Differential Expression of Ribosomal Genes in Brain and Blood of Alzheimer's Disease Patients.

Abstract:

:Changes in rRNA and rDNA expression have been associated with cellular and organism aging and have been linked to Alzheimer's disease (AD) pathogenesis. In this study, we investigated the mRNA expression of ribosomal genes (28S/18S) and β-amyloid precursor protein (APP) in different post mortem brain tissue regions (the entorhinal and auditory cortices and the hippocampus) of AD patients and elderly control subjects and also evaluated the extent of expression in peripheral blood from young, healthy, elderly, and Alzheimer's disease patients in order to investigate whether these individuals experienced the effects of aging. The comparative threshold cycle (CT) method via Real Time Polymerase Chain Reaction and the Polymerase Chain Reaction- Restriction Fragment Length Polymorphism (PCR-RFLP) were used to analyze gene expression and the Apolipoprotein E (APOE) genotype, respectively. When the brain areas were analyzed collectively, we observed a significant decrease in APP expression and a significant increase in levels of mRNA of 18S and 28S in Alzheimer's disease patients compared to healthy elderly individuals. Furthermore, there was a significant upregulation of 28SrRNA in the entorhinal cortex and hippocampus, but not in the auditory cortex of patients with AD. On the other hand, tests of blood samples verified a decreased expression of 28S rRNA in patients with AD. These results support the hypothesis that changes in rRNA are present in AD patients, are tissue-specific, and seem to occur independently and differently in each tissue. However, the next challenge is to discover the mechanisms responsible for the differences in expression observed in the blood and the brain in both healthy elderly individuals and Alzheimer's disease patients, as well as the impact of these genes on AD pathogenesis.

journal_name

Curr Alzheimer Res

authors

Rasmussen L,de Labio RW,Viani GA,Chen E,Villares J,Bertolucci PH,Minett TS,Turecki G,Cecyre D,Drigo SA,Smith MC,Payao SL

doi

10.2174/1567205012666151027124017

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

984-9

issue

10

eissn

1567-2050

issn

1875-5828

pii

CAR-EPUB-71315

journal_volume

12

pub_type

杂志文章
  • Biological Evaluation of 8-Hydroxyquinolines as Multi-Target Directed Ligands for Treating Alzheimer's Disease.

    abstract:BACKGROUND:Accumulating evidence suggests that multi-target directed ligands have great potential for the treatment of complex diseases such as Alzheimer's Disease (AD). OBJECTIVE:To evaluate novel chimeric 8-hydroxyquinoline ligands with merged pharmacophores as potential multifunctional ligands for AD. METHODS:Nitr...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205016666191010130351

    authors: Knez D,Sosič I,Pišlar A,Mitrović A,Jukič M,Kos J,Gobec S

    更新日期:2019-01-01 00:00:00

  • Alzheimer's disease: spect and pet tracers for beta-amyloid imaging.

    abstract::The definite diagnosis of Alzheimer's disease (AD) is based on the detection of beta amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) - which are the pathological hallmarks of the disease- in the postmortem brains. Although regional Cerebral Blood Flow (rCBF) and Cerebral Glucose Metabolism (CGM) abnormalities ...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/156720510792231757

    authors: Valotassiou V,Archimandritis S,Sifakis N,Papatriantafyllou J,Georgoulias P

    更新日期:2010-09-01 00:00:00

  • Early diagnosis of Alzheimer's disease: is MCI too late?

    abstract::The field of aging and dementia research is advancing rapidly toward the stage of earlier identification of clinical symptoms. Ultimately, clinicians would like to be able to identify individuals who are asymptomatic but at risk for developing dementia. In the interim, the construct of mild cognitive impairment (MCI) ...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/156720509788929237

    authors: Petersen RC

    更新日期:2009-08-01 00:00:00

  • Auditory Verbal Learning Test is Superior to Rey-Osterrieth Complex Figure Memory for Predicting Mild Cognitive Impairment to Alzheimer's Disease.

