Relationship between glucose phosphorylating activities and erythrocyte age.

abstract：:A pronounced suppression of the humoral, hemolytic, primary immune response in old (22 months) mice was demonstrated as compared with this response in young (10 weeks) mice. The suppression is associated with a lower thymus weight:body weight ratio. In contrast, the ratios spleen weight:body weight and liver weight:bo...

journal_title：Mechanisms of ageing and development

authors： Bliznakov EG

更新日期：1978-03-01 00:00:00

abstract：:Endothelin (ET) is a powerful vasopressor agent that is activated in a number of pathophysiologic states where renal perfusion is reduced. Since renal vasoconstriction occurs as part of renal aging, we investigated the possibility that ET may be activated in the old kidney. These experiments involved acutely blocking ...

journal_title：Mechanisms of ageing and development

authors： Greenfeld Z,Engels K,Samsell L,Baylis C

更新日期：1998-03-16 00:00:00

abstract：:The bone marrow of old adult mice ( approximately 2 years old) has reduced B lymphopoiesis; however, whether the B1 pathway in adult bone marrow is also compromised in senescence is not known. Herein, we show that phenotypic (IgM(-)Lin(-)CD93(+)[AA4.1(+)] CD19(+)B220(low/-)) B1 progenitors are retained in old bone mar...

journal_title：Mechanisms of ageing and development

authors： Alter-Wolf S,Blomberg BB,Riley RL

更新日期：2009-06-01 00:00:00

abstract：:Long-Evans female rats three weeks, three months and 13-14 months of age were placed on tryptophan-deficient diets for periods ranging from a few months to nearly two years. Growth was interupted during the period of tryptophan-deficiency, but when the animals were returned to a complete diet, they gained weight and g...

journal_title：Mechanisms of ageing and development

authors： Segall PE,Timiras PS

更新日期：1976-03-01 00:00:00

abstract：:It has been shown that enhanced levels of p53 activity contribute to reduced cancer susceptibility in mice, however longevity is compromised due to the onset of an early-ageing phenotype. The effects of enhanced levels of p53 in these in mice could therefore have implications for human premature ageing disorders. We e...

journal_title：Mechanisms of ageing and development

authors： O'Neill M,Núñez F,Melton DW

更新日期：2003-05-01 00:00:00

abstract：:The present study examined the effect of a 40% reduction in caloric intake (CR) versus ad libitum (AL) feeding on retinal aging. CR- and AL-fed Brown Norway (BN) rats were obtained at 12, 24 and 30 months of age from the National Center for Toxicological Research (NCTR). Age-dependent declines in outer nuclear layer (...

journal_title：Mechanisms of ageing and development

authors： Obin M,Pike A,Halbleib M,Lipman R,Taylor A,Bronson R

更新日期：2000-03-13 00:00:00

abstract：:The decline in phytohemagglutinin (PHA) responsiveness of spleen cells from aged mice was studied in an effort to determine the nature of the depressed PHA reactivity. The reduced response of DNA synthesis (thymidine incorporation) to PHA stimulation could not be attributed to a decreased viability of spleen lymphocyt...

journal_title：Mechanisms of ageing and development

authors： Hung CY,Perkins EH,Yang WK

更新日期：1975-01-01 00:00:00

abstract：:On a DNA basis, there is higher concentration of polysomes in the brain of newborn than in the brain of adult mice, but there is no maturation-dependent decrease in tRNA content during postnatal development. The amino acid incorporating activity of cell-free systems with polysomes or mitochondria from newborn brain ex...

journal_title：Mechanisms of ageing and development

authors： Goertz B

更新日期：1979-05-01 00:00:00

abstract：:One to 24 month old rats were anesthetized with alpha-chloralose, their cerebral cortices exposed surgically and subjected in vivo to stimulation by norepinephrine (1.0mM for 5 minutes) or electrical pulses (100 pulses/s for 10 s). After microwave fixation, cortical samples were analyzed for cyclic-AMP by the Gilman m...

journal_title：Mechanisms of ageing and development

authors： Berg A,Zimmerman ID

更新日期：1975-09-01 00:00:00

abstract：:Four tRNAs are known to contain Q, a hypermodified form of guanosine, in one of their isoacceptor forms; these are tRNATyr, tRNAHis, tRNAAsp, and tRNAAsn. The first three have been examined in Drosophila melanogaster at different ages in four genotypes. As the adult flies age, the ratio of the Q/non-Q isoacceptors inc...

