Neuropsychiatric Disturbances in Mild Cognitive Impairment (MCI): A Systematic Review of Population-Based Studies.

abstract：:In this review, the basic mechanism of the parasympathetic nervous effect on the heart is discussed. This is expanded to clinical situations to clarify what can happen to patients after cholinesterase (ChE) inhibitor is administered and to avoid unnecessary adverse effects. The parasympathetic nervous system can affec...

journal_title：Current Alzheimer research

authors： Masuda Y

更新日期：2004-11-01 00:00:00

abstract：:The serine hydrolase butyrylcholinesterase (BChE), like the related enzyme acetylcholinesterase (AChE), co-regulates metabolism of the neurotransmitter acetylcholine. In the human brain BChE is mainly expressed in white matter and glia and in distinct populations of neurons in regions that are important in cognition a...

journal_title：Current Alzheimer research

authors： Darvesh S

更新日期：2016-01-01 00:00:00

abstract：:In the present study we set up a model of slow progression of neuronal injury by exposing organotypic hippocampal cultures to a low concentration of Amyloid β (25-35) peptide (Aβ, 2 μM) to analyze the time-related effects of 17-β estradiol (17β-E2, 10 nM). Neuronal death occurs after 7 d and is prevented by addition o...

journal_title：Current Alzheimer research

authors： Merlo S,Spampinato SF,Capani F,Sortino MA

更新日期：2016-01-01 00:00:00

abstract：:Elevated amyloid-beta peptide (Abeta) and loss of nicotinic acetylcholine receptors (nAChRs) stand prominently in the etiology of Alzheimer's disease (AD). Since the discovery of an Abeta - nAChR interaction, much effort has been expended to characterize the consequences of high versus low concentrations of Abeta on n...

journal_title：Current Alzheimer research

authors： Parri RH,Dineley TK

更新日期：2010-02-01 00:00:00

abstract：:At present, the search for preventive strategies for cognitive decline and dementia appears to be of crucial importance, given that the therapeutic options currently available have demonstrated limited efficacy. Cumulative epidemiological evidence suggested that vascular and vascular-related factors may be important f...

journal_title：Current Alzheimer research

authors： Panza F,Frisardi V,Seripa D,Imbimbo BP,Sancarlo D,D'Onofrio G,Addante F,Paris F,Pilotto A,Solfrizzi V

更新日期：2011-08-01 00:00:00

abstract：:Differential diagnosis of AD is still a challenge due to overlapping features with other types of dementia. Biomarkers for the differential diagnosis of AD can improve the diagnostic value of the disease and ensure an appropriate treatment of patients. The aim of this study was to evaluate the potential of two neo-epi...

journal_title：Current Alzheimer research

authors： Inekci D,Henriksen K,Linemann T,Karsdal MA,Habib A,Bisgaard C,Eriksen FB,Vilholm OJ

更新日期：2015-01-01 00:00:00

abstract：:To search for potential mechanism that might alter synaptic transmission following Abeta increase we have examined the presynaptic component of transmitter release. As parameters of synaptic transmission that might underlie presynaptic mechanisms, we have used paired-pulse facilitation (PPF), post-tetanic potentiation...

journal_title：Current Alzheimer research

authors： Zhang H,Gong B,Liu S,Fa' M,Ninan I,Staniszewski A,Arancio O

更新日期：2005-04-01 00:00:00

abstract：:Amyloid-β protein (Aβ) accumulates in the neurons of Alzheimer's disease (AD) patients at an early stage of the disease. Recently, we found that Aβ with a toxic turn at positions 22 and 23 accumulates in neurons in AD brain. Here, we studied the accumulation of Aβ, toxic turn Aβ and high-molecular-weight Aβ oligomers ...

journal_title：Current Alzheimer research

authors： Soejima N,Ohyagi Y,Nakamura N,Himeno E,Iinuma KM,Sakae N,Yamasaki R,Tabira T,Murakami K,Irie K,Kinoshita N,LaFerla FM,Kiyohara Y,Iwaki T,Kira J

更新日期：2013-01-01 00:00:00

abstract：:Despite the known validity of clinical diagnostic criteria, significant overlap of clinical symptoms between Frontotemporal dementia (FTD) subtypes exists in several cases, resulting in great uncertainty of the diagnostic boundaries. We evaluated the perfusion between FTD subtypes using brain perfusion (99m)Tc-HMPAO S...

