Abstract:
:Alzheimer's disease is a neurodegenerative disorder characterized by amyloid deposits and neurofibrillary tangles. Cholinergic dysfunction is also a main pathological feature of the disease. Nevertheless, the links between cholinergic dysfunction and neuropathological hallmarks of Alzheimer's are still unknown. In the present study, we aimed to further investigate Tau aggregation in cholinergic systems, in a Tau transgenic mouse model. THY-Tau22 mice have recently been described as a novel model of Alzheimer-like Tau pathology without motor deficits. This strain presents an age-dependent development of Tau pathology leading to synaptic dysfunctions as well as learning and memory impairments. In the present work, we observed that Tau pathology differentially affects cerebral structures. Interestingly, early Tau pathology was observed in both hippocampus and basal forebrain. Moreover, some morphological as well as functional alterations of the septohippocampal pathway suggest a disconnection between these two key brain regions in Alzheimer's disease. Finally, these data suggest that Tau pathology may participate in cholinergic degeneration.
journal_name
Curr Alzheimer Resjournal_title
Current Alzheimer researchauthors
Belarbi K,Schindowski K,Burnouf S,Caillierez R,Grosjean ME,Demeyer D,Hamdane M,Sergeant N,Blum D,Buée Ldoi
10.2174/156720509787602843subject
Has Abstractpub_date
2009-04-01 00:00:00pages
152-7issue
2eissn
1567-2050issn
1875-5828journal_volume
6pub_type
杂志文章abstract::Today, the most reliable diagnosis for Alzheimer's disease (AD) is the post mortem identification of amyloid plaques, consisting of the Amyloid-beta (Abeta) peptide, (and neurofibrillary tangles) in the brain of the patient. Great efforts are being made to identify reliable biomarkers for AD that are suitable for mini...
journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
doi:10.2174/156720509788486536
更新日期:2009-06-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
doi:10.2174/156720509789207967
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pub_type: 杂志文章,评审
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更新日期:2006-12-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 历史文章,杂志文章,评审
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更新日期:2007-07-01 00:00:00
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更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Current Alzheimer research
pub_type: 杂志文章,评审
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abstract:BACKGROUND:The current study aimed to compare the effects of different cholinesterase inhibitors on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities and protein levels, in the cerebrospinal fluid (CSF) of Alzheimer disease (AD) patients. METHODS AND FINDINGS:AD patients aged 50-85 years were ra...
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pub_type: 杂志文章,随机对照试验
doi:10.2174/156720509787313961
更新日期:2009-02-01 00:00:00
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pub_type: 历史文章,杂志文章,评审
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更新日期:2007-09-01 00:00:00
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doi:10.2174/1567205013666160219112712
更新日期:2016-01-01 00:00:00
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更新日期:2006-09-01 00:00:00
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journal_title:Current Alzheimer research
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pub_type: 杂志文章,收录出版
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更新日期:2014-01-01 00:00:00
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更新日期:2010-09-01 00:00:00
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journal_title:Current Alzheimer research
pub_type: 杂志文章
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更新日期:2015-03-24 00:00:00