Perispinal etanercept for treatment of Alzheimer's disease.

abstract：:Rigorous scientific research has identified multiple interactive mechanisms that parallel and are likely causative of the development of Alzheimer's disease (AD). Causative mechanisms include genomics, the creation of amyloid beta (Abeta), factors inhibiting the Abeta removal process, the transformation of Abeta to it...

journal_title：Current Alzheimer research

authors： Standridge JB

更新日期：2006-04-01 00:00:00

abstract：:Recent studies of Alzheimer's disease (AD) and other neuropsychiatric drug developments raise questions whether failures of some drugs occur due to flaws in methods. In three case studies of recent AD drug development failures with phenserine, metrifonate, and tarenflurbil we identified methodological lapses able to a...

journal_title：Current Alzheimer research

authors： Becker RE,Greig NH

更新日期：2010-11-01 00:00:00

abstract：:The use of natural compounds is an interesting stratagem in the search of drugs with therapeutic potential for the treatment of Alzheimer's disease (AD). We report here the effect of the hyperforin derivative (IDN5706, tetrahydrohyperforin), a semi-synthetic derivative of the St. John's Wort, on the brain neuropatholo...

journal_title：Current Alzheimer research

authors： Cerpa W,Hancke JL,Morazzoni P,Bombardelli E,Riva A,Marin PP,Inestrosa NC

更新日期：2010-03-01 00:00:00

abstract：:CATIE-AD was a multicenter effectiveness trial of atypical antipsychotics in patients with agitation and psychosis associated with AD who resided in the community. The study enrolled 421 participants. In this paper we present and discuss baseline characteristics of participants (demographics, cognitive, behavioral, an...

journal_title：Current Alzheimer research

authors： Ismail MS,Dagerman K,Tariot PN,Abbott S,Kavanagh S,Schneider LS

更新日期：2007-07-01 00:00:00

abstract：:Alzheimer's disease (AD) is one of the most common causes of dementia. Despite several decades of research in AD, there is no standard disease- modifying therapy available and currentlyapproved drugs provide only symptomatic relief. Stem cells hold immense potential to regenerate damaged tissues and are currently test...

journal_title：Current Alzheimer research

authors： Bali P,Lahiri DK,Banik A,Nehru B,Anand A

更新日期：2017-01-01 00:00:00

abstract：:Identification of genes and pathways that alter lifespan has allowed for new insights into factors that control the aging process as well as disease. While strong molecular links exist between aging and metabolism, we hypothesize that targeting the mechanisms involved in aging will also give rise to therapeutics that ...

journal_title：Current Alzheimer research

authors： DiStefano PS,Curtis R,Geddes BJ

更新日期：2007-04-01 00:00:00

abstract：:Despite the known validity of clinical diagnostic criteria, significant overlap of clinical symptoms between Frontotemporal dementia (FTD) subtypes exists in several cases, resulting in great uncertainty of the diagnostic boundaries. We evaluated the perfusion between FTD subtypes using brain perfusion (99m)Tc-HMPAO S...

journal_title：Current Alzheimer research

authors： Valotassiou V,Papatriantafyllou J,Sifakis N,Tzavara C,Tsougos I,Psimadas D,Kapsalaki E,Fezoulidis I,Hadjigeorgiou G,Georgoulias P

更新日期：2014-01-01 00:00:00

abstract：:Lipids have many important yet distinct functions in cellular homeostasis such as forming an impermeable barrier separating intracellular and extracellular compartments, providing a matrix for the appropriate interactions of membrane-associated proteins, and serving as storage reservoirs for biologically active second...

journal_title：Current Alzheimer research

authors： Han X

更新日期：2005-01-01 00:00:00

abstract：:Evidence from basic molecular biology has noted a critical role of GSK-3 in Alzheimer's disease (AD) pathogenesis such as beta-amyloid (Aβ) production and accumulation, the formation of neurofibrillary tangle (NFT), and neuronal degeneration. Aβ generation and deposition represents a key feature and is generated from ...

journal_title：Current Alzheimer research

authors： Cai Z,Zhao Y,Zhao B

更新日期：2012-09-01 00:00:00

abstract：:Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the most common types of dementia in the presenile population. Episodic memory impairment, the clinical hallmark of AD, can also be encountered in patients with FTD, complicating accurate diagnosis. Several studies in FTD have correlated memory deficits wi...

journal_title：Current Alzheimer research

authors： Papma JM,Seelaar H,de Koning I,Hasan D,Reijs A,Valkema R,Prins ND,van Swieten JC

