An Optimal Approach for Selecting Discriminant Regions for the Diagnosis of Alzheimer's Disease.

abstract：BACKGROUND:In recent years, 5-hydroxytryptamine subtype 6 receptor (5-HT6 receptor, 5- HT6R) has emerged as a promising therapeutic target for the treatment of neuropathological disorders, including Alzheimer's disease (AD) and schizophrenia. 5-HT6 receptors were hypothesized to be implicated in the processes of learni...

journal_title：Current Alzheimer research

authors： Ivachtchenko AV,Ivanenkov YA,Veselov MS,Okun IM

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The Montreal Cognitive Assessment (MoCA) test has high sensitivity and specificity for detecting mild cognitive impairment or early dementia. How the MoCA score relates to findings of positron emission tomography imaging, however, remains unclear. OBJECTIVE:This prospective study examined the relationship b...

journal_title：Current Alzheimer research

authors： Eguchi A,Kimura N,Aso Y,Yabuuchi K,Ishibashi M,Hori D,Sasaki Y,Nakamichi A,Uesugi S,Jikumaru M,Sumi K,Shimomura T,Matsubara E

更新日期：2019-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is one of the most common causes of dementia. Despite several decades of research in AD, there is no standard disease- modifying therapy available and currentlyapproved drugs provide only symptomatic relief. Stem cells hold immense potential to regenerate damaged tissues and are currently test...

journal_title：Current Alzheimer research

authors： Bali P,Lahiri DK,Banik A,Nehru B,Anand A

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES:REM sleep behavior disorder (RBD), with its main clinical symptoms of nightmares with dream-enacting behavior, is considered as a possible precursor of neurodegenerative disease. Obstructive Sleep Apnea Syndrome (OSAS) is known to be capable of provoking RBD-like symptoms by apneic event related arousals. Th...

journal_title：Current Alzheimer research

authors： Schaefer C,Kunz D,Bes F

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:It is well known that alterations in astrocytes occur in Alzheimer's disease and reactive astrogliosis is one of the hallmarks of the disease. Recently, data has emerged that suggests that alterations in astrocytes may also occur early in the pathogenesis of the disease. OBJECTIVE:The aim of present work wa...

journal_title：Current Alzheimer research

authors： Ruffinatti F,Tapella L,Gregnanin I,Stevano A,Chiorino G,Canonico PL,Distasi C,Genazzani AA,Lim D

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The lack of diagnostic tools and disease-modifying treatments against Alzheimer's disease (AD) and related disorders, collectively known as tauopathies, has led to a socioeconomic burden of epidemic proportion. Proteomics approaches can be used to identify novel proteome changes that could help us understand...

journal_title：Current Alzheimer research

authors： Vega IE,Umstead A,Wygant CM,Beck JS,Counts SE

更新日期：2018-01-01 00:00:00

abstract：:To search for potential mechanism that might alter synaptic transmission following Abeta increase we have examined the presynaptic component of transmitter release. As parameters of synaptic transmission that might underlie presynaptic mechanisms, we have used paired-pulse facilitation (PPF), post-tetanic potentiation...

journal_title：Current Alzheimer research

authors： Zhang H,Gong B,Liu S,Fa' M,Ninan I,Staniszewski A,Arancio O

更新日期：2005-04-01 00:00:00

abstract：:Based on the amyloid hypothesis, studies for AD therapy have been mostly focused on removing β-amyloid. Recent results of amyloid immunotherapy raised the question whether β-amyloid is sufficient target for AD therapy. Neurofibrillary tangles (NFTs), which contain hyperphosphorylated tau, are another pathological hall...

journal_title：Current Alzheimer research

authors： Takashima A

更新日期：2010-12-01 00:00:00

abstract：:Recent studies have shown that the translocase of outer mitochondrial membrane 40 homolog (TOMM40) contains a polymorphic poly-T variant, the long variant of which is associated with an increase in AD incidence among APOE 3 carriers. Current methods to isotype the poly-T region rely on long PCR, subcloning and sequenc...

journal_title：Current Alzheimer research

authors： Greco SJ,Hamzelou A,Johnston JM,Richardson S,Smith MA,Perry G,Ashford JW,Tezapsidis N

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Accumulating evidence suggests that multi-target directed ligands have great potential for the treatment of complex diseases such as Alzheimer's Disease (AD). OBJECTIVE:To evaluate novel chimeric 8-hydroxyquinoline ligands with merged pharmacophores as potential multifunctional ligands for AD. METHODS:Nitr...

