Effect of aging on cyclic AMP levels and adenylate cyclase and phosphodiesterase activities in the rat corpus striatum.

abstract：:A highly sensitive nucleic acid hybridization assay was used to compare the extent of nonrepetitive DNA transcription in rat liver between the ages of two and ten months. The basic approach consisted on initially purifying the DNA expressed in liver at these ages and then using it in reactions with homologous and hete...

journal_title：Mechanisms of ageing and development

authors： Grady LJ,Campbell WP

更新日期：1981-04-01 00:00:00

abstract：:Considerable amount of data has accumulated during the past few years showing several changes in gene expression as a function of age. However, the basic mechanism of aging still remains poorly understood. In this review, we have mainly analysed the data pertaining to the hypothesis that aging is associated with genet...

journal_title：Mechanisms of ageing and development

authors： Thakur MK,Oka T,Natori Y

更新日期：1993-01-01 00:00:00

abstract：:Food intake, body weight and serum LH, FSH, progesterone and oestradiol-17 beta were monitored from weaning to puberty in fully fed females housed in groups of four or individually and in females individually housed and dietary restricted. Restriction of food intake from weaning delayed the onset of puberty (34-39 day...

journal_title：Mechanisms of ageing and development

authors： Holehan AM,Merry BJ

更新日期：1985-11-01 00:00:00

abstract：:To investigate age-related changes in gene expression in WI-38 cells, we isolated RNA from young and senescent, quiescent cultures and made subtracted cDNA libraries. Density-arrested cells were incubated in serum-free MCDB-104 for 3 days. RNA was then isolated and subtracted cDNA libraries were made in the phagemid v...

journal_title：Mechanisms of ageing and development

authors： Doggett DL,Rotenberg MO,Pignolo RJ,Phillips PD,Cristofalo VJ

更新日期：1992-09-01 00:00:00

abstract：:We have isolated a new type of Paramecium tetraurelia mutant, named rie-2, that has a long immaturity period until autogamy. We previously isolated such an autogamy mutant, designated rie-1. These two mutants had some additional common features such as dependence of the occurrence of autogamy on the temperature, invol...

journal_title：Mechanisms of ageing and development

authors： Komori R,Sato H,Harumoto T,Takagi Y

更新日期：2005-06-01 00:00:00

abstract：:Metabolite concentrations in gastrocnemius and soleus muscles were compared in young-adult (4 months), mature (12 months) and senescent (24 months) rats after continuous (72 consecutive hours) exposure to normobaric hypoxia or normoxia with the intraperitoneal administration of the vasodilator naftidrofuryl or saline ...

journal_title：Mechanisms of ageing and development

authors： Pastoris O,Dossena M,Allorio F,Vercesi L

更新日期：1990-06-01 00:00:00

abstract：:delta-Aminolevulinic acid synthase and heme oxygenase are closely functionally connected with the hepatic microsomal mixed function oxydase system. There is a wide range of changes in microsomal heme oxygenase activity, cytochrome P-450 level and mitochondrial delta-aminolevulinic acid synthase activity in rat livers ...

journal_title：Mechanisms of ageing and development

authors： Plewka A,Bienioszek M,Plewka D

更新日期：1994-05-01 00:00:00

abstract：:Protein synthetic activity was determined in postmitochondrial preparations from heart, brain, kidney, liver and skeletal muscle of 5-26-month-old female C57B1/6J mice. An age-dependent decrease in the rate of protein synthesis was exhibited by all preparations except heart muscle. A 65% decrease in translational rate...

journal_title：Mechanisms of ageing and development

authors： Blazejowski CA,Webster GC

更新日期：1983-03-01 00:00:00

abstract：:Epidermal mass of the skin of Balb/c female mice of 2, 6, 12, and 20 months of age was determined by measuring epidermal wet weight, RNA, DNA, and protein per unit area (100 cm2) of skin. Epidermal wet weight is significantly decreased in 20-month-old mice compared to 2-month-old mice. This represents a real decrease ...

journal_title：Mechanisms of ageing and development

authors： Argyris TS

更新日期：1983-07-01 00:00:00

abstract：:Relationships between nutrition and longevity are of growing interest. Here we analysed the influences of dietary restriction on the survival of Drosophila exposed to atmospheric oxygen or to chronic hypoxia. Dietary restriction was achieved by food dilution, by sucrose restriction or by yeast restriction. Sucrose and...

