Differential Expression of Ribosomal Genes in Brain and Blood of Alzheimer's Disease Patients.

Abstract:

:Changes in rRNA and rDNA expression have been associated with cellular and organism aging and have been linked to Alzheimer's disease (AD) pathogenesis. In this study, we investigated the mRNA expression of ribosomal genes (28S/18S) and β-amyloid precursor protein (APP) in different post mortem brain tissue regions (the entorhinal and auditory cortices and the hippocampus) of AD patients and elderly control subjects and also evaluated the extent of expression in peripheral blood from young, healthy, elderly, and Alzheimer's disease patients in order to investigate whether these individuals experienced the effects of aging. The comparative threshold cycle (CT) method via Real Time Polymerase Chain Reaction and the Polymerase Chain Reaction- Restriction Fragment Length Polymorphism (PCR-RFLP) were used to analyze gene expression and the Apolipoprotein E (APOE) genotype, respectively. When the brain areas were analyzed collectively, we observed a significant decrease in APP expression and a significant increase in levels of mRNA of 18S and 28S in Alzheimer's disease patients compared to healthy elderly individuals. Furthermore, there was a significant upregulation of 28SrRNA in the entorhinal cortex and hippocampus, but not in the auditory cortex of patients with AD. On the other hand, tests of blood samples verified a decreased expression of 28S rRNA in patients with AD. These results support the hypothesis that changes in rRNA are present in AD patients, are tissue-specific, and seem to occur independently and differently in each tissue. However, the next challenge is to discover the mechanisms responsible for the differences in expression observed in the blood and the brain in both healthy elderly individuals and Alzheimer's disease patients, as well as the impact of these genes on AD pathogenesis.

journal_name

Curr Alzheimer Res

authors

Rasmussen L,de Labio RW,Viani GA,Chen E,Villares J,Bertolucci PH,Minett TS,Turecki G,Cecyre D,Drigo SA,Smith MC,Payao SL

doi

10.2174/1567205012666151027124017

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

984-9

issue

10

eissn

1567-2050

issn

1875-5828

pii

CAR-EPUB-71315

journal_volume

12

pub_type

杂志文章
  • Alzheimer's Disease and Retinal Degeneration: A Glimpse at Essential Trace Metals in Ocular Fluids and Tissues.

    abstract:BACKGROUND:Life expectancy is increasing all over the world, although neurodegenerative disorders might drastically affect the individual activity of aged people. Of those, Alzheimer's Disease (AD) is one of the most social-cost age-linked diseases of industrialized countries. To date, retinal diseases seem to be more ...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/1567205016666191023114015

    authors: Micera A,Bruno L,Cacciamani A,Rongioletti M,Squitti R

    更新日期:2019-01-01 00:00:00

  • Auditory Verbal Learning Test is Superior to Rey-Osterrieth Complex Figure Memory for Predicting Mild Cognitive Impairment to Alzheimer's Disease.

    abstract:OBJECTIVE:To carry out meaningful comparisons on results of different research studies on mild cognitive impairment (MCI), it is critical to select an appropriate objective memory test to examine memory deficit. We aim to refine the operational criteria of amnestic MCI (aMCI) on neuropsychological tests that optimally ...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205012666150530202729

    authors: Zhao Q,Guo Q,Liang X,Chen M,Zhou Y,Ding D,Hong Z

    更新日期:2015-01-01 00:00:00

  • National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness- Alzheimer's Disease (CATIE-AD): baseline characteristics.

    abstract::CATIE-AD was a multicenter effectiveness trial of atypical antipsychotics in patients with agitation and psychosis associated with AD who resided in the community. The study enrolled 421 participants. In this paper we present and discuss baseline characteristics of participants (demographics, cognitive, behavioral, an...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2174/156720507781077214

    authors: Ismail MS,Dagerman K,Tariot PN,Abbott S,Kavanagh S,Schneider LS

    更新日期:2007-07-01 00:00:00

  • Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome.

