The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease.

abstract：:Normal diploid Syrian hamster dermal mesenchymal cell strains, regardless of the age of the tissue of origin, exhibit in vitro cellular senescence. The frequency of spontaneous escape from senescence and conversion to a permanent cell line is less than 5% among replicate flasks. The overall pattern of senescence of ce...

journal_title：Mechanisms of ageing and development

authors： Bruce SA,Deamond SF,Ts'o PO

更新日期：1986-04-01 00:00:00

abstract：:A comprehensive study on GSH metabolism in relation to some markers of oxidative and energy status in rat cerebral cortex as a function of age was performed. Reduced GSH, total GSH and the GSH Redox Index decreased both during growth (defined as the period between 1 and 5 months) and during aging (defined as the perio...

journal_title：Mechanisms of ageing and development

authors： Iantomasi T,Favilli F,Marraccini P,Stio M,Treves C,Quattrone A,Capaccioli S,Vincenzini MT,Quatrone A corrected to Quattrone A

更新日期：1993-08-01 00:00:00

abstract：:The survival rate was measured of differently aged rabbit erythrocytes that had been taken from young and old animals, tagged with 51Cr and injected into young and old animals. The survival rate of the donor erythrocytes depends mostly on the age of the recipient animals. The life span of the injected cells found in o...

journal_title：Mechanisms of ageing and development

authors： Vömel T,Platt D

更新日期：1981-11-01 00:00:00

abstract：:Aqueous solutions of zirconium oxychloride were added to human peripheral blood lymphocyte culture. Cultures were set up from healthy donors of both sexes belonging to age groups of 0-10, 11-20, 21-30, 31-40, 41-50 and 51-60 years. Airdried Giemsa schedule was followed for preparation of chromosomal aberrations and mi...

journal_title：Mechanisms of ageing and development

authors： Ghosh S,Talukder G,Sharma A

更新日期：1992-03-01 00:00:00

abstract：:The functional deterioration of an organism with age causes the major problem of maintaining the quality of life at old age. Degenerative changes in the organism may to some extent reflect alterations that can be observed in cells during in vitro replicative senescence. At the cellular level, the receptor-mediated end...

journal_title：Mechanisms of ageing and development

authors： Park SC

更新日期：2002-04-30 00:00:00

abstract：:delta-Aminolevulinic acid synthase and heme oxygenase are closely functionally connected with the hepatic microsomal mixed function oxydase system. There is a wide range of changes in microsomal heme oxygenase activity, cytochrome P-450 level and mitochondrial delta-aminolevulinic acid synthase activity in rat livers ...

journal_title：Mechanisms of ageing and development

authors： Plewka A,Bienioszek M,Plewka D

更新日期：1994-05-01 00:00:00

abstract：:Age-related changes in regulation of receptor response have been observed in several tissues and include regulation of beta-adrenergic receptor (beta-receptor) responses. The role of cellular aging in age-related changes in receptor response is not clear. We have examined the effect of aging in vitro on human fibrobla...

journal_title：Mechanisms of ageing and development

authors： Kilfeather SA,Collins D,McCormack P,Cotter T,O'Malley K

更新日期：1992-05-01 00:00:00

abstract：:To examine the effect of an aging environment on sister chromatid exchange (SCE) induction, Ehrlich ascites tumor (EAT) cells were introduced into young and old C57BL/6J mice. Background SCE levels were not significantly different in either EAT cell or normal bone marrow cell populations between young and old animals....

journal_title：Mechanisms of ageing and development

authors： Schneider EL,Lewis J

更新日期：1981-12-01 00:00:00

abstract：:The conserved SIR2 protein regulates life span in both yeast and worms: in both organisms overexpression of SIR2 can extend life span and in Caenorhabditis elegans this life span extension is dependent on the forkhead transcription factor, DAF-16. Here, we have done extensive genetic analysis with sir-2.1(ok434), a nu...

journal_title：Mechanisms of ageing and development

authors： Wang Y,Tissenbaum HA

更新日期：2006-01-01 00:00:00

abstract：:Aging is a biological process associated with impairment of mitochondrial bioenergetic function, increased oxidative stress, attenuated ability to respond to stresses and increased risk in contracting age-associated diseases. When mitochondria are subjected to oxidative stress, accompanied by calcium overload and ATP ...

journal_title：Mechanisms of ageing and development

authors： Paradies G,Paradies V,Ruggiero FM,Petrosillo G

更新日期：2013-01-01 00:00:00

abstract：:We have developed a relatively rapid, safe and simple method for the quantification of sjTREC levels in samples of peripheral blood. The assay uses an image analysis package to measure the brightness of PCR product bands on an image of the standard agarose gel. Comparison of the brightness of the band with that obtain...

