Prevalence of Cognitive Impairment and Dementia in Malays - Epidemiology of Dementia in Singapore Study.

abstract：BACKGROUND:Impairment in instrumental activities of daily living (IADL) emerges in the transition from mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia. Some IADL scales are sensitive to early deficits in MCI, but none have been validated for detecting subtle functional changes in clinically normal ...

journal_title：Current Alzheimer research

authors： Marshall GA,Zoller AS,Lorius N,Amariglio RE,Locascio JJ,Johnson KA,Sperling RA,Rentz DM

更新日期：2015-01-01 00:00:00

abstract：:A significant body of evidence has accumulated suggesting that individual variation in intellectual ability, whether assessed directly by intelligence tests or indirectly through proxy measures, is related to risk of developing Alzheimer's disease (AD) in later life. Important questions remain unanswered, however, suc...

journal_title：Current Alzheimer research

authors： Yeo RA,Arden R,Jung RE

更新日期：2011-06-01 00:00:00

abstract：:Lipids have many important yet distinct functions in cellular homeostasis such as forming an impermeable barrier separating intracellular and extracellular compartments, providing a matrix for the appropriate interactions of membrane-associated proteins, and serving as storage reservoirs for biologically active second...

journal_title：Current Alzheimer research

authors： Han X

更新日期：2005-01-01 00:00:00

abstract：:The field of aging and dementia research is advancing rapidly toward the stage of earlier identification of clinical symptoms. Ultimately, clinicians would like to be able to identify individuals who are asymptomatic but at risk for developing dementia. In the interim, the construct of mild cognitive impairment (MCI) ...

journal_title：Current Alzheimer research

authors： Petersen RC

更新日期：2009-08-01 00:00:00

abstract：:Acetylcholinesterase (AChE) plays a crucial physiological role in termination of impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine. In addition, it was implicated in amyloid plaque formation, a hallmark of Alzheimer's disease (AD), and most of the drugs used in AD treatment are ACh...

journal_title：Current Alzheimer research

authors： Hasin Y,Avidan N,Bercovich D,Korczyn AD,Silman I,Beckmann JS,Sussman JL

更新日期：2005-04-01 00:00:00

abstract：:In the last decade, several radiolabeled compounds have been developed for the imaging in vivo of amyloid pathology by means of Positron Emission Tomography (PET). Among these, 18F Florbetaben appear to be one of the most reliable for its high affinity for amyloid plaques in brain and its radio-chemical properties tha...

journal_title：Current Alzheimer research

authors： Chiaravalloti A,Danieli R,Lacanfora A,Palumbo B,Caltagirone C,Schillaci O

更新日期：2017-01-01 00:00:00

abstract：:Changes in rRNA and rDNA expression have been associated with cellular and organism aging and have been linked to Alzheimer's disease (AD) pathogenesis. In this study, we investigated the mRNA expression of ribosomal genes (28S/18S) and β-amyloid precursor protein (APP) in different post mortem brain tissue regions (t...

journal_title：Current Alzheimer research

authors： Rasmussen L,de Labio RW,Viani GA,Chen E,Villares J,Bertolucci PH,Minett TS,Turecki G,Cecyre D,Drigo SA,Smith MC,Payao SL

更新日期：2015-01-01 00:00:00

abstract：:Despite the known validity of clinical diagnostic criteria, significant overlap of clinical symptoms between Frontotemporal dementia (FTD) subtypes exists in several cases, resulting in great uncertainty of the diagnostic boundaries. We evaluated the perfusion between FTD subtypes using brain perfusion (99m)Tc-HMPAO S...

journal_title：Current Alzheimer research

authors： Valotassiou V,Papatriantafyllou J,Sifakis N,Tzavara C,Tsougos I,Psimadas D,Kapsalaki E,Fezoulidis I,Hadjigeorgiou G,Georgoulias P

更新日期：2014-01-01 00:00:00

abstract：:Trisomy 21 and the consequent extra copy of the amyloid precursor protein (APP) gene and increased beta-amyloid (Aβ) peptide production underlie the universal development of Alzheimer's disease (AD) pathology and high risk of AD dementia in people with Down syndrome (DS). Trisomy 21 and other forms of aneuploidy also ...

journal_title：Current Alzheimer research

authors： Potter H,Granic A,Caneus J

更新日期：2016-01-01 00:00:00

abstract：:Alzheimer's disease is a neurodegenerative disorder characterized by amyloid deposits and neurofibrillary tangles. Cholinergic dysfunction is also a main pathological feature of the disease. Nevertheless, the links between cholinergic dysfunction and neuropathological hallmarks of Alzheimer's are still unknown. In the...

