Functional Activities Questionnaire Items that Best Discriminate and Predict Progression from Clinically Normal to Mild Cognitive Impairment.

abstract：:Accumulating evidence has suggested the involvement of oxidative stress in the pathogenesis of Alzheimer's disease (AD). The main endogenous antioxidant, glutathione (GSH), has been shown to decline with ageing and in several age-related degenerative diseases, including AD. Potential options for replenishing GSH level...

journal_title：Current Alzheimer research

authors： Peter C,Braidy N,Zarka M,Welch J,Bridge W

更新日期：2015-01-01 00:00:00

abstract：:Serum levels of β-amyloid (Aβ) peptides may represent an early biomarker in the diagnosis of Alzheimer's disease (AD). In the present study, we investigated the temporal kinetic changes in the levels of serum Aβ 1-42 and 40 in an amyloid precursor protein (APP)/presenilin (PS)1 double transgenic mouse model of AD. Ser...

journal_title：Current Alzheimer research

authors： He J,Qiao JP,Zhu S,Xue M,Chen W,Wang X,Tempier A,Huang Q,Kong J,Li XM

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:The Alzheimer's Disease Assessment Scale - cognitive subscale (ADAS-cog) is the most widely used cognitive outcome measure in AD trials. Although errors in administration and scoring have been suggested as factors masking accurate estimates and potential effects of treatments, there have been few formal exam...

journal_title：Current Alzheimer research

authors： Schafer K,De Santi S,Schneider LS

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:The design of new heterodimeric dual binding site acetylcholinesterase inhibitors constitutes the main goal-directed to the development of new anticholinesterase agents with the expanded pharmacological profile. Multi-target compounds are usually designed by combining in a hybrid molecule with two or more ph...

journal_title：Current Alzheimer research

authors： Hamulakova S,Janovec L,Soukup O,Jun D,Janockova J,Hrabinova M,Sepsova V,Kuca K

更新日期：2018-01-01 00:00:00

abstract：:A significant body of evidence has accumulated suggesting that individual variation in intellectual ability, whether assessed directly by intelligence tests or indirectly through proxy measures, is related to risk of developing Alzheimer's disease (AD) in later life. Important questions remain unanswered, however, suc...

journal_title：Current Alzheimer research

authors： Yeo RA,Arden R,Jung RE

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:The USA National Task Group (NTG) guidelines advocate the use of an adapted version of Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID) for dementia screening of individuals with Down syndrome (DS) and with other forms of ID (non-DS). OBJECTIVE:In order to meet these ...

journal_title：Current Alzheimer research

authors： Gomiero T,Bertelli M,Deb S,Weger E,Marangoni A,De Bastiani E,Mantesso U,De Vreese LP

更新日期：2017-01-01 00:00:00

abstract：:Lipids have many important yet distinct functions in cellular homeostasis such as forming an impermeable barrier separating intracellular and extracellular compartments, providing a matrix for the appropriate interactions of membrane-associated proteins, and serving as storage reservoirs for biologically active second...

journal_title：Current Alzheimer research

authors： Han X

更新日期：2005-01-01 00:00:00

abstract：:With a longer life expectancy and an increased prevalence of neurodegenerative diseases, investigations on trajectories of cognitive aging have become exciting and promising. This study aimed to estimate the patterns of age-related cognitive decline and the potential associated factors of cognitive function in communi...

journal_title：Current Alzheimer research

authors： Li H,Lv C,Zhang T,Chen K,Chen C,Gai G,Hu L,Wang Y,Zhang Z

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To carry out meaningful comparisons on results of different research studies on mild cognitive impairment (MCI), it is critical to select an appropriate objective memory test to examine memory deficit. We aim to refine the operational criteria of amnestic MCI (aMCI) on neuropsychological tests that optimally ...

journal_title：Current Alzheimer research

authors： Zhao Q,Guo Q,Liang X,Chen M,Zhou Y,Ding D,Hong Z

更新日期：2015-01-01 00:00:00

abstract：:Memory loss is a prominent health concern, second only to heart disease for older individuals. Docosahexaenoic acid (DHA), the principle omega-3 fatty acid in brain and heart, plays an important role in neural and cardiac function. Decreases in plasma DHA are associated with cognitive decline in healthy elderly and Al...

journal_title：Current Alzheimer research

authors： Yurko-Mauro K

更新日期：2010-05-01 00:00:00

abstract：:At present, the search for preventive strategies for cognitive decline and dementia appears to be of crucial importance, given that the therapeutic options currently available have demonstrated limited efficacy. Cumulative epidemiological evidence suggested that vascular and vascular-related factors may be important f...

