Acetylcholinesterase Inhibitor Donepezil Effects on Plasma β-Hydroxybutyrate Levels in the Treatment of Alzheimer's Disease.

abstract：BACKGROUND:There is a growing body of pre-clinical evidence suggesting that lithium (Li) may protect neurons from a range of neurotoxic insults, hence the term neuroprotective effects. Does Li have similar effects also in human subjects? METHODS:We reviewed the neuroimaging literature investigating the association bet...

journal_title：Current Alzheimer research

authors： Hajek T,Weiner MW

更新日期：2016-01-01 00:00:00

abstract：:Memory loss is a prominent health concern, second only to heart disease for older individuals. Docosahexaenoic acid (DHA), the principle omega-3 fatty acid in brain and heart, plays an important role in neural and cardiac function. Decreases in plasma DHA are associated with cognitive decline in healthy elderly and Al...

journal_title：Current Alzheimer research

authors： Yurko-Mauro K

更新日期：2010-05-01 00:00:00

abstract：:The definite diagnosis of Alzheimer's disease (AD) is based on the detection of beta amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) - which are the pathological hallmarks of the disease- in the postmortem brains. Although regional Cerebral Blood Flow (rCBF) and Cerebral Glucose Metabolism (CGM) abnormalities ...

journal_title：Current Alzheimer research

authors： Valotassiou V,Archimandritis S,Sifakis N,Papatriantafyllou J,Georgoulias P

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:The Alzheimer's Disease Assessment Scale - cognitive subscale (ADAS-cog) is the most widely used cognitive outcome measure in AD trials. Although errors in administration and scoring have been suggested as factors masking accurate estimates and potential effects of treatments, there have been few formal exam...

journal_title：Current Alzheimer research

authors： Schafer K,De Santi S,Schneider LS

更新日期：2011-06-01 00:00:00

abstract：:Cholesterol-induced production of amyloid beta (Abeta) as a putative neurotoxin in Alzheimer's disease (AD), along with epidemiological evidence, suggests that statin drugs may provide benefit in treatment of the disorder. We tested the effect of once daily atorvastatin calcium (80 mg; two 40 mg tablets) on cognitive ...

journal_title：Current Alzheimer research

authors： Sparks DL,Sabbagh MN,Connor DJ,Lopez J,Launer LJ,Petanceska S,Browne P,Wassar D,Johnson-Traver S,Lochhead J,Ziolkowski C

更新日期：2005-07-01 00:00:00

abstract：:Metabolic syndrome (MetS), i.e., meeting criteria for any three of the following: hyperglycemia, hypertension, hypertriglyceridemia, low high-density lipoprotein and/or abdominal obesity, is associated with negative health outcomes. For example, MetS negatively impacts cognition; however, less is known about increment...

journal_title：Current Alzheimer research

authors： Lamar M,Rubin LH,Ajilore O,Charlton R,Zhang A,Yang S,Cohen J,Kumar A

更新日期：2015-01-01 00:00:00

abstract：:Despite the known validity of clinical diagnostic criteria, significant overlap of clinical symptoms between Frontotemporal dementia (FTD) subtypes exists in several cases, resulting in great uncertainty of the diagnostic boundaries. We evaluated the perfusion between FTD subtypes using brain perfusion (99m)Tc-HMPAO S...

journal_title：Current Alzheimer research

authors： Valotassiou V,Papatriantafyllou J,Sifakis N,Tzavara C,Tsougos I,Psimadas D,Kapsalaki E,Fezoulidis I,Hadjigeorgiou G,Georgoulias P

更新日期：2014-01-01 00:00:00

abstract：:Anesthesia and surgery have been reported to produce long-term cognitive problems, and to accelerate neurodegenerative disorders in the elderly. In previous work, we found that inhaled anesthetics enhance fibril formation and cytotoxicity of amyloid beta peptide. In this work we show that the inhaled anesthetics halot...

journal_title：Current Alzheimer research

authors： Carnini A,Lear JD,Eckenhoff RG

更新日期：2007-07-01 00:00:00

abstract：:At present, the search for preventive strategies for cognitive decline and dementia appears to be of crucial importance, given that the therapeutic options currently available have demonstrated limited efficacy. Cumulative epidemiological evidence suggested that vascular and vascular-related factors may be important f...

journal_title：Current Alzheimer research

authors： Panza F,Frisardi V,Seripa D,Imbimbo BP,Sancarlo D,D'Onofrio G,Addante F,Paris F,Pilotto A,Solfrizzi V