journal_title：Mechanisms of ageing and development

authors： Vigne P,Frelin C

更新日期：2007-05-01 00:00:00

abstract：:A quantitative ultrastructural study of the posterior pituitary was undertaken. The posterior pituitary is the storage of the hormones vasopressin and oxytocin. Female C57BL/Icrfat mice which were under conditions of normal hydration were sampled at 8 and 32 months of age. There was a slight age-related decline in the...

journal_title：Mechanisms of ageing and development

authors： Wilkinson A,Davies I

更新日期：1981-02-01 00:00:00

abstract：:The present study examined the effect of repeated vaccination and of dehydroepiandrosterone (DHEA) treatment on the immune response to influenza vaccine in elderly subjects. Seventy-one elderly volunteers, aged 61-89 years, enrolled in a prospective randomized, double-blind study to receive either DHEA (50 mg qd p.o. ...

journal_title：Mechanisms of ageing and development

authors： Ben-Yehuda A,Danenberg HD,Zakay-Rones Z,Gross DJ,Friedman G

更新日期：1998-05-15 00:00:00

abstract：:In an attempt to provide additional quantitative markers of senescence in the nematode Caenorhabditis elegans, we have identified age-dependent increases in four lysosomal enzymes: acid phosphatase, beta-N-acetyl-D-glucosaminidase, beta-D-glucosidase, and alpha-D-mannosidase. These enzymes were judged to be lysosomal ...

journal_title：Mechanisms of ageing and development

authors： Bolanowski MA,Jacobson LA,Russell RL

更新日期：1983-03-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) establishes a highly prevalent life-long latent infection. Though generally subclinical, HCMV infection may have severe consequences during fetal development and in immunocompromised individuals. Based on epidemiological studies HCMV(+) serology has been associated with the development of ...

journal_title：Mechanisms of ageing and development

authors： López-Botet M,Muntasell A,Martínez-Rodríguez JE,López-Montañés M,Costa-García M,Pupuleku A

更新日期：2016-09-01 00:00:00

abstract：:The growing proportion of older people, especially the very old, is often thought of in negative terms such as the need for more health care. But the implications are wider and affect the future of family care as well as issues of intergenerational relations, employment, living arrangements and attitudes. This paper l...

journal_title：Mechanisms of ageing and development

authors： Tinker A

更新日期：2002-04-01 00:00:00

abstract：:Telomeres are supposed to play a role in cellular aging and might contribute to the genetic background of human aging and longevity. During the past few years telomere length has been measured in various human tissues. However, very little is known about the individual telomere loss in different tissues from the same ...

journal_title：Mechanisms of ageing and development

authors： Friedrich U,Griese E,Schwab M,Fritz P,Thon K,Klotz U

更新日期：2000-11-15 00:00:00

abstract：:The polyphenol quercetin has recently been found to extend lifespan and increase stress resistance in the nematode Caenorhabditis elegans. The forkhead transcription factor DAF-16 has previously been linked to these effects. However, by using a daf-16(mgDf50) mutant strain, we show that quercetin exposure leads to inc...

journal_title：Mechanisms of ageing and development

authors： Saul N,Pietsch K,Menzel R,Steinberg CE

更新日期：2008-10-01 00:00:00

abstract：:The effect of life-long diets containing different concentrations of selenium and vitamin E on the age pigment accumulation in the rat superior cervical ganglion, vagal ganglion and dorsal root ganglion, was studied using microspectrofluorometry. All types of ganglia showed unchanged amounts of age pigments at low or ...

journal_title：Mechanisms of ageing and development

authors： Koistinaho J,Alho H,Hervonen A

更新日期：1990-01-01 00:00:00

abstract：:Food restriction is known to ameliorate many of the adverse physiologic effects of age. In this study, we have examined the effect of food restriction on the induction of the gluconeogenic enzyme, phosphoenolpyruvate carboxykinase (PEPCK) in liver and kidney following a 12-h fasting period in young (6 month) and old (...

journal_title：Mechanisms of ageing and development

authors： Van Remmen H,Ward WF

更新日期：1998-09-01 00:00:00

abstract：:Lymphatic lipid transport in the intestine of adult and ageing rats was compared. Adult (8-10 months old) and old (24-26 months old) male Wistar rats were cannulated into the mesenteric lymph under ethrane anesthesia. On the following day, lipid emulsion containing 35.4 mg/h of olive oil was infused intraduodenally fo...

journal_title：Mechanisms of ageing and development

authors： Hayashi H,Sato Y,Kanai S,Masuda M,Ohta M,Funakoshi A,Nagao K,Imaizumi K,Miyasaka K