journal_title：Current Alzheimer research

authors： Knez D,Sosič I,Pišlar A,Mitrović A,Jukič M,Kos J,Gobec S

更新日期：2019-01-01 00:00:00

abstract：:High levels of cholesterol have been proposed as a risk factor for Alzheimer's disease (AD). Polymorphism of genes encoding proteins that regulate cholesterol metabolism have also been associated with the frequency of Alzheimer's development. Some studies have shown that cholesterol-lowering drugs reduce the frequency...

journal_title：Current Alzheimer research

authors： Vestergaard M,Hamada T,Morita M,Takagi M

更新日期：2010-05-01 00:00:00

abstract：:The marginal division (MrD) is a neostriatum subregion that links the limbic system and basal nucleus of Meynert; it is an important subcortical center that is involved in learning and memory. Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia in the elderly. AD clinically m...

journal_title：Current Alzheimer research

authors： Zhang Z,Liu Y,Zhou B,Zheng J,Yao H,An N,Wang P,Guo Y,Dai H,Wang L,Shu S,Zhang X,Jiang T

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:The longitudinal change of neuropsychological tests (NPTs) in treated Alzheimer's disease (AD) is essential to understand the interplay of a therapeutic response from medication and a disease decline due to degenerative processes. The aim of our study is to investigate the annual cognitive progression as mea...

journal_title：Current Alzheimer research

authors： Yang YH,Wu MN,Chou PS,Su HC,Lin SH,Sung PS

更新日期：2018-03-14 00:00:00

abstract：:Today, the most reliable diagnosis for Alzheimer's disease (AD) is the post mortem identification of amyloid plaques, consisting of the Amyloid-beta (Abeta) peptide, (and neurofibrillary tangles) in the brain of the patient. Great efforts are being made to identify reliable biomarkers for AD that are suitable for mini...

journal_title：Current Alzheimer research

authors： Funke SA,Birkmann E,Willbold D

更新日期：2009-06-01 00:00:00

abstract：:The increasing prevalence of obesity world-wide has an expected consequent increase in diabetes and cardiovascular disease. Less attention has been paid to the effect of obesity on dementia. This overview discusses methodological issues related to the epidemiologic study of obesity and dementia, reviews results of lon...

journal_title：Current Alzheimer research

authors： Barrett-Connor E

更新日期：2007-04-01 00:00:00

abstract：:Differential diagnosis of AD is still a challenge due to overlapping features with other types of dementia. Biomarkers for the differential diagnosis of AD can improve the diagnostic value of the disease and ensure an appropriate treatment of patients. The aim of this study was to evaluate the potential of two neo-epi...

journal_title：Current Alzheimer research

authors： Inekci D,Henriksen K,Linemann T,Karsdal MA,Habib A,Bisgaard C,Eriksen FB,Vilholm OJ

更新日期：2015-01-01 00:00:00

abstract：:The aetiology of major neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) is still unknown, but increasing evidences suggest that glutamate and mitochondria are two prominent players in the oxidative stress (OS) process that underlie these illnesses. Although AD and PD have distin...

journal_title：Current Alzheimer research

authors： Cassano T,Pace L,Bedse G,Lavecchia AM,De Marco F,Gaetani S,Serviddio G

更新日期：2016-01-01 00:00:00

abstract：:In this review, the basic mechanism of the parasympathetic nervous effect on the heart is discussed. This is expanded to clinical situations to clarify what can happen to patients after cholinesterase (ChE) inhibitor is administered and to avoid unnecessary adverse effects. The parasympathetic nervous system can affec...

journal_title：Current Alzheimer research

authors： Masuda Y

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by a multi-factorial etiology that is not completely understood. Donepezil is a first-line acetylcholinesterase inhibitor used for the treatment of AD that has been found, in addition to its potent acetylcholinesterase inhibitory ...

journal_title：Current Alzheimer research

authors： Wan L,Lu J,Fu J,Huang J,Yang Q,Xin B,Chen L,Huo Y,Zhong Y,Guo C

更新日期：2018-01-01 00:00:00

abstract：:Rodents housed in an enriched environment, exercise by running or perform learning and memory tasks show an increase in hippocampal neurogenesis. We show that both environmental enrichment, as well as performance in the Morris water maze, a hippocampal-dependent learning task, leads to an increase in local VEGF expres...

