Calcium signalling toolkits in astrocytes and spatio-temporal progression of Alzheimer's disease.

abstract：:The serine hydrolase butyrylcholinesterase (BChE), like the related enzyme acetylcholinesterase (AChE), co-regulates metabolism of the neurotransmitter acetylcholine. In the human brain BChE is mainly expressed in white matter and glia and in distinct populations of neurons in regions that are important in cognition a...

journal_title：Current Alzheimer research

authors： Darvesh S

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:Centrifuges are the principal means of generating physiological hypergravity and have been used for many medical purposes, including the therapy of psychiatric diseases and evaluation of vestibular system in the pilots. In particular, modern centrifuges have evolved into mechanically sophisticated precision i...

journal_title：Current Alzheimer research

authors： Hashimoto M,Ho G,Shimizu Y,Sugama S,Takenouchi T,Waragai M,Wei J,Takamatsu Y

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Impairment in instrumental activities of daily living (IADL) emerges in the transition from mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia. Some IADL scales are sensitive to early deficits in MCI, but none have been validated for detecting subtle functional changes in clinically normal ...

journal_title：Current Alzheimer research

authors： Marshall GA,Zoller AS,Lorius N,Amariglio RE,Locascio JJ,Johnson KA,Sperling RA,Rentz DM

更新日期：2015-01-01 00:00:00

abstract：:The aggregation of the microtubule-associated protein tau into paired-helical filaments is the defining characteristic of the tauopathies. It has become apparent that the hyperphosphorylation of tau likely plays a role in the aggregation process and thus strategies to reduce tau phosphorylation are generating wide int...

journal_title：Current Alzheimer research

authors： Yuzwa SA,Vocadlo DJ

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Cholinesterase inhibitors are the first line of therapy for the management of Alzheimer's disease (AD), however, it is now established that they provide only temporary and symptomatic relief, besides, having several inherited side-effects. Therefore, an alternative drug discovery method is used to identify n...

journal_title：Current Alzheimer research

authors： Kumar A,Mehta V,Raj U,Varadwaj PK,Udayabanu M,Yennamalli RM,Singh TR

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Curcumin has been of interest in the field of Alzheimer's disease. Early studies on transgenic mice showed promising results in the reduction of amyloid plaques.However, curcumin is very poorly soluble in aqueous solutions and not easily accessible to coupling as it contains only phenolic groups as potential...

journal_title：Current Alzheimer research

authors： Sturzu A,Sheikh S,Kalbacher H,Nägele T,Weidenmaier C,Wegenast-Braun BM,Schilling N,Ernemann U,Heckl S

更新日期：2019-01-01 00:00:00

abstract：:The definite diagnosis of Alzheimer's disease (AD) is based on the detection of beta amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) - which are the pathological hallmarks of the disease- in the postmortem brains. Although regional Cerebral Blood Flow (rCBF) and Cerebral Glucose Metabolism (CGM) abnormalities ...

journal_title：Current Alzheimer research

authors： Valotassiou V,Archimandritis S,Sifakis N,Papatriantafyllou J,Georgoulias P

更新日期：2010-09-01 00:00:00

abstract：:The marginal division (MrD) is a neostriatum subregion that links the limbic system and basal nucleus of Meynert; it is an important subcortical center that is involved in learning and memory. Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia in the elderly. AD clinically m...

journal_title：Current Alzheimer research

authors： Zhang Z,Liu Y,Zhou B,Zheng J,Yao H,An N,Wang P,Guo Y,Dai H,Wang L,Shu S,Zhang X,Jiang T

更新日期：2014-02-01 00:00:00

abstract：:Today, the most reliable diagnosis for Alzheimer's disease (AD) is the post mortem identification of amyloid plaques, consisting of the Amyloid-beta (Abeta) peptide, (and neurofibrillary tangles) in the brain of the patient. Great efforts are being made to identify reliable biomarkers for AD that are suitable for mini...

journal_title：Current Alzheimer research

authors： Funke SA,Birkmann E,Willbold D

更新日期：2009-06-01 00:00:00

abstract：:Elevated amyloid-beta peptide (Abeta) and loss of nicotinic acetylcholine receptors (nAChRs) stand prominently in the etiology of Alzheimer's disease (AD). Since the discovery of an Abeta - nAChR interaction, much effort has been expended to characterize the consequences of high versus low concentrations of Abeta on n...

