Amyloid-β in the Cerebrospinal Fluid of APP Transgenic Mice Does not Show Prion-like Properties.

abstract：:Protein folding, protein degradation, and protein stability are regulated by the molecular chaperones. Under pathogenic conditions, aberrant proteins can be dysfunctional, unregulated, or pathogenically mutated. These aberrant proteins are triaged by the chaperone network for the maintenance of cellular homeostasis. T...

journal_title：Current Alzheimer research

authors： Carman A,Kishinevsky S,Koren J 3rd,Luo W,Chiosis G

更新日期：2014-01-01 00:00:00

abstract：:Amyloid beta (Aβ) binding alcohol dehydrogenase (ABAD) is a cellular cofactor for promoting (Aβ)-mediated mitochondrial and neuronal dysfunction, and cognitive decline in transgenic Alzheimer's disease (AD) mouse models. Targeting mitochondrial ABAD may represent a novel therapeutic strategy against AD. Here, we repor...

journal_title：Current Alzheimer research

authors： Valaasani KR,Sun Q,Hu G,Li J,Du F,Guo Y,Carlson EA,Gan X,Yan SS

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the diagnostic accuracy and clinical usability of a Dutch translation of the Test Your Memory (TYM) test in patients with mild cognitive impairment (MCI) and dementia as compared to the Mini-Mental State Examination (MMSE), in the setting of the memory clinic of a general...

journal_title：Current Alzheimer research

authors： van de Zande E,van de Nes JC,Jansen I,van den Berg MN,Zwart AF,Bimmel D,Rijkers GT,Andringa G

更新日期：2017-01-01 00:00:00

abstract：:Recent studies have shown that the translocase of outer mitochondrial membrane 40 homolog (TOMM40) contains a polymorphic poly-T variant, the long variant of which is associated with an increase in AD incidence among APOE 3 carriers. Current methods to isotype the poly-T region rely on long PCR, subcloning and sequenc...

journal_title：Current Alzheimer research

authors： Greco SJ,Hamzelou A,Johnston JM,Richardson S,Smith MA,Perry G,Ashford JW,Tezapsidis N

更新日期：2012-12-01 00:00:00

abstract：:Cholesterol-induced production of amyloid beta (Abeta) as a putative neurotoxin in Alzheimer's disease (AD), along with epidemiological evidence, suggests that statin drugs may provide benefit in treatment of the disorder. We tested the effect of once daily atorvastatin calcium (80 mg; two 40 mg tablets) on cognitive ...

journal_title：Current Alzheimer research

authors： Sparks DL,Sabbagh MN,Connor DJ,Lopez J,Launer LJ,Petanceska S,Browne P,Wassar D,Johnson-Traver S,Lochhead J,Ziolkowski C

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:The USA National Task Group (NTG) guidelines advocate the use of an adapted version of Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID) for dementia screening of individuals with Down syndrome (DS) and with other forms of ID (non-DS). OBJECTIVE:In order to meet these ...

journal_title：Current Alzheimer research

authors： Gomiero T,Bertelli M,Deb S,Weger E,Marangoni A,De Bastiani E,Mantesso U,De Vreese LP

更新日期：2017-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is one of the most common causes of dementia. Despite several decades of research in AD, there is no standard disease- modifying therapy available and currentlyapproved drugs provide only symptomatic relief. Stem cells hold immense potential to regenerate damaged tissues and are currently test...

journal_title：Current Alzheimer research

authors： Bali P,Lahiri DK,Banik A,Nehru B,Anand A

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The Alzheimer's Disease Assessment Scale - cognitive subscale (ADAS-cog) is the most widely used cognitive outcome measure in AD trials. Although errors in administration and scoring have been suggested as factors masking accurate estimates and potential effects of treatments, there have been few formal exam...

journal_title：Current Alzheimer research

authors： Schafer K,De Santi S,Schneider LS

更新日期：2011-06-01 00:00:00

abstract：:In this review, the basic mechanism of the parasympathetic nervous effect on the heart is discussed. This is expanded to clinical situations to clarify what can happen to patients after cholinesterase (ChE) inhibitor is administered and to avoid unnecessary adverse effects. The parasympathetic nervous system can affec...

journal_title：Current Alzheimer research

authors： Masuda Y

更新日期：2004-11-01 00:00:00

abstract：:Amyloid-β protein (Aβ) accumulates in the neurons of Alzheimer's disease (AD) patients at an early stage of the disease. Recently, we found that Aβ with a toxic turn at positions 22 and 23 accumulates in neurons in AD brain. Here, we studied the accumulation of Aβ, toxic turn Aβ and high-molecular-weight Aβ oligomers ...