journal_title：Current Alzheimer research

authors： Valotassiou V,Papatriantafyllou J,Sifakis N,Tzavara C,Tsougos I,Psimadas D,Kapsalaki E,Fezoulidis I,Hadjigeorgiou G,Georgoulias P

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by a multi-factorial etiology that is not completely understood. Donepezil is a first-line acetylcholinesterase inhibitor used for the treatment of AD that has been found, in addition to its potent acetylcholinesterase inhibitory ...

journal_title：Current Alzheimer research

authors： Wan L,Lu J,Fu J,Huang J,Yang Q,Xin B,Chen L,Huo Y,Zhong Y,Guo C

更新日期：2018-01-01 00:00:00

abstract：:Serum levels of β-amyloid (Aβ) peptides may represent an early biomarker in the diagnosis of Alzheimer's disease (AD). In the present study, we investigated the temporal kinetic changes in the levels of serum Aβ 1-42 and 40 in an amyloid precursor protein (APP)/presenilin (PS)1 double transgenic mouse model of AD. Ser...

journal_title：Current Alzheimer research

authors： He J,Qiao JP,Zhu S,Xue M,Chen W,Wang X,Tempier A,Huang Q,Kong J,Li XM

更新日期：2013-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the fourth leading cause of death in the United States and most common cause of adult-onset dementia. The major hallmarks of AD are the formation of senile amyloid plaques made of beta amyloid and neurofibrillary tangles (NFT) which are primarily...

journal_title：Current Alzheimer research

authors： Sarkar S,Raymick J,Ray B,Lahiri DK,Paule MG,Schmued L

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Vascular disease is associated with increased risk of dementia. Vascular health worsens with age. We investigated the relationship between self-reported vascular disease and brain pathology. METHODS:Brain donations to the population-based MRC Cognitive Function and Ageing Study (n=456, age range 66-103 year...

journal_title：Current Alzheimer research

authors： Richardson K,Stephan BC,Ince PG,Brayne C,Matthews FE,Esiri MM

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:The lack of diagnostic tools and disease-modifying treatments against Alzheimer's disease (AD) and related disorders, collectively known as tauopathies, has led to a socioeconomic burden of epidemic proportion. Proteomics approaches can be used to identify novel proteome changes that could help us understand...

journal_title：Current Alzheimer research

authors： Vega IE,Umstead A,Wygant CM,Beck JS,Counts SE

更新日期：2018-01-01 00:00:00

abstract：:The aetiology of major neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) is still unknown, but increasing evidences suggest that glutamate and mitochondria are two prominent players in the oxidative stress (OS) process that underlie these illnesses. Although AD and PD have distin...

journal_title：Current Alzheimer research

authors： Cassano T,Pace L,Bedse G,Lavecchia AM,De Marco F,Gaetani S,Serviddio G

更新日期：2016-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is currently the most prominent form of dementia among the elderly. Although AD manifests in late adult life, it is not clear when the disease actually starts and how long the neuropathological processes take to develop AD. The major unresolved question is the timing and the nature of triggeri...

journal_title：Current Alzheimer research

authors： Lahiri DK,Maloney B,Basha MR,Ge YW,Zawia NH

更新日期：2007-04-01 00:00:00

abstract：:Apoptosis has been postulated to play a possible causal role in the onset of Alzheimer's disease due to shortage of trophic supply, deafferentation and excessive production of free radicals. Many experiments in the past have demonstrated the requirement of de novo gene expression during neuronal apoptosis. In view of ...

journal_title：Current Alzheimer research

authors： Cavallaro S,Calissano P

更新日期：2006-09-01 00:00:00

abstract：:The field of aging and dementia research is advancing rapidly toward the stage of earlier identification of clinical symptoms. Ultimately, clinicians would like to be able to identify individuals who are asymptomatic but at risk for developing dementia. In the interim, the construct of mild cognitive impairment (MCI) ...

journal_title：Current Alzheimer research

authors： Petersen RC

更新日期：2009-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common diagnosis among dementia. As increasing longevity results in larger numbers of AD patients and thus rising economic costs, there has been intense research about the pathophysiology and treatment strategies during the last years. Since neurotrophic factors are not only respon...

journal_title：Current Alzheimer research

authors： Schulte-Herbrüggen O,Jockers-Scherübl MC,Hellweg R

更新日期：2008-02-01 00:00:00

abstract：:The use of natural compounds is an interesting stratagem in the search of drugs with therapeutic potential for the treatment of Alzheimer's disease (AD). We report here the effect of the hyperforin derivative (IDN5706, tetrahydrohyperforin), a semi-synthetic derivative of the St. John's Wort, on the brain neuropatholo...

