Bone marrow-derived mesenchymal stem cells contribute to the reduction of amyloid-β deposits and the improvement of synaptic transmission in a mouse model of pre-dementia Alzheimer's disease.

abstract：:Protein folding, protein degradation, and protein stability are regulated by the molecular chaperones. Under pathogenic conditions, aberrant proteins can be dysfunctional, unregulated, or pathogenically mutated. These aberrant proteins are triaged by the chaperone network for the maintenance of cellular homeostasis. T...

journal_title：Current Alzheimer research

authors： Carman A,Kishinevsky S,Koren J 3rd,Luo W,Chiosis G

更新日期：2014-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the fourth leading cause of death in the United States and most common cause of adult-onset dementia. The major hallmarks of AD are the formation of senile amyloid plaques made of beta amyloid and neurofibrillary tangles (NFT) which are primarily...

journal_title：Current Alzheimer research

authors： Sarkar S,Raymick J,Ray B,Lahiri DK,Paule MG,Schmued L

更新日期：2015-01-01 00:00:00

abstract：:Alzheimer's disease is a neurodegenerative disorder characterized by amyloid deposits and neurofibrillary tangles. Cholinergic dysfunction is also a main pathological feature of the disease. Nevertheless, the links between cholinergic dysfunction and neuropathological hallmarks of Alzheimer's are still unknown. In the...

journal_title：Current Alzheimer research

authors： Belarbi K,Schindowski K,Burnouf S,Caillierez R,Grosjean ME,Demeyer D,Hamdane M,Sergeant N,Blum D,Buée L

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Recent work on Alzheimer's disease (AD) diagnosis focuses on neuroimaging modalities; however, these methods are expensive, invasive, and not available to all patients. Ocular imaging of biomarkers, such as drusen in the peripheral retina, could provide an alternative method to diagnose AD. OBJECTIVE:This s...

journal_title：Current Alzheimer research

authors： Ukalovic K,Cao S,Lee S,Tang Q,Beg MF,Sarunic MV,Hsiung GR,Mackenzie IR,Hirsch-Reinshagen V,Cui JZ,Matsubara JA

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:It is well known that alterations in astrocytes occur in Alzheimer's disease and reactive astrogliosis is one of the hallmarks of the disease. Recently, data has emerged that suggests that alterations in astrocytes may also occur early in the pathogenesis of the disease. OBJECTIVE:The aim of present work wa...

journal_title：Current Alzheimer research

authors： Ruffinatti F,Tapella L,Gregnanin I,Stevano A,Chiorino G,Canonico PL,Distasi C,Genazzani AA,Lim D

更新日期：2018-01-01 00:00:00

abstract：:Early diagnosis of Alzheimer`s disease (AD) is currently difficult and involves a complex approach including clinical assessment, neuroimaging, and measurement of amyloid-β (Aβ) and tau levels in cerebrospinal fluid (CSF). A better mechanistic understanding is needed to develop more accurate and even presymptomatic di...

journal_title：Current Alzheimer research

authors： Skachokova Z,Sprenger F,Breu K,Abramowski D,Clavaguera F,Hench J,Staufenbiel M,Tolnay M,Winkler DT

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Impairment in instrumental activities of daily living (IADL) emerges in the transition from mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia. Some IADL scales are sensitive to early deficits in MCI, but none have been validated for detecting subtle functional changes in clinically normal ...

journal_title：Current Alzheimer research

authors： Marshall GA,Zoller AS,Lorius N,Amariglio RE,Locascio JJ,Johnson KA,Sperling RA,Rentz DM

更新日期：2015-01-01 00:00:00

abstract：:The increasing prevalence of obesity world-wide has an expected consequent increase in diabetes and cardiovascular disease. Less attention has been paid to the effect of obesity on dementia. This overview discusses methodological issues related to the epidemiologic study of obesity and dementia, reviews results of lon...

journal_title：Current Alzheimer research

authors： Barrett-Connor E

更新日期：2007-04-01 00:00:00

abstract：:Mild cognitive impairment (MCI) is a nosological entity associated with a higher risk of developing dementia. Previous evidence indicates that behavioral and psychological symptoms of dementia (BPSDs) frequently occur in individuals of MCI. These neuropsychiatric manifestations may predict conversion to dementia. Howe...

journal_title：Current Alzheimer research

authors： Köhler CA,Magalhaes TF,Oliveira JM,Alves GS,Knochel C,Oertel-Knöchel V,Pantel J,Carvalho AF

更新日期：2016-01-01 00:00:00

abstract：:The serine hydrolase butyrylcholinesterase (BChE), like the related enzyme acetylcholinesterase (AChE), co-regulates metabolism of the neurotransmitter acetylcholine. In the human brain BChE is mainly expressed in white matter and glia and in distinct populations of neurons in regions that are important in cognition a...