journal_title：Current Alzheimer research

authors： Soejima N,Ohyagi Y,Nakamura N,Himeno E,Iinuma KM,Sakae N,Yamasaki R,Tabira T,Murakami K,Irie K,Kinoshita N,LaFerla FM,Kiyohara Y,Iwaki T,Kira J

更新日期：2013-01-01 00:00:00

abstract：:Based on the amyloid hypothesis, studies for AD therapy have been mostly focused on removing β-amyloid. Recent results of amyloid immunotherapy raised the question whether β-amyloid is sufficient target for AD therapy. Neurofibrillary tangles (NFTs), which contain hyperphosphorylated tau, are another pathological hall...

journal_title：Current Alzheimer research

authors： Takashima A

更新日期：2010-12-01 00:00:00

abstract：:CATIE-AD was a multicenter effectiveness trial of atypical antipsychotics in patients with agitation and psychosis associated with AD who resided in the community. The study enrolled 421 participants. In this paper we present and discuss baseline characteristics of participants (demographics, cognitive, behavioral, an...

journal_title：Current Alzheimer research

authors： Ismail MS,Dagerman K,Tariot PN,Abbott S,Kavanagh S,Schneider LS

更新日期：2007-07-01 00:00:00

abstract：:Anesthesia and surgery have been reported to produce long-term cognitive problems, and to accelerate neurodegenerative disorders in the elderly. In previous work, we found that inhaled anesthetics enhance fibril formation and cytotoxicity of amyloid beta peptide. In this work we show that the inhaled anesthetics halot...

journal_title：Current Alzheimer research

authors： Carnini A,Lear JD,Eckenhoff RG

更新日期：2007-07-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the fourth leading cause of death in the United States and most common cause of adult-onset dementia. The major hallmarks of AD are the formation of senile amyloid plaques made of beta amyloid and neurofibrillary tangles (NFT) which are primarily...

journal_title：Current Alzheimer research

authors： Sarkar S,Raymick J,Ray B,Lahiri DK,Paule MG,Schmued L

更新日期：2015-01-01 00:00:00

abstract：:As the average ages of North Americans and Europeans continue to rise; similarly the incidence of "old age" associated illnesses likewise increases. Most notably among these ailments are conditions linked to dementia-related neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD) and st...

journal_title：Current Alzheimer research

authors： Tweedie D,Sambamurti K,Greig NH

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a neurodegenerative disease characterised by a progressive decline in cognitive function and represents a major healthcare challenge worldwide. Increasing evidence indicates that mitochondrial dysfunction mediated oxidative stress plays a significant role in the pathophysiological...

journal_title：Current Alzheimer research

authors： Chhetri J,King AE,Gueven N

更新日期：2018-01-01 00:00:00

abstract：:Rigorous scientific research has identified multiple interactive mechanisms that parallel and are likely causative of the development of Alzheimer's disease (AD). Causative mechanisms include genomics, the creation of amyloid beta (Abeta), factors inhibiting the Abeta removal process, the transformation of Abeta to it...

journal_title：Current Alzheimer research

authors： Standridge JB

更新日期：2006-04-01 00:00:00

abstract：:High levels of cholesterol have been proposed as a risk factor for Alzheimer's disease (AD). Polymorphism of genes encoding proteins that regulate cholesterol metabolism have also been associated with the frequency of Alzheimer's development. Some studies have shown that cholesterol-lowering drugs reduce the frequency...

journal_title：Current Alzheimer research

authors： Vestergaard M,Hamada T,Morita M,Takagi M

更新日期：2010-05-01 00:00:00

abstract：:Neurodegenerative diseases may directly affect memory performance, thus leading to functional impairments. An increasing body of evidence suggests an association between dietary intake of omega-3 fatty acids and memory functioning in animal models as well as in human studies. Recent evidence supports a potential benef...

journal_title：Current Alzheimer research

authors： Knöchel C,Voss M,Gruter F,Alves GS,Matura S,Sepanski B,Stablein M,Kraft D,Prvulovic D,Carvalho AF,Reif A,Oertel-Knochel V

更新日期：2017-01-01 00:00:00

abstract：:The first reports of disorders that in terms of cognitive and behavioral symptoms resemble frontotemporal dementia (FTD) and in terms of motor symptoms resemble amyotrophic lateral sclerosis (ALS) bring us back to the second half of the 1800s. Over the last 150 years, and especially in the last two decades, there has ...

