Emerging Cellular Therapies for Cancer.

Abstract:

:Genetically engineered T cells are powerful new medicines, offering hope for curative responses in patients with cancer. Chimeric antigen receptor (CAR) T cells were recently approved by the US Food and Drug Administration and are poised to enter the practice of medicine for leukemia and lymphoma, demonstrating that engineered immune cells can serve as a powerful new class of cancer therapeutics. The emergence of synthetic biology approaches for cellular engineering provides a broadly expanded set of tools for programming immune cells for enhanced function. Advances in T cell engineering, genetic editing, the selection of optimal lymphocytes, and cell manufacturing have the potential to broaden T cell-based therapies and foster new applications beyond oncology, in infectious diseases, organ transplantation, and autoimmunity.

journal_name

Annu Rev Immunol

authors

Guedan S,Ruella M,June CH

doi

10.1146/annurev-immunol-042718-041407

subject

Has Abstract

pub_date

2019-04-26 00:00:00

pages

145-171

eissn

0732-0582

issn

1545-3278

journal_volume

37

pub_type

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