： Kirkwood TB,Proctor CJ

更新日期：2003-01-01 00:00:00

abstract：:The effect of life-long diets containing different concentrations of selenium and vitamin E on the age pigment accumulation in the rat superior cervical ganglion, vagal ganglion and dorsal root ganglion, was studied using microspectrofluorometry. All types of ganglia showed unchanged amounts of age pigments at low or ...

journal_title：Mechanisms of ageing and development

authors： Koistinaho J,Alho H,Hervonen A

更新日期：1990-01-01 00:00:00

abstract：:Thymic atrophy or thymus absence causes depressed thyroid-thymus axis (TTA) efficiency in old, young propyl-thiouracil (PTU) (experimental hypothyroidism) and in young-adult thymectomised (Tx) mice, respectively. Altered zinc turnover may be also involved in depressed TTA efficiency. Zinc turnover is under the control...

journal_title：Mechanisms of ageing and development

authors： Mocchegiani E,Giacconi R,Cipriano C,Gasparini N,Orlando F,Stecconi R,Muzzioli M,Isani G,Carpenè E

更新日期：2002-03-31 00:00:00

abstract：:There are reports demonstrating elevated levels of autoantibodies in elderly people. We now analyzed whether the strong inflammatory response associated with aging is interrelated with the production of autoantibodies, antinuclear antibodies (ANA). In a cohort of 284 nonagenarians the rate of ANA positivity was 12.3%,...

journal_title：Mechanisms of ageing and development

authors： Hurme M,Korkki S,Lehtimäki T,Karhunen PJ,Jylhä M,Hervonen A,Pertovaara M

更新日期：2007-05-01 00:00:00

abstract：:We are interested in membrane phospholipid and triglyceride synthesis and turnover in aging cells. As a preliminary, short-term feasibility study we have used an established in vivo-in vitro technique to estimate the initial rates of [1-14C] palmitate (complexed to albumin) esterification to triglycerides and phosphol...

journal_title：Mechanisms of ageing and development

authors： Baker N,Hill V

更新日期：1982-08-01 00:00:00

abstract：:There is an alteration of the immune response in aging that leads to the increased incidence of infections, cancers and autoimmune disorders. The aim of the present study was to investigate whether there exists changes in signal transduction under the IL-2 receptor stimulation and the role of plasma membrane cholester...

journal_title：Mechanisms of ageing and development

authors： Fülöp T Jr,Douziech N,Goulet AC,Desgeorges S,Linteau A,Lacombe G,Dupuis G

更新日期：2001-09-15 00:00:00

abstract：:Anucleate minicells produced by a mutated strain of Escherichia coli remain metabolically active for up to 48 h at 37 degrees C. Minicells of increasing age have been infected with the coliphage T7. Infection results in the onset of transcription and translation producing T7 encoded polypeptides. Quantitative and qual...

journal_title：Mechanisms of ageing and development

authors： Libby RT,Shaw JE,Reeve JN

更新日期：1984-10-15 00:00:00

abstract：:Changes in glycosaminoglycans during in vitro aging were investigated in human diploid fibroblasts. The cells were found to produce predominantly hyaluronate and smaller amounts of chondroitin 4-sulfate, chondroitin 6-sulfate, dermatan sulfate and heparan sulfate. Accumulation of heparan sulfate on the cell surface wa...

journal_title：Mechanisms of ageing and development

authors： Matuoka K,Mitsui Y

更新日期：1981-02-01 00:00:00

abstract：:Filopodia in log and stationary phase populations of human fetal lung fibroblasts (WI-38) at low and high population doubling levels (PDLs) and of SV40 transformed WI-38 cells (VA13A), were observed and counted under different conditions of in vitro growth by scanning electron microscopy. Cells from old non-vigorously...

journal_title：Mechanisms of ageing and development

authors： Stanulis-Praeger BM

更新日期：1986-02-01 00:00:00

abstract：:Patients with X-linked lymphoproliferative syndrome (XLP) experience excessive T cell proliferation after primary Epstein-Barr virus (EBV) infection, due to mutations in the signalling lymphocyte activation molecule (SLAM) associated protein (SAP) molecule. We examined the impact of dysfunctional proliferative control...

