The effect of age on release of norepinephrine by tyramine from rat heart.

abstract：:A population of 291 healthy North American Black subjects of different ages was studied for immunoglobulin (Ig) allotypes and the prevalence of autoantibodies, to determine possible associations between Ig allotypes and age, autoantibodies and age, and Ig allotypes and autoantibodies. Indirect immunofluorescence was u...

journal_title：Mechanisms of ageing and development

authors： Ockhuizen T,Pandey JP,Galbraith GM,Fudenberg HH,Hames CG

更新日期：1982-06-01 00:00:00

abstract：:The impairment of brown adipose tissue (BAT) thermogenic activity with aging has been well documented. The current study investigated the effect of swimming training on BAT activity in 2-month-old (young) and 26-month-old (old) male mice. The trained mice underwent a 6-week swimming program (1 h/day, 5 days/week) in w...

journal_title：Mechanisms of ageing and development

authors： Oh-ishi S,Kizaki T,Toshinai K,Haga S,Fukuda K,Nagata N,Ohno H

更新日期：1996-08-15 00:00:00

abstract：:Great importance is attached to structural and functional deterioration of mitochondria as a reason for ageing of an organism; the attention of many scientists has been concentrated on such questions as age changes in the system of oxidative phosphorylation, damage of mitochondrial DNA by free radicals generated in th...

journal_title：Mechanisms of ageing and development

authors： Lemeshko VV,Shekh VE

更新日期：1993-05-01 00:00:00

abstract：:The most relevant theories on the sex-dependent longevity at population level are critically re-examined in the light of the knowledge available today on the aging process at cellular and molecular level. The aim of this perspective is to help in the understanding of the cellular and molecular bases of longevity and t...

journal_title：Mechanisms of ageing and development

authors： Magnani M,Accorsi A

更新日期：1993-12-15 00:00:00

abstract：:Quantitative interference microscopy was used to determine changes in nuclear and nucleolar indices (dry mass and cross-sectional area) in upper and lower epidermal cells and adjacent leaf-margin hair cells of the May apple (Podophyllum peltatum L.) leaves over a 42-day period (after leaves emerged above the ground li...

journal_title：Mechanisms of ageing and development

authors： Bhattacharya PK,Pappelis AJ,Lee SC,BeMiller JN,Karagiannis CS

更新日期：1996-12-20 00:00:00

abstract：:Ceramide mediates the effects of several agonists leading to differentiation, apoptosis or senescence. We previously showed that ceramide becomes elevated in senescent fibroblasts. In the present study, senescent cultures of Wi-38 fibroblasts and human umbilical-vein endothelial cells were compared to low-passage cult...

journal_title：Mechanisms of ageing and development

authors： Venable ME,Webb-Froehlich LM,Sloan EF,Thomley JE

更新日期：2006-05-01 00:00:00

abstract：:In this investigation the effect of 4 months of 40% restriction of calories on defined markers of oxidative, glycoxidative or lipoxidative damage to heart mitochondrial proteins was studied. The protein markers assessed were N(epsilon)-(carboxyethyl)lysine (CEL), N(epsilon)-(carboxymethyl)lysine (CML), N(epsilon)-(mal...

journal_title：Mechanisms of ageing and development

authors： Pamplona R,Portero-Otín M,Requena J,Gredilla R,Barja G

更新日期：2002-09-01 00:00:00

abstract：:A 3'-->5' exonuclease found in rat liver excises mispaired nucleotides at the 3'-hydroxyl end of primer chains such as poly dA-d(T9-C). Consequently, the priming activity of the chain from which the mispaired base was cut is greatly increased during DNA synthesis. These results suggest that the 3'-->5' exonuclease act...

journal_title：Mechanisms of ageing and development

authors： Taguchi T,Fukuda M,Toda T,Ohashi M

更新日期：1998-09-15 00:00:00

abstract：:Protein oxidation, one of a number of brain biomarkers of oxidative stress, is increased in several age-related neurodegenerative disorders or animal models thereof, including Alzheimer's disease, Huntington's disease, prion disorders, such as Creutzfeld-Jakob disease, and alpha-synuclein disorders, such as Parkinson'...

journal_title：Mechanisms of ageing and development

authors： Butterfield DA,Kanski J

更新日期：2001-07-15 00:00:00

abstract：:In this paper we investigate nucleic acid content in neurons from the dorsocaudal region of the thalamic reticular nucleus in ageing Wistar rats. Nucleic acid per surface unit was analysed by calculating mean extinction using cytophotometric methods. Once the mean extinction and nuclear and cytoplasmic areas were know...