journal_title：Current Alzheimer research

authors： Belarbi K,Schindowski K,Burnouf S,Caillierez R,Grosjean ME,Demeyer D,Hamdane M,Sergeant N,Blum D,Buée L

更新日期：2009-04-01 00:00:00

abstract：:Recent studies of Alzheimer's disease (AD) and other neuropsychiatric drug developments raise questions whether failures of some drugs occur due to flaws in methods. In three case studies of recent AD drug development failures with phenserine, metrifonate, and tarenflurbil we identified methodological lapses able to a...

journal_title：Current Alzheimer research

authors： Becker RE,Greig NH

更新日期：2010-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by mental and cognitive problems, particularly with memory, language, visuospatial skills (VS), and executive functions (EF). Advances in the neuroimaging of AD have highlighted dysfunctions in functional connectivity networks (FCNs), especially in the memory related default m...

journal_title：Current Alzheimer research

authors： Weiler M,Fukuda A,Massabki LH,Lopes TM,Franco AR,Damasceno BP,Cendes F,Balthazar ML

更新日期：2014-03-01 00:00:00

abstract：:A crucial need exists for reliable Alzheimer's disease (AD) diagnostic and prognostic tests. Given its intimate communication with the brain, the cerebrospinal fluid (CSF) has been surveyed intensively for reliable AD biomarkers. The heterogeneity of AD pathology and the unavoidable difficulties associated with the cl...

journal_title：Current Alzheimer research

authors： Maarouf CL,Andacht TM,Kokjohn TA,Castaño EM,Sue LI,Beach TG,Roher AE

更新日期：2009-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common type of dementia in the US and much of the world with rates increasing exponentially from age 65. Increases in life expectancy in the last century have resulted in a large number of people living to old ages and will result in a quadrupling of AD cases by the middle of the c...

journal_title：Current Alzheimer research

authors： Kawas CH,Corrada MM

更新日期：2006-12-01 00:00:00

abstract：:Based on the amyloid hypothesis, studies for AD therapy have been mostly focused on removing β-amyloid. Recent results of amyloid immunotherapy raised the question whether β-amyloid is sufficient target for AD therapy. Neurofibrillary tangles (NFTs), which contain hyperphosphorylated tau, are another pathological hall...

journal_title：Current Alzheimer research

authors： Takashima A

更新日期：2010-12-01 00:00:00

abstract：:Down syndrome (DS) is the most common non-lethal genetic condition that affects approximately 1 in 700 births in the United States of America. DS is characterized by complete or segmental chromosome 21 trisomy, which leads to variable intellectual disabilities, progressive memory loss, and accelerated neurodegeneratio...

journal_title：Current Alzheimer research

authors： Hamlett ED,Boger HA,Ledreux A,Kelley CM,Mufson EJ,Falangola MF,Guilfoyle DN,Nixon RA,Patterson D,Duval N,Granholm AC

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The USA National Task Group (NTG) guidelines advocate the use of an adapted version of Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID) for dementia screening of individuals with Down syndrome (DS) and with other forms of ID (non-DS). OBJECTIVE:In order to meet these ...

journal_title：Current Alzheimer research

authors： Gomiero T,Bertelli M,Deb S,Weger E,Marangoni A,De Bastiani E,Mantesso U,De Vreese LP

更新日期：2017-01-01 00:00:00

abstract：:In this review, the basic mechanism of the parasympathetic nervous effect on the heart is discussed. This is expanded to clinical situations to clarify what can happen to patients after cholinesterase (ChE) inhibitor is administered and to avoid unnecessary adverse effects. The parasympathetic nervous system can affec...

journal_title：Current Alzheimer research

authors： Masuda Y

更新日期：2004-11-01 00:00:00

abstract：:Differential diagnosis of AD is still a challenge due to overlapping features with other types of dementia. Biomarkers for the differential diagnosis of AD can improve the diagnostic value of the disease and ensure an appropriate treatment of patients. The aim of this study was to evaluate the potential of two neo-epi...

journal_title：Current Alzheimer research

authors： Inekci D,Henriksen K,Linemann T,Karsdal MA,Habib A,Bisgaard C,Eriksen FB,Vilholm OJ

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The design of new heterodimeric dual binding site acetylcholinesterase inhibitors constitutes the main goal-directed to the development of new anticholinesterase agents with the expanded pharmacological profile. Multi-target compounds are usually designed by combining in a hybrid molecule with two or more ph...

