Abstract:
:Altered progranulin levels play a major role in neurodegenerative diseases, like Alzheimer's dementia (AD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), even in the absence of GRN mutations. Increasing progranulin levels could hereby provide a novel treatment strategy. However, knowledge on progranulin regulation in neurodegenerative diseases remains limited. We here demonstrate that cerebrospinal fluid progranulin levels do not correlate with its serum levels in AD, FTD and ALS, indicating a differential regulation of its central and peripheral levels in neurodegeneration. Blood progranulin levels thus do not reliably predict central nervous progranulin levels and their response to future progranulin-increasing therapeutics.
journal_name
Curr Alzheimer Resjournal_title
Current Alzheimer researchauthors
Wilke C,Gillardon F,Deuschle C,Dubois E,Hobert MA,Müller vom Hagen J,Krüger S,Biskup S,Blauwendraat C,Hruscha M,Kaeser SA,Heutink P,Maetzler W,Synofzik Mdoi
10.2174/1567205013666160314151247subject
Has Abstractpub_date
2016-01-01 00:00:00pages
654-62issue
6eissn
1567-2050issn
1875-5828pii
CAR-EPUB-74362journal_volume
13pub_type
杂志文章abstract::Identification of genes and pathways that alter lifespan has allowed for new insights into factors that control the aging process as well as disease. While strong molecular links exist between aging and metabolism, we hypothesize that targeting the mechanisms involved in aging will also give rise to therapeutics that ...
journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Current Alzheimer research
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journal_title:Current Alzheimer research
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journal_title:Current Alzheimer research
pub_type: 历史文章,杂志文章,评审
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pub_type: 杂志文章,收录出版
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2014-01-01 00:00:00
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journal_title:Current Alzheimer research
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更新日期:2011-06-01 00:00:00
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