journal_title：Current Alzheimer research

authors： Darvesh S

更新日期：2016-01-01 00:00:00

abstract：:High levels of cholesterol have been proposed as a risk factor for Alzheimer's disease (AD). Polymorphism of genes encoding proteins that regulate cholesterol metabolism have also been associated with the frequency of Alzheimer's development. Some studies have shown that cholesterol-lowering drugs reduce the frequency...

journal_title：Current Alzheimer research

authors： Vestergaard M,Hamada T,Morita M,Takagi M

更新日期：2010-05-01 00:00:00

abstract：:The definite diagnosis of Alzheimer's disease (AD) is based on the detection of beta amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) - which are the pathological hallmarks of the disease- in the postmortem brains. Although regional Cerebral Blood Flow (rCBF) and Cerebral Glucose Metabolism (CGM) abnormalities ...

journal_title：Current Alzheimer research

authors： Valotassiou V,Archimandritis S,Sifakis N,Papatriantafyllou J,Georgoulias P

更新日期：2010-09-01 00:00:00

abstract：:Evidence from basic molecular biology has noted a critical role of GSK-3 in Alzheimer's disease (AD) pathogenesis such as beta-amyloid (Aβ) production and accumulation, the formation of neurofibrillary tangle (NFT), and neuronal degeneration. Aβ generation and deposition represents a key feature and is generated from ...

journal_title：Current Alzheimer research

authors： Cai Z,Zhao Y,Zhao B

更新日期：2012-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. A characteristic of AD is the accumulation of plaques in the brain of AD patients, and theses plaques mainly consist of aggregates of amyloid beta-peptide (Abeta). All converging lines of evidence sugg...

journal_title：Current Alzheimer research

authors： Cerpa W,Dinamarca MC,Inestrosa NC

更新日期：2008-06-01 00:00:00

abstract：:Amyloid beta (Aβ) binding alcohol dehydrogenase (ABAD) is a cellular cofactor for promoting (Aβ)-mediated mitochondrial and neuronal dysfunction, and cognitive decline in transgenic Alzheimer's disease (AD) mouse models. Targeting mitochondrial ABAD may represent a novel therapeutic strategy against AD. Here, we repor...

journal_title：Current Alzheimer research

authors： Valaasani KR,Sun Q,Hu G,Li J,Du F,Guo Y,Carlson EA,Gan X,Yan SS

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Determining the underlying etiology of dementia can be challenging. Computer- based Clinical Decision Support Systems (CDSS) have the potential to provide an objective comparison of data and assist clinicians. OBJECTIVES:To assess the diagnostic impact of a CDSS, the PredictND tool, for differential diagnos...

journal_title：Current Alzheimer research

authors： Bruun M,Frederiksen KS,Rhodius-Meester HFM,Baroni M,Gjerum L,Koikkalainen J,Urhemaa T,Tolonen A,van Gils M,Tong T,Guerrero R,Rueckert D,Dyremose N,Andersen BB,Simonsen AH,Lemstra A,Hallikainen M,Kurl S,Herukka SK,Re

更新日期：2019-01-01 00:00:00

abstract：:This article presents a new paradigm of Artificial Neural Networks (ANNs): the Auto-Contractive Maps (Auto-CM). The Auto-CM differ from the traditional ANNs under many viewpoints: the Auto-CM start their learning task without a random initialization of their weights, they meet their convergence criterion when all thei...

journal_title：Current Alzheimer research

authors： Buscema M,Grossi E,Snowdon D,Antuono P

更新日期：2008-10-01 00:00:00

abstract：:With a longer life expectancy and an increased prevalence of neurodegenerative diseases, investigations on trajectories of cognitive aging have become exciting and promising. This study aimed to estimate the patterns of age-related cognitive decline and the potential associated factors of cognitive function in communi...

journal_title：Current Alzheimer research

authors： Li H,Lv C,Zhang T,Chen K,Chen C,Gai G,Hu L,Wang Y,Zhang Z

更新日期：2014-01-01 00:00:00

abstract：:In the present study we set up a model of slow progression of neuronal injury by exposing organotypic hippocampal cultures to a low concentration of Amyloid β (25-35) peptide (Aβ, 2 μM) to analyze the time-related effects of 17-β estradiol (17β-E2, 10 nM). Neuronal death occurs after 7 d and is prevented by addition o...

journal_title：Current Alzheimer research

authors： Merlo S,Spampinato SF,Capani F,Sortino MA

更新日期：2016-01-01 00:00:00

abstract：:Gamma-secretase is a multi-protein complex that proteolyzes the transmembrane region of the amyloid beta-peptide (Abeta) precursor (APP), producing the Abeta peptide implicated in the pathogenesis of Alzheimer's disease (AD). This protease has been a top target for AD, and various inhibitors have been identified, incl...