journal_title：Mechanisms of ageing and development

authors： Owenby RK,Stulberg MP,Jacobson KB

更新日期：1979-09-01 00:00:00

abstract：:Although myocardial actomyosin ATPase specific activity determined at Ca2+ levels of 1 x 10(-3) to 1 x 10(-2) M is consistently higher in two-month old male Fischer rats than in twelve-month old individuals, this difference can be eliminated if the enzyme is assayed at lower calcium concentrations. This suggests that ...

journal_title：Mechanisms of ageing and development

authors： Rockstein M,Chesky JA,Lopez T

更新日期：1978-12-01 00:00:00

abstract：:Tumor cells express NADPH oxidase-1 (NOX1) in their membrane and control NOX1-based intercellular reactive oxygen and nitrogen species (ROS/RNS)-dependent apoptosis-inducing signaling through membrane-associated catalase and superoxide dismutase. TREATMENT:of tumor cells with high concentrations of H2O2, peroxnitrite...

journal_title：Mechanisms of ageing and development

authors： Bauer G

更新日期：2018-06-01 00:00:00

abstract：:Several laboratory animal models have shown that dietary energy restriction (ER) can promote longevity and improve various health aspects in old age. However, whether the entire spectrum of ER-induced short- and long-term physiological and metabolic adaptions is translatable to humans remains to be determined. In this...

journal_title：Mechanisms of ageing and development

authors： Xie K,Kapetanou M,Sidiropoulou K,Bano D,Gonos ES,Djordjevic AM,Ehninger D

更新日期：2020-12-01 00:00:00

abstract：:Age-related and ambient temperature-related changes in motor activity, body temperature, body weight (b.w.), and food consumption were studied in the long-lived Peromyscus leucopus mouse at environmental temperatures of 29 and 21 degrees C. Major changes in physiological performance were observed between the young (6 ...

journal_title：Mechanisms of ageing and development

authors： Duffy PH,Feuers RJ,Pipkin JL,Turturro A,Hart RW

更新日期：1997-04-01 00:00:00

abstract：:We examined physiological changes in CD5(+) B lymphocytes in mice associated with aging (from 1 or 5 to 50 weeks of age). The most predominant populations of lymphocytes among these mice were mainly CD5(-) B cells in the spleen and peritoneal cavity, and T cells in the thymus. However, in the spleen, CD5(+) B cells in...

journal_title：Mechanisms of ageing and development

authors： Watanabe K,Watanabe M,Maruoka H,Amino N,Iwatani Y

更新日期：2001-10-01 00:00:00

abstract：:Previous studies have suggested a possible relationship between the ubiquitin-proteasome pathway and some pathological manifestations of Alzheimer's disease (AD). This study investigated the possibility that the Abeta peptides interact with the ubiquitin-proteasome pathway inside neuronal cells. The ubiquitin-proteaso...

journal_title：Mechanisms of ageing and development

authors： Oh S,Hong HS,Hwang E,Sim HJ,Lee W,Shin SJ,Mook-Jung I

更新日期：2005-12-01 00:00:00

abstract：:Cellular senescence is a fundamental trait of many eukaryotic organisms. Senescent cells participate both in the developmental program and in normal ageing and age-related diseases. Senescence of proliferation-prone cells is a state of permanent cell cycle arrest accompanied by metabolic activity manifested by high se...

journal_title：Mechanisms of ageing and development

authors： Bielak-Zmijewska A,Mosieniak G,Sikora E

更新日期：2018-03-01 00:00:00

abstract：:Caloric restriction (CR) is the most effective intervention to improve health span and extend lifespan in preclinical models. This anti-aging effect of CR is related to attenuation of oxidative damage in various tissues, with divergent results in the brain. We addressed how brain oxidoreductive balance would be modula...

journal_title：Mechanisms of ageing and development

authors： Moyse E,Arsenault M,Gaudreau P,Ferland G,Ramassamy C

更新日期：2019-04-01 00:00:00

abstract：:The bone marrow content, proliferative potential and proliferative activity of precursor cells for stromal fibroblast colony forming cells (CFC-F) were investigated in young and old CBA mice. The relationship between CFC-F and the number of bone marrow nucleated cells and granulocytic-macrophagal precursors (GM-CFC) w...

journal_title：Mechanisms of ageing and development

authors： Sidorenko AV,Andrianova LF,Macsyuk TV,Butenko GM

更新日期：1990-05-30 00:00:00

abstract：:Accumulation of oxidative DNA damage in the human brain has been implicated in etiologies of post-traumatic and age-associated declines in neuronal function. In neurons, because of high metabolic rates and prolonged life span, exposure to free radicals is intense and risk for accumulation of damaged DNA is amplified. ...

