Brain perfusion SPECT with Brodmann areas analysis in differentiating frontotemporal dementia subtypes.

abstract：:Amyloid beta (Aβ) binding alcohol dehydrogenase (ABAD) is a cellular cofactor for promoting (Aβ)-mediated mitochondrial and neuronal dysfunction, and cognitive decline in transgenic Alzheimer's disease (AD) mouse models. Targeting mitochondrial ABAD may represent a novel therapeutic strategy against AD. Here, we repor...

journal_title：Current Alzheimer research

authors： Valaasani KR,Sun Q,Hu G,Li J,Du F,Guo Y,Carlson EA,Gan X,Yan SS

更新日期：2014-02-01 00:00:00

abstract：:To search for potential mechanism that might alter synaptic transmission following Abeta increase we have examined the presynaptic component of transmitter release. As parameters of synaptic transmission that might underlie presynaptic mechanisms, we have used paired-pulse facilitation (PPF), post-tetanic potentiation...

journal_title：Current Alzheimer research

authors： Zhang H,Gong B,Liu S,Fa' M,Ninan I,Staniszewski A,Arancio O

更新日期：2005-04-01 00:00:00

abstract：:Amyloid beta peptide (Abeta), 42-residue peptide and its variations, is known to form amyloid fibrils in Alzheimer's disease. Solid-state NMR study reveals a parallel beta-sheet structure in the Abeta fibrils. The atomic level structure of Abeta in aqueous environment, however, has not been determined, because of its ...

journal_title：Current Alzheimer research

authors： Takano K

更新日期：2008-12-01 00:00:00

abstract：:The remarkable potentiality of bone marrow-derived mesenchymal stem cells (BM-MSCs) after transplantation to models of neurological disease and injury has been described. We have previously published data confirming the influence of BM-MSCs on β-amyloid (Aβ) deposition in an Alzheimer's disease (AD) mouse model. Howev...

journal_title：Current Alzheimer research

authors： Bae JS,Jin HK,Lee JK,Richardson JC,Carter JE

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Various methodologies have been employed for the localization of amyloid plaques in numerous studies on Alzheimer's disease. The majority of these stains are thought to label the plaques by virtue of their affinity for aggregated Aβ. However, plaques are known to contain numerous other components, including ...

journal_title：Current Alzheimer research

authors： Schmued L,Raymick J,Sarkar S

更新日期：2019-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the fourth leading cause of death in the United States and most common cause of adult-onset dementia. The major hallmarks of AD are the formation of senile amyloid plaques made of beta amyloid and neurofibrillary tangles (NFT) which are primarily...

journal_title：Current Alzheimer research

authors： Sarkar S,Raymick J,Ray B,Lahiri DK,Paule MG,Schmued L

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:REM sleep behavior disorder (RBD), with its main clinical symptoms of nightmares with dream-enacting behavior, is considered as a possible precursor of neurodegenerative disease. Obstructive Sleep Apnea Syndrome (OSAS) is known to be capable of provoking RBD-like symptoms by apneic event related arousals. Th...

journal_title：Current Alzheimer research

authors： Schaefer C,Kunz D,Bes F

更新日期：2017-01-01 00:00:00

abstract：:Apoptosis has been postulated to play a possible causal role in the onset of Alzheimer's disease due to shortage of trophic supply, deafferentation and excessive production of free radicals. Many experiments in the past have demonstrated the requirement of de novo gene expression during neuronal apoptosis. In view of ...

journal_title：Current Alzheimer research

authors： Cavallaro S,Calissano P

更新日期：2006-09-01 00:00:00

abstract：:Lipids participate in Amyloid Precursor Protein (APP) trafficking and processing - important factors in the initiation of Alzheimer's disease (AD) pathogenesis and influence the formation of neurotoxic β-amyloid (Aβ) peptides. An important risk factor, the presence of ApoE4 protein in AD brain cells binds the lipids t...

journal_title：Current Alzheimer research

authors： Penke B,Paragi G,Gera J,Berkecz R,Kovács Z,Crul T,VÍgh L

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Recent studies have identified the correlation between dementia and certain vocal features, such as voice and speech changes. Vocal features may act as early markers of Alzheimer's disease (AD). Despite being present in non-pathological senescence and Mild Cognitive Impairment, especially in its amnesic subt...

journal_title：Current Alzheimer research

authors： Meilan JJG,Martinez-Sanchez F,Carro J,Carcavilla N,Ivanova O

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by a multi-factorial etiology that is not completely understood. Donepezil is a first-line acetylcholinesterase inhibitor used for the treatment of AD that has been found, in addition to its potent acetylcholinesterase inhibitory ...

