VEGF, a mediator of the effect of experience on hippocampal neurogenesis.

abstract：:According to the current paradigm, the main cause of AD is the accumulation of neurotoxic amyloid beta (Aβ) peptide aggregates resulting from the cleavage of the amyloid precursor protein into peptides of different length, with the 42 amino acid long Aβ42 being the most toxic form. Aβ can aggregate and form plaques in...

journal_title：Current Alzheimer research

authors： Goldeck D,Witkowski JM,Fülop T,Pawelec G

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by extracellular amyloid plaque and neurofibrillary tangles in the brain. Studies have shown that neurons are able to re-enter the cell cycle, but not enough to enable full replication. This leads to cell death and consequent neurodegener...

journal_title：Current Alzheimer research

authors： Fukasawa JT,de Labio RW,Rasmussen LT,de Oliveira LC,Chen E,Villares J,Tureck G,de Arruda C Smith M,Payao SLM

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a neurodegenerative disease characterised by a progressive decline in cognitive function and represents a major healthcare challenge worldwide. Increasing evidence indicates that mitochondrial dysfunction mediated oxidative stress plays a significant role in the pathophysiological...

journal_title：Current Alzheimer research

authors： Chhetri J,King AE,Gueven N

更新日期：2018-01-01 00:00:00

abstract：:The aggregation of the microtubule-associated protein tau into paired-helical filaments is the defining characteristic of the tauopathies. It has become apparent that the hyperphosphorylation of tau likely plays a role in the aggregation process and thus strategies to reduce tau phosphorylation are generating wide int...

journal_title：Current Alzheimer research

authors： Yuzwa SA,Vocadlo DJ

更新日期：2009-10-01 00:00:00

abstract：:The currently available experimental data supports the hypothesis that the neuroprotective effect of dimebon is related to the protection of the brain-mitochondria from neurodegeneration. In this study, the influence of dimebon on mitochondria was investigated to gain a better understanding of the neuroprotective effe...

journal_title：Current Alzheimer research

authors： Shevtsova EF,Vinogradova DV,Kireeva EG,Reddy VP,Aliev G,Bachurin SO

更新日期：2014-01-01 00:00:00

abstract：:Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the most common types of dementia in the presenile population. Episodic memory impairment, the clinical hallmark of AD, can also be encountered in patients with FTD, complicating accurate diagnosis. Several studies in FTD have correlated memory deficits wi...

journal_title：Current Alzheimer research

authors： Papma JM,Seelaar H,de Koning I,Hasan D,Reijs A,Valkema R,Prins ND,van Swieten JC

更新日期：2013-03-01 00:00:00

abstract：:Gamma-secretase is a multi-protein complex that proteolyzes the transmembrane region of the amyloid beta-peptide (Abeta) precursor (APP), producing the Abeta peptide implicated in the pathogenesis of Alzheimer's disease (AD). This protease has been a top target for AD, and various inhibitors have been identified, incl...

journal_title：Current Alzheimer research

authors： Wolfe MS

更新日期：2008-04-01 00:00:00

abstract：:The marginal division (MrD) is a neostriatum subregion that links the limbic system and basal nucleus of Meynert; it is an important subcortical center that is involved in learning and memory. Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia in the elderly. AD clinically m...

journal_title：Current Alzheimer research

authors： Zhang Z,Liu Y,Zhou B,Zheng J,Yao H,An N,Wang P,Guo Y,Dai H,Wang L,Shu S,Zhang X,Jiang T

更新日期：2014-02-01 00:00:00

abstract：:Apoptosis has been postulated to play a possible causal role in the onset of Alzheimer's disease due to shortage of trophic supply, deafferentation and excessive production of free radicals. Many experiments in the past have demonstrated the requirement of de novo gene expression during neuronal apoptosis. In view of ...

journal_title：Current Alzheimer research

authors： Cavallaro S,Calissano P

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:The longitudinal change of neuropsychological tests (NPTs) in treated Alzheimer's disease (AD) is essential to understand the interplay of a therapeutic response from medication and a disease decline due to degenerative processes. The aim of our study is to investigate the annual cognitive progression as mea...

journal_title：Current Alzheimer research

authors： Yang YH,Wu MN,Chou PS,Su HC,Lin SH,Sung PS

更新日期：2018-03-14 00:00:00

abstract：:Recent studies of Alzheimer's disease (AD) and other neuropsychiatric drug developments raise questions whether failures of some drugs occur due to flaws in methods. In three case studies of recent AD drug development failures with phenserine, metrifonate, and tarenflurbil we identified methodological lapses able to a...