journal_title：Current Alzheimer research

authors： During MJ,Cao L

更新日期：2006-02-01 00:00:00

abstract：:The aggregation of the microtubule-associated protein tau into paired-helical filaments is the defining characteristic of the tauopathies. It has become apparent that the hyperphosphorylation of tau likely plays a role in the aggregation process and thus strategies to reduce tau phosphorylation are generating wide int...

journal_title：Current Alzheimer research

authors： Yuzwa SA,Vocadlo DJ

更新日期：2009-10-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by mental and cognitive problems, particularly with memory, language, visuospatial skills (VS), and executive functions (EF). Advances in the neuroimaging of AD have highlighted dysfunctions in functional connectivity networks (FCNs), especially in the memory related default m...

journal_title：Current Alzheimer research

authors： Weiler M,Fukuda A,Massabki LH,Lopes TM,Franco AR,Damasceno BP,Cendes F,Balthazar ML

更新日期：2014-03-01 00:00:00

abstract：:Deterioration of the cortical cholinergic system is a leading neurochemical feature of Alzheimer's Disease (AD). This review summarizes evidence that the homomeric α7- nicotinic acetylcholine receptor (nAChR) plays a crucial role in the pathogenesis of this disease, which is characterized by amyloid-β (Aβ) accumulatio...

journal_title：Current Alzheimer research

authors： Oz M,Lorke DE,Yang KH,Petroianu G

更新日期：2013-07-01 00:00:00

abstract：:The remarkable potentiality of bone marrow-derived mesenchymal stem cells (BM-MSCs) after transplantation to models of neurological disease and injury has been described. We have previously published data confirming the influence of BM-MSCs on β-amyloid (Aβ) deposition in an Alzheimer's disease (AD) mouse model. Howev...

journal_title：Current Alzheimer research

authors： Bae JS,Jin HK,Lee JK,Richardson JC,Carter JE

更新日期：2013-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder linked to protein misfolding and aggregation. AD is pathologically characterized by senile plaques formed by extracellular Amyloid-β (Aβ) peptide and Intracellular Neurofibrillary Tangles (NFT) formed by hyperphosphorylated tau protein. Extensive synaptic loss a...

journal_title：Current Alzheimer research

authors： Pinheiro L,Faustino C

更新日期：2019-01-01 00:00:00

abstract：:Metabolic syndrome (MetS), i.e., meeting criteria for any three of the following: hyperglycemia, hypertension, hypertriglyceridemia, low high-density lipoprotein and/or abdominal obesity, is associated with negative health outcomes. For example, MetS negatively impacts cognition; however, less is known about increment...

journal_title：Current Alzheimer research

authors： Lamar M,Rubin LH,Ajilore O,Charlton R,Zhang A,Yang S,Cohen J,Kumar A

更新日期：2015-01-01 00:00:00

abstract：:At present, the search for preventive strategies for cognitive decline and dementia appears to be of crucial importance, given that the therapeutic options currently available have demonstrated limited efficacy. Cumulative epidemiological evidence suggested that vascular and vascular-related factors may be important f...

journal_title：Current Alzheimer research

authors： Panza F,Frisardi V,Seripa D,Imbimbo BP,Sancarlo D,D'Onofrio G,Addante F,Paris F,Pilotto A,Solfrizzi V

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that eventually leads to severe cognitive impairment. Although the exact etiologies of AD still remain elusive, increasing evidence suggests that neuroinflammation cascades mediated by microglial cells are associated with AD. Piper sarme...

journal_title：Current Alzheimer research

authors： Chan EWL,Yeo ETY,Wong KWL,See ML,Wong KY,Gan SY

更新日期：2019-01-01 00:00:00

abstract：:Pathological remodelling of astroglia represents an important component of the pathogenesis of Alzheimer's disease (AD). In AD astrocytes undergo both atrophy and reactivity; which may be specific for different stages of the disease evolution. Astroglial reactivity represents the generic defensive mechanism, and inhib...

journal_title：Current Alzheimer research

authors： Lim D,Rodríguez-Arellano JJ,Parpura V,Zorec R,Zeidán-Chuliá F,Genazzani AA,Verkhratsky A

更新日期：2016-01-01 00:00:00

abstract：:Rigorous scientific research has identified multiple interactive mechanisms that parallel and are likely causative of the development of Alzheimer's disease (AD). Causative mechanisms include genomics, the creation of amyloid beta (Abeta), factors inhibiting the Abeta removal process, the transformation of Abeta to it...

journal_title：Current Alzheimer research

authors： Standridge JB

更新日期：2006-04-01 00:00:00