journal_title：Current Alzheimer research

authors： Parri RH,Dineley TK

更新日期：2010-02-01 00:00:00

abstract：:In the present study we set up a model of slow progression of neuronal injury by exposing organotypic hippocampal cultures to a low concentration of Amyloid β (25-35) peptide (Aβ, 2 μM) to analyze the time-related effects of 17-β estradiol (17β-E2, 10 nM). Neuronal death occurs after 7 d and is prevented by addition o...

journal_title：Current Alzheimer research

authors： Merlo S,Spampinato SF,Capani F,Sortino MA

更新日期：2016-01-01 00:00:00

abstract：:Deterioration of the cortical cholinergic system is a leading neurochemical feature of Alzheimer's Disease (AD). This review summarizes evidence that the homomeric α7- nicotinic acetylcholine receptor (nAChR) plays a crucial role in the pathogenesis of this disease, which is characterized by amyloid-β (Aβ) accumulatio...

journal_title：Current Alzheimer research

authors： Oz M,Lorke DE,Yang KH,Petroianu G

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Previous work designed a network-based protocol of cognitive training. This programme exploits a mechanism of induced task-oriented co-activation of multiple regions that are part of the default mode network (DMN), to induce functional rewiring and increased functional connectivity within this network. OBJE...

journal_title：Current Alzheimer research

authors： De Marco M,Meneghello F,Pilosio C,Rigon J,Venneri A

更新日期：2018-01-01 00:00:00

abstract：:Mutations in presenilin 1 (PS1) cause early-onset familial Alzheimer;s disease (FAD). Although FAD accounts for less than 5% of all cases of Alzheimer;s disease (AD), extensive analyses of PS1 function have elucidated an important neuronal mechanism underling AD pathogenesis. PS1 is considered to be an essential compo...

journal_title：Current Alzheimer research

authors： Uemura K,Kuzuya A,Shimohama S

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Vascular disease is associated with increased risk of dementia. Vascular health worsens with age. We investigated the relationship between self-reported vascular disease and brain pathology. METHODS:Brain donations to the population-based MRC Cognitive Function and Ageing Study (n=456, age range 66-103 year...

journal_title：Current Alzheimer research

authors： Richardson K,Stephan BC,Ince PG,Brayne C,Matthews FE,Esiri MM

更新日期：2012-07-01 00:00:00

abstract：:From a clinical as well as a neuropathological point of view Alzheimer's disease (AD) has been the focus of intense research for more than three decades. Most studies to identify morphometric correlates with the declining cognitive function in normal aging and AD have employed semi-quantitative methods to assess neuro...

journal_title：Current Alzheimer research

authors： Stark AK,Pelvig DP,Jørgensen AM,Andersen BB,Pakkenberg B

更新日期：2005-10-01 00:00:00

abstract：:Mutations in the presenilin genes cause the majority of early-onset familial Alzheimer’s disease. Recently, presenilin mutations have been identified in patients with dilated cardiomyopathy (DCM), a common cause of heart failure and the most prevalent diagnosis in cardiac transplantation patients. However, the molecul...

journal_title：Current Alzheimer research

authors： Li A,Zhou C,Moore J,Zhang P,Tsai TH,Lee HC,Romano DM,McKee ML,Schoenfeld DA,Serra MJ,Raygor K,Cantiello HF,Fujimoto JG,Tanzi RE

更新日期：2011-05-01 00:00:00

abstract：:Based on the amyloid hypothesis, studies for AD therapy have been mostly focused on removing β-amyloid. Recent results of amyloid immunotherapy raised the question whether β-amyloid is sufficient target for AD therapy. Neurofibrillary tangles (NFTs), which contain hyperphosphorylated tau, are another pathological hall...

journal_title：Current Alzheimer research

authors： Takashima A

更新日期：2010-12-01 00:00:00

abstract：:Mitochondrial dysfunction has been implicated in causing metabolic abnormalities in Alzheimer's disease (AD). The searches for mitochondrial DNA variants associated with AD susceptibility have generated conflicting results. The age-related accumulation of somatic mitochondrial DNA deletion has been suggested to play a...

journal_title：Current Alzheimer research

authors： Chen X,Stern D,Yan SD

更新日期：2006-12-01 00:00:00

abstract：:This article presents a new paradigm of Artificial Neural Networks (ANNs): the Auto-Contractive Maps (Auto-CM). The Auto-CM differ from the traditional ANNs under many viewpoints: the Auto-CM start their learning task without a random initialization of their weights, they meet their convergence criterion when all thei...

