Abstract：
:Alzheimer's disease (AD) is the most common type of dementia in the US and much of the world with rates increasing exponentially from age 65. Increases in life expectancy in the last century have resulted in a large number of people living to old ages and will result in a quadrupling of AD cases by the middle of the century. Preventing or delaying the onset of AD could have a huge impact in the number of cases expected to develop. The oldest-old are the fastest growing segment of the population and are estimated to account for 12% of the population over 65. Establishing accurate estimates of dementia and AD rates in this group is crucial for public health planning. Prevalence and incidence estimates above age 85 are imprecise and inconsistent because of the lack of very old individuals in most studies. Moreover, risk and protective factors in our oldest citizens have been studied little, and clinical-pathological correlations appear to be poor. We introduce The 90+ Study, established to address some of the unanswered questions about AD and dementia in the oldest-old. Our preliminary results show that close to half of demented oldest-old do not have known cerebral pathology to account for their cognitive deficits. Furthermore, the APOE-e4 allele appears to be a risk factor for AD only in the women in our study. In addition to the challenge of preventing and treating AD, the oldest-old will require major investigative energy to better understand the concomitants of longevity, the causes of dementia, and the factors that promote successful aging in oldest citizens.
journal_name
Curr Alzheimer Resjournal_title
Current Alzheimer researchauthors
Kawas CH,Corrada MMdoi
10.2174/156720506779025233subject
Has Abstractpub_date
2006-12-01 00:00:00pages
411-9issue
5eissn
1567-2050issn
1875-5828journal_volume
3pub_type
历史文章,杂志文章,评审abstract：BACKGROUND:Alzheimer's Dementia (AD) has a complex pathophysiology that is incompletely understood. Chronic, low-level environmental lead (Pb) exposure is associated with cognitive impairment, hypertension and mortality, and has been proposed as a potential cause of AD. OBJECTIVE:We aimed to review the literature to c...
journal_title：Current Alzheimer research
pub_type： 杂志文章
doi：10.2174/1567205016666190311101445
更新日期：2019-01-01 00:00:00
abstract：:Amyloid beta (Aβ) binding alcohol dehydrogenase (ABAD) is a cellular cofactor for promoting (Aβ)-mediated mitochondrial and neuronal dysfunction, and cognitive decline in transgenic Alzheimer's disease (AD) mouse models. Targeting mitochondrial ABAD may represent a novel therapeutic strategy against AD. Here, we repor...
journal_title：Current Alzheimer research
pub_type： 杂志文章
doi：10.2174/1567205011666140130150108
更新日期：2014-02-01 00:00:00
abstract：:To search for potential mechanism that might alter synaptic transmission following Abeta increase we have examined the presynaptic component of transmitter release. As parameters of synaptic transmission that might underlie presynaptic mechanisms, we have used paired-pulse facilitation (PPF), post-tetanic potentiation...
journal_title：Current Alzheimer research
pub_type： 杂志文章
doi：10.2174/1567205053585936
更新日期：2005-04-01 00:00:00
abstract：:Apoptosis has been postulated to play a possible causal role in the onset of Alzheimer's disease due to shortage of trophic supply, deafferentation and excessive production of free radicals. Many experiments in the past have demonstrated the requirement of de novo gene expression during neuronal apoptosis. In view of ...
journal_title：Current Alzheimer research
pub_type： 杂志文章,评审
doi：10.2174/156720506778249416
更新日期：2006-09-01 00:00:00
abstract：:The serine hydrolase butyrylcholinesterase (BChE), like the related enzyme acetylcholinesterase (AChE), co-regulates metabolism of the neurotransmitter acetylcholine. In the human brain BChE is mainly expressed in white matter and glia and in distinct populations of neurons in regions that are important in cognition a...
journal_title：Current Alzheimer research
pub_type： 杂志文章,评审
doi：10.2174/1567205013666160404120542
更新日期：2016-01-01 00:00:00
abstract：:Accumulating evidence has suggested the involvement of oxidative stress in the pathogenesis of Alzheimer's disease (AD). The main endogenous antioxidant, glutathione (GSH), has been shown to decline with ageing and in several age-related degenerative diseases, including AD. Potential options for replenishing GSH level...
journal_title：Current Alzheimer research
pub_type： 杂志文章,评审
doi：10.2174/1567205012666150302160308
更新日期：2015-01-01 00:00:00
abstract：:The occurrence of a plaque-dependent inflammation in Alzheimer's disease has been extensively documented in both human specimens and transgenic models of the disease. Since insoluble plaques are present in AD patients from early preclinical stages of the pathology, the point at which neuroinflammation first occurs in ...
journal_title：Current Alzheimer research
pub_type： 杂志文章
doi：10.2174/156720511795255982
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND:Impairment in instrumental activities of daily living (IADL) emerges in the transition from mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia. Some IADL scales are sensitive to early deficits in MCI, but none have been validated for detecting subtle functional changes in clinically normal ...
