On the role of genes relative to the environment in carcinogenesis.

abstract：:Antioxidants and telomere length are potential biomarkers for individuals' exposure and ability to cope with environmental stressors. However, intraspecific variations in antioxidant alterations due to natural, life cycle related stress, have been rarely estimated. We investigated those changes in wild-derived house m...

journal_title：Mechanisms of ageing and development

authors： Stauffer J,Panda B,Ilmonen P

更新日期：2018-01-01 00:00:00

abstract：:We tested the hypothesis that Ca(2+)-activated myosin ATPase activity is lower in muscles of aged rats relative to muscles of young rats, independent of changes in myosin isoform expression. Myofibrils were prepared from permeabilized fibers of soleus, plantaris, and semimembranosus muscles of young (8-12 months) and ...

journal_title：Mechanisms of ageing and development

authors： Lowe DA,Husom AD,Ferrington DA,Thompson LV

更新日期：2004-09-01 00:00:00

abstract：:The progression of many neurodegenerative diseases is assumed to be caused by misfolding of specific characteristic diseases related proteins, resulting in aggregation and fibril formation of these proteins. Protein misfolding associated age related diseases, although different in disease manifestations, share strikin...

journal_title：Mechanisms of ageing and development

authors： Eftekharzadeh B,Hyman BT,Wegmann S

更新日期：2016-06-01 00:00:00

abstract：:The incidence of chronic diseases such as cardiovascular diseases is lower in Mediterranean Southern Europe than Northern Europe. This may be due to a lower level of oxidative stress and a higher antioxidant status in people living around the Mediterranean Sea. Oxidative stress may influence the rate of shortening of ...

journal_title：Mechanisms of ageing and development

authors： de Vos-Houben JM,Ottenheim NR,Kafatos A,Buijsse B,Hageman GJ,Kromhout D,Giltay EJ

更新日期：2012-06-01 00:00:00

abstract：:Chronic low-grade inflammation is involved in the pathogenesis of many disease conditions in humans and it is frequently quantified by measuring the blood concentration of C-reactive protein (CRP). Here we show that the CRP concentration in old people (nonagenarians) is, at least partially, genetically determined, and...

journal_title：Mechanisms of ageing and development

authors： Hurme M,Kivimäki M,Pertovaara M,Lehtimäki T,Karhunen PJ,Jylhä M,Hervonen A,Eklund C

更新日期：2007-10-01 00:00:00

abstract：:Non-proliferative and proliferative myeloid, and lymphoid and erythroid bone marrow cells were studied in aging female C3H mice. A chronobiological approach was used and mice aged 16, 21 and 26 months were examined vs. 3 month-old mice every 3 h during the 24-h period in three different experiments. Significant circad...

journal_title：Mechanisms of ageing and development

authors： Sletvold O,Laerum OD,Riise T

更新日期：1988-01-01 00:00:00

abstract：:Human diploid cells, TIG-7, were serially cultivated under 1%, 5% or 21% (air) oxygen. The limit of their cumulative population doublings was extended by 16% or 10% under 1% or 5% oxygen, respectively, as compared with that under 21% oxygen. When TIG-7 cells were serially cultivated in the presence of 10 mM or 20 mM 3...

journal_title：Mechanisms of ageing and development

authors： Yuan H,Kaneko T,Matsuo M

更新日期：1995-07-14 00:00:00

abstract：:Previous studies have demonstrated an increase in brain-reactive antibodies (BRA) in sera of various mammals as a function of age. The present study attempts to obtain a better understanding of the mode of formation of BRA by using various immunologic manipulations in young and old C57BL/6 mice. The mean BRA levels we...

journal_title：Mechanisms of ageing and development

authors： Nandy K,Bennett M

更新日期：1983-07-01 00:00:00

abstract：:This paper is the second one in a series of two papers hypothesizing and testing systemic grounds of reproductive life history in the female fruit fly. In the first paper, we analyzed mechanisms of individual fecundity scheduling and have drawn the following conclusions. Individual fecundity in female flies is endowed...

journal_title：Mechanisms of ageing and development

authors： Novoseltsev VN,Carey RJ,Novoseltseva JA,Papadopoulos NT,Blay S,Yashin AI

更新日期：2004-01-01 00:00:00

abstract：:A progressive decrease of dopamine and related enzyme activities and a decline in the dopaminergic receptor functions in the striatum and limbic system controlling behavior have been observed in senescent brain. These changes provide a neurochemical basis for some behavioral and mental disturbances of the aged and sug...