journal_title：Mechanisms of ageing and development

authors： Englander EW

更新日期：2008-07-01 00:00:00

abstract：:In this paper, we approach the problem of attempting to understand senescence by understanding the complexity and hierarchical structure of mammalian organisms. To do this, we make use of some concepts from abstract relational biology; in particular, graph theory. We subsequently utilize these concepts to develop the ...

journal_title：Mechanisms of ageing and development

authors： Witten M

更新日期：1984-10-31 00:00:00

abstract：:Ascorbic acid content decreased with age in livers of male rats but not in those of female rats. The influence of aging on the regeneration of ascorbic acid from dehydroascorbic acid was investigated as a possible cause of declining ascorbate concentrations. The results demonstrate that hepatic NADPH-dehydroascorbic a...

journal_title：Mechanisms of ageing and development

authors： Rikans LE,Lopez TR,Hornbrook KR

更新日期：1996-11-13 00:00:00

abstract：:The aim of this study was to investigate the effect of physical training on balance, strength, and general well-being in adult people with intellectual disability (ID). This study evaluated how physical training can effect physical and psychological change among 'older' adults with mild ID. Participants consisted of n...

journal_title：Mechanisms of ageing and development

authors： Carmeli E,Zinger-Vaknin T,Morad M,Merrick J

更新日期：2005-02-01 00:00:00

abstract：:Hutchinson-Gilford Progeria syndrome (HGPS) is a rare genetic disorder that displays features of segmental aging. It is manifested predominantly in connective tissue, with most prominent histological changes occurring in the skin, cartilage, bone and cardiovascular tissues. Detailed quantitative real time reverse-tran...

journal_title：Mechanisms of ageing and development

authors： Lemire JM,Patis C,Gordon LB,Sandy JD,Toole BP,Weiss AS

更新日期：2006-08-01 00:00:00

abstract：:The effects of age and chronic propranolol treatment on the agonist-induced rise in intracellular free Ca2+ ([Ca2+]i), an index for the coupling of receptor-second messenger generation, was studied using a dispersed rat submandibular gland preparation. Muscarinic stimulation (10 microns carbachol) caused a rapid (T1/2...

journal_title：Mechanisms of ageing and development

authors： Melvin JE,O'Connell AC,Koek L,Bowen WH

更新日期：1991-11-15 00:00:00

abstract：:Understanding mechanisms underlying longevity, and endeavor towards the specific goals of alleviating frailty in old age, require a comprehensive approach that considers the various theoretical and experimental approaches, as well as compiling the data on humans. This logistic has underlined the program of the confere...

journal_title：Mechanisms of ageing and development

authors： Globerson A,Barzilai N

更新日期：2005-02-01 00:00:00

abstract：:Neutral endopeptidase 24.11 (NEP) inhibitors prevent breakdown of atrial natriuretic peptide (ANP), and may be useful therapeutically, in sodium overload states as often occurs in the aged. However, age-dependent changes in ANP/NEP may limit the activity of these agents in the elderly. To investigate this we conducted...

journal_title：Mechanisms of ageing and development

authors： Greenfeld Z,Engels K,Samsell L,Baylis C

更新日期：2001-09-01 00:00:00

abstract：:The binding of the lectin Concanavalin-A (Con-A) to crystallins was investigated. For this purpose, human fetal and juvenile lens crystallins were isofocused and specifically stained brown for glycoproteins by the lectin Con-A, and purple by the periodic acid Schiff's reagent (PAS). In reference experiments protein ba...

journal_title：Mechanisms of ageing and development

authors： Ahrend MH,Bours J

更新日期：1997-12-30 00:00:00

abstract：:DNA synthesis is a remarkably vulnerable phase in the cell cycle. In addition to introduction of errors during semi-conservative replication, the inherently labile structure of the replication fork, as well as numerous pitfalls encountered in the course of fork progression, make the normally stable double stranded mol...

journal_title：Mechanisms of ageing and development

authors： Ruzankina Y,Asare A,Brown EJ

更新日期：2008-07-01 00:00:00

abstract：:The effect of age on the capacity of tyramine to promote the release of norepinephrine (NE) at the cardiac adrenergic neuroeffector junction was investigated in isolated hearts of rats, 6, 12 and 24 months of age. Hearts were perfused by the method of Langendorff and tyramine was administered in increasing doses as a ...

journal_title：Mechanisms of ageing and development

authors： Kreider MS,Goldberg PB,Roberts J

更新日期：1986-11-14 00:00:00