journal_title：Mechanisms of ageing and development

authors： Requena V,González F,Díaz F,Villena A,Peláez A,Pérez de Vargas I

更新日期：1997-12-01 00:00:00

abstract：:In an attempt to understand the molecular mechanisms of age-dependent degenerative alteration in human periodontal tissues, we examined mRNA level and DNA methylation of collagen alpha1(I) gene. Using healthy periodontal ligament tissues from humans aged 9-76 years, we found that the collagen alpha1(I) mRNA level decr...

journal_title：Mechanisms of ageing and development

authors： Takatsu M,Uyeno S,Komura J,Watanabe M,Ono T

更新日期：1999-10-01 00:00:00

abstract：:The mTOR deregulation has a role in chronic kidney disease including diabetic nephropathy. SIRT1 is an important participant in renal cytoprotective responses to aging and stress. However, whether both mTOR and SIRT1 are involved in high glucose-inducing mesangial cells (MCs) senescence still remains to be explored. H...

journal_title：Mechanisms of ageing and development

authors： Zhang S,Cai G,Fu B,Feng Z,Ding R,Bai X,Liu W,Zhuo L,Sun L,Liu F,Chen X

更新日期：2012-06-01 00:00:00

abstract：:Levels of the beta-subunit of nerve growth factor (beta-NGF) were determined in various tissues from senescence-accelerated mice (SAM-P/8) and compared with those from senescence-resistant control mice (SAM-R/1) at 4 months of age. (1) In SAM-P/8, the testis was 30% larger in terms of wet weight than that from SAM-R/1...

journal_title：Mechanisms of ageing and development

authors： Katoh-Semba R,Semba R,Kashiwamata S,Kato K

更新日期：1991-06-14 00:00:00

abstract：:The serotonin content of platelets, serum and plasma from rats of various ages was examined. In male rats, platelet serotonin content, which was about 0.65 nmol/10(8) platelets at young age (6-7 months), increased slightly at middle age (12-14 months) but decreased markedly at old age (25-26 months). Significant diffe...

journal_title：Mechanisms of ageing and development

authors： Yonezawa Y,Kondo H,Nomaguchi TA

更新日期：1989-01-01 00:00:00

abstract：:Iron deficiency anaemia is prevalent in older age, particularly after the age of 80. Serum ferritin concentrations also decline, although there is no evidence to suggest that changes in iron stores are an inevitable consequence of ageing. Chronic inflammation is a common condition in older people, making the measureme...

journal_title：Mechanisms of ageing and development

authors： Fairweather-Tait SJ,Wawer AA,Gillings R,Jennings A,Myint PK

更新日期：2014-03-01 00:00:00

abstract：:With recent sequencing of the genome and development of high-density array technology, it is now possible to assess global gene expression in cells/tissues by a technique that is sensitive, quantitative, and rapid. Gene expression array technology is extremely useful in studying a complex, multigenetic process, such a...

journal_title：Mechanisms of ageing and development

authors： Han E,Hilsenbeck SG

更新日期：2001-07-31 00:00:00

abstract：:The circulating antibody titers to bovine serum albumin (BSA) were determined for two groups of aged Fischer 344 rats obtained form the National Institute on Aging. One group received a single immunization of BSA in complete Freund's adjuvant, and the second group was immunized three times at two-week intervals with t...

journal_title：Mechanisms of ageing and development

authors： Kaplan PJ,Caperna TJ,Garvey JS

更新日期：1981-05-01 00:00:00

abstract：:Food intake, body weight and serum LH, FSH, progesterone and oestradiol-17 beta were monitored from weaning to puberty in fully fed females housed in groups of four or individually and in females individually housed and dietary restricted. Restriction of food intake from weaning delayed the onset of puberty (34-39 day...

journal_title：Mechanisms of ageing and development

authors： Holehan AM,Merry BJ

更新日期：1985-11-01 00:00:00

abstract：:Sarcoplasmic reticulum (SR) vesicles isolated from skeletal muscle of Sprague-Dawley rats ranging in age from 4 months to 28 months were studied and compared. A marked decline, with age, was observed in the amount of (total) SR proteins isolated per gram of muscle tissue used. This decline is in line with the known lo...

journal_title：Mechanisms of ageing and development

authors： Gafni A,Yuh KC

更新日期：1989-08-01 00:00:00

abstract：:T cells in vivo have been shown to accumulate DNA damage with age. To investigate the effects of DNA damage on T cell biology we have utilised an in vitro human CD4+ T cell clone model. Levels and types of DNA damage were determined in 11 independent T cell clones as a function of their in vitro lifespan. Increased le...

