Gamma-secretase inhibition and modulation for Alzheimer's disease.

abstract：INTRODUCTION:Histaminergic H3 receptors may play a role in modulating cholinergic and monoaminergic neurotransmission. This Phase II study evaluated the efficacy and safety of GSK239512, a highly potent, brain penetrant H3 receptor antagonist as monotherapy treatment for subjects with mild-to-moderate probable Alzheime...

journal_title：Current Alzheimer research

authors： Grove RA,Harrington CM,Mahler A,Beresford I,Maruff P,Lowy MT,Nicholls AP,Boardley RL,Berges AC,Nathan PJ,Horrigan JP

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Previous work designed a network-based protocol of cognitive training. This programme exploits a mechanism of induced task-oriented co-activation of multiple regions that are part of the default mode network (DMN), to induce functional rewiring and increased functional connectivity within this network. OBJE...

journal_title：Current Alzheimer research

authors： De Marco M,Meneghello F,Pilosio C,Rigon J,Venneri A

更新日期：2018-01-01 00:00:00

abstract：:Despite the known validity of clinical diagnostic criteria, significant overlap of clinical symptoms between Frontotemporal dementia (FTD) subtypes exists in several cases, resulting in great uncertainty of the diagnostic boundaries. We evaluated the perfusion between FTD subtypes using brain perfusion (99m)Tc-HMPAO S...

journal_title：Current Alzheimer research

authors： Valotassiou V,Papatriantafyllou J,Sifakis N,Tzavara C,Tsougos I,Psimadas D,Kapsalaki E,Fezoulidis I,Hadjigeorgiou G,Georgoulias P

更新日期：2014-01-01 00:00:00

abstract：:The definite diagnosis of Alzheimer's disease (AD) is based on the detection of beta amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) - which are the pathological hallmarks of the disease- in the postmortem brains. Although regional Cerebral Blood Flow (rCBF) and Cerebral Glucose Metabolism (CGM) abnormalities ...

journal_title：Current Alzheimer research

authors： Valotassiou V,Archimandritis S,Sifakis N,Papatriantafyllou J,Georgoulias P

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Curcumin has been of interest in the field of Alzheimer's disease. Early studies on transgenic mice showed promising results in the reduction of amyloid plaques.However, curcumin is very poorly soluble in aqueous solutions and not easily accessible to coupling as it contains only phenolic groups as potential...

journal_title：Current Alzheimer research

authors： Sturzu A,Sheikh S,Kalbacher H,Nägele T,Weidenmaier C,Wegenast-Braun BM,Schilling N,Ernemann U,Heckl S

更新日期：2019-01-01 00:00:00

abstract：:At present, the search for preventive strategies for cognitive decline and dementia appears to be of crucial importance, given that the therapeutic options currently available have demonstrated limited efficacy. Cumulative epidemiological evidence suggested that vascular and vascular-related factors may be important f...

journal_title：Current Alzheimer research

authors： Panza F,Frisardi V,Seripa D,Imbimbo BP,Sancarlo D,D'Onofrio G,Addante F,Paris F,Pilotto A,Solfrizzi V

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:There is a growing body of pre-clinical evidence suggesting that lithium (Li) may protect neurons from a range of neurotoxic insults, hence the term neuroprotective effects. Does Li have similar effects also in human subjects? METHODS:We reviewed the neuroimaging literature investigating the association bet...

journal_title：Current Alzheimer research

authors： Hajek T,Weiner MW

更新日期：2016-01-01 00:00:00

abstract：:Features of autoimmunity have been associated with both Alzheimer's disease (AD) and with diabetes. In both diseases high levels of advanced glycation end products (AGEs) and their receptor (RAGE) have been detected in tissues and in the circulation. In addition high titers of antibodies directed against a RAGE-like p...

journal_title：Current Alzheimer research

authors： Mruthinti S,Schade RF,Harrell DU,Gulati NK,Swamy-Mruthinti S,Lee GP,Buccafusco JJ

更新日期：2006-07-01 00:00:00

abstract：:With a longer life expectancy and an increased prevalence of neurodegenerative diseases, investigations on trajectories of cognitive aging have become exciting and promising. This study aimed to estimate the patterns of age-related cognitive decline and the potential associated factors of cognitive function in communi...

journal_title：Current Alzheimer research

authors： Li H,Lv C,Zhang T,Chen K,Chen C,Gai G,Hu L,Wang Y,Zhang Z

更新日期：2014-01-01 00:00:00

abstract：:The aggregation of the microtubule-associated protein tau into paired-helical filaments is the defining characteristic of the tauopathies. It has become apparent that the hyperphosphorylation of tau likely plays a role in the aggregation process and thus strategies to reduce tau phosphorylation are generating wide int...