journal_title：Current Alzheimer research

authors： Wolfe MS

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by a multi-factorial etiology that is not completely understood. Donepezil is a first-line acetylcholinesterase inhibitor used for the treatment of AD that has been found, in addition to its potent acetylcholinesterase inhibitory ...

journal_title：Current Alzheimer research

authors： Wan L,Lu J,Fu J,Huang J,Yang Q,Xin B,Chen L,Huo Y,Zhong Y,Guo C

更新日期：2018-01-01 00:00:00

abstract：:Neurodegenerative diseases may directly affect memory performance, thus leading to functional impairments. An increasing body of evidence suggests an association between dietary intake of omega-3 fatty acids and memory functioning in animal models as well as in human studies. Recent evidence supports a potential benef...

journal_title：Current Alzheimer research

authors： Knöchel C,Voss M,Gruter F,Alves GS,Matura S,Sepanski B,Stablein M,Kraft D,Prvulovic D,Carvalho AF,Reif A,Oertel-Knochel V

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES:REM sleep behavior disorder (RBD), with its main clinical symptoms of nightmares with dream-enacting behavior, is considered as a possible precursor of neurodegenerative disease. Obstructive Sleep Apnea Syndrome (OSAS) is known to be capable of provoking RBD-like symptoms by apneic event related arousals. Th...

journal_title：Current Alzheimer research

authors： Schaefer C,Kunz D,Bes F

更新日期：2017-01-01 00:00:00

abstract：:To search for potential mechanism that might alter synaptic transmission following Abeta increase we have examined the presynaptic component of transmitter release. As parameters of synaptic transmission that might underlie presynaptic mechanisms, we have used paired-pulse facilitation (PPF), post-tetanic potentiation...

journal_title：Current Alzheimer research

authors： Zhang H,Gong B,Liu S,Fa' M,Ninan I,Staniszewski A,Arancio O

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVES:Memory evaluation is a key component in the accurate diagnosis of cognitive disorders.One memory procedure that has shown promise in discriminating disease-related cognitive decline from normal cognitive aging is the New York University Paragraph Recall Test; however, the effects of education have been unexa...

journal_title：Current Alzheimer research

authors： Mathews M,Abner E,Caban-Holt A,Dennis BC,Kryscio R,Schmitt F

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Previous work designed a network-based protocol of cognitive training. This programme exploits a mechanism of induced task-oriented co-activation of multiple regions that are part of the default mode network (DMN), to induce functional rewiring and increased functional connectivity within this network. OBJE...

journal_title：Current Alzheimer research

authors： De Marco M,Meneghello F,Pilosio C,Rigon J,Venneri A

更新日期：2018-01-01 00:00:00

abstract：:Serum levels of β-amyloid (Aβ) peptides may represent an early biomarker in the diagnosis of Alzheimer's disease (AD). In the present study, we investigated the temporal kinetic changes in the levels of serum Aβ 1-42 and 40 in an amyloid precursor protein (APP)/presenilin (PS)1 double transgenic mouse model of AD. Ser...

journal_title：Current Alzheimer research

authors： He J,Qiao JP,Zhu S,Xue M,Chen W,Wang X,Tempier A,Huang Q,Kong J,Li XM

更新日期：2013-11-01 00:00:00

abstract：:Recent studies of Alzheimer's disease (AD) and other neuropsychiatric drug developments raise questions whether failures of some drugs occur due to flaws in methods. In three case studies of recent AD drug development failures with phenserine, metrifonate, and tarenflurbil we identified methodological lapses able to a...

journal_title：Current Alzheimer research

authors： Becker RE,Greig NH

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Impairment in instrumental activities of daily living (IADL) starts as individuals with amnestic mild cognitive impairment (MCI) transition to Alzheimer's disease (AD) dementia. However, most IADL scales have not shown IADL alterations in clinically normal (CN) elderly. The objective of this study was to det...

journal_title：Current Alzheimer research

authors： Marshall GA,Zoller AS,Kelly KE,Amariglio RE,Locascio JJ,Johnson KA,Sperling RA,Rentz DM,For The Alzheimer's Disease Neuroimaging Initiative

更新日期：2014-01-01 00:00:00

abstract：:Acetylcholinesterase (AChE) plays a crucial physiological role in termination of impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine. In addition, it was implicated in amyloid plaque formation, a hallmark of Alzheimer's disease (AD), and most of the drugs used in AD treatment are ACh...

journal_title：Current Alzheimer research

authors： Hasin Y,Avidan N,Bercovich D,Korczyn AD,Silman I,Beckmann JS,Sussman JL

更新日期：2005-04-01 00:00:00