Abstract:
AIM:Although peripheral low-grade inflammation and brain-derived neurotrophic factor (BDNF) levels have been implicated in schizophrenia (SCZ), the interactions between them remain to be fully revealed. We aimed to compare BDNF and cytokines in patients with SCZ and healthy controls (HC). Additionally, we aimed to investigate the association between peripheral levels of cytokines and BDNF in patients with SCZ. METHODS:Plasma levels of BDNF, interferon gamma, interleukin (IL)-10, IL-12, IL-1, IL-6, IL-8, tumor necrosis factor alpha, macrophage migration inhibitory factor, IL-1 receptor antagonist (IL-1Ra), and CD40 Ligand were compared in 45 SCZ patients and 38 HC using Luminex technology. RESULTS:Compared to HC, patients had significantly higher IL-1Ra levels (P = 0.031). We found a strong positive association between BDNF and CD40 Ligand in the patient group (rho = 0.858, P < 0.001) as well as in the HC group (rho = 0.822, P < 0.001), respectively. Furthermore, there was a negative association between BDNF and tumor necrosis factor alpha in patients (rho = -0.429, P = 0.030) as well as in HC (rho = -0.649, P < 0.001). CONCLUSION:These results suggest that the cytokine IL-1Ra may play a role in SCZ pathophysiology. Additionally, the interaction between cytokines and BDNF levels further indicated the diverse actions of these cytokines.
journal_name
Psychiatry Clin Neuroscijournal_title
Psychiatry and clinical neurosciencesauthors
Zhou Y,Peng W,Wang J,Zhou W,Zhou Y,Ying Bdoi
10.1111/pcn.12794subject
Has Abstractpub_date
2019-03-01 00:00:00pages
109-115issue
3eissn
1323-1316issn
1440-1819journal_volume
73pub_type
杂志文章abstract::The lifetime prevalence of social anxiety disorder (SAD) is high at 3-13%, but there have been only limited reports investigating the clinical features of this disorder in a large number of Japanese patients. The authors have conducted a retrospective, chart review study of 52 patients with SAD and obtained the follow...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2006.01524.x
更新日期:2006-08-01 00:00:00
abstract:AIMS:Near-infrared spectroscopy has the potential for aiding the diagnosis of major depressive disorder. The purpose of this study was to systematically review the evidence from observational studies regarding the use of near-infrared spectroscopy in patients with major depressive disorder and to identify the character...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章,meta分析
doi:10.1111/pcn.12209
更新日期:2015-01-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2004.01281.x
更新日期:2004-08-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/pcn.12863
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.2000.00653.x
更新日期:2000-04-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2011.02252.x
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/pcn.13099
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journal_title:Psychiatry and clinical neurosciences
pub_type: 临床试验,杂志文章
doi:10.1111/j.1440-1819.2004.01228.x
更新日期:2004-06-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
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doi:10.1111/j.1440-1819.1997.tb02611.x
更新日期:1997-12-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2005.01331.x
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.1998.tb00989.x
更新日期:1998-04-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.2002.01061.x
更新日期:2002-12-01 00:00:00
abstract::In September 1987 in Japan, the Mental Hygiene Law was amended to the Mental Health Law. This Law emphasizes the protection of human rights of the mentally disabled as well as the promotion of their social rehabilitation. In 1993, Mental Health Law was partially revised in the following four areas: (i) social rehabili...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.1998.tb03235.x
更新日期:1998-12-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2005.01397.x
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.2003.01150.x
更新日期:2003-10-01 00:00:00
abstract::Little is known about the neuronal mechanism underpinning the pathophysiology of compulsive hoarding. We report the cerebral blood flow changes in an obsessive-convulsive patient with severe hoarding. The patient showed hyperperfusion of the fronto-temporal region and hypoperfusion of the striatal, the middle cingulat...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2010.02120.x
更新日期:2010-10-01 00:00:00
abstract:AIM:Internet addiction disrupts the daily lives of adolescents. We investigated the prevalence of Internet addiction in junior high school students, elucidated the relation between Internet addiction and mental states, and determined the factors associated with Internet addiction in adolescents. METHODS:Junior high sc...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/pcn.12402
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
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journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.2000.00757.x
更新日期:2000-10-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2009.01996.x
更新日期:2009-08-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.1999.00489.x
更新日期:1999-04-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2008.01903.x
更新日期:2009-02-01 00:00:00
abstract::The National Adult Reading Test (NART) is widely used as a measure of premorbid IQ of the English-speaking patients with dementia. The purpose of the present study was to develop a Japanese version of the NART (JART), using 50 Japanese irregular words, all of which are Kanji (ideographic script) compound words. Readin...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2006.01510.x
更新日期:2006-06-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
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doi:10.1111/pcn.12375
更新日期:2016-04-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.1999.00466.x
更新日期:1999-02-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/j.1440-1819.2010.02180.x
更新日期:2011-03-01 00:00:00
abstract:AIM:The Wechsler Intelligence Scale for Children 4th edition-Chinese version (WISC-IV-Chinese) has been in clinical use in Taiwan since 2007. Research is needed to determine how the WISC-IV, modified from its earlier version, will affect its interpretation in clinical practice in a Mandarin-speaking context. METHODS:W...
journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1111/pcn.12014
更新日期:2013-02-01 00:00:00
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journal_title:Psychiatry and clinical neurosciences
pub_type: 杂志文章
doi:10.1046/j.1440-1819.2002.00957.x
更新日期:2002-06-01 00:00:00