Calcium sensitivity of myocardial actomyosin ATPase in young and mature male Fischer rats. A brief note.

abstract：:The human fibroblast cell line WI-38 shows a gradual decline in glutamine synthetase specific activity with increasing age in culture. However, the level of functional enzyme per cell does not change with age. Heat inactivation profiles indicate that glutamine synthetase from younger cell cultures is more heat labile ...

journal_title：Mechanisms of ageing and development

authors： Viceps-Madore D,Cristofalo VJ

更新日期：1978-07-01 00:00:00

abstract：:Human diploid cells, TIG-7, were serially cultivated under 1%, 5% or 21% (air) oxygen. The limit of their cumulative population doublings was extended by 16% or 10% under 1% or 5% oxygen, respectively, as compared with that under 21% oxygen. When TIG-7 cells were serially cultivated in the presence of 10 mM or 20 mM 3...

journal_title：Mechanisms of ageing and development

authors： Yuan H,Kaneko T,Matsuo M

更新日期：1995-07-14 00:00:00

abstract：:Aflatoxin B1(AFB1)-glutathione(GSH) conjugation is the major pathway for the detoxification of aflatoxin metabolites. This reaction is catalysed by GSH S-transferase (GST) and play a major role in modulation of AFB1 adduct formation to nuclear DNA. Changes recorded in hepatic GST activity during development of rats ca...

journal_title：Mechanisms of ageing and development

authors： Allameh A,Farahani M,Zarghi A

更新日期：2000-05-18 00:00:00

abstract：:This is the first in a series of articles in which we intend to critically review some of the currently used models in gerontology research and evaluate their contribution to advancing our understanding of the phenomenon of senescence. The major theories of aging are considered. We discuss what makes a model useful in...

journal_title：Mechanisms of ageing and development

authors： Gershon H,Gershon D

更新日期：2000-08-15 00:00:00

abstract：:Lymphatic lipid transport in the intestine of adult and ageing rats was compared. Adult (8-10 months old) and old (24-26 months old) male Wistar rats were cannulated into the mesenteric lymph under ethrane anesthesia. On the following day, lipid emulsion containing 35.4 mg/h of olive oil was infused intraduodenally fo...

journal_title：Mechanisms of ageing and development

authors： Hayashi H,Sato Y,Kanai S,Masuda M,Ohta M,Funakoshi A,Nagao K,Imaizumi K,Miyasaka K

更新日期：2000-02-15 00:00:00

abstract：:We investigated the production of IL-2 and IFN-gamma (Th1 type) and IL-4 (Th2 type) cytokines by mitogen-activated spleen cells from young, adult and old mice. Cytokine production was evaluated in culture supernatants by CTLL proliferation (IL-2), ELISA (IFN-gamma), CT4.S proliferation (IL-4) and in mRNA extracted fro...

journal_title：Mechanisms of ageing and development

authors： Frasca D,Pucci S,Goso C,Barattini P,Barile S,Pioli C,Doria G

更新日期：1997-02-01 00:00:00

abstract：:Food restriction increases maximal life span in rodents. Male rats that exercise in voluntary running wheels do not have an increase in maximal longevity despite a relative caloric deficit. In contrast, sedentary rats that are food restricted so as to cause the same caloric deficit have an extension of maximal longevi...

journal_title：Mechanisms of ageing and development

authors： Holloszy JO

更新日期：1998-02-16 00:00:00

abstract：:The effects of age and chronic propranolol treatment on the agonist-induced rise in intracellular free Ca2+ ([Ca2+]i), an index for the coupling of receptor-second messenger generation, was studied using a dispersed rat submandibular gland preparation. Muscarinic stimulation (10 microns carbachol) caused a rapid (T1/2...

journal_title：Mechanisms of ageing and development

authors： Melvin JE,O'Connell AC,Koek L,Bowen WH

更新日期：1991-11-15 00:00:00

abstract：:Researchers and clinicians interested in human diseases of DNA repair deficiency and premature aging gathered at the National Conference Center in Lansdowne, Virginia on 5-8 September 2006 to attend a workshop co-organized by Vilhelm Bohr (National Institute of Aging) and Kenneth Kraemer (National Cancer Institute). A...

journal_title：Mechanisms of ageing and development

authors： Kraemer KH,Sander M,Bohr VA

更新日期：2007-02-01 00:00:00

abstract：:While deviations from the optimal phenotype are deleterious, increased variation can prevent population extinction under severe stresses. Cell division asymmetry is an important source of microbial phenotypic heterogeneity. A consecutive set of asymmetric divisions can cause the gradual accumulation of deleterious fac...