    abstract::Down syndrome (DS) is the most common non-lethal genetic condition that affects approximately 1 in 700 births in the United States of America. DS is characterized by complete or segmental chromosome 21 trisomy, which leads to variable intellectual disabilities, progressive memory loss, and accelerated neurodegeneratio...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/1567205012666150921095505

    authors: Hamlett ED,Boger HA,Ledreux A,Kelley CM,Mufson EJ,Falangola MF,Guilfoyle DN,Nixon RA,Patterson D,Duval N,Granholm AC

    更新日期:2016-01-01 00:00:00

  • TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets.

    abstract::As the average ages of North Americans and Europeans continue to rise; similarly the incidence of "old age" associated illnesses likewise increases. Most notably among these ailments are conditions linked to dementia-related neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD) and st...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/156720507781788873

    authors: Tweedie D,Sambamurti K,Greig NH

    更新日期:2007-09-01 00:00:00

  • Atorvastatin therapy lowers circulating cholesterol but not free radical activity in advance of identifiable clinical benefit in the treatment of mild-to-moderate AD.

    abstract::Cholesterol-induced production of amyloid beta (Abeta) as a putative neurotoxin in Alzheimer's disease (AD), along with epidemiological evidence, suggests that statin drugs may provide benefit in treatment of the disorder. We tested the effect of once daily atorvastatin calcium (80 mg; two 40 mg tablets) on cognitive ...

    journal_title:Current Alzheimer research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2174/1567205054367900

    authors: Sparks DL,Sabbagh MN,Connor DJ,Lopez J,Launer LJ,Petanceska S,Browne P,Wassar D,Johnson-Traver S,Lochhead J,Ziolkowski C

    更新日期:2005-07-01 00:00:00

  • A Multicentre Italian Validation Study in Aging Adults with Down Syndrome and Other Forms of Intellectual Disabilities: Dementia Screening Questionnaire for Individuals with Intellectual Disabilities.

    abstract:BACKGROUND:The USA National Task Group (NTG) guidelines advocate the use of an adapted version of Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID) for dementia screening of individuals with Down syndrome (DS) and with other forms of ID (non-DS). OBJECTIVE:In order to meet these ...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2174/1567205014666170117094757

    authors: Gomiero T,Bertelli M,Deb S,Weger E,Marangoni A,De Bastiani E,Mantesso U,De Vreese LP

    更新日期:2017-01-01 00:00:00

  • Amyloid beta conformation in aqueous environment.

    abstract::Amyloid beta peptide (Abeta), 42-residue peptide and its variations, is known to form amyloid fibrils in Alzheimer's disease. Solid-state NMR study reveals a parallel beta-sheet structure in the Abeta fibrils. The atomic level structure of Abeta in aqueous environment, however, has not been determined, because of its ...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/156720508786898424

    authors: Takano K

    更新日期:2008-12-01 00:00:00

  • Lessons from Darwin: 21st century designs for clinical trials.

    abstract::What are the resources needed by clinical pharmacology to test drugs in ways that model how the practitioner achieves optimal effectiveness and safety with each patient? I describe the applications of test-retest standard error of measurement, clinical decision rules, means or other statistical summaries of observatio...

    journal_title:Current Alzheimer research

    pub_type: 历史文章,杂志文章,评审

    doi:10.2174/156720507781788828

    authors: Becker RE

    更新日期:2007-09-01 00:00:00

  • The Role of Lipids and Membranes in the Pathogenesis of Alzheimer's Disease: A Comprehensive View.

    abstract::Lipids participate in Amyloid Precursor Protein (APP) trafficking and processing - important factors in the initiation of Alzheimer's disease (AD) pathogenesis and influence the formation of neurotoxic β-amyloid (Aβ) peptides. An important risk factor, the presence of ApoE4 protein in AD brain cells binds the lipids t...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/1567205015666180911151716

    authors: Penke B,Paragi G,Gera J,Berkecz R,Kovács Z,Crul T,VÍgh L

    更新日期:2018-01-01 00:00:00

  • Metabotropic glutamate receptor 5 in Down's syndrome hippocampus during development: increased expression in astrocytes.