journal_title：Mechanisms of ageing and development

authors： Plunkett FJ,Franzese O,Belaramani LL,Fletcher JM,Gilmour KC,Sharifi R,Khan N,Hislop AD,Cara A,Salmon M,Gaspar HB,Rustin MH,Webster D,Akbar AN

更新日期：2005-08-01 00:00:00

abstract：:Gut microbiota is among the factors that may be involved in healthy aging. Broader and geographically spread studies on gut microbiota of centenarians can help in identifying a common signature of longevity. We identified an endogamous Indian population with high centenarian prevalence. Here, we compared the gut micro...

journal_title：Mechanisms of ageing and development

authors： Tuikhar N,Keisam S,Labala RK,Imrat,Ramakrishnan P,Arunkumar MC,Ahmed G,Biagi E,Jeyaram K

更新日期：2019-04-01 00:00:00

abstract：:The DNA repair capabilities of cultured hepatocytes derived from five mammalian species in response to a broad range of ultraviolet light exposures were measured. Differences in the induction of DNA repair synthesis and the proportion of responding cells were noted only for the lowest fluences. These differences appea...

journal_title：Mechanisms of ageing and development

authors： Maslansky CJ,Williams GM

更新日期：1985-02-01 00:00:00

abstract：:In order to gain a better understanding of tissue plasticity with aging, we investigated the adaptive responses of young and adult animals to both 7 and 28 days of hypobaric hypoxia. Senescence is associated with a decreased tolerance to hypoxia that may be related to an age-associated decline in glucose transporter s...

journal_title：Mechanisms of ageing and development

authors： Dill RP,Chadan SG,Li C,Parkhouse WS

更新日期：2001-05-15 00:00:00

abstract：:An increase in natural (innate) immunity with age (through 65 weeks) of NBR rats to a syngeneic methylcholanthrene-induced fibrosarcoma (MCA) is described. This increase is characterized by the appearance of spontaneous tumor regressor animals and an increase in the incidence of tumor non-takes by rats 45 weeks of age...

journal_title：Mechanisms of ageing and development

authors： Hollingsworth MA,Barrowclough J,Evans DL

更新日期：1981-09-01 00:00:00

abstract：:The oral health of older people is changing with reducing numbers of people relying on complete dentures for function, and retaining some natural teeth. Despite this there are substantial numbers of older people whose ability to chew foods is compromised by their oral health status, either because they have few or no ...

journal_title：Mechanisms of ageing and development

authors： Walls AW,Steele JG

更新日期：2004-12-01 00:00:00

abstract：:Women enjoy a superior longevity, possibly at the price of a heavy loss of female conceptuses at an early stage of gestation. An immunological mechanism is proposed. A theory of selection at implantation is developed and generalized which leads to a new approach of longevity. ...

journal_title：Mechanisms of ageing and development

authors： Vernier MC

更新日期：1977-01-01 00:00:00

abstract：:Recent studies show that cellular and mitochondrial iron increases with age. Iron overload, especially in mitochondria, increases the availability of redox-active iron, which may be a causal factor in the extensive age-related biomolecular oxidative damage observed in aged organisms. Such damage is thought to play a m...

journal_title：Mechanisms of ageing and development

authors： Xu J,Marzetti E,Seo AY,Kim JS,Prolla TA,Leeuwenburgh C

更新日期：2010-07-01 00:00:00

abstract：:Nuclear envelopes of mammalian cells contain a nucleoside triphosphatase which is probably involved in mRNA transport through the nuclear membrane. The activity of the enzyme, studied in RNA-depleted nuclear ghosts, can be stimulated by poly(A) or by poly(A) (+)mRNA. Using nuclear ghost preparations from mature (8-10 ...

journal_title：Mechanisms of ageing and development

authors： Bernd A,Schröder HC,Zahn RK,Müller WE

更新日期：1982-12-01 00:00:00

abstract：:Age-related loss of hearing and vision are two very common disabling conditions, but the underlying mechanisms are still poorly understood. Damage by reactive oxygen species and other reactive cellular metabolites, which in turn may damage macromolecules such as DNA, has been implicated in both processes. To investiga...

journal_title：Mechanisms of ageing and development

authors： Spoor M,Nagtegaal AP,Ridwan Y,Borgesius NZ,van Alphen B,van der Pluijm I,Hoeijmakers JH,Frens MA,Borst JG

更新日期：2012-02-01 00:00:00