Abstract:
:We examined the effects of voluntary exercise on glucose transporter concentration in skeletal muscle from young adult and old female Long-Evans rats. Rats had free access to voluntary running wheels beginning at 4 months of age or remained sedentary. Exercising rats ran approximately 7.5, 6.2, 5.6 and 5.3 km/day during their 6th, 8th, 9th and 10th month of age, respectively. During the 23rd, 24th and 25th month of age running distance averaged 3.0, 2.8 and 2.4 km/day, respectively. At 10 and 25 months of age, glucose transporter protein concentration was assessed in epitrochlearis and flexor digitorum brevis muscles with a polyclonal antibody directed against the GLUT4 transporter isoform. GLUT4 protein concentration was not altered by the aging process (i.e., comparing 10- and 25-month-old rats) in either muscle type. Wheel running increased GLUT4 protein concentration by 45% in epitrochlearis muscles of 10-month-old rats relative to age-matched sedentary controls. The training-induced adaptation in GLUT4 protein was no longer present at age 25 months, probably because the running distance had declined by 50%. In the flexor digitorum brevis, exercise did not alter GLUT4 concentration at either 10 or 25 months, presumably due to insufficient recruitment of this muscle during wheel running as assessed by measurement of citrate synthase and hexokinase enzyme activities. Wheel running induced cardiac and soleus muscle hypertrophy in 10- and 25-month-old rats. In summary, voluntary wheel running can induce an increase in skeletal muscle GLUT4 protein concentration in adult rats. Older rats that run less exhibit cardiac and soleus muscle hypertrophy, but do not maintain an elevated GLUT4 protein concentration in the epitrochlearis muscle. Aging does not alter GLUT4 protein concentration in the epitrochlearis or FDB muscles.
journal_name
Mech Ageing Devjournal_title
Mechanisms of ageing and developmentauthors
Gulve EA,Rodnick KJ,Henriksen EJ,Holloszy JOdoi
10.1016/0047-6374(93)90122-8subject
Has Abstractpub_date
1993-02-01 00:00:00pages
187-200issue
1-2eissn
0047-6374issn
1872-6216pii
0047-6374(93)90122-8journal_volume
67pub_type
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
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更新日期:2009-06-01 00:00:00
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journal_title:Mechanisms of ageing and development
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doi:10.1016/0047-6374(91)90040-7
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journal_title:Mechanisms of ageing and development
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更新日期:2010-11-01 00:00:00
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
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更新日期:1983-03-01 00:00:00
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journal_title:Mechanisms of ageing and development
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doi:10.1016/0047-6374(78)90024-6
更新日期:1978-10-01 00:00:00
abstract::A mutant of rad-8, originally isolated on the basis of its hypersensitivity to ultraviolet radiation, is also hypersensitive to oxygen and methyl viologen, a superoxide-anion generator. Oxygen also retarded development and reduced fecundity in a concentration-dependent fashion in rad-8 but not in wild type. In additio...
journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
doi:10.1016/0047-6374(93)90135-e
更新日期:1993-05-01 00:00:00
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journal_title:Mechanisms of ageing and development
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更新日期:1998-01-12 00:00:00
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
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更新日期:2008-04-01 00:00:00
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
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更新日期:1996-03-29 00:00:00
abstract::Caenorhabiditis elegans males live longer than hermaphrodites when cultured individually. Since hermaphrodites contain a pair of X chromosomes (XX) and males are XO (there is no Y chromosome in C. elegans), we questioned whether chromosomal differences per se might impact life span. The use of mutations in the sex-det...
journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
doi:10.1016/j.mad.2007.06.001
更新日期:2007-07-01 00:00:00
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
doi:10.1016/0047-6374(79)90004-6
更新日期:1979-11-01 00:00:00
abstract::Ageing is the most complex phenotype currently known, since it becomes manifest in all organs and tissues, affects an organism's entire physiology, impacts function at all levels and increases susceptibility to all major chronic diseases. Insight into the molecular and cellular targets of the ageing process would offe...