journal_title：Mechanisms of ageing and development

authors： Aspinall R,Pido J,Andrew D

更新日期：2000-12-20 00:00:00

abstract：:A major cause of ageing is thought to be the accumulation of damage to macromolecules. Accumulation to DNA damage in cells therefore presupposes that aged cells are unable to repair this damage. We have used the in vitro model of cellular ageing to test the idea that senescent cells are deficient in some aspect of DNA...

journal_title：Mechanisms of ageing and development

authors： Al-Baker EA,Oshin M,Hutchison CJ,Kill IR

更新日期：2005-06-01 00:00:00

abstract：:Circulating antibodies in the sera of normal, healthy humans of different age groups to native DNA (nDNA) and reactive oxygen species modified DNA (ROS-DNA) was studied by competition ELISA. Sera from the young population (< 50 years of age) showed negligible levels of anti-DNA antibodies. In contrast, anti-DNA antibo...

journal_title：Mechanisms of ageing and development

authors： Ashok BT,Ali R

更新日期：1998-06-01 00:00:00

abstract：:Published data on age-related human biological functions are surveyed. For the many showing a linear decrease, regressions were calculated, or existing functions extrapolated, to yield an intercept on the abscissa. The values of chi(0), the age at which a function ceases, provide a tentative common means of comparison...

journal_title：Mechanisms of ageing and development

authors： Weale RA

更新日期：1993-06-01 00:00:00

abstract：:We investigated the production of IL-2 and IFN-gamma (Th1 type) and IL-4 (Th2 type) cytokines by mitogen-activated spleen cells from young, adult and old mice. Cytokine production was evaluated in culture supernatants by CTLL proliferation (IL-2), ELISA (IFN-gamma), CT4.S proliferation (IL-4) and in mRNA extracted fro...

journal_title：Mechanisms of ageing and development

authors： Frasca D,Pucci S,Goso C,Barattini P,Barile S,Pioli C,Doria G

更新日期：1997-02-01 00:00:00

abstract：:The steroid hormone ecdysone influences Drosophila lifespan. Longevity is extended in mutants deficient for ecdysone synthesis or mutants of the ecdysone receptor (EcR). However, the underlying mechanisms remain unclear. Here we conditionally inactivated EcR by RNA interference or expression of dominant negative forms...

journal_title：Mechanisms of ageing and development

authors： Tricoire H,Battisti V,Trannoy S,Lasbleiz C,Pret AM,Monnier V

更新日期：2009-08-01 00:00:00

abstract：:Age-related loss of hearing and vision are two very common disabling conditions, but the underlying mechanisms are still poorly understood. Damage by reactive oxygen species and other reactive cellular metabolites, which in turn may damage macromolecules such as DNA, has been implicated in both processes. To investiga...

journal_title：Mechanisms of ageing and development

authors： Spoor M,Nagtegaal AP,Ridwan Y,Borgesius NZ,van Alphen B,van der Pluijm I,Hoeijmakers JH,Frens MA,Borst JG

更新日期：2012-02-01 00:00:00

abstract：:The human fibroblast cell line WI-38 shows a gradual decline in glutamine synthetase specific activity with increasing age in culture. However, the level of functional enzyme per cell does not change with age. Heat inactivation profiles indicate that glutamine synthetase from younger cell cultures is more heat labile ...

journal_title：Mechanisms of ageing and development

authors： Viceps-Madore D,Cristofalo VJ

更新日期：1978-07-01 00:00:00

abstract：:T cell activation involves events at the plasma membrane; therefore, molecules such as long chain omega-3 fatty acids that alter the structure of the plasma membrane may affect the activation of aged T cells. In this project we investigated whether the incorporation of omega-3 fatty acids (from fish oil), in the prese...

journal_title：Mechanisms of ageing and development

authors： VanMeter AR,Ehringer WD,Stillwell W,Blumenthal EJ,Jenski LJ

更新日期：1994-08-01 00:00:00

abstract：:As the endothelium ages it may become more susceptible to damage by atherogenic plasma components such as toxic lipid oxidation products. Vitamin E (vit E) might prove to be anti-atherogenic by reducing oxidative injury. This study investigated the effects of age and chronic exposure to fatty acid hydroperoxides (OFA)...

