Abstract:
:Stress caused by adverse and demanding conditions, a risk factor for mental illnesses, induces adaptive or maladaptive neural and behavioral consequences, depending on the conditions. Studies using rodent stress models have revealed multiple mechanisms related to dopamine and inflammation for stress-induced neural and behavioral changes. Thus, repeated stress alters activities of ventral tegmental area dopamine neurons projecting to the nucleus accumbens and the medial prefrontal cortex in distinct manners. In the nucleus accumbens, repeated stress decreases activities of D1 receptor-expressing neurons. In the medial prefrontal cortex, single stress increases dopamine D1 receptor signaling, leading to dendritic hypertrophy of excitatory neurons and stress resilience. These changes are attenuated with repetition of stress via prostaglandin E2 , an inflammation-related lipid mediator. Repeated stress activates microglia in the medial prefrontal cortex and the hippocampus. Innate immune receptors, such as the toll-like receptor 2/4 and P2X7, are crucial for repeated stress-induced microglial activation, leading to neural and behavioral changes through proinflammatory cytokines. In addition, repeated stress induces monocyte infiltration to the brain, and impairs the blood-brain barrier in the nucleus accumbens, leading to cytokine leakage to the brain. These monocyte-derived responses are involved in stress-induced behavioral changes. These findings show crucial roles of the accumbal and prefrontal dopamine pathways and inflammatory responses in the brain and body to direct adaptive and maladaptive consequences of stress, and pave the way for identifying a neural origin of stress and understanding the stress-related pathology of mental illnesses.
journal_name
Psychiatry Clin Neuroscijournal_title
Psychiatry and clinical neurosciencesauthors
Furuyashiki T,Kitaoka Sdoi
10.1111/pcn.12901subject
Has Abstractpub_date
2019-11-01 00:00:00pages
669-675issue
11eissn
1323-1316issn
1440-1819journal_volume
73pub_type
杂志文章,评审abstract::The aim of this study was to test different definitions of depressive mixed state (DMX) (major depressive episode (MDE) with some concurrent hypomanic symptoms), to find which one could better define DMX. Unipolar and bipolar II MDE outpatients (n = 168) were interviewed with the DSM-IV Structured Clinical Interview. ...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.2001.00919.x
更新日期:2001-12-01 00:00:00
abstract:AIM:We compared the 1-year rehospitalization rates of first-episode bipolar manic patients who were discharged while being treated with lithium or valproate in combination with an atypical antipsychotic. METHODS:We investigated the rehospitalization status of first-episode bipolar manic patients who were discharged be...
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doi:10.1111/pcn.12145
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journal_title:Psychiatry and clinical neurosciences
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doi:10.1046/j.1440-1819.2003.01094.x
更新日期:2003-04-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.2002.00938.x
更新日期:2002-02-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章,随机对照试验
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更新日期:2007-10-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.1998.00418.x
更新日期:1998-08-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/pcn.12153
更新日期:2014-06-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.1998.tb01009.x
更新日期:1998-04-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
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doi:10.1111/j.1440-1819.2011.02204.x
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2007.01611.x
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journal_title:Psychiatry and clinical neurosciences
pub_type: 临床试验,杂志文章
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2008.01806.x
更新日期:2008-06-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
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更新日期:2003-04-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.1998.tb01019.x
更新日期:1998-04-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章,评审
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更新日期:2020-03-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
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更新日期:2013-11-01 00:00:00
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更新日期:1997-08-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章,评审
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journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
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更新日期:2002-06-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
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更新日期:2009-04-01 00:00:00
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更新日期:2008-08-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
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更新日期:2010-08-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.1995.tb01877.x
更新日期:1995-05-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2010.02131.x
更新日期:2010-10-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 临床试验,杂志文章
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更新日期:2004-06-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.1999.00526.x
更新日期:1999-04-01 00:00:00