journal_title:Mechanisms of ageing and development
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
doi:10.1016/0047-6374(86)90048-5
更新日期:1986-02-01 00:00:00
abstract::Age-related changes in regulation of receptor response have been observed in several tissues and include regulation of beta-adrenergic receptor (beta-receptor) responses. The role of cellular aging in age-related changes in receptor response is not clear. We have examined the effect of aging in vitro on human fibrobla...
journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
doi:10.1016/0047-6374(92)90003-v
更新日期:1992-05-01 00:00:00
abstract::We determined the number of fibroblastoid progenitors (fibroblastoid colony-forming units, CFU-F) in femurs and spleens derived from (CBA X C57BL)F1 mice of different ages. The femoral CFU-F population size increased from 350 at 1 week of age and plateaued at approximately 1900 CFU-F at 8 weeks of age. The mean incide...
journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
doi:10.1016/0047-6374(83)90003-9
更新日期:1983-05-01 00:00:00
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journal_title:Mechanisms of ageing and development
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更新日期:1990-03-31 00:00:00
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
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更新日期:1992-02-01 00:00:00
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
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更新日期:1975-05-01 00:00:00
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
doi:10.1016/s0047-6374(97)00137-1
更新日期:1998-01-30 00:00:00
abstract::The effects of ageing and of exercise on muscle mass, fiber cross-sectional area, and fiber type composition of a weight-bearing muscle, the soleus and a non-weight-bearing muscle, the extensor digitorum longus (EDL) were investigated in female Long-Evans rats. The animals were exercised by means of voluntary wheel ru...
journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
doi:10.1016/0047-6374(92)90017-8
更新日期:1992-03-15 00:00:00
abstract::In this review we discuss the yeast as a paradigm for the study of aging. The budding yeast Saccharomyces cerevisiae, which can proliferate in both haploid and diploid states, has been used extensively in aging research. The budding yeast divides asymmetrically to form a 'mother' cell and a bud. Two major approaches, ...
journal_title:Mechanisms of ageing and development
pub_type: 杂志文章,评审
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更新日期:2000-12-01 00:00:00
abstract::Aging is a biological process associated with impairment of mitochondrial bioenergetic function, increased oxidative stress, attenuated ability to respond to stresses and increased risk in contracting age-associated diseases. When mitochondria are subjected to oxidative stress, accompanied by calcium overload and ATP ...
journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
doi:10.1016/j.mad.2012.12.006
更新日期:2013-01-01 00:00:00
abstract::Age-specific incidence rates for cancers of the female breast, ovary, corpus uteri, testis, prostate and male and female cancers of the stomach, colon, rectum, lung, and male and female Hodgkin's disease in 51 worldwide populations in the 1990 era were obtained from a published source. For each cancer in each populati...
journal_title:Mechanisms of ageing and development
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更新日期:2003-03-01 00:00:00
abstract::The bone marrow content, proliferative potential and proliferative activity of precursor cells for stromal fibroblast colony forming cells (CFC-F) were investigated in young and old CBA mice. The relationship between CFC-F and the number of bone marrow nucleated cells and granulocytic-macrophagal precursors (GM-CFC) w...
journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
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更新日期:1990-05-30 00:00:00
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
doi:10.1016/0047-6374(94)01516-o
更新日期:1995-01-31 00:00:00
abstract::A few reports suggest that pigmented granules found in molluscan neurons accumulate with age as do lipofuscin granules in vertebrate cells; however, no reports on molluscan neurons include detailed descriptions of granule accumulation or histochemical tests to identify the pigment as lipofuscin-like. In this study lig...
journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
doi:10.1016/0047-6374(78)90052-0
更新日期:1978-01-01 00:00:00
abstract::Motor neurons and ventral root motor fibres innervating extensor digitorum longus (EDL) muscle in rats of 0.5-3.5 months of age were studied by HRP-retrograde labelling and in vivo muscle tension recording, respectively. EDL nucleus size increased with age but motor neurons number and size did not change. Twitch and t...
journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
doi:10.1016/s0047-6374(96)01839-8
更新日期:1996-12-20 00:00:00