journal_title：Current Alzheimer research

authors： Buscema M,Grossi E,Snowdon D,Antuono P

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:The longitudinal change of neuropsychological tests (NPTs) in treated Alzheimer's disease (AD) is essential to understand the interplay of a therapeutic response from medication and a disease decline due to degenerative processes. The aim of our study is to investigate the annual cognitive progression as mea...

journal_title：Current Alzheimer research

authors： Yang YH,Wu MN,Chou PS,Su HC,Lin SH,Sung PS

更新日期：2018-03-14 00:00:00

abstract：:Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder among the elderly. Nmethyl- D-aspartate receptor (NMDAR) overactivation has been implicated in early synaptic dysfunction that precedes late neurodegeneration in AD. Moreover, oligomers of amyloid-beta peptide (Aβ) 1-42 are considered t...

journal_title：Current Alzheimer research

authors： Mota SI,Ferreira IL,Pereira C,Oliveira CR,Rego AC

更新日期：2012-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder linked to protein misfolding and aggregation. AD is pathologically characterized by senile plaques formed by extracellular Amyloid-β (Aβ) peptide and Intracellular Neurofibrillary Tangles (NFT) formed by hyperphosphorylated tau protein. Extensive synaptic loss a...

journal_title：Current Alzheimer research

authors： Pinheiro L,Faustino C

更新日期：2019-01-01 00:00:00

abstract：:At present, the etiology of Alzheimer's disease (AD) is still unclear, but both genetic and non-genetic factors are thought to take part in the etiopathogenesis of AD. Epidemiologic researches revealed that genetic factors played a decisive role in the development of both early-onset AD (EOAD) and late-onset AD (LOAD)...

journal_title：Current Alzheimer research

authors： Jiang T,Yu JT,Tian Y,Tan L

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that eventually leads to severe cognitive impairment. Although the exact etiologies of AD still remain elusive, increasing evidence suggests that neuroinflammation cascades mediated by microglial cells are associated with AD. Piper sarme...

journal_title：Current Alzheimer research

authors： Chan EWL,Yeo ETY,Wong KWL,See ML,Wong KY,Gan SY

更新日期：2019-01-01 00:00:00

abstract：:In the last decade, several radiolabeled compounds have been developed for the imaging in vivo of amyloid pathology by means of Positron Emission Tomography (PET). Among these, 18F Florbetaben appear to be one of the most reliable for its high affinity for amyloid plaques in brain and its radio-chemical properties tha...

journal_title：Current Alzheimer research

authors： Chiaravalloti A,Danieli R,Lacanfora A,Palumbo B,Caltagirone C,Schillaci O

更新日期：2017-01-01 00:00:00

abstract：:The remarkable potentiality of bone marrow-derived mesenchymal stem cells (BM-MSCs) after transplantation to models of neurological disease and injury has been described. We have previously published data confirming the influence of BM-MSCs on β-amyloid (Aβ) deposition in an Alzheimer's disease (AD) mouse model. Howev...

journal_title：Current Alzheimer research

authors： Bae JS,Jin HK,Lee JK,Richardson JC,Carter JE

更新日期：2013-06-01 00:00:00

abstract：:In this work, we present a fully automatic computer-aided diagnosis method for the early diagnosis of the Alzheimer's disease. We study the distance between classes (labelled as normal controls and possible Alzheimer's disease) calculated in 116 regions of the brain using the Welchs's t-test. We select the regions wit...

journal_title：Current Alzheimer research

authors： Salas-Gonzalez D,Segovia F,Martínez-Murcia FJ,Lang EW,Gorriz JM,Ramırez J

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The Montreal Cognitive Assessment (MoCA) test has high sensitivity and specificity for detecting mild cognitive impairment or early dementia. How the MoCA score relates to findings of positron emission tomography imaging, however, remains unclear. OBJECTIVE:This prospective study examined the relationship b...

journal_title：Current Alzheimer research

authors： Eguchi A,Kimura N,Aso Y,Yabuuchi K,Ishibashi M,Hori D,Sasaki Y,Nakamichi A,Uesugi S,Jikumaru M,Sumi K,Shimomura T,Matsubara E

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:It is well known that alterations in astrocytes occur in Alzheimer's disease and reactive astrogliosis is one of the hallmarks of the disease. Recently, data has emerged that suggests that alterations in astrocytes may also occur early in the pathogenesis of the disease. OBJECTIVE:The aim of present work wa...

journal_title：Current Alzheimer research

authors： Ruffinatti F,Tapella L,Gregnanin I,Stevano A,Chiorino G,Canonico PL,Distasi C,Genazzani AA,Lim D

更新日期：2018-01-01 00:00:00