Glutamate and Mitochondria: Two Prominent Players in the Oxidative Stress-Induced Neurodegeneration.

Abstract:

:The aetiology of major neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) is still unknown, but increasing evidences suggest that glutamate and mitochondria are two prominent players in the oxidative stress (OS) process that underlie these illnesses. Although AD and PD have distinct pathological and clinical features, OS is a common mechanism contributing to neuronal damage. Glutamate is an important neurotransmitter in neurons and glial cells and is strongly dependent on calcium homeostasis and on mitochondrial function. In the present work we focused on glutamate- induced calcium signaling and its relation to the mitochondrial dysfunction with cell death processes. In addition, we have discussed how alterations in this pathway may lead or aggravate the neurodegenerative diseases. Finally, this review aims to stimulate further studies on this issue and thereby engage a new perspective regarding the design of possible therapeutic agents or the identification of biomarkers.

journal_name

Curr Alzheimer Res

authors

Cassano T,Pace L,Bedse G,Lavecchia AM,De Marco F,Gaetani S,Serviddio G

doi

10.2174/1567205013666151218132725

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

185-97

issue

2

eissn

1567-2050

issn

1875-5828

pii

CAR-EPUB-72614

journal_volume

13

pub_type

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