journal_title：Mechanisms of ageing and development

authors： Knorre DA,Azbarova AV,Galkina KV,Feniouk BA,Severin FF

更新日期：2018-12-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) was isolated from liver mitochondria of rats between 2 and 24 months of age. The mtDNA was purified by cesium chloride--ethidium bromide isopycnic density gradient centrifugation. In the gradients, in addition to the two expected bands of ethidium--DNA complex, there was observed a third, mor...

journal_title：Mechanisms of ageing and development

authors： Murray MA,Balcavage WX

更新日期：1982-11-01 00:00:00

abstract：:The functional deterioration of an organism with age causes the major problem of maintaining the quality of life at old age. Degenerative changes in the organism may to some extent reflect alterations that can be observed in cells during in vitro replicative senescence. At the cellular level, the receptor-mediated end...

journal_title：Mechanisms of ageing and development

authors： Park SC

更新日期：2002-04-30 00:00:00

abstract：:In this study, we showed that in flies kept for 2 weeks at 1 (terrestrial gravity), 3 or 5 x g (hypergravity, HG) before transfer to 1 x g, resistance to heat remained higher in HG flies for several weeks after the transfer. The measurement of heat shock protein 70 (hsp70) indicated no induction of the protein in HG, ...

journal_title：Mechanisms of ageing and development

authors： Minois N,Guinaudy MJ,Payre F,Le Bourg E

更新日期：1999-06-01 00:00:00

abstract：:The effect of various immunosuppressive treatments on mean life-span and disease incidence have been studied. Significant life shortening was seen only in mice which recieved X-irradiation early in life and can be ascribed primarily to an increased incidence of certain malignancies. Marginal life shortening was seen i...

journal_title：Mechanisms of ageing and development

authors： Peter CP,Perkins EH,Peterson WJ,Walburg HE,Makinodan T

更新日期：1975-05-01 00:00:00

abstract：:A mutant of rad-8, originally isolated on the basis of its hypersensitivity to ultraviolet radiation, is also hypersensitive to oxygen and methyl viologen, a superoxide-anion generator. Oxygen also retarded development and reduced fecundity in a concentration-dependent fashion in rad-8 but not in wild type. In additio...

journal_title：Mechanisms of ageing and development

authors： Ishi N,Suzuki N,Hartman PS,Suzuki K

更新日期：1993-05-01 00:00:00

abstract：:Impaired lymphocyte and granulocyte function in the aged may, in part, reflect intrinsic aged-related biochemical alterations. In this study we compared the ribonucleotide contents of lymphocytes and granulocytes from young and old subjects evaluated by means of an HPLC-anion exchange method. We found that in general ...

journal_title：Mechanisms of ageing and development

authors： Borzì RM,Dal Monte P,Uguccioni M,Meliconi R,Facchini A

更新日期：1992-06-01 00:00:00

abstract：:To test the hypothesis that the aging mammalian heart and brain might have increased vulnerability to acute stress, DNA fragmentation was studied after hypoxia-reoygenation in young adult (6 months) and old (22-24 months) F344 rats. Heart and brain tissue were examined at the following time points: 30, 60, or 90 min o...

journal_title：Mechanisms of ageing and development

authors： Azhar G,Liu L,Zhang X,Wei JY

更新日期：1999-12-07 00:00:00

abstract：:The present study examined the effect of a 40% reduction in caloric intake (CR) versus ad libitum (AL) feeding on retinal aging. CR- and AL-fed Brown Norway (BN) rats were obtained at 12, 24 and 30 months of age from the National Center for Toxicological Research (NCTR). Age-dependent declines in outer nuclear layer (...

journal_title：Mechanisms of ageing and development

authors： Obin M,Pike A,Halbleib M,Lipman R,Taylor A,Bronson R

更新日期：2000-03-13 00:00:00

abstract：:It has been shown in several studies that 2-mercaptoethanol (2-ME) improves the life span and aspects of life performance of laboratory animals. To obtain further details on the beneficial effects of 2-ME, a long-term study has been performed on male CBA/Ca inbred mice treated with this antioxidant. Four month-old mic...

journal_title：Mechanisms of ageing and development

authors： Pénzes L,Noble RC,Beregi E,Imre S,Izsák J,Regius O

更新日期：1988-10-01 00:00:00

abstract：:Taurine is a sulfur amino acid that is present in high concentration in mammalian tissues and previously has been reported to decline in a number of tissues with advancing age. The aims of the present study were to examine: (1) the effects of dietary taurine supplementation; (2) the effects of taurine-free diets; (3) ...