    abstract::Metabotropic glutamate receptor 5 (mGluR5) is highly expressed throughout the forebrain and hippocampus. Several lines of evidence support the role of this receptor in brain development and developmental disorders, as well as in neurodegenerative disorders like Alzheimer's disease (AD). In the present study, the expre...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205011666140812115423

    authors: Iyer AM,van Scheppingen J,Milenkovic I,Anink JJ,Lim D,Genazzani AA,Adle-Biassette H,Kovacs GG,Aronica E

    更新日期:2014-01-01 00:00:00

  • Synthesis of a Novel Curcumin Derivative as a Potential Imaging Probe in Alzheimer's Disease Imaging.

    abstract:BACKGROUND:Curcumin has been of interest in the field of Alzheimer's disease. Early studies on transgenic mice showed promising results in the reduction of amyloid plaques.However, curcumin is very poorly soluble in aqueous solutions and not easily accessible to coupling as it contains only phenolic groups as potential...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205016666190816130516

    authors: Sturzu A,Sheikh S,Kalbacher H,Nägele T,Weidenmaier C,Wegenast-Braun BM,Schilling N,Ernemann U,Heckl S

    更新日期:2019-01-01 00:00:00

  • Isotyping the human TOMM40 variable-length polymorphism by gene amplification and restriction digest.

    abstract::Recent studies have shown that the translocase of outer mitochondrial membrane 40 homolog (TOMM40) contains a polymorphic poly-T variant, the long variant of which is associated with an increase in AD incidence among APOE 3 carriers. Current methods to isotype the poly-T region rely on long PCR, subcloning and sequenc...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/156720512804142921

    authors: Greco SJ,Hamzelou A,Johnston JM,Richardson S,Smith MA,Perry G,Ashford JW,Tezapsidis N

    更新日期:2012-12-01 00:00:00

  • Usefulness of 18F Florbetaben in Diagnosis of Alzheimer's Disease and Other Types of Dementia.

    abstract::In the last decade, several radiolabeled compounds have been developed for the imaging in vivo of amyloid pathology by means of Positron Emission Tomography (PET). Among these, 18F Florbetaben appear to be one of the most reliable for its high affinity for amyloid plaques in brain and its radio-chemical properties tha...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/1567205013666160620114309

    authors: Chiaravalloti A,Danieli R,Lacanfora A,Palumbo B,Caltagirone C,Schillaci O

    更新日期:2017-01-01 00:00:00

  • Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier.

    abstract:BACKGROUND:The design of new heterodimeric dual binding site acetylcholinesterase inhibitors constitutes the main goal-directed to the development of new anticholinesterase agents with the expanded pharmacological profile. Multi-target compounds are usually designed by combining in a hybrid molecule with two or more ph...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205015666180711110750

    authors: Hamulakova S,Janovec L,Soukup O,Jun D,Janockova J,Hrabinova M,Sepsova V,Kuca K

    更新日期:2018-01-01 00:00:00

  • Drusen in the Peripheral Retina of the Alzheimer's Eye.

    abstract:BACKGROUND:Recent work on Alzheimer's disease (AD) diagnosis focuses on neuroimaging modalities; however, these methods are expensive, invasive, and not available to all patients. Ocular imaging of biomarkers, such as drusen in the peripheral retina, could provide an alternative method to diagnose AD. OBJECTIVE:This s...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205015666180123122637

    authors: Ukalovic K,Cao S,Lee S,Tang Q,Beg MF,Sarunic MV,Hsiung GR,Mackenzie IR,Hirsch-Reinshagen V,Cui JZ,Matsubara JA

    更新日期:2018-01-01 00:00:00

  • Relationship Between the Japanese Version of the Montreal Cognitive Assessment and PET Imaging in Subjects with Mild Cognitive Impairment.

    abstract:BACKGROUND:The Montreal Cognitive Assessment (MoCA) test has high sensitivity and specificity for detecting mild cognitive impairment or early dementia. How the MoCA score relates to findings of positron emission tomography imaging, however, remains unclear. OBJECTIVE:This prospective study examined the relationship b...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205016666190805155230

    authors: Eguchi A,Kimura N,Aso Y,Yabuuchi K,Ishibashi M,Hori D,Sasaki Y,Nakamichi A,Uesugi S,Jikumaru M,Sumi K,Shimomura T,Matsubara E