journal_title：Current Alzheimer research
pub_type： 杂志文章,多中心研究
doi：10.2174/156720501205150526115003
更新日期：2015-01-01 00:00:00
abstract：:Rodents housed in an enriched environment, exercise by running or perform learning and memory tasks show an increase in hippocampal neurogenesis. We show that both environmental enrichment, as well as performance in the Morris water maze, a hippocampal-dependent learning task, leads to an increase in local VEGF expres...
journal_title：Current Alzheimer research
pub_type： 杂志文章,评审
doi：10.2174/156720506775697133
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND:Vascular disease is associated with increased risk of dementia. Vascular health worsens with age. We investigated the relationship between self-reported vascular disease and brain pathology. METHODS:Brain donations to the population-based MRC Cognitive Function and Ageing Study (n=456, age range 66-103 year...
journal_title：Current Alzheimer research
pub_type： 杂志文章
doi：10.2174/156720512801322654
更新日期：2012-07-01 00:00:00
abstract：:Based on the amyloid hypothesis, studies for AD therapy have been mostly focused on removing β-amyloid. Recent results of amyloid immunotherapy raised the question whether β-amyloid is sufficient target for AD therapy. Neurofibrillary tangles (NFTs), which contain hyperphosphorylated tau, are another pathological hall...
journal_title：Current Alzheimer research
pub_type： 杂志文章,评审
doi：10.2174/156720510793611600
更新日期：2010-12-01 00:00:00
abstract：:Serum levels of β-amyloid (Aβ) peptides may represent an early biomarker in the diagnosis of Alzheimer's disease (AD). In the present study, we investigated the temporal kinetic changes in the levels of serum Aβ 1-42 and 40 in an amyloid precursor protein (APP)/presenilin (PS)1 double transgenic mouse model of AD. Ser...
journal_title：Current Alzheimer research
pub_type： 杂志文章
doi：10.2174/15672050113106660159
更新日期：2013-11-01 00:00:00
abstract：:Amyloid beta peptide (Abeta), 42-residue peptide and its variations, is known to form amyloid fibrils in Alzheimer's disease. Solid-state NMR study reveals a parallel beta-sheet structure in the Abeta fibrils. The atomic level structure of Abeta in aqueous environment, however, has not been determined, because of its ...
journal_title：Current Alzheimer research
pub_type： 杂志文章,评审
doi：10.2174/156720508786898424
更新日期：2008-12-01 00:00:00
abstract：:The increasing prevalence of obesity world-wide has an expected consequent increase in diabetes and cardiovascular disease. Less attention has been paid to the effect of obesity on dementia. This overview discusses methodological issues related to the epidemiologic study of obesity and dementia, reviews results of lon...
journal_title：Current Alzheimer research
pub_type： 杂志文章,评审
doi：10.2174/156720507780362074
更新日期：2007-04-01 00:00:00
abstract：:At present, the etiology of Alzheimer's disease (AD) is still unclear, but both genetic and non-genetic factors are thought to take part in the etiopathogenesis of AD. Epidemiologic researches revealed that genetic factors played a decisive role in the development of both early-onset AD (EOAD) and late-onset AD (LOAD)...
journal_title：Current Alzheimer research
pub_type： 杂志文章,评审
doi：10.2174/15672050113109990155
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:The lack of diagnostic tools and disease-modifying treatments against Alzheimer's disease (AD) and related disorders, collectively known as tauopathies, has led to a socioeconomic burden of epidemic proportion. Proteomics approaches can be used to identify novel proteome changes that could help us understand...
journal_title：Current Alzheimer research
pub_type： 杂志文章
doi：10.2174/1567205015666180813152043
更新日期：2018-01-01 00:00:00
abstract：:Amyloid oligomers have a critical function in the pathologic processes of various amyloidoses, such as Alzheimer's disease (AD), Parkinson disease (PD), Huntington's disease, prion-related diseases, type 2 diabetes, and hereditary renal amyloidosis. Our previous reports demonstrated that a conformation-dependent oligo...
journal_title：Current Alzheimer research
pub_type： 杂志文章
doi：10.2174/15672050113106660176
更新日期：2014-01-01 00:00:00
abstract：:A crucial need exists for reliable Alzheimer's disease (AD) diagnostic and prognostic tests. Given its intimate communication with the brain, the cerebrospinal fluid (CSF) has been surveyed intensively for reliable AD biomarkers. The heterogeneity of AD pathology and the unavoidable difficulties associated with the cl...
journal_title：Current Alzheimer research
pub_type： 杂志文章
doi：10.2174/156720509788929318
更新日期：2009-08-01 00:00:00
abstract：:The Twentieth Century witnessed tremendous advances in our understanding of neurodegenerative diseases. Not least among them were the contributions from hyperendemic foci of neurodegenerative disorders in isolated human groups worldwide, with the knowledge gained applicable to our understanding of related neurodegener...