journal_title：Current Alzheimer research

authors： Cerpa W,Hancke JL,Morazzoni P,Bombardelli E,Riva A,Marin PP,Inestrosa NC

更新日期：2010-03-01 00:00:00

abstract：:Accumulating evidence has suggested the involvement of oxidative stress in the pathogenesis of Alzheimer's disease (AD). The main endogenous antioxidant, glutathione (GSH), has been shown to decline with ageing and in several age-related degenerative diseases, including AD. Potential options for replenishing GSH level...

journal_title：Current Alzheimer research

authors： Peter C,Braidy N,Zarka M,Welch J,Bridge W

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that eventually leads to severe cognitive impairment. Although the exact etiologies of AD still remain elusive, increasing evidence suggests that neuroinflammation cascades mediated by microglial cells are associated with AD. Piper sarme...

journal_title：Current Alzheimer research

authors： Chan EWL,Yeo ETY,Wong KWL,See ML,Wong KY,Gan SY

更新日期：2019-01-01 00:00:00

abstract：:At present, the etiology of Alzheimer's disease (AD) is still unclear, but both genetic and non-genetic factors are thought to take part in the etiopathogenesis of AD. Epidemiologic researches revealed that genetic factors played a decisive role in the development of both early-onset AD (EOAD) and late-onset AD (LOAD)...

journal_title：Current Alzheimer research

authors： Jiang T,Yu JT,Tian Y,Tan L

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:The current study aimed to compare the effects of different cholinesterase inhibitors on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities and protein levels, in the cerebrospinal fluid (CSF) of Alzheimer disease (AD) patients. METHODS AND FINDINGS:AD patients aged 50-85 years were ra...

journal_title：Current Alzheimer research

authors： Nordberg A,Darreh-Shori T,Peskind E,Soininen H,Mousavi M,Eagle G,Lane R

更新日期：2009-02-01 00:00:00

abstract：:In this study, we aimed to classify MR images for recognizing Alzheimer Disease (AD) in a group of patients who were recently diagnosed by clinical history and neuropsychiatric exams by using non-biased machine-learning techniques. T1 weighted MRI scans of 31 patients with probable AD and 31 age- and gender-matched co...

journal_title：Current Alzheimer research

authors： Polat F,Demirel SO,Kitis O,Simsek F,Haznedaroglu DI,Coburn K,Kumral E,Gonul AS

更新日期：2012-09-01 00:00:00

abstract：:Rodents housed in an enriched environment, exercise by running or perform learning and memory tasks show an increase in hippocampal neurogenesis. We show that both environmental enrichment, as well as performance in the Morris water maze, a hippocampal-dependent learning task, leads to an increase in local VEGF expres...

journal_title：Current Alzheimer research

authors： During MJ,Cao L

更新日期：2006-02-01 00:00:00

abstract：:Amyloid beta (Aβ) binding alcohol dehydrogenase (ABAD) is a cellular cofactor for promoting (Aβ)-mediated mitochondrial and neuronal dysfunction, and cognitive decline in transgenic Alzheimer's disease (AD) mouse models. Targeting mitochondrial ABAD may represent a novel therapeutic strategy against AD. Here, we repor...

journal_title：Current Alzheimer research

authors： Valaasani KR,Sun Q,Hu G,Li J,Du F,Guo Y,Carlson EA,Gan X,Yan SS

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a neurodegenerative disease characterised by a progressive decline in cognitive function and represents a major healthcare challenge worldwide. Increasing evidence indicates that mitochondrial dysfunction mediated oxidative stress plays a significant role in the pathophysiological...

journal_title：Current Alzheimer research

authors： Chhetri J,King AE,Gueven N

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Life expectancy is increasing all over the world, although neurodegenerative disorders might drastically affect the individual activity of aged people. Of those, Alzheimer's Disease (AD) is one of the most social-cost age-linked diseases of industrialized countries. To date, retinal diseases seem to be more ...

journal_title：Current Alzheimer research

authors： Micera A,Bruno L,Cacciamani A,Rongioletti M,Squitti R

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:Memory evaluation is a key component in the accurate diagnosis of cognitive disorders.One memory procedure that has shown promise in discriminating disease-related cognitive decline from normal cognitive aging is the New York University Paragraph Recall Test; however, the effects of education have been unexa...

journal_title：Current Alzheimer research

authors： Mathews M,Abner E,Caban-Holt A,Dennis BC,Kryscio R,Schmitt F

更新日期：2013-09-01 00:00:00