Early diagnosis of Alzheimer's disease: is MCI too late?

abstract：:Soluble amyloid beta (Abeta) oligomers might trigger early cognitive impairment in Alzheimer's Disease (AD) through the impairment of proper neuronal network function. We have recently shown that the short sequence Abeta(25-35) affects the spontaneous activity in hippocampal slices, when was added to the bath, at high...

journal_title：Current Alzheimer research

authors： Balleza-Tapia H,Huanosta-Gutiérrez A,Márquez-Ramos A,Arias N,Peña F

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a neurodegenerative disease featured by memory loss, neuroinflammation and oxidative stress. Overproduction or insufficient clearance of Aβ leads to its pathological aggregation and deposition, which is considered the predominant neuropathological hallmark of AD. Therefore, reduci...

journal_title：Current Alzheimer research

authors： Liu SY,Lu S,Yu XL,Yang SG,Liu W,Liu XM,Wang SW,Zhu J,Ji M,Liu DQ,Zhang ZP,Liu RT

更新日期：2018-01-01 00:00:00

abstract：:To search for potential mechanism that might alter synaptic transmission following Abeta increase we have examined the presynaptic component of transmitter release. As parameters of synaptic transmission that might underlie presynaptic mechanisms, we have used paired-pulse facilitation (PPF), post-tetanic potentiation...

journal_title：Current Alzheimer research

authors： Zhang H,Gong B,Liu S,Fa' M,Ninan I,Staniszewski A,Arancio O

更新日期：2005-04-01 00:00:00

abstract：:Rodents housed in an enriched environment, exercise by running or perform learning and memory tasks show an increase in hippocampal neurogenesis. We show that both environmental enrichment, as well as performance in the Morris water maze, a hippocampal-dependent learning task, leads to an increase in local VEGF expres...

journal_title：Current Alzheimer research

authors： During MJ,Cao L

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Previous work designed a network-based protocol of cognitive training. This programme exploits a mechanism of induced task-oriented co-activation of multiple regions that are part of the default mode network (DMN), to induce functional rewiring and increased functional connectivity within this network. OBJE...

journal_title：Current Alzheimer research

authors： De Marco M,Meneghello F,Pilosio C,Rigon J,Venneri A

更新日期：2018-01-01 00:00:00

abstract：:The marginal division (MrD) is a neostriatum subregion that links the limbic system and basal nucleus of Meynert; it is an important subcortical center that is involved in learning and memory. Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia in the elderly. AD clinically m...

journal_title：Current Alzheimer research

authors： Zhang Z,Liu Y,Zhou B,Zheng J,Yao H,An N,Wang P,Guo Y,Dai H,Wang L,Shu S,Zhang X,Jiang T

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:The Alzheimer's Disease Assessment Scale - cognitive subscale (ADAS-cog) is the most widely used cognitive outcome measure in AD trials. Although errors in administration and scoring have been suggested as factors masking accurate estimates and potential effects of treatments, there have been few formal exam...

journal_title：Current Alzheimer research

authors： Schafer K,De Santi S,Schneider LS

更新日期：2011-06-01 00:00:00

abstract：:The Twentieth Century witnessed tremendous advances in our understanding of neurodegenerative diseases. Not least among them were the contributions from hyperendemic foci of neurodegenerative disorders in isolated human groups worldwide, with the knowledge gained applicable to our understanding of related neurodegener...

journal_title：Current Alzheimer research

authors： Garruto RM

更新日期：2006-09-01 00:00:00

abstract：:Serum levels of β-amyloid (Aβ) peptides may represent an early biomarker in the diagnosis of Alzheimer's disease (AD). In the present study, we investigated the temporal kinetic changes in the levels of serum Aβ 1-42 and 40 in an amyloid precursor protein (APP)/presenilin (PS)1 double transgenic mouse model of AD. Ser...

journal_title：Current Alzheimer research

authors： He J,Qiao JP,Zhu S,Xue M,Chen W,Wang X,Tempier A,Huang Q,Kong J,Li XM

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Vascular disease is associated with increased risk of dementia. Vascular health worsens with age. We investigated the relationship between self-reported vascular disease and brain pathology. METHODS:Brain donations to the population-based MRC Cognitive Function and Ageing Study (n=456, age range 66-103 year...

journal_title：Current Alzheimer research

authors： Richardson K,Stephan BC,Ince PG,Brayne C,Matthews FE,Esiri MM

更新日期：2012-07-01 00:00:00

abstract：:Lipids have many important yet distinct functions in cellular homeostasis such as forming an impermeable barrier separating intracellular and extracellular compartments, providing a matrix for the appropriate interactions of membrane-associated proteins, and serving as storage reservoirs for biologically active second...