更新日期：2013-03-01 00:00:00

abstract：:With a longer life expectancy and an increased prevalence of neurodegenerative diseases, investigations on trajectories of cognitive aging have become exciting and promising. This study aimed to estimate the patterns of age-related cognitive decline and the potential associated factors of cognitive function in communi...

journal_title：Current Alzheimer research

authors： Li H,Lv C,Zhang T,Chen K,Chen C,Gai G,Hu L,Wang Y,Zhang Z

更新日期：2014-01-01 00:00:00

abstract：:High levels of cholesterol have been proposed as a risk factor for Alzheimer's disease (AD). Polymorphism of genes encoding proteins that regulate cholesterol metabolism have also been associated with the frequency of Alzheimer's development. Some studies have shown that cholesterol-lowering drugs reduce the frequency...

journal_title：Current Alzheimer research

authors： Vestergaard M,Hamada T,Morita M,Takagi M

更新日期：2010-05-01 00:00:00

abstract：:Differential diagnosis of AD is still a challenge due to overlapping features with other types of dementia. Biomarkers for the differential diagnosis of AD can improve the diagnostic value of the disease and ensure an appropriate treatment of patients. The aim of this study was to evaluate the potential of two neo-epi...

journal_title：Current Alzheimer research

authors： Inekci D,Henriksen K,Linemann T,Karsdal MA,Habib A,Bisgaard C,Eriksen FB,Vilholm OJ

更新日期：2015-01-01 00:00:00

abstract：:Heme is essential for the survival of most organisms, despite the fact of being potentially toxic. This dual effect is due to the ability of the iron (Fe) atom contained within the protoporphyrin ring of the heme molecule to participate in redox reactions and exchange electrons with a variety of substrates. Therefore,...

journal_title：Current Alzheimer research

authors： Gozzelino R

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the diagnostic accuracy and clinical usability of a Dutch translation of the Test Your Memory (TYM) test in patients with mild cognitive impairment (MCI) and dementia as compared to the Mini-Mental State Examination (MMSE), in the setting of the memory clinic of a general...

journal_title：Current Alzheimer research

authors： van de Zande E,van de Nes JC,Jansen I,van den Berg MN,Zwart AF,Bimmel D,Rijkers GT,Andringa G

更新日期：2017-01-01 00:00:00

abstract：:The first reports of disorders that in terms of cognitive and behavioral symptoms resemble frontotemporal dementia (FTD) and in terms of motor symptoms resemble amyotrophic lateral sclerosis (ALS) bring us back to the second half of the 1800s. Over the last 150 years, and especially in the last two decades, there has ...

journal_title：Current Alzheimer research

authors： Ferrari R,Kapogiannis D,Huey ED,Momeni P

更新日期：2011-05-01 00:00:00

abstract：:In this study, we aimed to classify MR images for recognizing Alzheimer Disease (AD) in a group of patients who were recently diagnosed by clinical history and neuropsychiatric exams by using non-biased machine-learning techniques. T1 weighted MRI scans of 31 patients with probable AD and 31 age- and gender-matched co...

journal_title：Current Alzheimer research

authors： Polat F,Demirel SO,Kitis O,Simsek F,Haznedaroglu DI,Coburn K,Kumral E,Gonul AS

更新日期：2012-09-01 00:00:00

abstract：:The currently available experimental data supports the hypothesis that the neuroprotective effect of dimebon is related to the protection of the brain-mitochondria from neurodegeneration. In this study, the influence of dimebon on mitochondria was investigated to gain a better understanding of the neuroprotective effe...

journal_title：Current Alzheimer research

authors： Shevtsova EF,Vinogradova DV,Kireeva EG,Reddy VP,Aliev G,Bachurin SO

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:There is a growing body of pre-clinical evidence suggesting that lithium (Li) may protect neurons from a range of neurotoxic insults, hence the term neuroprotective effects. Does Li have similar effects also in human subjects? METHODS:We reviewed the neuroimaging literature investigating the association bet...

journal_title：Current Alzheimer research

authors： Hajek T,Weiner MW

更新日期：2016-01-01 00:00:00

abstract：:Alzheimer's disease is a neurodegenerative disorder characterized by amyloid deposits and neurofibrillary tangles. Cholinergic dysfunction is also a main pathological feature of the disease. Nevertheless, the links between cholinergic dysfunction and neuropathological hallmarks of Alzheimer's are still unknown. In the...

journal_title：Current Alzheimer research

authors： Belarbi K,Schindowski K,Burnouf S,Caillierez R,Grosjean ME,Demeyer D,Hamdane M,Sergeant N,Blum D,Buée L