journal_title：Mechanisms of ageing and development

authors： Jellinger K,Flament H,Riederer P,Schmid H,Ambrozi L

更新日期：1980-09-01 00:00:00

abstract：:Here we show that a labyrinth channel compartment and slit diaphragms, which are the histological structures enabling insect nephrocytes ultrafiltration, are established during embryogenesis first by the garland nephrocytes (GCNs). The later pericardial nephrocytes, which represent the majority of functional nephrocyt...

journal_title：Mechanisms of ageing and development

authors： Psathaki OE,Dehnen L,Hartley PS,Paululat A

更新日期：2018-07-01 00:00:00

abstract：:In a longitudinal design in which each animal was examined repeatedly throughout its life, we used flow cytometry to determine the numbers or proportions of a variety of T lymphocyte subsets in the peripheral blood of mice aged 8-20 months. Half of the 128 mice were given a low calorie diet which is known to extend li...

journal_title：Mechanisms of ageing and development

authors： Miller RA

更新日期：1997-06-01 00:00:00

abstract：:Hepatocytes isolated from 6-, 12-, 18-, and 30-month-old female Fischer F344 rats were examined by scanning electron microscopy. No significant change in cell size with age was observed. However, the surface morphology of the cells isolated from the older animals exhibited a significant increase in surface folds. This...

journal_title：Mechanisms of ageing and development

authors： Engelmann GL,Richardson A,Katz A,Fierer JA

更新日期：1981-01-01 00:00:00

abstract：:T cell responses are altered in the aged in a manner usually interpreted as detrimental to host defences against infectious agents and possibly also against cancer. T cell dysregulation may be caused by any or a combination of stem cell deficits, compromised T cell differentiation, inefficient antigen processing and p...

journal_title：Mechanisms of ageing and development

authors： Pawelec G,Hirokawa K,Fülöp T

更新日期：2001-09-30 00:00:00

abstract：:This review addresses a novel facet of human T cell biology that constitutes a fundamental problem for long-term maintenance of immunological memory against viruses. The finite proliferative capacity of human T lymphocytes is sufficiently great to accommodate the waves of clonal expansion associated with primary and e...

journal_title：Mechanisms of ageing and development

authors： Effros RB

更新日期：2000-12-20 00:00:00

abstract：:The tumor suppressors p16(INK4a) and p53 have been implicated as contributors to age-associated stem cell decline. Key functions of p53 are the induction of cell cycle arrest, senescence, or apoptosis in response to DNA damage. Here, we examine senescence, apoptosis, and DNA damage responses in a mouse accelerated agi...

journal_title：Mechanisms of ageing and development

authors： Hinkal GW,Gatza CE,Parikh N,Donehower LA

更新日期：2009-04-01 00:00:00

abstract：:Food restriction is known to ameliorate many of the adverse physiologic effects of age. In this study, we have examined the effect of food restriction on the induction of the gluconeogenic enzyme, phosphoenolpyruvate carboxykinase (PEPCK) in liver and kidney following a 12-h fasting period in young (6 month) and old (...

journal_title：Mechanisms of ageing and development

authors： Van Remmen H,Ward WF

更新日期：1998-09-01 00:00:00

abstract：:The paper of Kitani cited in the title has raised an apparent contradiction regarding the validity of certain aspects of the membrane hypothesis of aging (MHA). He collected data showing that a number of detoxifying liver enzyme activities, although decline with age in male Fischer 344 rats, remain at an unchanged lev...

journal_title：Mechanisms of ageing and development

authors： Zs-Nagy I

更新日期：2001-06-01 00:00:00

abstract：:Gut microbiota is among the factors that may be involved in healthy aging. Broader and geographically spread studies on gut microbiota of centenarians can help in identifying a common signature of longevity. We identified an endogamous Indian population with high centenarian prevalence. Here, we compared the gut micro...

journal_title：Mechanisms of ageing and development

authors： Tuikhar N,Keisam S,Labala RK,Imrat,Ramakrishnan P,Arunkumar MC,Ahmed G,Biagi E,Jeyaram K

更新日期：2019-04-01 00:00:00

abstract：:Cell proliferation, cell injury and aging are connected with changes in the cell membrane structure. Apparently these changes activate, in mammalian as well as in plant cells, lipases which liberate polyunsaturated fatty acids (PUFAs). PUFAs are the substrates for lipoxygenases which convert them to corresponding hydr...