journal_title：Current Alzheimer research

authors： Panza F,Frisardi V,Seripa D,Imbimbo BP,Sancarlo D,D'Onofrio G,Addante F,Paris F,Pilotto A,Solfrizzi V

更新日期：2011-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is a devastating chronic neurodegenerative disease with currently no available disease modifying treatment. In recent years, the peptide amyloid-beta has been proposed as the major pathogenic force in the development and progression of AD. Microglia, the resident immune and phagocytic cells of...

journal_title：Current Alzheimer research

authors： Schlachetzki JC,Hüll M

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:ACTION, a 24-week, prospective, randomized, parallel-group, double-blind study in patients with severe Alzheimer's disease (AD), demonstrated significant efficacy of 13.3 mg/24 h versus 4.6 mg/24 h rivastigmine patch on the Severe Impairment Battery (SIB) and Alzheimer's Disease Cooperative Study-Activities ...

journal_title：Current Alzheimer research

authors： Grossberg GT,Farlow MR,Meng X,Velting DM

更新日期：2015-01-01 00:00:00

abstract：:Changes in rRNA and rDNA expression have been associated with cellular and organism aging and have been linked to Alzheimer's disease (AD) pathogenesis. In this study, we investigated the mRNA expression of ribosomal genes (28S/18S) and β-amyloid precursor protein (APP) in different post mortem brain tissue regions (t...

journal_title：Current Alzheimer research

authors： Rasmussen L,de Labio RW,Viani GA,Chen E,Villares J,Bertolucci PH,Minett TS,Turecki G,Cecyre D,Drigo SA,Smith MC,Payao SL

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Histaminergic H3 receptors may play a role in modulating cholinergic and monoaminergic neurotransmission. This Phase II study evaluated the efficacy and safety of GSK239512, a highly potent, brain penetrant H3 receptor antagonist as monotherapy treatment for subjects with mild-to-moderate probable Alzheime...

journal_title：Current Alzheimer research

authors： Grove RA,Harrington CM,Mahler A,Beresford I,Maruff P,Lowy MT,Nicholls AP,Boardley RL,Berges AC,Nathan PJ,Horrigan JP

更新日期：2014-01-01 00:00:00

abstract：:Amyloid oligomers have a critical function in the pathologic processes of various amyloidoses, such as Alzheimer's disease (AD), Parkinson disease (PD), Huntington's disease, prion-related diseases, type 2 diabetes, and hereditary renal amyloidosis. Our previous reports demonstrated that a conformation-dependent oligo...

journal_title：Current Alzheimer research

authors： Zhao M,Wang SW,Wang YJ,Zhang R,Li YN,Su YJ,Zhou WW,Yu XL,Liu RT

更新日期：2014-01-01 00:00:00

abstract：:CATIE-AD was a multicenter effectiveness trial of atypical antipsychotics in patients with agitation and psychosis associated with AD who resided in the community. The study enrolled 421 participants. In this paper we present and discuss baseline characteristics of participants (demographics, cognitive, behavioral, an...

journal_title：Current Alzheimer research

authors： Ismail MS,Dagerman K,Tariot PN,Abbott S,Kavanagh S,Schneider LS

更新日期：2007-07-01 00:00:00

abstract：:Alzheimer's disease (AD) is currently the most prominent form of dementia among the elderly. Although AD manifests in late adult life, it is not clear when the disease actually starts and how long the neuropathological processes take to develop AD. The major unresolved question is the timing and the nature of triggeri...

journal_title：Current Alzheimer research

authors： Lahiri DK,Maloney B,Basha MR,Ge YW,Zawia NH

更新日期：2007-04-01 00:00:00

abstract：:Alzheimer's disease is a neurodegenerative disorder characterized by amyloid deposits and neurofibrillary tangles. Cholinergic dysfunction is also a main pathological feature of the disease. Nevertheless, the links between cholinergic dysfunction and neuropathological hallmarks of Alzheimer's are still unknown. In the...

journal_title：Current Alzheimer research

authors： Belarbi K,Schindowski K,Burnouf S,Caillierez R,Grosjean ME,Demeyer D,Hamdane M,Sergeant N,Blum D,Buée L

更新日期：2009-04-01 00:00:00

abstract：:The currently available experimental data supports the hypothesis that the neuroprotective effect of dimebon is related to the protection of the brain-mitochondria from neurodegeneration. In this study, the influence of dimebon on mitochondria was investigated to gain a better understanding of the neuroprotective effe...