更新日期：2011-08-01 00:00:00

abstract：:Soluble amyloid beta (Abeta) oligomers might trigger early cognitive impairment in Alzheimer's Disease (AD) through the impairment of proper neuronal network function. We have recently shown that the short sequence Abeta(25-35) affects the spontaneous activity in hippocampal slices, when was added to the bath, at high...

journal_title：Current Alzheimer research

authors： Balleza-Tapia H,Huanosta-Gutiérrez A,Márquez-Ramos A,Arias N,Peña F

更新日期：2010-08-01 00:00:00

abstract：:Heme is essential for the survival of most organisms, despite the fact of being potentially toxic. This dual effect is due to the ability of the iron (Fe) atom contained within the protoporphyrin ring of the heme molecule to participate in redox reactions and exchange electrons with a variety of substrates. Therefore,...

journal_title：Current Alzheimer research

authors： Gozzelino R

更新日期：2016-01-01 00:00:00

abstract：:Pathological remodelling of astroglia represents an important component of the pathogenesis of Alzheimer's disease (AD). In AD astrocytes undergo both atrophy and reactivity; which may be specific for different stages of the disease evolution. Astroglial reactivity represents the generic defensive mechanism, and inhib...

journal_title：Current Alzheimer research

authors： Lim D,Rodríguez-Arellano JJ,Parpura V,Zorec R,Zeidán-Chuliá F,Genazzani AA,Verkhratsky A

更新日期：2016-01-01 00:00:00

abstract：:According to the current paradigm, the main cause of AD is the accumulation of neurotoxic amyloid beta (Aβ) peptide aggregates resulting from the cleavage of the amyloid precursor protein into peptides of different length, with the 42 amino acid long Aβ42 being the most toxic form. Aβ can aggregate and form plaques in...

journal_title：Current Alzheimer research

authors： Goldeck D,Witkowski JM,Fülop T,Pawelec G

更新日期：2016-01-01 00:00:00

abstract：:The first reports of disorders that in terms of cognitive and behavioral symptoms resemble frontotemporal dementia (FTD) and in terms of motor symptoms resemble amyotrophic lateral sclerosis (ALS) bring us back to the second half of the 1800s. Over the last 150 years, and especially in the last two decades, there has ...

journal_title：Current Alzheimer research

authors： Ferrari R,Kapogiannis D,Huey ED,Momeni P

更新日期：2011-05-01 00:00:00

abstract：:The use of natural compounds is an interesting stratagem in the search of drugs with therapeutic potential for the treatment of Alzheimer's disease (AD). We report here the effect of the hyperforin derivative (IDN5706, tetrahydrohyperforin), a semi-synthetic derivative of the St. John's Wort, on the brain neuropatholo...

journal_title：Current Alzheimer research

authors： Cerpa W,Hancke JL,Morazzoni P,Bombardelli E,Riva A,Marin PP,Inestrosa NC

更新日期：2010-03-01 00:00:00

abstract：:As the average ages of North Americans and Europeans continue to rise; similarly the incidence of "old age" associated illnesses likewise increases. Most notably among these ailments are conditions linked to dementia-related neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD) and st...

journal_title：Current Alzheimer research

authors： Tweedie D,Sambamurti K,Greig NH

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Recent studies have identified the correlation between dementia and certain vocal features, such as voice and speech changes. Vocal features may act as early markers of Alzheimer's disease (AD). Despite being present in non-pathological senescence and Mild Cognitive Impairment, especially in its amnesic subt...

journal_title：Current Alzheimer research

authors： Meilan JJG,Martinez-Sanchez F,Carro J,Carcavilla N,Ivanova O

更新日期：2018-01-01 00:00:00

abstract：:Evidence from basic molecular biology has noted a critical role of GSK-3 in Alzheimer's disease (AD) pathogenesis such as beta-amyloid (Aβ) production and accumulation, the formation of neurofibrillary tangle (NFT), and neuronal degeneration. Aβ generation and deposition represents a key feature and is generated from ...

journal_title：Current Alzheimer research

authors： Cai Z,Zhao Y,Zhao B

更新日期：2012-09-01 00:00:00

abstract：:Lipids participate in Amyloid Precursor Protein (APP) trafficking and processing - important factors in the initiation of Alzheimer's disease (AD) pathogenesis and influence the formation of neurotoxic β-amyloid (Aβ) peptides. An important risk factor, the presence of ApoE4 protein in AD brain cells binds the lipids t...

journal_title：Current Alzheimer research

authors： Penke B,Paragi G,Gera J,Berkecz R,Kovács Z,Crul T,VÍgh L

更新日期：2018-01-01 00:00:00

abstract：:The increasing prevalence of obesity world-wide has an expected consequent increase in diabetes and cardiovascular disease. Less attention has been paid to the effect of obesity on dementia. This overview discusses methodological issues related to the epidemiologic study of obesity and dementia, reviews results of lon...