journal_title：Mechanisms of ageing and development

authors： Spiteller G

更新日期：2001-05-31 00:00:00

abstract：:Dietary factors have a profound effect on many aspects of health including ageing and do so, at least partly, through interactions with the genome which result in altered gene expression. The application of high throughput genomics technologies in nutritional research (nutrigenomics) offers a new approach to understan...

journal_title：Mechanisms of ageing and development

authors： Mathers JC

更新日期：2006-06-01 00:00:00

abstract：:Following a 3 hour in vivo labelling of cytoplasmic RNA in rat liver with orotic acid-6-14C under conditions where ribosomal RNA synthesis was suppressed, the proportion of labelled messenger-like RNA released to the cytoplasm which contained polyadenylate (poly(A)) tracts was about 3.0 times higher in the livers of j...

journal_title：Mechanisms of ageing and development

authors： Yannarell A,Schumm DE,Webb TE

更新日期：1977-07-01 00:00:00

abstract：:Extrachromosomal circular DNA complexes from peripheral blood lymphocytes from inbred mice of accelerated senescence, were detected by mica-press-adsorption method. In senescence-resistant series (SAM-R), polydisperse circular DNAs were observed at 7 weeks of age and a restricted size class of small circular forms of ...

journal_title：Mechanisms of ageing and development

authors： Yamagishi H,Kunisada T,Takeda T

更新日期：1985-01-01 00:00:00

abstract：:Nearly 40 years ago it was proposed that accumulation of mutations or increased levels of DNA damage might contribute to aging processes. Despite several correlative studies in this area, the answer as to whether genomic integrity contributes to aging has remained illusive. More recently it has been hypothesized that ...

journal_title：Mechanisms of ageing and development

authors： Walter CA,Grabowski DT,Street KA,Conrad CC,Richardson A

更新日期：1997-12-01 00:00:00

abstract：:Protein oxidation, one of a number of brain biomarkers of oxidative stress, is increased in several age-related neurodegenerative disorders or animal models thereof, including Alzheimer's disease, Huntington's disease, prion disorders, such as Creutzfeld-Jakob disease, and alpha-synuclein disorders, such as Parkinson'...

journal_title：Mechanisms of ageing and development

authors： Butterfield DA,Kanski J

更新日期：2001-07-15 00:00:00

abstract：:To examine the effect of an aging environment on sister chromatid exchange (SCE) induction, Ehrlich ascites tumor (EAT) cells were introduced into young and old C57BL/6J mice. Background SCE levels were not significantly different in either EAT cell or normal bone marrow cell populations between young and old animals....

journal_title：Mechanisms of ageing and development

authors： Schneider EL,Lewis J

更新日期：1981-12-01 00:00:00

abstract：:Oxidative damage to macromolecules, including lipids, has been hypothesized as a mechanism of aging. One end product of lipid peroxidation, malondialdehyde (MDA), is often quantified as a measure of oxidative damage to lipids. We used a commercial colorimetric assay for MDA (Bioxytech LPO-586, Oxis International, Port...

journal_title：Mechanisms of ageing and development

authors： Gerhard GS,Kaufmann EJ,Wang X,Erikson KM,Abraham J,Grundy M,Beard JL,Chorney MJ

更新日期：2002-01-01 00:00:00

abstract：:The present study investigated whether age-related changes in the production of Th1 and Th2 cytokines by human T cells might be linked to altered frequencies of naive (CD45RA+) and memory (CD45RO+) T cell subsets. T cells from healthy elderly humans (n = 32) stimulated with anti-CD3epsilon monoclonal antibody OKT3 plu...

journal_title：Mechanisms of ageing and development

authors： Karanfilov CI,Liu B,Fox CC,Lakshmanan RR,Whisler RL

更新日期：1999-08-30 00:00:00

abstract：:We have studied effects of long-term, low-dose growth hormone therapy on the immune function and life expectancy of Balb/c mice. Sixty male Balb/c mice were aged up to the time when they started showing signs of senescence and causal death (deaths started when they became 17 months old). The aged mice were divided int...

journal_title：Mechanisms of ageing and development

authors： Khansari DN,Gustad T

更新日期：1991-01-01 00:00:00

abstract：:We used a fluorescence differential display--PCR (FDD-PCR) technique to analyze the genes expressed in mouse kidneys collected at nine different developmental stages ranging from 3 days to 15 months after birth. We found ten genes that were age-dependent and differentially-expressed in the kidneys during our experimen...

journal_title：Mechanisms of ageing and development

authors： Iida R,Yasuda T,Aoyama M,Tsubota E,Matsuki T,Kishi K

更新日期：2000-02-07 00:00:00