journal_title：Current Alzheimer research

authors： Han X

更新日期：2005-01-01 00:00:00

abstract：:Metabotropic glutamate receptor 5 (mGluR5) is highly expressed throughout the forebrain and hippocampus. Several lines of evidence support the role of this receptor in brain development and developmental disorders, as well as in neurodegenerative disorders like Alzheimer's disease (AD). In the present study, the expre...

journal_title：Current Alzheimer research

authors： Iyer AM,van Scheppingen J,Milenkovic I,Anink JJ,Lim D,Genazzani AA,Adle-Biassette H,Kovacs GG,Aronica E

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the diagnostic accuracy and clinical usability of a Dutch translation of the Test Your Memory (TYM) test in patients with mild cognitive impairment (MCI) and dementia as compared to the Mini-Mental State Examination (MMSE), in the setting of the memory clinic of a general...

journal_title：Current Alzheimer research

authors： van de Zande E,van de Nes JC,Jansen I,van den Berg MN,Zwart AF,Bimmel D,Rijkers GT,Andringa G

更新日期：2017-01-01 00:00:00

abstract：:High levels of cholesterol have been proposed as a risk factor for Alzheimer's disease (AD). Polymorphism of genes encoding proteins that regulate cholesterol metabolism have also been associated with the frequency of Alzheimer's development. Some studies have shown that cholesterol-lowering drugs reduce the frequency...

journal_title：Current Alzheimer research

authors： Vestergaard M,Hamada T,Morita M,Takagi M

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Recent work on Alzheimer's disease (AD) diagnosis focuses on neuroimaging modalities; however, these methods are expensive, invasive, and not available to all patients. Ocular imaging of biomarkers, such as drusen in the peripheral retina, could provide an alternative method to diagnose AD. OBJECTIVE:This s...

journal_title：Current Alzheimer research

authors： Ukalovic K,Cao S,Lee S,Tang Q,Beg MF,Sarunic MV,Hsiung GR,Mackenzie IR,Hirsch-Reinshagen V,Cui JZ,Matsubara JA

更新日期：2018-01-01 00:00:00

abstract：:Changes in rRNA and rDNA expression have been associated with cellular and organism aging and have been linked to Alzheimer's disease (AD) pathogenesis. In this study, we investigated the mRNA expression of ribosomal genes (28S/18S) and β-amyloid precursor protein (APP) in different post mortem brain tissue regions (t...

journal_title：Current Alzheimer research

authors： Rasmussen L,de Labio RW,Viani GA,Chen E,Villares J,Bertolucci PH,Minett TS,Turecki G,Cecyre D,Drigo SA,Smith MC,Payao SL

更新日期：2015-01-01 00:00:00

abstract：:In this work, we present a fully automatic computer-aided diagnosis method for the early diagnosis of the Alzheimer's disease. We study the distance between classes (labelled as normal controls and possible Alzheimer's disease) calculated in 116 regions of the brain using the Welchs's t-test. We select the regions wit...

journal_title：Current Alzheimer research

authors： Salas-Gonzalez D,Segovia F,Martínez-Murcia FJ,Lang EW,Gorriz JM,Ramırez J

更新日期：2016-01-01 00:00:00

abstract：:Mitochondrial dysfunction has been implicated in causing metabolic abnormalities in Alzheimer's disease (AD). The searches for mitochondrial DNA variants associated with AD susceptibility have generated conflicting results. The age-related accumulation of somatic mitochondrial DNA deletion has been suggested to play a...

journal_title：Current Alzheimer research

authors： Chen X,Stern D,Yan SD

更新日期：2006-12-01 00:00:00

abstract：:The remarkable potentiality of bone marrow-derived mesenchymal stem cells (BM-MSCs) after transplantation to models of neurological disease and injury has been described. We have previously published data confirming the influence of BM-MSCs on β-amyloid (Aβ) deposition in an Alzheimer's disease (AD) mouse model. Howev...

journal_title：Current Alzheimer research

authors： Bae JS,Jin HK,Lee JK,Richardson JC,Carter JE

更新日期：2013-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is currently the most prominent form of dementia among the elderly. Although AD manifests in late adult life, it is not clear when the disease actually starts and how long the neuropathological processes take to develop AD. The major unresolved question is the timing and the nature of triggeri...