journal_title：Mechanisms of ageing and development

authors： Hyland P,Barnett C,Pawelec G,Barnett Y

更新日期：2001-08-01 00:00:00

abstract：:A mutant of rad-8, originally isolated on the basis of its hypersensitivity to ultraviolet radiation, is also hypersensitive to oxygen and methyl viologen, a superoxide-anion generator. Oxygen also retarded development and reduced fecundity in a concentration-dependent fashion in rad-8 but not in wild type. In additio...

journal_title：Mechanisms of ageing and development

authors： Ishi N,Suzuki N,Hartman PS,Suzuki K

更新日期：1993-05-01 00:00:00

abstract：:Aging is known to affect adversely the corticosterone status and the brain function including cognition. Calorie restricted (CR) diet has been found to improve brain aging. The objective of the present investigation is to study the effect of short-term CR diet without any food deprivation on aging-induced impairment o...

journal_title：Mechanisms of ageing and development

authors： Chakraborty A,Banerjee S,Mukherjee B,Poddar MK

更新日期：2020-07-01 00:00:00

abstract：:Endogenous retroelements, transposons that mobilize through RNA intermediates, include some of the most abundant repetitive sequences of the human genome, such as Alu and LINE-1 sequences, and human endogenous retroviruses. Recent discoveries demonstrate that these mobile genetic elements not only act as intragenomic ...

journal_title：Mechanisms of ageing and development

authors： Cardelli M

更新日期：2018-09-01 00:00:00

abstract：:Hematopoietic stem cell performance and identity, crucial for homeostasis of the blood-forming system, is governed by extrinsic factors found in the bone marrow microenvironment. Communication within hematopoietic stem cell niches occurs via soluble factors or cell-to-cell contacts between niche and blood-forming cell...

journal_title：Mechanisms of ageing and development

authors： Böhm L,Helbing DL,Oraha N,Morrison H

更新日期：2020-10-01 00:00:00

abstract：:The responses of the left and right ventricles (LV and RV) to physical conditioning in cold (25 degrees C) and thermoneutral temperatures (35 degrees C), with special reference to lactate dehydrogenase (LDH) and its isoenzyme profile, were studied in the 2-month (young)- and 12-month (middle-aged)-old rats. Moderate h...

journal_title：Mechanisms of ageing and development

authors： Prathima S,Devi SA

更新日期：1999-04-01 00:00:00

abstract：:Mutated huntingtin is expressed in nervous and non nervous system included lymphoblasts. Eneregetic metabolism is impaired in Huntington's disease (HD) and other neurodegenerative diseases. Human HD lymphoblasts have provided clear-cut data on mitochondnal disruption. Here we report morphological, morphometric and mem...

journal_title：Mechanisms of ageing and development

authors： Squitieri F,Cannella M,Sgarbi G,Maglione V,Falleni A,Lenzi P,Baracca A,Cislaghi G,Saft C,Ragona G,Russo MA,Thompson LM,Solaini G,Fornai F

更新日期：2006-02-01 00:00:00

abstract：:The effect of life-long diets containing different concentrations of selenium and vitamin E on the age pigment accumulation in the rat superior cervical ganglion, vagal ganglion and dorsal root ganglion, was studied using microspectrofluorometry. All types of ganglia showed unchanged amounts of age pigments at low or ...

journal_title：Mechanisms of ageing and development

authors： Koistinaho J,Alho H,Hervonen A

更新日期：1990-01-01 00:00:00

abstract：:Mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism is reportedly associated with longevity and susceptibility to age-related diseases in Japanese individuals. We previously reported an association between mt5178 A/C polymorphism and serum protein fraction levels in healthy Japanese women. An association...

journal_title：Mechanisms of ageing and development

authors： Kokaze A,Ishikawa M,Matsunaga N,Yoshida M,Sekine Y,Sekiguchi K,Satoh M,Harada M,Teruya K,Takeda N,Uchida Y,Takashima Y

更新日期：2003-06-01 00:00:00

abstract：:In adult rats 3, 6 and 9 months post-orchidectomy performed at the age of 30 days the thymus weight, thymocyte yield and relative proportions of thymocyte subsets (delineated by expression of CD4/CD8 molecules and TCRalphabeta) were analyzed in order to elucidate a putative role of male gonadal hormones in the shaping...

journal_title：Mechanisms of ageing and development

authors： Leposavic G,Pejcić-Karapetrović B,Kosec D

更新日期：2002-02-01 00:00:00

abstract：:Considerable evidence points to an accumulation of somatic mutations in older cells and organisms but the causal role of mutations in the ageing process is still unclear. In addition to demonstrating that mutations accumulate, it is important to address the question of whether they do so at a sufficient rate and with ...

journal_title：Mechanisms of ageing and development

authors： Kirkwood TB,Proctor CJ

更新日期：2003-01-01 00:00:00