Abstract:
:From a clinical as well as a neuropathological point of view Alzheimer's disease (AD) has been the focus of intense research for more than three decades. Most studies to identify morphometric correlates with the declining cognitive function in normal aging and AD have employed semi-quantitative methods to assess neuropathological markers such as neurofibrillary tangles, senile plaques, neuronal, or glial cell densities, and neuron sizes. To this end, many cell counting methods have employed two-dimensional designs in single sections, yielding estimates of cell numbers either as neuron densities (number of cell profiles per area) or estimates of the size distribution of neuron profiles in columns vertical to the cortical surface. This approach gives rise to difficulties in interpretation because of the three-dimensional size, shape, and orientation of the counted cells, and the effect of shrinkage artifacts. Modern stereological techniques offer a more rigorous approach for quantifying neuropathological changes associated with aging and degenerative disease. However the stereological studies also suffer from the limitations of high biological variability in AD-type neuropathology, and the relative scarcity of autopsied brains from well-studied non-demented comparison subjects. As a result, the clinicopathological associations between neuropathology and indices of cognitive performance in aging and AD are not yet firmly established. The requirement for the proper description of morphologic neuropathology of AD is clear: any macroscopic or microscopic abnormalities, are subtle and must consequently be demonstrated reproducibly in well-controlled studies. In this review we try to evaluate which, if any, of the contemporary claims for morphometric brain abnormalities in AD can be said to be well established, with special emphasis placed on human stereological post-mortal studies.
journal_name
Curr Alzheimer Resjournal_title
Current Alzheimer researchauthors
Stark AK,Pelvig DP,Jørgensen AM,Andersen BB,Pakkenberg Bdoi
10.2174/156720505774330528keywords:
subject
Has Abstractpub_date
2005-10-01 00:00:00pages
449-81issue
4eissn
1567-2050issn
1875-5828journal_volume
2pub_type
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journal_title:Current Alzheimer research
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journal_title:Current Alzheimer research
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journal_title:Current Alzheimer research
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journal_title:Current Alzheimer research
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更新日期:2013-07-01 00:00:00
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journal_title:Current Alzheimer research
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journal_title:Current Alzheimer research
pub_type: 杂志文章,随机对照试验
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journal_title:Current Alzheimer research
pub_type: 杂志文章
doi:10.2174/1567205015666180123122637
更新日期:2018-01-01 00:00:00
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更新日期:2014-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-07-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
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更新日期:2018-02-22 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
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journal_title:Current Alzheimer research
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更新日期:2012-12-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,收录出版
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2014-01-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
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更新日期:2008-02-01 00:00:00
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更新日期:2017-01-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00