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Everyday cognition scale items that best discriminate between and predict progression from clinically normal to mild cognitive impairment.

Abstract：

BACKGROUND:Impairment in instrumental activities of daily living (IADL) starts as individuals with amnestic mild cognitive impairment (MCI) transition to Alzheimer's disease (AD) dementia. However, most IADL scales have not shown IADL alterations in clinically normal (CN) elderly. The objective of this study was to determine which of the IADL-related Everyday Cognition (ECog) scale items are most sensitive for detection of early functional changes. METHODS:We assessed 290 CN and 495 MCI participants from the Alzheimer's Disease Neuroimaging Initiative. We performed logistic regression analyses predicting the probability of CN vs. MCI diagnosis using only the 17 participant-based and 17 informant-based ECog items related to IADL. We then performed Cox regression analyses to predict progression from CN to MCI. All analyses were adjusted for demographic characteristics. RESULTS:We found that worse performance on "remembering a few shopping items" (participant and informant-based p<0.0001), "remembering appointments" (participant and informant-based p<0.0001), "developing a schedule in advance of anticipated events" (participant-based p=0.007), "balancing checkbook" (participant-based p=0.02), and "keeping mail and papers organized" (informant-based p=0.002) best discriminated MCI from CN. We found that worse performance on "keeping mail and papers organized" (participant-based Hazard Ratio (HR)=2.27, p=0.07) marginally predicted greater hazard of progressing from CN to MCI. CONCLUSIONS:Our results indicate that a few simple questions targeting early functional changes, addressed either to the individual or informant, can effectively distinguish between CN elderly and individuals with MCI. Additionally, one of the above questions related to organization suggested which CN individuals are likely to progress to MCI.

journal_name

Curr Alzheimer Res

journal_title

Current Alzheimer research

authors

Marshall GA,Zoller AS,Kelly KE,Amariglio RE,Locascio JJ,Johnson KA,Sperling RA,Rentz DM,For The Alzheimer's Disease Neuroimaging Initiative

doi

10.2174/1567205011666141001120903

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

853-61

issue

eissn

1567-2050

issn

1875-5828

pii

CAR-EPUB-62631

journal_volume

pub_type

杂志文章

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Everyday cognition scale items that best discriminate between and predict progression from clinically normal to mild cognitive impairment.