    abstract:OBJECTIVE:To carry out meaningful comparisons on results of different research studies on mild cognitive impairment (MCI), it is critical to select an appropriate objective memory test to examine memory deficit. We aim to refine the operational criteria of amnestic MCI (aMCI) on neuropsychological tests that optimally ...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205012666150530202729

    authors: Zhao Q,Guo Q,Liang X,Chen M,Zhou Y,Ding D,Hong Z

    更新日期:2015-01-01 00:00:00

  • Impact of a Clinical Decision Support Tool on Dementia Diagnostics in Memory Clinics: The PredictND Validation Study.

    abstract:BACKGROUND:Determining the underlying etiology of dementia can be challenging. Computer- based Clinical Decision Support Systems (CDSS) have the potential to provide an objective comparison of data and assist clinicians. OBJECTIVES:To assess the diagnostic impact of a CDSS, the PredictND tool, for differential diagnos...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,多中心研究

    doi:10.2174/1567205016666190103152425

    authors: Bruun M,Frederiksen KS,Rhodius-Meester HFM,Baroni M,Gjerum L,Koikkalainen J,Urhemaa T,Tolonen A,van Gils M,Tong T,Guerrero R,Rueckert D,Dyremose N,Andersen BB,Simonsen AH,Lemstra A,Hallikainen M,Kurl S,Herukka SK,Re

    更新日期:2019-01-01 00:00:00

  • Lead (Pb) in Alzheimer's Dementia: A Systematic Review of Human Case- Control Studies.

    abstract:BACKGROUND:Alzheimer's Dementia (AD) has a complex pathophysiology that is incompletely understood. Chronic, low-level environmental lead (Pb) exposure is associated with cognitive impairment, hypertension and mortality, and has been proposed as a potential cause of AD. OBJECTIVE:We aimed to review the literature to c...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205016666190311101445

    authors: Brown EE,Shah P,Pollock BG,Gerretsen P,Graff-Guerrero A

    更新日期:2019-01-01 00:00:00

  • TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets.

    abstract::As the average ages of North Americans and Europeans continue to rise; similarly the incidence of "old age" associated illnesses likewise increases. Most notably among these ailments are conditions linked to dementia-related neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD) and st...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/156720507781788873

    authors: Tweedie D,Sambamurti K,Greig NH

    更新日期:2007-09-01 00:00:00

  • Auto-Contractive Maps: an artificial adaptive system for data mining. An application to Alzheimer disease.

    abstract::This article presents a new paradigm of Artificial Neural Networks (ANNs): the Auto-Contractive Maps (Auto-CM). The Auto-CM differ from the traditional ANNs under many viewpoints: the Auto-CM start their learning task without a random initialization of their weights, they meet their convergence criterion when all thei...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/156720508785908928

    authors: Buscema M,Grossi E,Snowdon D,Antuono P

    更新日期:2008-10-01 00:00:00

  • An introduction to obesity and dementia.

    abstract::The increasing prevalence of obesity world-wide has an expected consequent increase in diabetes and cardiovascular disease. Less attention has been paid to the effect of obesity on dementia. This overview discusses methodological issues related to the epidemiologic study of obesity and dementia, reviews results of lon...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/156720507780362074

    authors: Barrett-Connor E

    更新日期:2007-04-01 00:00:00

  • Analysis of genetic polymorphisms in acetylcholinesterase as reflected in different populations.

    abstract::Acetylcholinesterase (AChE) plays a crucial physiological role in termination of impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine. In addition, it was implicated in amyloid plaque formation, a hallmark of Alzheimer's disease (AD), and most of the drugs used in AD treatment are ACh...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205053585909

    authors: Hasin Y,Avidan N,Bercovich D,Korczyn AD,Silman I,Beckmann JS,Sussman JL

    更新日期:2005-04-01 00:00:00

  • Proteomic analysis of Alzheimer's disease cerebrospinal fluid from neuropathologically diagnosed subjects.