journal_title：Current Alzheimer research

authors： Wan L,Lu J,Fu J,Huang J,Yang Q,Xin B,Chen L,Huo Y,Zhong Y,Guo C

更新日期：2018-01-01 00:00:00

abstract：:The first reports of disorders that in terms of cognitive and behavioral symptoms resemble frontotemporal dementia (FTD) and in terms of motor symptoms resemble amyotrophic lateral sclerosis (ALS) bring us back to the second half of the 1800s. Over the last 150 years, and especially in the last two decades, there has ...

journal_title：Current Alzheimer research

authors： Ferrari R,Kapogiannis D,Huey ED,Momeni P

更新日期：2011-05-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. A characteristic of AD is the accumulation of plaques in the brain of AD patients, and theses plaques mainly consist of aggregates of amyloid beta-peptide (Abeta). All converging lines of evidence sugg...

journal_title：Current Alzheimer research

authors： Cerpa W,Dinamarca MC,Inestrosa NC

更新日期：2008-06-01 00:00:00

abstract：:Deterioration of the cortical cholinergic system is a leading neurochemical feature of Alzheimer's Disease (AD). This review summarizes evidence that the homomeric α7- nicotinic acetylcholine receptor (nAChR) plays a crucial role in the pathogenesis of this disease, which is characterized by amyloid-β (Aβ) accumulatio...

journal_title：Current Alzheimer research

authors： Oz M,Lorke DE,Yang KH,Petroianu G

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:It is well known that alterations in astrocytes occur in Alzheimer's disease and reactive astrogliosis is one of the hallmarks of the disease. Recently, data has emerged that suggests that alterations in astrocytes may also occur early in the pathogenesis of the disease. OBJECTIVE:The aim of present work wa...

journal_title：Current Alzheimer research

authors： Ruffinatti F,Tapella L,Gregnanin I,Stevano A,Chiorino G,Canonico PL,Distasi C,Genazzani AA,Lim D

更新日期：2018-01-01 00:00:00

abstract：:Human memory can be split into familiarity and recollection processes which contribute to different aspects of memory function. These separate processes result in different experiential states. In this review, we examine how this dominant theoretical framework can explain the subjective experience of people with Alzhe...

journal_title：Current Alzheimer research

authors： Souchay C,Moulin CJ

更新日期：2009-06-01 00:00:00

abstract：:At present, the etiology of Alzheimer's disease (AD) is still unclear, but both genetic and non-genetic factors are thought to take part in the etiopathogenesis of AD. Epidemiologic researches revealed that genetic factors played a decisive role in the development of both early-onset AD (EOAD) and late-onset AD (LOAD)...

journal_title：Current Alzheimer research

authors： Jiang T,Yu JT,Tian Y,Tan L

更新日期：2013-10-01 00:00:00

abstract：:Lipids have many important yet distinct functions in cellular homeostasis such as forming an impermeable barrier separating intracellular and extracellular compartments, providing a matrix for the appropriate interactions of membrane-associated proteins, and serving as storage reservoirs for biologically active second...

journal_title：Current Alzheimer research

authors： Han X

更新日期：2005-01-01 00:00:00

abstract：:Early diagnosis of Alzheimer`s disease (AD) is currently difficult and involves a complex approach including clinical assessment, neuroimaging, and measurement of amyloid-β (Aβ) and tau levels in cerebrospinal fluid (CSF). A better mechanistic understanding is needed to develop more accurate and even presymptomatic di...

journal_title：Current Alzheimer research

authors： Skachokova Z,Sprenger F,Breu K,Abramowski D,Clavaguera F,Hench J,Staufenbiel M,Tolnay M,Winkler DT

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To study the prevalence of cognitive impairment and dementia in communitydwelling Malays from Singapore; and to examine differences in prevalence among Chinese and Malays. METHODS:Subjects (≥ 60 years) - drawn from the Malay component of the on-going multiethnic Epidemiology of Dementia in Singapore study - ...

journal_title：Current Alzheimer research

authors： Hilal S,Tan CS,Xin X,Amin SM,Wong TY,Chen C,Venketasubramanian N,Ikram MK

更新日期：2017-01-01 00:00:00

abstract：:A crucial need exists for reliable Alzheimer's disease (AD) diagnostic and prognostic tests. Given its intimate communication with the brain, the cerebrospinal fluid (CSF) has been surveyed intensively for reliable AD biomarkers. The heterogeneity of AD pathology and the unavoidable difficulties associated with the cl...