journal_title：Current Alzheimer research

authors： Lahiri DK,Maloney B,Basha MR,Ge YW,Zawia NH

更新日期：2007-04-01 00:00:00

abstract：:Altered progranulin levels play a major role in neurodegenerative diseases, like Alzheimer's dementia (AD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), even in the absence of GRN mutations. Increasing progranulin levels could hereby provide a novel treatment strategy. However, knowledge on p...

journal_title：Current Alzheimer research

authors： Wilke C,Gillardon F,Deuschle C,Dubois E,Hobert MA,Müller vom Hagen J,Krüger S,Biskup S,Blauwendraat C,Hruscha M,Kaeser SA,Heutink P,Maetzler W,Synofzik M

更新日期：2016-01-01 00:00:00

abstract：:In this study, we aimed to classify MR images for recognizing Alzheimer Disease (AD) in a group of patients who were recently diagnosed by clinical history and neuropsychiatric exams by using non-biased machine-learning techniques. T1 weighted MRI scans of 31 patients with probable AD and 31 age- and gender-matched co...

journal_title：Current Alzheimer research

authors： Polat F,Demirel SO,Kitis O,Simsek F,Haznedaroglu DI,Coburn K,Kumral E,Gonul AS

更新日期：2012-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common diagnosis among dementia. As increasing longevity results in larger numbers of AD patients and thus rising economic costs, there has been intense research about the pathophysiology and treatment strategies during the last years. Since neurotrophic factors are not only respon...

journal_title：Current Alzheimer research

authors： Schulte-Herbrüggen O,Jockers-Scherübl MC,Hellweg R

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:ACTION, a 24-week, prospective, randomized, parallel-group, double-blind study in patients with severe Alzheimer's disease (AD), demonstrated significant efficacy of 13.3 mg/24 h versus 4.6 mg/24 h rivastigmine patch on the Severe Impairment Battery (SIB) and Alzheimer's Disease Cooperative Study-Activities ...

journal_title：Current Alzheimer research

authors： Grossberg GT,Farlow MR,Meng X,Velting DM

更新日期：2015-01-01 00:00:00

abstract：:Heme is essential for the survival of most organisms, despite the fact of being potentially toxic. This dual effect is due to the ability of the iron (Fe) atom contained within the protoporphyrin ring of the heme molecule to participate in redox reactions and exchange electrons with a variety of substrates. Therefore,...

journal_title：Current Alzheimer research

authors： Gozzelino R

更新日期：2016-01-01 00:00:00

abstract：:Amyloid beta peptide (Abeta), 42-residue peptide and its variations, is known to form amyloid fibrils in Alzheimer's disease. Solid-state NMR study reveals a parallel beta-sheet structure in the Abeta fibrils. The atomic level structure of Abeta in aqueous environment, however, has not been determined, because of its ...

journal_title：Current Alzheimer research

authors： Takano K

更新日期：2008-12-01 00:00:00

abstract：:Human memory can be split into familiarity and recollection processes which contribute to different aspects of memory function. These separate processes result in different experiential states. In this review, we examine how this dominant theoretical framework can explain the subjective experience of people with Alzhe...

journal_title：Current Alzheimer research

authors： Souchay C,Moulin CJ

更新日期：2009-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive degenerative disorder of the brain and is the most common form of dementia. To-date no simple, inexpensive and minimally invasive procedure is available to confirm with certainty the early diagnosis of AD prior to the manifestations of symptoms characteristic of the disease. T...

journal_title：Current Alzheimer research

authors： François M,Leifert W,Martins R,Thomas P,Fenech M

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:Memory evaluation is a key component in the accurate diagnosis of cognitive disorders.One memory procedure that has shown promise in discriminating disease-related cognitive decline from normal cognitive aging is the New York University Paragraph Recall Test; however, the effects of education have been unexa...

journal_title：Current Alzheimer research

authors： Mathews M,Abner E,Caban-Holt A,Dennis BC,Kryscio R,Schmitt F

更新日期：2013-09-01 00:00:00

abstract：:Recent studies have shown that the translocase of outer mitochondrial membrane 40 homolog (TOMM40) contains a polymorphic poly-T variant, the long variant of which is associated with an increase in AD incidence among APOE 3 carriers. Current methods to isotype the poly-T region rely on long PCR, subcloning and sequenc...

journal_title：Current Alzheimer research

authors： Greco SJ,Hamzelou A,Johnston JM,Richardson S,Smith MA,Perry G,Ashford JW,Tezapsidis N

更新日期：2012-12-01 00:00:00