journal_title：Current Alzheimer research

authors： Yuzwa SA,Vocadlo DJ

更新日期：2009-10-01 00:00:00

abstract：:Mitochondrial dysfunction has been implicated in causing metabolic abnormalities in Alzheimer's disease (AD). The searches for mitochondrial DNA variants associated with AD susceptibility have generated conflicting results. The age-related accumulation of somatic mitochondrial DNA deletion has been suggested to play a...

journal_title：Current Alzheimer research

authors： Chen X,Stern D,Yan SD

更新日期：2006-12-01 00:00:00

abstract：:Recent studies of Alzheimer's disease (AD) and other neuropsychiatric drug developments raise questions whether failures of some drugs occur due to flaws in methods. In three case studies of recent AD drug development failures with phenserine, metrifonate, and tarenflurbil we identified methodological lapses able to a...

journal_title：Current Alzheimer research

authors： Becker RE,Greig NH

更新日期：2010-11-01 00:00:00

abstract：:According to the current paradigm, the main cause of AD is the accumulation of neurotoxic amyloid beta (Aβ) peptide aggregates resulting from the cleavage of the amyloid precursor protein into peptides of different length, with the 42 amino acid long Aβ42 being the most toxic form. Aβ can aggregate and form plaques in...

journal_title：Current Alzheimer research

authors： Goldeck D,Witkowski JM,Fülop T,Pawelec G

更新日期：2016-01-01 00:00:00

abstract：:Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the most common types of dementia in the presenile population. Episodic memory impairment, the clinical hallmark of AD, can also be encountered in patients with FTD, complicating accurate diagnosis. Several studies in FTD have correlated memory deficits wi...

journal_title：Current Alzheimer research

authors： Papma JM,Seelaar H,de Koning I,Hasan D,Reijs A,Valkema R,Prins ND,van Swieten JC

更新日期：2013-03-01 00:00:00

abstract：:The Twentieth Century witnessed tremendous advances in our understanding of neurodegenerative diseases. Not least among them were the contributions from hyperendemic foci of neurodegenerative disorders in isolated human groups worldwide, with the knowledge gained applicable to our understanding of related neurodegener...

journal_title：Current Alzheimer research

authors： Garruto RM

更新日期：2006-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is a devastating chronic neurodegenerative disease with currently no available disease modifying treatment. In recent years, the peptide amyloid-beta has been proposed as the major pathogenic force in the development and progression of AD. Microglia, the resident immune and phagocytic cells of...

journal_title：Current Alzheimer research

authors： Schlachetzki JC,Hüll M

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:ACTION, a 24-week, prospective, randomized, parallel-group, double-blind study in patients with severe Alzheimer's disease (AD), demonstrated significant efficacy of 13.3 mg/24 h versus 4.6 mg/24 h rivastigmine patch on the Severe Impairment Battery (SIB) and Alzheimer's Disease Cooperative Study-Activities ...

journal_title：Current Alzheimer research

authors： Grossberg GT,Farlow MR,Meng X,Velting DM

更新日期：2015-01-01 00:00:00

abstract：:From a clinical as well as a neuropathological point of view Alzheimer's disease (AD) has been the focus of intense research for more than three decades. Most studies to identify morphometric correlates with the declining cognitive function in normal aging and AD have employed semi-quantitative methods to assess neuro...

journal_title：Current Alzheimer research

authors： Stark AK,Pelvig DP,Jørgensen AM,Andersen BB,Pakkenberg B

更新日期：2005-10-01 00:00:00

abstract：:Mutations in the presenilin genes cause the majority of early-onset familial Alzheimer’s disease. Recently, presenilin mutations have been identified in patients with dilated cardiomyopathy (DCM), a common cause of heart failure and the most prevalent diagnosis in cardiac transplantation patients. However, the molecul...

journal_title：Current Alzheimer research

authors： Li A,Zhou C,Moore J,Zhang P,Tsai TH,Lee HC,Romano DM,McKee ML,Schoenfeld DA,Serra MJ,Raygor K,Cantiello HF,Fujimoto JG,Tanzi RE

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a neurodegenerative disease characterised by a progressive decline in cognitive function and represents a major healthcare challenge worldwide. Increasing evidence indicates that mitochondrial dysfunction mediated oxidative stress plays a significant role in the pathophysiological...