更新日期：2000-02-15 00:00:00

abstract：:Experimental studies have not shown that the 'common' clinical experience, which suggests that wound healing is impaired in an old organism, is valid for healthy old experimental animals. We have developed a model in the rat for ischemic wound healing by using an H-shaped double skin flap, where the test wound is the ...

journal_title：Mechanisms of ageing and development

authors： Quirinia A,Viidik A

更新日期：1991-05-01 00:00:00

abstract：:DNA synthesis is a remarkably vulnerable phase in the cell cycle. In addition to introduction of errors during semi-conservative replication, the inherently labile structure of the replication fork, as well as numerous pitfalls encountered in the course of fork progression, make the normally stable double stranded mol...

journal_title：Mechanisms of ageing and development

authors： Ruzankina Y,Asare A,Brown EJ

更新日期：2008-07-01 00:00:00

abstract：:The DNA repair capabilities of cultured hepatocytes derived from five mammalian species in response to a broad range of ultraviolet light exposures were measured. Differences in the induction of DNA repair synthesis and the proportion of responding cells were noted only for the lowest fluences. These differences appea...

journal_title：Mechanisms of ageing and development

authors： Maslansky CJ,Williams GM

更新日期：1985-02-01 00:00:00

abstract：:The antigen-specific antibody secretion in vitro after immunisation with the primary T-cell dependent antigen Helix pomatia Haemocyanin (HPH) was investigated in both young and elderly individuals, who all met the health admission criteria for immunogerontological studies as detailed in the SENIEUR protocol. In additi...

journal_title：Mechanisms of ageing and development

authors： De Greef GE,Van Staalduinen GJ,Van Doorninck H,Van Tol MJ,Hijmans W

更新日期：1992-01-01 00:00:00

abstract：:We tested the hypothesis that Ca(2+)-activated myosin ATPase activity is lower in muscles of aged rats relative to muscles of young rats, independent of changes in myosin isoform expression. Myofibrils were prepared from permeabilized fibers of soleus, plantaris, and semimembranosus muscles of young (8-12 months) and ...

journal_title：Mechanisms of ageing and development

authors： Lowe DA,Husom AD,Ferrington DA,Thompson LV

更新日期：2004-09-01 00:00:00

abstract：:This study attempts to elucidate the molecular mechanisms underlying the ageing-dependent cAMP profiles in human diploid fibroblasts stimulated by lysophosphatidic acid (LPA). In senescent cells, LPA-dependent Gialpha activation was reduced, with a consequent reduction in Gi-suppressed cAMP levels, without alterations...

journal_title：Mechanisms of ageing and development

authors： Jang IS,Rhim JH,Kim KT,Cho KA,Yeo EJ,Park SC

更新日期：2006-05-01 00:00:00

abstract：:Selenium (Se) is an essential trace mineral mediating its biological function primarily through selenoproteins. Accumulated lines of evidence indicate important roles of selenoproteins in the maintenance of optimal brain functions via redox regulation. Decreased expression of several selenoproteins is associated with ...

journal_title：Mechanisms of ageing and development

authors： Zhang S,Rocourt C,Cheng WH

更新日期：2010-04-01 00:00:00

abstract：:Arteriosclerosis is believed by many to represent the aging process of arteries and to be responsible for the cause-specific deaths at any age in industrialized countries. However, the increasing rate of (A) associated with steadily increasing life expectancy invited studies of the average age at death (AAD) of condit...

journal_title：Mechanisms of ageing and development

authors： Kaunitz H

更新日期：1991-02-01 00:00:00

abstract：:Hepatocytes isolated from 6-, 12-, 18-, and 30-month-old female Fischer F344 rats were examined by scanning electron microscopy. No significant change in cell size with age was observed. However, the surface morphology of the cells isolated from the older animals exhibited a significant increase in surface folds. This...

journal_title：Mechanisms of ageing and development

authors： Engelmann GL,Richardson A,Katz A,Fierer JA

更新日期：1981-01-01 00:00:00

abstract：:Bone marrow (BM) from young (3 months) and old (24 months) C57BL/6J mice were tested for the total number of colony forming units, which remain unchanged with age. The BM from both groups was used to reconstitute syngeneic, lethally irradiated mice that were 3 months' old. The reconstituted mice were followed for a pe...

journal_title：Mechanisms of ageing and development

authors： Gozes Y,Umiel T,Trainin N

更新日期：1982-03-01 00:00:00