journal_title：Current Alzheimer research

authors： Shevtsova EF,Vinogradova DV,Kireeva EG,Reddy VP,Aliev G,Bachurin SO

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Life expectancy is increasing all over the world, although neurodegenerative disorders might drastically affect the individual activity of aged people. Of those, Alzheimer's Disease (AD) is one of the most social-cost age-linked diseases of industrialized countries. To date, retinal diseases seem to be more ...

journal_title：Current Alzheimer research

authors： Micera A,Bruno L,Cacciamani A,Rongioletti M,Squitti R

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a neurodegenerative disease characterised by a progressive decline in cognitive function and represents a major healthcare challenge worldwide. Increasing evidence indicates that mitochondrial dysfunction mediated oxidative stress plays a significant role in the pathophysiological...

journal_title：Current Alzheimer research

authors： Chhetri J,King AE,Gueven N

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The lack of diagnostic tools and disease-modifying treatments against Alzheimer's disease (AD) and related disorders, collectively known as tauopathies, has led to a socioeconomic burden of epidemic proportion. Proteomics approaches can be used to identify novel proteome changes that could help us understand...

journal_title：Current Alzheimer research

authors： Vega IE,Umstead A,Wygant CM,Beck JS,Counts SE

更新日期：2018-01-01 00:00:00

abstract：:Gamma-secretase is a multi-protein complex that proteolyzes the transmembrane region of the amyloid beta-peptide (Abeta) precursor (APP), producing the Abeta peptide implicated in the pathogenesis of Alzheimer's disease (AD). This protease has been a top target for AD, and various inhibitors have been identified, incl...

journal_title：Current Alzheimer research

authors： Wolfe MS

更新日期：2008-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder among the elderly. Nmethyl- D-aspartate receptor (NMDAR) overactivation has been implicated in early synaptic dysfunction that precedes late neurodegeneration in AD. Moreover, oligomers of amyloid-beta peptide (Aβ) 1-42 are considered t...

journal_title：Current Alzheimer research

authors： Mota SI,Ferreira IL,Pereira C,Oliveira CR,Rego AC

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The Montreal Cognitive Assessment (MoCA) test has high sensitivity and specificity for detecting mild cognitive impairment or early dementia. How the MoCA score relates to findings of positron emission tomography imaging, however, remains unclear. OBJECTIVE:This prospective study examined the relationship b...

journal_title：Current Alzheimer research

authors： Eguchi A,Kimura N,Aso Y,Yabuuchi K,Ishibashi M,Hori D,Sasaki Y,Nakamichi A,Uesugi S,Jikumaru M,Sumi K,Shimomura T,Matsubara E

更新日期：2019-01-01 00:00:00

abstract：:A crucial need exists for reliable Alzheimer's disease (AD) diagnostic and prognostic tests. Given its intimate communication with the brain, the cerebrospinal fluid (CSF) has been surveyed intensively for reliable AD biomarkers. The heterogeneity of AD pathology and the unavoidable difficulties associated with the cl...

journal_title：Current Alzheimer research

authors： Maarouf CL,Andacht TM,Kokjohn TA,Castaño EM,Sue LI,Beach TG,Roher AE

更新日期：2009-08-01 00:00:00

abstract：:As the average ages of North Americans and Europeans continue to rise; similarly the incidence of "old age" associated illnesses likewise increases. Most notably among these ailments are conditions linked to dementia-related neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD) and st...

journal_title：Current Alzheimer research

authors： Tweedie D,Sambamurti K,Greig NH

更新日期：2007-09-01 00:00:00

abstract：:Apoptosis has been postulated to play a possible causal role in the onset of Alzheimer's disease due to shortage of trophic supply, deafferentation and excessive production of free radicals. Many experiments in the past have demonstrated the requirement of de novo gene expression during neuronal apoptosis. In view of ...

journal_title：Current Alzheimer research

authors： Cavallaro S,Calissano P

更新日期：2006-09-01 00:00:00

abstract：:Soluble amyloid beta (Abeta) oligomers might trigger early cognitive impairment in Alzheimer's Disease (AD) through the impairment of proper neuronal network function. We have recently shown that the short sequence Abeta(25-35) affects the spontaneous activity in hippocampal slices, when was added to the bath, at high...

journal_title：Current Alzheimer research

authors： Balleza-Tapia H,Huanosta-Gutiérrez A,Márquez-Ramos A,Arias N,Peña F

更新日期：2010-08-01 00:00:00