    abstract::A crucial need exists for reliable Alzheimer's disease (AD) diagnostic and prognostic tests. Given its intimate communication with the brain, the cerebrospinal fluid (CSF) has been surveyed intensively for reliable AD biomarkers. The heterogeneity of AD pathology and the unavoidable difficulties associated with the cl...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/156720509788929318

    authors: Maarouf CL,Andacht TM,Kokjohn TA,Castaño EM,Sue LI,Beach TG,Roher AE

    更新日期:2009-08-01 00:00:00

  • A randomized, double-blind, placebo-controlled, 16-week study of the H3 receptor antagonist, GSK239512 as a monotherapy in subjects with mild-to-moderate Alzheimer's disease.

    abstract:INTRODUCTION:Histaminergic H3 receptors may play a role in modulating cholinergic and monoaminergic neurotransmission. This Phase II study evaluated the efficacy and safety of GSK239512, a highly potent, brain penetrant H3 receptor antagonist as monotherapy treatment for subjects with mild-to-moderate probable Alzheime...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2174/1567205010666131212110148

    authors: Grove RA,Harrington CM,Mahler A,Beresford I,Maruff P,Lowy MT,Nicholls AP,Boardley RL,Berges AC,Nathan PJ,Horrigan JP

    更新日期:2014-01-01 00:00:00

  • Amyloid-beta peptide 1-42 causes microtubule deregulation through N-methyl-D-aspartate receptors in mature hippocampal cultures.

    abstract::Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder among the elderly. Nmethyl- D-aspartate receptor (NMDAR) overactivation has been implicated in early synaptic dysfunction that precedes late neurodegeneration in AD. Moreover, oligomers of amyloid-beta peptide (Aβ) 1-42 are considered t...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/156720512802455322

    authors: Mota SI,Ferreira IL,Pereira C,Oliveira CR,Rego AC

    更新日期:2012-09-01 00:00:00

  • How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the "LEARn" model (latent early-life associated regulation) may explain the triggering of AD.

    abstract::Alzheimer's disease (AD) is currently the most prominent form of dementia among the elderly. Although AD manifests in late adult life, it is not clear when the disease actually starts and how long the neuropathological processes take to develop AD. The major unresolved question is the timing and the nature of triggeri...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/156720507780362164

    authors: Lahiri DK,Maloney B,Basha MR,Ge YW,Zawia NH

    更新日期:2007-04-01 00:00:00

  • Transcriptional Remodeling in Primary Hippocampal Astrocytes from an Alzheimer's Disease Mouse Model.

    abstract:BACKGROUND:It is well known that alterations in astrocytes occur in Alzheimer's disease and reactive astrogliosis is one of the hallmarks of the disease. Recently, data has emerged that suggests that alterations in astrocytes may also occur early in the pathogenesis of the disease. OBJECTIVE:The aim of present work wa...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205015666180613113924

    authors: Ruffinatti F,Tapella L,Gregnanin I,Stevano A,Chiorino G,Canonico PL,Distasi C,Genazzani AA,Lim D

    更新日期:2018-01-01 00:00:00

  • Default mode, executive function, and language functional connectivity networks are compromised in mild Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is characterized by mental and cognitive problems, particularly with memory, language, visuospatial skills (VS), and executive functions (EF). Advances in the neuroimaging of AD have highlighted dysfunctions in functional connectivity networks (FCNs), especially in the memory related default m...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205011666140131114716

    authors: Weiler M,Fukuda A,Massabki LH,Lopes TM,Franco AR,Damasceno BP,Cendes F,Balthazar ML

    更新日期:2014-03-01 00:00:00

  • Epidemiology and etiology of Alzheimer's disease: from genetic to non-genetic factors.

    abstract::At present, the etiology of Alzheimer's disease (AD) is still unclear, but both genetic and non-genetic factors are thought to take part in the etiopathogenesis of AD. Epidemiologic researches revealed that genetic factors played a decisive role in the development of both early-onset AD (EOAD) and late-onset AD (LOAD)...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/15672050113109990155

    authors: Jiang T,Yu JT,Tian Y,Tan L

    更新日期:2013-10-01 00:00:00

  • Measuring morphological and cellular changes in Alzheimer's dementia: a review emphasizing stereology.