journal_title：Current Alzheimer research

authors： Hamulakova S,Janovec L,Soukup O,Jun D,Janockova J,Hrabinova M,Sepsova V,Kuca K

更新日期：2018-01-01 00:00:00

abstract：:Rigorous scientific research has identified multiple interactive mechanisms that parallel and are likely causative of the development of Alzheimer's disease (AD). Causative mechanisms include genomics, the creation of amyloid beta (Abeta), factors inhibiting the Abeta removal process, the transformation of Abeta to it...

journal_title：Current Alzheimer research

authors： Standridge JB

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Various methodologies have been employed for the localization of amyloid plaques in numerous studies on Alzheimer's disease. The majority of these stains are thought to label the plaques by virtue of their affinity for aggregated Aβ. However, plaques are known to contain numerous other components, including ...

journal_title：Current Alzheimer research

authors： Schmued L,Raymick J,Sarkar S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The longitudinal change of neuropsychological tests (NPTs) in treated Alzheimer's disease (AD) is essential to understand the interplay of a therapeutic response from medication and a disease decline due to degenerative processes. The aim of our study is to investigate the annual cognitive progression as mea...

journal_title：Current Alzheimer research

authors： Yang YH,Wu MN,Chou PS,Su HC,Lin SH,Sung PS

更新日期：2018-03-14 00:00:00

abstract：:The increasing prevalence of obesity world-wide has an expected consequent increase in diabetes and cardiovascular disease. Less attention has been paid to the effect of obesity on dementia. This overview discusses methodological issues related to the epidemiologic study of obesity and dementia, reviews results of lon...

journal_title：Current Alzheimer research

authors： Barrett-Connor E

更新日期：2007-04-01 00:00:00

abstract：:The definite diagnosis of Alzheimer's disease (AD) is based on the detection of beta amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) - which are the pathological hallmarks of the disease- in the postmortem brains. Although regional Cerebral Blood Flow (rCBF) and Cerebral Glucose Metabolism (CGM) abnormalities ...

journal_title：Current Alzheimer research

authors： Valotassiou V,Archimandritis S,Sifakis N,Papatriantafyllou J,Georgoulias P

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:The lack of diagnostic tools and disease-modifying treatments against Alzheimer's disease (AD) and related disorders, collectively known as tauopathies, has led to a socioeconomic burden of epidemic proportion. Proteomics approaches can be used to identify novel proteome changes that could help us understand...

journal_title：Current Alzheimer research

authors： Vega IE,Umstead A,Wygant CM,Beck JS,Counts SE

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:It is well known that alterations in astrocytes occur in Alzheimer's disease and reactive astrogliosis is one of the hallmarks of the disease. Recently, data has emerged that suggests that alterations in astrocytes may also occur early in the pathogenesis of the disease. OBJECTIVE:The aim of present work wa...

journal_title：Current Alzheimer research

authors： Ruffinatti F,Tapella L,Gregnanin I,Stevano A,Chiorino G,Canonico PL,Distasi C,Genazzani AA,Lim D

更新日期：2018-01-01 00:00:00

abstract：:Deterioration of the cortical cholinergic system is a leading neurochemical feature of Alzheimer's Disease (AD). This review summarizes evidence that the homomeric α7- nicotinic acetylcholine receptor (nAChR) plays a crucial role in the pathogenesis of this disease, which is characterized by amyloid-β (Aβ) accumulatio...

journal_title：Current Alzheimer research

authors： Oz M,Lorke DE,Yang KH,Petroianu G

更新日期：2013-07-01 00:00:00

abstract：:Metabolic syndrome (MetS), i.e., meeting criteria for any three of the following: hyperglycemia, hypertension, hypertriglyceridemia, low high-density lipoprotein and/or abdominal obesity, is associated with negative health outcomes. For example, MetS negatively impacts cognition; however, less is known about increment...

journal_title：Current Alzheimer research

authors： Lamar M,Rubin LH,Ajilore O,Charlton R,Zhang A,Yang S,Cohen J,Kumar A

更新日期：2015-01-01 00:00:00

abstract：:Protein folding, protein degradation, and protein stability are regulated by the molecular chaperones. Under pathogenic conditions, aberrant proteins can be dysfunctional, unregulated, or pathogenically mutated. These aberrant proteins are triaged by the chaperone network for the maintenance of cellular homeostasis. T...

journal_title：Current Alzheimer research

authors： Carman A,Kishinevsky S,Koren J 3rd,Luo W,Chiosis G

更新日期：2014-01-01 00:00:00