journal_title：Mechanisms of ageing and development

authors： Boissonneault GA,Hennig B,Wang Y,Wood CL

更新日期：1990-10-01 00:00:00

abstract：:Cellular senescence is a phenomenon of irreversible growth arrest in mammalian somatic cells in culture. Various stresses induce cellular senescence and indeed, we have found that excess thymidine effectively induces cellular senescence in human cells. Further, many reports indicate the implication of chromatin protei...

journal_title：Mechanisms of ageing and development

authors： Arai R,En A,Takauji Y,Maki K,Miki K,Fujii M,Ayusawa D

更新日期：2019-03-01 00:00:00

abstract：:The present study was designed to determine whether the memory sparing effects of dietary restriction during aging could be through an effect on ionotropic glutamate receptors. Quantitative autoradiography was performed on 3, 10, and 26 month old mice to examine the density changes of NMDA, AMPA and kainate binding si...

journal_title：Mechanisms of ageing and development

authors： Magnusson KR

更新日期：1997-05-01 00:00:00

abstract：:The peripheral-type benzodiazepine receptor (PBR) is a protein predominantly located in the mitochondrial outer membrane that plays an important role in the regulation of cell survival and proliferation. Previous studies have shown an enhanced expression of PBR in the regenerating sciatic nerve, suggesting that this p...

journal_title：Mechanisms of ageing and development

authors： Leonelli E,Yague JG,Ballabio M,Azcoitia I,Magnaghi V,Schumacher M,Garcia-Segura LM,Melcangi RC

更新日期：2005-11-01 00:00:00

abstract：:A 3'-->5' exonuclease found in rat liver excises mispaired nucleotides at the 3'-hydroxyl end of primer chains such as poly dA-d(T9-C). Consequently, the priming activity of the chain from which the mispaired base was cut is greatly increased during DNA synthesis. These results suggest that the 3'-->5' exonuclease act...

journal_title：Mechanisms of ageing and development

authors： Taguchi T,Fukuda M,Toda T,Ohashi M

更新日期：1998-09-15 00:00:00

abstract：:A progressive decrease of dopamine and related enzyme activities and a decline in the dopaminergic receptor functions in the striatum and limbic system controlling behavior have been observed in senescent brain. These changes provide a neurochemical basis for some behavioral and mental disturbances of the aged and sug...

journal_title：Mechanisms of ageing and development

authors： Jellinger K,Flament H,Riederer P,Schmid H,Ambrozi L

更新日期：1980-09-01 00:00:00

abstract：:Interfibrillar mitochondria (IFM) of the heart in aged Fischer 344 rats show a biochemical defect which might be reflected in their morphology. We examined by high resolution scanning electron microscopy over 5500 mitochondria to determine if a concomitant structural alteration existed. This methodology provides a mea...

journal_title：Mechanisms of ageing and development

authors： Riva A,Tandler B,Lesnefsky EJ,Conti G,Loffredo F,Vazquez E,Hoppel CL

更新日期：2006-12-01 00:00:00

abstract：:Functional defects that accumulate in the T cell compartment are thought to be responsible for the pronounced immunodeficiency that develops during ageing, and reduced production of T cells by the thymus as it undergoes involution has been suggested to contribute to this phenomenon. Understanding the mechanisms respon...

journal_title：Mechanisms of ageing and development

authors： Montecino-Rodriguez E,Dorshkind K

更新日期：1997-02-01 00:00:00

abstract：:This paper is part of a series aimed to investigate the mechanism of the action of Folcysteine, a substance that has the capacity to release in the body active -SH groups and has been proved to be effective in the control of menopausal troubles. As an experimental model the ovariectomized rat, rather similar, from the...

journal_title：Mechanisms of ageing and development

authors： Moldoveanu E,Klein R,Bartoc R,Bruhis S,Oeriu I

更新日期：1975-09-01 00:00:00

abstract：:Extrachromosomal circular DNA complexes from peripheral blood lymphocytes from inbred mice of accelerated senescence, were detected by mica-press-adsorption method. In senescence-resistant series (SAM-R), polydisperse circular DNAs were observed at 7 weeks of age and a restricted size class of small circular forms of ...

journal_title：Mechanisms of ageing and development

authors： Yamagishi H,Kunisada T,Takeda T

更新日期：1985-01-01 00:00:00

abstract：:The paper of Kitani cited in the title has raised an apparent contradiction regarding the validity of certain aspects of the membrane hypothesis of aging (MHA). He collected data showing that a number of detoxifying liver enzyme activities, although decline with age in male Fischer 344 rats, remain at an unchanged lev...

journal_title：Mechanisms of ageing and development

authors： Zs-Nagy I

更新日期：2001-06-01 00:00:00