journal_title：Current Alzheimer research

authors： Maarouf CL,Andacht TM,Kokjohn TA,Castaño EM,Sue LI,Beach TG,Roher AE

更新日期：2009-08-01 00:00:00

abstract：:Protein folding, protein degradation, and protein stability are regulated by the molecular chaperones. Under pathogenic conditions, aberrant proteins can be dysfunctional, unregulated, or pathogenically mutated. These aberrant proteins are triaged by the chaperone network for the maintenance of cellular homeostasis. T...

journal_title：Current Alzheimer research

authors： Carman A,Kishinevsky S,Koren J 3rd,Luo W,Chiosis G

更新日期：2014-01-01 00:00:00

abstract：:The aetiology of major neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) is still unknown, but increasing evidences suggest that glutamate and mitochondria are two prominent players in the oxidative stress (OS) process that underlie these illnesses. Although AD and PD have distin...

journal_title：Current Alzheimer research

authors： Cassano T,Pace L,Bedse G,Lavecchia AM,De Marco F,Gaetani S,Serviddio G

更新日期：2016-01-01 00:00:00

abstract：:Amyloid oligomers have a critical function in the pathologic processes of various amyloidoses, such as Alzheimer's disease (AD), Parkinson disease (PD), Huntington's disease, prion-related diseases, type 2 diabetes, and hereditary renal amyloidosis. Our previous reports demonstrated that a conformation-dependent oligo...

journal_title：Current Alzheimer research

authors： Zhao M,Wang SW,Wang YJ,Zhang R,Li YN,Su YJ,Zhou WW,Yu XL,Liu RT

更新日期：2014-01-01 00:00:00

abstract：:In this study, we aimed to classify MR images for recognizing Alzheimer Disease (AD) in a group of patients who were recently diagnosed by clinical history and neuropsychiatric exams by using non-biased machine-learning techniques. T1 weighted MRI scans of 31 patients with probable AD and 31 age- and gender-matched co...

journal_title：Current Alzheimer research

authors： Polat F,Demirel SO,Kitis O,Simsek F,Haznedaroglu DI,Coburn K,Kumral E,Gonul AS

更新日期：2012-09-01 00:00:00

abstract：:Features of autoimmunity have been associated with both Alzheimer's disease (AD) and with diabetes. In both diseases high levels of advanced glycation end products (AGEs) and their receptor (RAGE) have been detected in tissues and in the circulation. In addition high titers of antibodies directed against a RAGE-like p...

journal_title：Current Alzheimer research

authors： Mruthinti S,Schade RF,Harrell DU,Gulati NK,Swamy-Mruthinti S,Lee GP,Buccafusco JJ

更新日期：2006-07-01 00:00:00

abstract：:When Alzheimer's disease (AD) progresses, several pathological features arise including accumulation of misfolded protein aggregates [e.g., amyloid-β (Aβ) plaques], metal ion dyshomeostasis, and oxidative stress. These characteristics are recently suggested to be interconnected through a potential factor, metal-associ...

journal_title：Current Alzheimer research

authors： Kochi A,Lee HJ,Vithanarachchi SM,Padmini V,Allen MJ,Lim MH

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a neurodegenerative disease characterised by a progressive decline in cognitive function and represents a major healthcare challenge worldwide. Increasing evidence indicates that mitochondrial dysfunction mediated oxidative stress plays a significant role in the pathophysiological...

journal_title：Current Alzheimer research

authors： Chhetri J,King AE,Gueven N

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:Histaminergic H3 receptors may play a role in modulating cholinergic and monoaminergic neurotransmission. This Phase II study evaluated the efficacy and safety of GSK239512, a highly potent, brain penetrant H3 receptor antagonist as monotherapy treatment for subjects with mild-to-moderate probable Alzheime...

journal_title：Current Alzheimer research

authors： Grove RA,Harrington CM,Mahler A,Beresford I,Maruff P,Lowy MT,Nicholls AP,Boardley RL,Berges AC,Nathan PJ,Horrigan JP

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The lack of diagnostic tools and disease-modifying treatments against Alzheimer's disease (AD) and related disorders, collectively known as tauopathies, has led to a socioeconomic burden of epidemic proportion. Proteomics approaches can be used to identify novel proteome changes that could help us understand...

journal_title：Current Alzheimer research

authors： Vega IE,Umstead A,Wygant CM,Beck JS,Counts SE

更新日期：2018-01-01 00:00:00