    更新日期:2019-01-01 00:00:00

  • Measuring morphological and cellular changes in Alzheimer's dementia: a review emphasizing stereology.

    abstract::From a clinical as well as a neuropathological point of view Alzheimer's disease (AD) has been the focus of intense research for more than three decades. Most studies to identify morphometric correlates with the declining cognitive function in normal aging and AD have employed semi-quantitative methods to assess neuro...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/156720505774330528

    authors: Stark AK,Pelvig DP,Jørgensen AM,Andersen BB,Pakkenberg B

    更新日期:2005-10-01 00:00:00

  • Butyrylcholinesterase as a Diagnostic and Therapeutic Target for Alzheimer's Disease.

    abstract::The serine hydrolase butyrylcholinesterase (BChE), like the related enzyme acetylcholinesterase (AChE), co-regulates metabolism of the neurotransmitter acetylcholine. In the human brain BChE is mainly expressed in white matter and glia and in distinct populations of neurons in regions that are important in cognition a...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/1567205013666160404120542

    authors: Darvesh S

    更新日期:2016-01-01 00:00:00

  • Prevalence of Cognitive Impairment and Dementia in Malays - Epidemiology of Dementia in Singapore Study.

    abstract:OBJECTIVE:To study the prevalence of cognitive impairment and dementia in communitydwelling Malays from Singapore; and to examine differences in prevalence among Chinese and Malays. METHODS:Subjects (≥ 60 years) - drawn from the Malay component of the on-going multiethnic Epidemiology of Dementia in Singapore study - ...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205012666151002123813

    authors: Hilal S,Tan CS,Xin X,Amin SM,Wong TY,Chen C,Venketasubramanian N,Ikram MK

    更新日期:2017-01-01 00:00:00

  • A randomized, double-blind, placebo-controlled, 16-week study of the H3 receptor antagonist, GSK239512 as a monotherapy in subjects with mild-to-moderate Alzheimer's disease.

    abstract:INTRODUCTION:Histaminergic H3 receptors may play a role in modulating cholinergic and monoaminergic neurotransmission. This Phase II study evaluated the efficacy and safety of GSK239512, a highly potent, brain penetrant H3 receptor antagonist as monotherapy treatment for subjects with mild-to-moderate probable Alzheime...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2174/1567205010666131212110148

    authors: Grove RA,Harrington CM,Mahler A,Beresford I,Maruff P,Lowy MT,Nicholls AP,Boardley RL,Berges AC,Nathan PJ,Horrigan JP

    更新日期:2014-01-01 00:00:00

  • An Optimal Approach for Selecting Discriminant Regions for the Diagnosis of Alzheimer's Disease.

    abstract::In this work, we present a fully automatic computer-aided diagnosis method for the early diagnosis of the Alzheimer's disease. We study the distance between classes (labelled as normal controls and possible Alzheimer's disease) calculated in 116 regions of the brain using the Welchs's t-test. We select the regions wit...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205013666160415154852

    authors: Salas-Gonzalez D,Segovia F,Martínez-Murcia FJ,Lang EW,Gorriz JM,Ramırez J

    更新日期:2016-01-01 00:00:00

  • Mitochondrial dysfunction and Alzheimer's disease.

    abstract::Mitochondrial dysfunction has been implicated in causing metabolic abnormalities in Alzheimer's disease (AD). The searches for mitochondrial DNA variants associated with AD susceptibility have generated conflicting results. The age-related accumulation of somatic mitochondrial DNA deletion has been suggested to play a...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/156720506779025215

    authors: Chen X,Stern D,Yan SD

    更新日期:2006-12-01 00:00:00

  • Impact of a Clinical Decision Support Tool on Dementia Diagnostics in Memory Clinics: The PredictND Validation Study.