journal_title：Current Alzheimer research
pub_type： 杂志文章,评审
doi：10.2174/156720506778249425
更新日期：2006-09-01 00:00:00
abstract：OBJECTIVE:Centrifuges are the principal means of generating physiological hypergravity and have been used for many medical purposes, including the therapy of psychiatric diseases and evaluation of vestibular system in the pilots. In particular, modern centrifuges have evolved into mechanically sophisticated precision i...
journal_title：Current Alzheimer research
pub_type： 杂志文章,评审
doi：10.2174/1567205015666171229225501
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:ACTION, a 24-week, prospective, randomized, parallel-group, double-blind study in patients with severe Alzheimer's disease (AD), demonstrated significant efficacy of 13.3 mg/24 h versus 4.6 mg/24 h rivastigmine patch on the Severe Impairment Battery (SIB) and Alzheimer's Disease Cooperative Study-Activities ...
journal_title：Current Alzheimer research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.2174/1567205011666141218122835
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Impairment in instrumental activities of daily living (IADL) starts as individuals with amnestic mild cognitive impairment (MCI) transition to Alzheimer's disease (AD) dementia. However, most IADL scales have not shown IADL alterations in clinically normal (CN) elderly. The objective of this study was to det...
journal_title：Current Alzheimer research
pub_type： 杂志文章
doi：10.2174/1567205011666141001120903
更新日期：2014-01-01 00:00:00
abstract：:Early diagnosis of Alzheimer`s disease (AD) is currently difficult and involves a complex approach including clinical assessment, neuroimaging, and measurement of amyloid-β (Aβ) and tau levels in cerebrospinal fluid (CSF). A better mechanistic understanding is needed to develop more accurate and even presymptomatic di...
journal_title：Current Alzheimer research
pub_type： 杂志文章
doi：10.2174/1567205012666150710115022
更新日期：2015-01-01 00:00:00
abstract：:Soluble amyloid beta (Abeta) oligomers might trigger early cognitive impairment in Alzheimer's Disease (AD) through the impairment of proper neuronal network function. We have recently shown that the short sequence Abeta(25-35) affects the spontaneous activity in hippocampal slices, when was added to the bath, at high...
journal_title：Current Alzheimer research
pub_type： 杂志文章
doi：10.2174/156720510791383859
更新日期：2010-08-01 00:00:00
abstract：:Anesthesia and surgery have been reported to produce long-term cognitive problems, and to accelerate neurodegenerative disorders in the elderly. In previous work, we found that inhaled anesthetics enhance fibril formation and cytotoxicity of amyloid beta peptide. In this work we show that the inhaled anesthetics halot...
journal_title：Current Alzheimer research
pub_type： 杂志文章
doi：10.2174/156720507781077278
更新日期：2007-07-01 00:00:00
abstract：:High levels of cholesterol have been proposed as a risk factor for Alzheimer's disease (AD). Polymorphism of genes encoding proteins that regulate cholesterol metabolism have also been associated with the frequency of Alzheimer's development. Some studies have shown that cholesterol-lowering drugs reduce the frequency...
journal_title：Current Alzheimer research
pub_type： 杂志文章,评审
doi：10.2174/156720510791050821
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVES:Memory evaluation is a key component in the accurate diagnosis of cognitive disorders.One memory procedure that has shown promise in discriminating disease-related cognitive decline from normal cognitive aging is the New York University Paragraph Recall Test; however, the effects of education have been unexa...
journal_title：Current Alzheimer research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.2174/15672050113109990140
更新日期：2013-09-01 00:00:00
abstract：:Mutations in the presenilin genes cause the majority of early-onset familial Alzheimer’s disease. Recently, presenilin mutations have been identified in patients with dilated cardiomyopathy (DCM), a common cause of heart failure and the most prevalent diagnosis in cardiac transplantation patients. However, the molecul...
journal_title：Current Alzheimer research
pub_type： 杂志文章
doi：10.2174/156720511795563746
更新日期：2011-05-01 00:00:00
abstract：:CATIE-AD was a multicenter effectiveness trial of atypical antipsychotics in patients with agitation and psychosis associated with AD who resided in the community. The study enrolled 421 participants. In this paper we present and discuss baseline characteristics of participants (demographics, cognitive, behavioral, an...
journal_title：Current Alzheimer research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.2174/156720507781077214
更新日期：2007-07-01 00:00:00
abstract：BACKGROUND:Previous work designed a network-based protocol of cognitive training. This programme exploits a mechanism of induced task-oriented co-activation of multiple regions that are part of the default mode network (DMN), to induce functional rewiring and increased functional connectivity within this network. OBJE...
journal_title：Current Alzheimer research
pub_type： 杂志文章
doi：10.2174/1567205015666171212103323
更新日期：2018-01-01 00:00:00