更新日期：2009-04-01 00:00:00

abstract：:Early diagnosis of Alzheimer`s disease (AD) is currently difficult and involves a complex approach including clinical assessment, neuroimaging, and measurement of amyloid-β (Aβ) and tau levels in cerebrospinal fluid (CSF). A better mechanistic understanding is needed to develop more accurate and even presymptomatic di...

journal_title：Current Alzheimer research

authors： Skachokova Z,Sprenger F,Breu K,Abramowski D,Clavaguera F,Hench J,Staufenbiel M,Tolnay M,Winkler DT

更新日期：2015-01-01 00:00:00

abstract：:Amyloid oligomers have a critical function in the pathologic processes of various amyloidoses, such as Alzheimer's disease (AD), Parkinson disease (PD), Huntington's disease, prion-related diseases, type 2 diabetes, and hereditary renal amyloidosis. Our previous reports demonstrated that a conformation-dependent oligo...

journal_title：Current Alzheimer research

authors： Zhao M,Wang SW,Wang YJ,Zhang R,Li YN,Su YJ,Zhou WW,Yu XL,Liu RT

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:It is well known that alterations in astrocytes occur in Alzheimer's disease and reactive astrogliosis is one of the hallmarks of the disease. Recently, data has emerged that suggests that alterations in astrocytes may also occur early in the pathogenesis of the disease. OBJECTIVE:The aim of present work wa...

journal_title：Current Alzheimer research

authors： Ruffinatti F,Tapella L,Gregnanin I,Stevano A,Chiorino G,Canonico PL,Distasi C,Genazzani AA,Lim D

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Accumulating evidence suggests that multi-target directed ligands have great potential for the treatment of complex diseases such as Alzheimer's Disease (AD). OBJECTIVE:To evaluate novel chimeric 8-hydroxyquinoline ligands with merged pharmacophores as potential multifunctional ligands for AD. METHODS:Nitr...

journal_title：Current Alzheimer research

authors： Knez D,Sosič I,Pišlar A,Mitrović A,Jukič M,Kos J,Gobec S

更新日期：2019-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is currently the most prominent form of dementia among the elderly. Although AD manifests in late adult life, it is not clear when the disease actually starts and how long the neuropathological processes take to develop AD. The major unresolved question is the timing and the nature of triggeri...

journal_title：Current Alzheimer research

authors： Lahiri DK,Maloney B,Basha MR,Ge YW,Zawia NH

更新日期：2007-04-01 00:00:00

abstract：:Mutations in the presenilin genes cause the majority of early-onset familial Alzheimer’s disease. Recently, presenilin mutations have been identified in patients with dilated cardiomyopathy (DCM), a common cause of heart failure and the most prevalent diagnosis in cardiac transplantation patients. However, the molecul...

journal_title：Current Alzheimer research

authors： Li A,Zhou C,Moore J,Zhang P,Tsai TH,Lee HC,Romano DM,McKee ML,Schoenfeld DA,Serra MJ,Raygor K,Cantiello HF,Fujimoto JG,Tanzi RE

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Previous work designed a network-based protocol of cognitive training. This programme exploits a mechanism of induced task-oriented co-activation of multiple regions that are part of the default mode network (DMN), to induce functional rewiring and increased functional connectivity within this network. OBJE...

journal_title：Current Alzheimer research

authors： De Marco M,Meneghello F,Pilosio C,Rigon J,Venneri A

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:To carry out meaningful comparisons on results of different research studies on mild cognitive impairment (MCI), it is critical to select an appropriate objective memory test to examine memory deficit. We aim to refine the operational criteria of amnestic MCI (aMCI) on neuropsychological tests that optimally ...

journal_title：Current Alzheimer research

authors： Zhao Q,Guo Q,Liang X,Chen M,Zhou Y,Ding D,Hong Z

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:Memory evaluation is a key component in the accurate diagnosis of cognitive disorders.One memory procedure that has shown promise in discriminating disease-related cognitive decline from normal cognitive aging is the New York University Paragraph Recall Test; however, the effects of education have been unexa...

journal_title：Current Alzheimer research

authors： Mathews M,Abner E,Caban-Holt A,Dennis BC,Kryscio R,Schmitt F

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:In recent years, 5-hydroxytryptamine subtype 6 receptor (5-HT6 receptor, 5- HT6R) has emerged as a promising therapeutic target for the treatment of neuropathological disorders, including Alzheimer's disease (AD) and schizophrenia. 5-HT6 receptors were hypothesized to be implicated in the processes of learni...

journal_title：Current Alzheimer research

authors： Ivachtchenko AV,Ivanenkov YA,Veselov MS,Okun IM

更新日期：2017-01-01 00:00:00