Abstract:
:Genetically engineered T cells are powerful new medicines, offering hope for curative responses in patients with cancer. Chimeric antigen receptor (CAR) T cells were recently approved by the US Food and Drug Administration and are poised to enter the practice of medicine for leukemia and lymphoma, demonstrating that engineered immune cells can serve as a powerful new class of cancer therapeutics. The emergence of synthetic biology approaches for cellular engineering provides a broadly expanded set of tools for programming immune cells for enhanced function. Advances in T cell engineering, genetic editing, the selection of optimal lymphocytes, and cell manufacturing have the potential to broaden T cell-based therapies and foster new applications beyond oncology, in infectious diseases, organ transplantation, and autoimmunity.
journal_name
Annu Rev Immunoljournal_title
Annual review of immunologyauthors
Guedan S,Ruella M,June CHdoi
10.1146/annurev-immunol-042718-041407subject
Has Abstractpub_date
2019-04-26 00:00:00pages
145-171eissn
0732-0582issn
1545-3278journal_volume
37pub_type
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journal_title:Annual review of immunology
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abstract::The signaling lymphocyte activation molecule (SLAM)-associated protein, SAP, was first identified as the protein affected in most cases of X-linked lymphoproliferative (XLP) syndrome, a rare genetic disorder characterized by abnormal responses to Epstein-Barr virus infection, lymphoproliferative syndromes, and dysgamm...
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journal_title:Annual review of immunology
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journal_title:Annual review of immunology
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journal_title:Annual review of immunology
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journal_title:Annual review of immunology
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journal_title:Annual review of immunology
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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更新日期:1992-01-01 00:00:00
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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更新日期:1991-01-01 00:00:00
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journal_title:Annual review of immunology
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更新日期:2002-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1146/annurev.immunol.25.022106.141718
更新日期:2007-01-01 00:00:00
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journal_title:Annual review of immunology
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更新日期:2001-01-01 00:00:00
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journal_title:Annual review of immunology
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journal_title:Annual review of immunology
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更新日期:2004-01-01 00:00:00
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journal_title:Annual review of immunology
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journal_title:Annual review of immunology
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更新日期:1991-01-01 00:00:00
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更新日期:2012-01-01 00:00:00
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journal_title:Annual review of immunology
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journal_title:Annual review of immunology
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更新日期:2000-01-01 00:00:00
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更新日期:2008-01-01 00:00:00
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00
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journal_title:Annual review of immunology
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更新日期:2003-01-01 00:00:00