journal_title：Mechanisms of ageing and development

authors： Dawson R Jr,Liu S,Eppler B,Patterson T

更新日期：1999-02-01 00:00:00

abstract：:A 3'-->5' exonuclease found in rat liver excises mispaired nucleotides at the 3'-hydroxyl end of primer chains such as poly dA-d(T9-C). Consequently, the priming activity of the chain from which the mispaired base was cut is greatly increased during DNA synthesis. These results suggest that the 3'-->5' exonuclease act...

journal_title：Mechanisms of ageing and development

authors： Taguchi T,Fukuda M,Toda T,Ohashi M

更新日期：1998-09-15 00:00:00

abstract：:Normal diploid Syrian hamster dermal mesenchymal cell strains, regardless of the age of the tissue of origin, exhibit in vitro cellular senescence. The frequency of spontaneous escape from senescence and conversion to a permanent cell line is less than 5% among replicate flasks. The overall pattern of senescence of ce...

journal_title：Mechanisms of ageing and development

authors： Bruce SA,Deamond SF,Ts'o PO

更新日期：1986-04-01 00:00:00

abstract：:A comparison was made of the resting membrane potential (MP) as well as the MP responses to K+, ACTH and gamma-MSH of superfused adrenocortical, zona fasciculata cells from young (Y) and old (O) male rats. The resting MP of these cells did not vary with age. However, the MP responses to altered extracellular [K+] vari...

journal_title：Mechanisms of ageing and development

authors： Lymangrover JR,Valego NK,Shilling RD

更新日期：1988-06-01 00:00:00

abstract：AIMS:To identify the geometrical alterations in the age-remodeled rat coronary artery network and to develop a useful technique to analyze network properties in the rat heart. METHODS AND RESULTS:We analyzed the networks of the left anterior descendent coronary arteries on in situ perfused hearts of young (3 months) a...

journal_title：Mechanisms of ageing and development

authors： Wappler EA,Antal P,Várbíró S,Székács B,Simon A,Nagy Z,Monos E,Nádasy GL

更新日期：2013-07-01 00:00:00

abstract：:The effects of long-term caloric restriction on the hepatic phase II drug metabolizing enzymes were investigated in the male Fischer 344 rat. Rats that had been restricted to 60% of their pair-fed control consumption from 14 weeks post-partum exhibited altered conjugating enzyme activities at 22 months. Caloric restri...

journal_title：Mechanisms of ageing and development

authors： Leakey JA,Cunny HC,Bazare J Jr,Webb PJ,Lipscomb JC,Slikker W Jr,Feuers RJ,Duffy PH,Hart RW

更新日期：1989-05-01 00:00:00

abstract：:Endothelin (ET) is a powerful vasopressor agent that is activated in a number of pathophysiologic states where renal perfusion is reduced. Since renal vasoconstriction occurs as part of renal aging, we investigated the possibility that ET may be activated in the old kidney. These experiments involved acutely blocking ...

journal_title：Mechanisms of ageing and development

authors： Greenfeld Z,Engels K,Samsell L,Baylis C

更新日期：1998-03-16 00:00:00

abstract：:Periodontal diseases are partly attributable to periodontopathic bacteria found in the host, whereas, butyric acid (BA) is a common secondary metabolite produced by periodontopathic bacterial pathogens. BA has been linked to oxidative stress induction while oxidative stress has long been associated with the ageing pro...

journal_title：Mechanisms of ageing and development

authors： Cueno ME,Seki K,Ochiai K,Imai K

更新日期：2017-03-01 00:00:00

abstract：:Endocrine hormones are thought to be involved in processes that contribute to aging. Long-living dwarf mice are growth hormone (GH)-deficient and exhibit enhanced expression of antioxidative defense molecules when compared to normal, wild type littermates. In this study, 3- and 12-month-old Ames dwarf mice received wi...

journal_title：Mechanisms of ageing and development

authors： Brown-Borg HM,Rakoczy SG

更新日期：2003-12-01 00:00:00

abstract：:Here we show that a labyrinth channel compartment and slit diaphragms, which are the histological structures enabling insect nephrocytes ultrafiltration, are established during embryogenesis first by the garland nephrocytes (GCNs). The later pericardial nephrocytes, which represent the majority of functional nephrocyt...

journal_title：Mechanisms of ageing and development

authors： Psathaki OE,Dehnen L,Hartley PS,Paululat A

更新日期：2018-07-01 00:00:00

abstract：:Four tRNAs are known to contain Q, a hypermodified form of guanosine, in one of their isoacceptor forms; these are tRNATyr, tRNAHis, tRNAAsp, and tRNAAsn. The first three have been examined in Drosophila melanogaster at different ages in four genotypes. As the adult flies age, the ratio of the Q/non-Q isoacceptors inc...

journal_title：Mechanisms of ageing and development

authors： Owenby RK,Stulberg MP,Jacobson KB

更新日期：1979-09-01 00:00:00