    abstract::From a clinical as well as a neuropathological point of view Alzheimer's disease (AD) has been the focus of intense research for more than three decades. Most studies to identify morphometric correlates with the declining cognitive function in normal aging and AD have employed semi-quantitative methods to assess neuro...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/156720505774330528

    authors: Stark AK,Pelvig DP,Jørgensen AM,Andersen BB,Pakkenberg B

    更新日期:2005-10-01 00:00:00

  • Computer based classification of MR scans in first time applicant Alzheimer patients.

    abstract::In this study, we aimed to classify MR images for recognizing Alzheimer Disease (AD) in a group of patients who were recently diagnosed by clinical history and neuropsychiatric exams by using non-biased machine-learning techniques. T1 weighted MRI scans of 31 patients with probable AD and 31 age- and gender-matched co...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/156720512802455359

    authors: Polat F,Demirel SO,Kitis O,Simsek F,Haznedaroglu DI,Coburn K,Kumral E,Gonul AS

    更新日期:2012-09-01 00:00:00

  • Computational and In-Vitro Validation of Natural Molecules as Potential Acetylcholinesterase Inhibitors and Neuroprotective Agents.

    abstract:BACKGROUND:Cholinesterase inhibitors are the first line of therapy for the management of Alzheimer's disease (AD), however, it is now established that they provide only temporary and symptomatic relief, besides, having several inherited side-effects. Therefore, an alternative drug discovery method is used to identify n...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205016666181212155147

    authors: Kumar A,Mehta V,Raj U,Varadwaj PK,Udayabanu M,Yennamalli RM,Singh TR

    更新日期:2019-01-01 00:00:00

  • Atorvastatin therapy lowers circulating cholesterol but not free radical activity in advance of identifiable clinical benefit in the treatment of mild-to-moderate AD.

    abstract::Cholesterol-induced production of amyloid beta (Abeta) as a putative neurotoxin in Alzheimer's disease (AD), along with epidemiological evidence, suggests that statin drugs may provide benefit in treatment of the disorder. We tested the effect of once daily atorvastatin calcium (80 mg; two 40 mg tablets) on cognitive ...

    journal_title:Current Alzheimer research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2174/1567205054367900

    authors: Sparks DL,Sabbagh MN,Connor DJ,Lopez J,Launer LJ,Petanceska S,Browne P,Wassar D,Johnson-Traver S,Lochhead J,Ziolkowski C

    更新日期:2005-07-01 00:00:00

  • Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier.

    abstract:BACKGROUND:The design of new heterodimeric dual binding site acetylcholinesterase inhibitors constitutes the main goal-directed to the development of new anticholinesterase agents with the expanded pharmacological profile. Multi-target compounds are usually designed by combining in a hybrid molecule with two or more ph...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205015666180711110750

    authors: Hamulakova S,Janovec L,Soukup O,Jun D,Janockova J,Hrabinova M,Sepsova V,Kuca K

    更新日期:2018-01-01 00:00:00

  • Pan-amyloid oligomer specific scFv antibody attenuates memory deficits and brain amyloid burden in mice with Alzheimer's disease.

    abstract::Amyloid oligomers have a critical function in the pathologic processes of various amyloidoses, such as Alzheimer's disease (AD), Parkinson disease (PD), Huntington's disease, prion-related diseases, type 2 diabetes, and hereditary renal amyloidosis. Our previous reports demonstrated that a conformation-dependent oligo...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/15672050113106660176

    authors: Zhao M,Wang SW,Wang YJ,Zhang R,Li YN,Su YJ,Zhou WW,Yu XL,Liu RT

    更新日期:2014-01-01 00:00:00

  • Relationship Between the Japanese Version of the Montreal Cognitive Assessment and PET Imaging in Subjects with Mild Cognitive Impairment.