journal_title：Current Alzheimer research

authors： Barrett-Connor E

更新日期：2007-04-01 00:00:00

abstract：:Recent studies of Alzheimer's disease (AD) and other neuropsychiatric drug developments raise questions whether failures of some drugs occur due to flaws in methods. In three case studies of recent AD drug development failures with phenserine, metrifonate, and tarenflurbil we identified methodological lapses able to a...

journal_title：Current Alzheimer research

authors： Becker RE,Greig NH

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVES:REM sleep behavior disorder (RBD), with its main clinical symptoms of nightmares with dream-enacting behavior, is considered as a possible precursor of neurodegenerative disease. Obstructive Sleep Apnea Syndrome (OSAS) is known to be capable of provoking RBD-like symptoms by apneic event related arousals. Th...

journal_title：Current Alzheimer research

authors： Schaefer C,Kunz D,Bes F

更新日期：2017-01-01 00:00:00

abstract：:Mitochondrial dysfunction has been implicated in causing metabolic abnormalities in Alzheimer's disease (AD). The searches for mitochondrial DNA variants associated with AD susceptibility have generated conflicting results. The age-related accumulation of somatic mitochondrial DNA deletion has been suggested to play a...

journal_title：Current Alzheimer research

authors： Chen X,Stern D,Yan SD

更新日期：2006-12-01 00:00:00

abstract：:The aggregation of the microtubule-associated protein tau into paired-helical filaments is the defining characteristic of the tauopathies. It has become apparent that the hyperphosphorylation of tau likely plays a role in the aggregation process and thus strategies to reduce tau phosphorylation are generating wide int...

journal_title：Current Alzheimer research

authors： Yuzwa SA,Vocadlo DJ

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Impairment in instrumental activities of daily living (IADL) starts as individuals with amnestic mild cognitive impairment (MCI) transition to Alzheimer's disease (AD) dementia. However, most IADL scales have not shown IADL alterations in clinically normal (CN) elderly. The objective of this study was to det...

journal_title：Current Alzheimer research

authors： Marshall GA,Zoller AS,Kelly KE,Amariglio RE,Locascio JJ,Johnson KA,Sperling RA,Rentz DM,For The Alzheimer's Disease Neuroimaging Initiative

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Life expectancy is increasing all over the world, although neurodegenerative disorders might drastically affect the individual activity of aged people. Of those, Alzheimer's Disease (AD) is one of the most social-cost age-linked diseases of industrialized countries. To date, retinal diseases seem to be more ...

journal_title：Current Alzheimer research

authors： Micera A,Bruno L,Cacciamani A,Rongioletti M,Squitti R

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Increasing basic science and clinical evidence implicates inflammatory processes and resulting glial activation in the pathogenesis of Alzheimer's Disease. Excess TNF-alpha, a cytokine with pleotropic effects in the CNS, has been suggested to be involved in the pathogenesis of AD. In addition to its pro-infl...

journal_title：Current Alzheimer research

authors： Tobinick E

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Curcumin has been of interest in the field of Alzheimer's disease. Early studies on transgenic mice showed promising results in the reduction of amyloid plaques.However, curcumin is very poorly soluble in aqueous solutions and not easily accessible to coupling as it contains only phenolic groups as potential...

journal_title：Current Alzheimer research

authors： Sturzu A,Sheikh S,Kalbacher H,Nägele T,Weidenmaier C,Wegenast-Braun BM,Schilling N,Ernemann U,Heckl S

更新日期：2019-01-01 00:00:00

abstract：:A crucial need exists for reliable Alzheimer's disease (AD) diagnostic and prognostic tests. Given its intimate communication with the brain, the cerebrospinal fluid (CSF) has been surveyed intensively for reliable AD biomarkers. The heterogeneity of AD pathology and the unavoidable difficulties associated with the cl...

journal_title：Current Alzheimer research

authors： Maarouf CL,Andacht TM,Kokjohn TA,Castaño EM,Sue LI,Beach TG,Roher AE

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Impairment in instrumental activities of daily living (IADL) emerges in the transition from mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia. Some IADL scales are sensitive to early deficits in MCI, but none have been validated for detecting subtle functional changes in clinically normal ...

journal_title：Current Alzheimer research

authors： Marshall GA,Zoller AS,Lorius N,Amariglio RE,Locascio JJ,Johnson KA,Sperling RA,Rentz DM

更新日期：2015-01-01 00:00:00