journal_title：Current Alzheimer research

authors： Becker RE,Greig NH

更新日期：2010-11-01 00:00:00

abstract：:The definite diagnosis of Alzheimer's disease (AD) is based on the detection of beta amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) - which are the pathological hallmarks of the disease- in the postmortem brains. Although regional Cerebral Blood Flow (rCBF) and Cerebral Glucose Metabolism (CGM) abnormalities ...

journal_title：Current Alzheimer research

authors： Valotassiou V,Archimandritis S,Sifakis N,Papatriantafyllou J,Georgoulias P

更新日期：2010-09-01 00:00:00

abstract：:Amyloid-β protein (Aβ) accumulates in the neurons of Alzheimer's disease (AD) patients at an early stage of the disease. Recently, we found that Aβ with a toxic turn at positions 22 and 23 accumulates in neurons in AD brain. Here, we studied the accumulation of Aβ, toxic turn Aβ and high-molecular-weight Aβ oligomers ...

journal_title：Current Alzheimer research

authors： Soejima N,Ohyagi Y,Nakamura N,Himeno E,Iinuma KM,Sakae N,Yamasaki R,Tabira T,Murakami K,Irie K,Kinoshita N,LaFerla FM,Kiyohara Y,Iwaki T,Kira J

更新日期：2013-01-01 00:00:00

abstract：:Pathological remodelling of astroglia represents an important component of the pathogenesis of Alzheimer's disease (AD). In AD astrocytes undergo both atrophy and reactivity; which may be specific for different stages of the disease evolution. Astroglial reactivity represents the generic defensive mechanism, and inhib...

journal_title：Current Alzheimer research

authors： Lim D,Rodríguez-Arellano JJ,Parpura V,Zorec R,Zeidán-Chuliá F,Genazzani AA,Verkhratsky A

更新日期：2016-01-01 00:00:00

abstract：:Mitochondrial dysfunction has been implicated in causing metabolic abnormalities in Alzheimer's disease (AD). The searches for mitochondrial DNA variants associated with AD susceptibility have generated conflicting results. The age-related accumulation of somatic mitochondrial DNA deletion has been suggested to play a...

journal_title：Current Alzheimer research

authors： Chen X,Stern D,Yan SD

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by a multi-factorial etiology that is not completely understood. Donepezil is a first-line acetylcholinesterase inhibitor used for the treatment of AD that has been found, in addition to its potent acetylcholinesterase inhibitory ...

journal_title：Current Alzheimer research

authors： Wan L,Lu J,Fu J,Huang J,Yang Q,Xin B,Chen L,Huo Y,Zhong Y,Guo C

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Alzheimer's Dementia (AD) has a complex pathophysiology that is incompletely understood. Chronic, low-level environmental lead (Pb) exposure is associated with cognitive impairment, hypertension and mortality, and has been proposed as a potential cause of AD. OBJECTIVE:We aimed to review the literature to c...

journal_title：Current Alzheimer research

authors： Brown EE,Shah P,Pollock BG,Gerretsen P,Graff-Guerrero A

更新日期：2019-01-01 00:00:00

abstract：:Evidence from basic molecular biology has noted a critical role of GSK-3 in Alzheimer's disease (AD) pathogenesis such as beta-amyloid (Aβ) production and accumulation, the formation of neurofibrillary tangle (NFT), and neuronal degeneration. Aβ generation and deposition represents a key feature and is generated from ...

journal_title：Current Alzheimer research

authors： Cai Z,Zhao Y,Zhao B

更新日期：2012-09-01 00:00:00

abstract：:Deterioration of the cortical cholinergic system is a leading neurochemical feature of Alzheimer's Disease (AD). This review summarizes evidence that the homomeric α7- nicotinic acetylcholine receptor (nAChR) plays a crucial role in the pathogenesis of this disease, which is characterized by amyloid-β (Aβ) accumulatio...

journal_title：Current Alzheimer research

authors： Oz M,Lorke DE,Yang KH,Petroianu G

更新日期：2013-07-01 00:00:00

abstract：:Protein folding, protein degradation, and protein stability are regulated by the molecular chaperones. Under pathogenic conditions, aberrant proteins can be dysfunctional, unregulated, or pathogenically mutated. These aberrant proteins are triaged by the chaperone network for the maintenance of cellular homeostasis. T...

journal_title：Current Alzheimer research

authors： Carman A,Kishinevsky S,Koren J 3rd,Luo W,Chiosis G

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:It is well known that alterations in astrocytes occur in Alzheimer's disease and reactive astrogliosis is one of the hallmarks of the disease. Recently, data has emerged that suggests that alterations in astrocytes may also occur early in the pathogenesis of the disease. OBJECTIVE:The aim of present work wa...

