Abstract:
:Anesthesia and surgery have been reported to produce long-term cognitive problems, and to accelerate neurodegenerative disorders in the elderly. In previous work, we found that inhaled anesthetics enhance fibril formation and cytotoxicity of amyloid beta peptide. In this work we show that the inhaled anesthetics halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) and isoflurane (1-chloro-2,2,2-trifluoroethyl difluoromethyl ether) also favor intermediate oligomers of amyloid beta(1-40), and reduce solubility of amyloid beta(1-40) monomer. Size-exclusion chromatography, analytical ultracentrifugation and photo-induced cross-linking experiments indicate halothane enhancement of oligomeric species having molecular weight approximately 44-100 kDa. Bis-ANS fluorescence experiments revealed that halothane stabilizes a population of diffusible oligomers relative to the monomer or the mature fibril. These data show that inhaled anesthetics lower the amyloid beta(1-40) concentration necessary to initiate oligomer formation, probably by preferential binding to intermediate oligomers en route to fibril formation.
journal_name
Curr Alzheimer Resjournal_title
Current Alzheimer researchauthors
Carnini A,Lear JD,Eckenhoff RGdoi
10.2174/156720507781077278subject
Has Abstractpub_date
2007-07-01 00:00:00pages
233-41issue
3eissn
1567-2050issn
1875-5828journal_volume
4pub_type
杂志文章abstract::Alzheimer's disease (AD) is one of the most common causes of dementia. Despite several decades of research in AD, there is no standard disease- modifying therapy available and currentlyapproved drugs provide only symptomatic relief. Stem cells hold immense potential to regenerate damaged tissues and are currently test...
journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
doi:10.2174/1567205013666160314145347
更新日期:2017-01-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章
doi:10.2174/156720512801322654
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journal_title:Current Alzheimer research
pub_type: 杂志文章
doi:10.2174/1567205012666150710111211
更新日期:2015-01-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章
doi:10.2174/1567205014666170713160407
更新日期:2018-01-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章
doi:10.2174/1567205011310030013
更新日期:2013-03-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Current Alzheimer research
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
doi:10.2174/1567205016666191023114015
更新日期:2019-01-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章
doi:10.2174/1567205016666181212155147
更新日期:2019-01-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章
doi:
更新日期:2013-06-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章
doi:10.2174/1567205013666161013091934
更新日期:2017-01-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
doi:10.2174/1567205013666160502123129
更新日期:2016-01-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,收录出版
doi:10.2174/1567205010666131119233044
更新日期:2014-01-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,多中心研究
doi:10.2174/1567205016666190103152425
更新日期:2019-01-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
doi:10.2174/1567205043480528
更新日期:2004-02-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
doi:10.2174/156720512802455386
更新日期:2012-09-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
doi:10.2174/1567205052772786
更新日期:2005-01-01 00:00:00
abstract::Alzheimer's disease (AD) is a progressive degenerative disorder of the brain and is the most common form of dementia. To-date no simple, inexpensive and minimally invasive procedure is available to confirm with certainty the early diagnosis of AD prior to the manifestations of symptoms characteristic of the disease. T...
journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
doi:10.2174/1567205011666140618103827
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The molecular mechanisms underlying Alzheimer's disease (AD) are yet to be fully elucidated. The so-called "amyloid cascade hypothesis" has long been the prevailing paradigm for causation of disease, and is today being revisited in relation to other pathogenic pathways, such as oxidative stress, neuroinflamm...
journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
doi:10.2174/1567205014666170505094549
更新日期:2018-02-22 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
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更新日期:2013-07-01 00:00:00
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journal_title:Current Alzheimer research
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doi:10.2174/1567205011666140130150108
更新日期:2014-02-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
doi:10.2174/156720508783954767
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:To carry out meaningful comparisons on results of different research studies on mild cognitive impairment (MCI), it is critical to select an appropriate objective memory test to examine memory deficit. We aim to refine the operational criteria of amnestic MCI (aMCI) on neuropsychological tests that optimally ...
journal_title:Current Alzheimer research
pub_type: 杂志文章
doi:10.2174/1567205012666150530202729
更新日期:2015-01-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
doi:10.2174/1567205012666150921103304
更新日期:2016-01-01 00:00:00
abstract::Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder among the elderly. Nmethyl- D-aspartate receptor (NMDAR) overactivation has been implicated in early synaptic dysfunction that precedes late neurodegeneration in AD. Moreover, oligomers of amyloid-beta peptide (Aβ) 1-42 are considered t...
journal_title:Current Alzheimer research
pub_type: 杂志文章
doi:10.2174/156720512802455322
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Various methodologies have been employed for the localization of amyloid plaques in numerous studies on Alzheimer's disease. The majority of these stains are thought to label the plaques by virtue of their affinity for aggregated Aβ. However, plaques are known to contain numerous other components, including ...
journal_title:Current Alzheimer research
pub_type: 杂志文章
doi:10.2174/1567205016666190725155038
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The USA National Task Group (NTG) guidelines advocate the use of an adapted version of Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID) for dementia screening of individuals with Down syndrome (DS) and with other forms of ID (non-DS). OBJECTIVE:In order to meet these ...
journal_title:Current Alzheimer research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2174/1567205014666170117094757
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Centrifuges are the principal means of generating physiological hypergravity and have been used for many medical purposes, including the therapy of psychiatric diseases and evaluation of vestibular system in the pilots. In particular, modern centrifuges have evolved into mechanically sophisticated precision i...
journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
doi:10.2174/1567205015666171229225501
更新日期:2018-01-01 00:00:00
abstract::Serum levels of β-amyloid (Aβ) peptides may represent an early biomarker in the diagnosis of Alzheimer's disease (AD). In the present study, we investigated the temporal kinetic changes in the levels of serum Aβ 1-42 and 40 in an amyloid precursor protein (APP)/presenilin (PS)1 double transgenic mouse model of AD. Ser...
journal_title:Current Alzheimer research
pub_type: 杂志文章
doi:10.2174/15672050113106660159
更新日期:2013-11-01 00:00:00