journal_title：Current Alzheimer research

authors： Ferrari R,Kapogiannis D,Huey ED,Momeni P

更新日期：2011-05-01 00:00:00

abstract：:The currently available experimental data supports the hypothesis that the neuroprotective effect of dimebon is related to the protection of the brain-mitochondria from neurodegeneration. In this study, the influence of dimebon on mitochondria was investigated to gain a better understanding of the neuroprotective effe...

journal_title：Current Alzheimer research

authors： Shevtsova EF,Vinogradova DV,Kireeva EG,Reddy VP,Aliev G,Bachurin SO

更新日期：2014-01-01 00:00:00

abstract：:Recent studies of Alzheimer's disease (AD) and other neuropsychiatric drug developments raise questions whether failures of some drugs occur due to flaws in methods. In three case studies of recent AD drug development failures with phenserine, metrifonate, and tarenflurbil we identified methodological lapses able to a...

journal_title：Current Alzheimer research

authors： Becker RE,Greig NH

更新日期：2010-11-01 00:00:00

abstract：:Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the most common types of dementia in the presenile population. Episodic memory impairment, the clinical hallmark of AD, can also be encountered in patients with FTD, complicating accurate diagnosis. Several studies in FTD have correlated memory deficits wi...

journal_title：Current Alzheimer research

authors： Papma JM,Seelaar H,de Koning I,Hasan D,Reijs A,Valkema R,Prins ND,van Swieten JC

更新日期：2013-03-01 00:00:00

abstract：:The aetiology of major neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) is still unknown, but increasing evidences suggest that glutamate and mitochondria are two prominent players in the oxidative stress (OS) process that underlie these illnesses. Although AD and PD have distin...

journal_title：Current Alzheimer research

authors： Cassano T,Pace L,Bedse G,Lavecchia AM,De Marco F,Gaetani S,Serviddio G

更新日期：2016-01-01 00:00:00

abstract：:The increasing prevalence of obesity world-wide has an expected consequent increase in diabetes and cardiovascular disease. Less attention has been paid to the effect of obesity on dementia. This overview discusses methodological issues related to the epidemiologic study of obesity and dementia, reviews results of lon...

journal_title：Current Alzheimer research

authors： Barrett-Connor E

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:To carry out meaningful comparisons on results of different research studies on mild cognitive impairment (MCI), it is critical to select an appropriate objective memory test to examine memory deficit. We aim to refine the operational criteria of amnestic MCI (aMCI) on neuropsychological tests that optimally ...

journal_title：Current Alzheimer research

authors： Zhao Q,Guo Q,Liang X,Chen M,Zhou Y,Ding D,Hong Z

更新日期：2015-01-01 00:00:00

abstract：:Altered progranulin levels play a major role in neurodegenerative diseases, like Alzheimer's dementia (AD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), even in the absence of GRN mutations. Increasing progranulin levels could hereby provide a novel treatment strategy. However, knowledge on p...

journal_title：Current Alzheimer research

authors： Wilke C,Gillardon F,Deuschle C,Dubois E,Hobert MA,Müller vom Hagen J,Krüger S,Biskup S,Blauwendraat C,Hruscha M,Kaeser SA,Heutink P,Maetzler W,Synofzik M

更新日期：2016-01-01 00:00:00

abstract：:Mild cognitive impairment (MCI) is a nosological entity associated with a higher risk of developing dementia. Previous evidence indicates that behavioral and psychological symptoms of dementia (BPSDs) frequently occur in individuals of MCI. These neuropsychiatric manifestations may predict conversion to dementia. Howe...

journal_title：Current Alzheimer research

authors： Köhler CA,Magalhaes TF,Oliveira JM,Alves GS,Knochel C,Oertel-Knöchel V,Pantel J,Carvalho AF

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Life expectancy is increasing all over the world, although neurodegenerative disorders might drastically affect the individual activity of aged people. Of those, Alzheimer's Disease (AD) is one of the most social-cost age-linked diseases of industrialized countries. To date, retinal diseases seem to be more ...

journal_title：Current Alzheimer research

authors： Micera A,Bruno L,Cacciamani A,Rongioletti M,Squitti R

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Alzheimer's Dementia (AD) has a complex pathophysiology that is incompletely understood. Chronic, low-level environmental lead (Pb) exposure is associated with cognitive impairment, hypertension and mortality, and has been proposed as a potential cause of AD. OBJECTIVE:We aimed to review the literature to c...

journal_title：Current Alzheimer research

authors： Brown EE,Shah P,Pollock BG,Gerretsen P,Graff-Guerrero A

更新日期：2019-01-01 00:00:00