    abstract:BACKGROUND:The Montreal Cognitive Assessment (MoCA) test has high sensitivity and specificity for detecting mild cognitive impairment or early dementia. How the MoCA score relates to findings of positron emission tomography imaging, however, remains unclear. OBJECTIVE:This prospective study examined the relationship b...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205016666190805155230

    authors: Eguchi A,Kimura N,Aso Y,Yabuuchi K,Ishibashi M,Hori D,Sasaki Y,Nakamichi A,Uesugi S,Jikumaru M,Sumi K,Shimomura T,Matsubara E

    更新日期:2019-01-01 00:00:00

  • High Contrast and Resolution Labeling of Amyloid Plaques in Tissue Sections from APP-PS1 Mice and Humans with Alzheimer's Disease with the Zinc Chelator HQ-O: Practical and Theoretical Considerations.

    abstract:BACKGROUND:Various methodologies have been employed for the localization of amyloid plaques in numerous studies on Alzheimer's disease. The majority of these stains are thought to label the plaques by virtue of their affinity for aggregated Aβ. However, plaques are known to contain numerous other components, including ...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205016666190725155038

    authors: Schmued L,Raymick J,Sarkar S

    更新日期:2019-01-01 00:00:00

  • Functional Activities Questionnaire Items that Best Discriminate and Predict Progression from Clinically Normal to Mild Cognitive Impairment.

    abstract:BACKGROUND:Impairment in instrumental activities of daily living (IADL) emerges in the transition from mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia. Some IADL scales are sensitive to early deficits in MCI, but none have been validated for detecting subtle functional changes in clinically normal ...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,多中心研究

    doi:10.2174/156720501205150526115003

    authors: Marshall GA,Zoller AS,Lorius N,Amariglio RE,Locascio JJ,Johnson KA,Sperling RA,Rentz DM

    更新日期:2015-01-01 00:00:00

  • Episodic memory impairment in frontotemporal dementia; a ⁹⁹mTc- HMPAO SPECT study.

    abstract::Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the most common types of dementia in the presenile population. Episodic memory impairment, the clinical hallmark of AD, can also be encountered in patients with FTD, complicating accurate diagnosis. Several studies in FTD have correlated memory deficits wi...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205011310030013

    authors: Papma JM,Seelaar H,de Koning I,Hasan D,Reijs A,Valkema R,Prins ND,van Swieten JC

    更新日期:2013-03-01 00:00:00

  • Mitochondrial dysfunction and Alzheimer's disease.

    abstract::Mitochondrial dysfunction has been implicated in causing metabolic abnormalities in Alzheimer's disease (AD). The searches for mitochondrial DNA variants associated with AD susceptibility have generated conflicting results. The age-related accumulation of somatic mitochondrial DNA deletion has been suggested to play a...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/156720506779025215

    authors: Chen X,Stern D,Yan SD

    更新日期:2006-12-01 00:00:00

  • Melatonin Effects in REM Sleep Behavior Disorder Associated with Obstructive Sleep Apnea Syndrome: A Case Series.

    abstract:OBJECTIVES:REM sleep behavior disorder (RBD), with its main clinical symptoms of nightmares with dream-enacting behavior, is considered as a possible precursor of neurodegenerative disease. Obstructive Sleep Apnea Syndrome (OSAS) is known to be capable of provoking RBD-like symptoms by apneic event related arousals. Th...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205014666170523094938

    authors: Schaefer C,Kunz D,Bes F

    更新日期:2017-01-01 00:00:00

  • Does a pro-inflammatory process precede Alzheimer's disease and mild cognitive impairment?

    abstract::The occurrence of a plaque-dependent inflammation in Alzheimer's disease has been extensively documented in both human specimens and transgenic models of the disease. Since insoluble plaques are present in AD patients from early preclinical stages of the pathology, the point at which neuroinflammation first occurs in ...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/156720511795255982

    authors: Ferretti MT,Cuello AC

    更新日期:2011-03-01 00:00:00