journal_title：Current Alzheimer research

authors： Chhetri J,King AE,Gueven N

更新日期：2018-01-01 00:00:00

abstract：:The occurrence of a plaque-dependent inflammation in Alzheimer's disease has been extensively documented in both human specimens and transgenic models of the disease. Since insoluble plaques are present in AD patients from early preclinical stages of the pathology, the point at which neuroinflammation first occurs in ...

journal_title：Current Alzheimer research

authors： Ferretti MT,Cuello AC

更新日期：2011-03-01 00:00:00

abstract：:Trisomy 21 and the consequent extra copy of the amyloid precursor protein (APP) gene and increased beta-amyloid (Aβ) peptide production underlie the universal development of Alzheimer's disease (AD) pathology and high risk of AD dementia in people with Down syndrome (DS). Trisomy 21 and other forms of aneuploidy also ...

journal_title：Current Alzheimer research

authors： Potter H,Granic A,Caneus J

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Accumulating evidence suggests that multi-target directed ligands have great potential for the treatment of complex diseases such as Alzheimer's Disease (AD). OBJECTIVE:To evaluate novel chimeric 8-hydroxyquinoline ligands with merged pharmacophores as potential multifunctional ligands for AD. METHODS:Nitr...

journal_title：Current Alzheimer research

authors： Knez D,Sosič I,Pišlar A,Mitrović A,Jukič M,Kos J,Gobec S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Cholinesterase inhibitors are the first line of therapy for the management of Alzheimer's disease (AD), however, it is now established that they provide only temporary and symptomatic relief, besides, having several inherited side-effects. Therefore, an alternative drug discovery method is used to identify n...

journal_title：Current Alzheimer research

authors： Kumar A,Mehta V,Raj U,Varadwaj PK,Udayabanu M,Yennamalli RM,Singh TR

更新日期：2019-01-01 00:00:00

abstract：:Rodents housed in an enriched environment, exercise by running or perform learning and memory tasks show an increase in hippocampal neurogenesis. We show that both environmental enrichment, as well as performance in the Morris water maze, a hippocampal-dependent learning task, leads to an increase in local VEGF expres...

journal_title：Current Alzheimer research

authors： During MJ,Cao L

更新日期：2006-02-01 00:00:00

abstract：:The remarkable potentiality of bone marrow-derived mesenchymal stem cells (BM-MSCs) after transplantation to models of neurological disease and injury has been described. We have previously published data confirming the influence of BM-MSCs on β-amyloid (Aβ) deposition in an Alzheimer's disease (AD) mouse model. Howev...

journal_title：Current Alzheimer research

authors： Bae JS,Jin HK,Lee JK,Richardson JC,Carter JE

更新日期：2013-06-01 00:00:00

abstract：:High levels of cholesterol have been proposed as a risk factor for Alzheimer's disease (AD). Polymorphism of genes encoding proteins that regulate cholesterol metabolism have also been associated with the frequency of Alzheimer's development. Some studies have shown that cholesterol-lowering drugs reduce the frequency...

journal_title：Current Alzheimer research

authors： Vestergaard M,Hamada T,Morita M,Takagi M

更新日期：2010-05-01 00:00:00

abstract：:In the last decade, several radiolabeled compounds have been developed for the imaging in vivo of amyloid pathology by means of Positron Emission Tomography (PET). Among these, 18F Florbetaben appear to be one of the most reliable for its high affinity for amyloid plaques in brain and its radio-chemical properties tha...

journal_title：Current Alzheimer research

authors： Chiaravalloti A,Danieli R,Lacanfora A,Palumbo B,Caltagirone C,Schillaci O

更新日期：2017-01-01 00:00:00

abstract：:To search for potential mechanism that might alter synaptic transmission following Abeta increase we have examined the presynaptic component of transmitter release. As parameters of synaptic transmission that might underlie presynaptic mechanisms, we have used paired-pulse facilitation (PPF), post-tetanic potentiation...

journal_title：Current Alzheimer research

authors： Zhang H,Gong B,Liu S,Fa' M,Ninan I,Staniszewski A,Arancio O

更新日期：2005-04-01 00:00:00

abstract：:Changes in rRNA and rDNA expression have been associated with cellular and organism aging and have been linked to Alzheimer's disease (AD) pathogenesis. In this study, we investigated the mRNA expression of ribosomal genes (28S/18S) and β-amyloid precursor protein (APP) in different post mortem brain tissue regions (t...

journal_title：Current Alzheimer research

authors： Rasmussen L,de Labio RW,Viani GA,Chen E,Villares J,Bertolucci PH,Minett TS,Turecki G,Cecyre D,Drigo SA,Smith MC,Payao SL

更新日期：2015-01-01 00:00:00