    abstract:BACKGROUND:Determining the underlying etiology of dementia can be challenging. Computer- based Clinical Decision Support Systems (CDSS) have the potential to provide an objective comparison of data and assist clinicians. OBJECTIVES:To assess the diagnostic impact of a CDSS, the PredictND tool, for differential diagnos...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,多中心研究

    doi:10.2174/1567205016666190103152425

    authors: Bruun M,Frederiksen KS,Rhodius-Meester HFM,Baroni M,Gjerum L,Koikkalainen J,Urhemaa T,Tolonen A,van Gils M,Tong T,Guerrero R,Rueckert D,Dyremose N,Andersen BB,Simonsen AH,Lemstra A,Hallikainen M,Kurl S,Herukka SK,Re

    更新日期:2019-01-01 00:00:00

  • The neuropathology of vascular disease in the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).

    abstract:BACKGROUND:Vascular disease is associated with increased risk of dementia. Vascular health worsens with age. We investigated the relationship between self-reported vascular disease and brain pathology. METHODS:Brain donations to the population-based MRC Cognitive Function and Ageing Study (n=456, age range 66-103 year...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/156720512801322654

    authors: Richardson K,Stephan BC,Ince PG,Brayne C,Matthews FE,Esiri MM

    更新日期:2012-07-01 00:00:00

  • Potential for Stem Cells Therapy in Alzheimer's Disease: Do Neurotrophic Factors Play Critical Role?

    abstract::Alzheimer's disease (AD) is one of the most common causes of dementia. Despite several decades of research in AD, there is no standard disease- modifying therapy available and currentlyapproved drugs provide only symptomatic relief. Stem cells hold immense potential to regenerate damaged tissues and are currently test...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/1567205013666160314145347

    authors: Bali P,Lahiri DK,Banik A,Nehru B,Anand A

    更新日期:2017-01-01 00:00:00

  • Pan-amyloid oligomer specific scFv antibody attenuates memory deficits and brain amyloid burden in mice with Alzheimer's disease.

    abstract::Amyloid oligomers have a critical function in the pathologic processes of various amyloidoses, such as Alzheimer's disease (AD), Parkinson disease (PD), Huntington's disease, prion-related diseases, type 2 diabetes, and hereditary renal amyloidosis. Our previous reports demonstrated that a conformation-dependent oligo...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/15672050113106660176

    authors: Zhao M,Wang SW,Wang YJ,Zhang R,Li YN,Su YJ,Zhou WW,Yu XL,Liu RT

    更新日期:2014-01-01 00:00:00

  • The Test Your Memory (TYM) Test Outperforms the MMSE in the Detection of MCI and Dementia.

    abstract:OBJECTIVE:The aim of this study was to evaluate the diagnostic accuracy and clinical usability of a Dutch translation of the Test Your Memory (TYM) test in patients with mild cognitive impairment (MCI) and dementia as compared to the Mini-Mental State Examination (MMSE), in the setting of the memory clinic of a general...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205013666161201202520

    authors: van de Zande E,van de Nes JC,Jansen I,van den Berg MN,Zwart AF,Bimmel D,Rijkers GT,Andringa G

    更新日期:2017-01-01 00:00:00

  • Perispinal etanercept for treatment of Alzheimer's disease.

    abstract:BACKGROUND:Increasing basic science and clinical evidence implicates inflammatory processes and resulting glial activation in the pathogenesis of Alzheimer's Disease. Excess TNF-alpha, a cytokine with pleotropic effects in the CNS, has been suggested to be involved in the pathogenesis of AD. In addition to its pro-infl...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章,评审

    doi:10.2174/156720507783018217

    authors: Tobinick E

    更新日期:2007-12-01 00:00:00

  • Episodic memory impairment in frontotemporal dementia; a ⁹⁹mTc- HMPAO SPECT study.

    abstract::Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the most common types of dementia in the presenile population. Episodic memory impairment, the clinical hallmark of AD, can also be encountered in patients with FTD, complicating accurate diagnosis. Several studies in FTD have correlated memory deficits wi...

    journal_title:Current Alzheimer research

    pub_type: 杂志文章

    doi:10.2174/1567205011310030013

    authors: Papma JM,Seelaar H,de Koning I,Hasan D,Reijs A,Valkema R,Prins ND,van Swieten JC

    更新日期:2013-03-01 00:00:00