Abstract:
:Merkel cell carcinoma (MCC) is a rare neuroendocrine carcinoma of the skin, for which the exact mechanisms of carcinogenesis remain unknown. Therapeutic options for this highly aggressive malignancy have historically been limited in both their initial response and response durability. Recent improvements in our understanding of MCC tumor biology have expanded therapeutic options for these patients, namely through the use of immunotherapies such as immune checkpoint inhibitors. Further elucidation of the tumor mutational landscape has identified molecular targets for therapies, which have demonstrated success in other cancer types. In this review, we discuss both current and investigational immune and molecular targets of therapy for MCC.
journal_name
Mol Carcinogjournal_title
Molecular carcinogenesisauthors
Cohen L,Tsai KYdoi
10.1002/mc.23042subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1602-1611issue
9eissn
0899-1987issn
1098-2744journal_volume
58pub_type
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