journal_title：Current Alzheimer research

authors： Ruffinatti F,Tapella L,Gregnanin I,Stevano A,Chiorino G,Canonico PL,Distasi C,Genazzani AA,Lim D

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The Alzheimer's Disease Assessment Scale - cognitive subscale (ADAS-cog) is the most widely used cognitive outcome measure in AD trials. Although errors in administration and scoring have been suggested as factors masking accurate estimates and potential effects of treatments, there have been few formal exam...

journal_title：Current Alzheimer research

authors： Schafer K,De Santi S,Schneider LS

更新日期：2011-06-01 00:00:00

abstract：:Recent studies have shown that the translocase of outer mitochondrial membrane 40 homolog (TOMM40) contains a polymorphic poly-T variant, the long variant of which is associated with an increase in AD incidence among APOE 3 carriers. Current methods to isotype the poly-T region rely on long PCR, subcloning and sequenc...

journal_title：Current Alzheimer research

authors： Greco SJ,Hamzelou A,Johnston JM,Richardson S,Smith MA,Perry G,Ashford JW,Tezapsidis N

更新日期：2012-12-01 00:00:00

abstract：:Alzheimer's disease is a neurodegenerative disorder characterized by amyloid deposits and neurofibrillary tangles. Cholinergic dysfunction is also a main pathological feature of the disease. Nevertheless, the links between cholinergic dysfunction and neuropathological hallmarks of Alzheimer's are still unknown. In the...

journal_title：Current Alzheimer research

authors： Belarbi K,Schindowski K,Burnouf S,Caillierez R,Grosjean ME,Demeyer D,Hamdane M,Sergeant N,Blum D,Buée L

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a neurodegenerative disease featured by memory loss, neuroinflammation and oxidative stress. Overproduction or insufficient clearance of Aβ leads to its pathological aggregation and deposition, which is considered the predominant neuropathological hallmark of AD. Therefore, reduci...

journal_title：Current Alzheimer research

authors： Liu SY,Lu S,Yu XL,Yang SG,Liu W,Liu XM,Wang SW,Zhu J,Ji M,Liu DQ,Zhang ZP,Liu RT

更新日期：2018-01-01 00:00:00

abstract：:Parkinson disease (PD) is the second most prevalent neurodegenerative disorder after Alzheimer's disease (AD). The formation of the cytoplasmic inclusions named "Lewy bodies" in the brain, considered to be a marker for neuronal degeneration in PD and dementia with Lewy bodies. However, Lewy bodies (LBs) are also obser...

journal_title：Current Alzheimer research

authors： Al-Mansoori KM,Hasan MY,Al-Hayani A,El-Agnaf OM

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Curcumin has been of interest in the field of Alzheimer's disease. Early studies on transgenic mice showed promising results in the reduction of amyloid plaques.However, curcumin is very poorly soluble in aqueous solutions and not easily accessible to coupling as it contains only phenolic groups as potential...

journal_title：Current Alzheimer research

authors： Sturzu A,Sheikh S,Kalbacher H,Nägele T,Weidenmaier C,Wegenast-Braun BM,Schilling N,Ernemann U,Heckl S

更新日期：2019-01-01 00:00:00

abstract：:Soluble amyloid beta (Abeta) oligomers might trigger early cognitive impairment in Alzheimer's Disease (AD) through the impairment of proper neuronal network function. We have recently shown that the short sequence Abeta(25-35) affects the spontaneous activity in hippocampal slices, when was added to the bath, at high...

journal_title：Current Alzheimer research

authors： Balleza-Tapia H,Huanosta-Gutiérrez A,Márquez-Ramos A,Arias N,Peña F

更新日期：2010-08-01 00:00:00

abstract：:Amyloid beta peptide (Abeta), 42-residue peptide and its variations, is known to form amyloid fibrils in Alzheimer's disease. Solid-state NMR study reveals a parallel beta-sheet structure in the Abeta fibrils. The atomic level structure of Abeta in aqueous environment, however, has not been determined, because of its ...

journal_title：Current Alzheimer research

authors： Takano K

更新日期：2008-12-01 00:00:00

abstract：:The occurrence of a plaque-dependent inflammation in Alzheimer's disease has been extensively documented in both human specimens and transgenic models of the disease. Since insoluble plaques are present in AD patients from early preclinical stages of the pathology, the point at which neuroinflammation first occurs in ...

journal_title：Current Alzheimer research

authors： Ferretti MT,Cuello AC

更新日期：2011-03-01 00:00:00